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Methodologies for Improving HDR Efficiency

Liu, Mingjie, Rehman, Saad, Tang, Xidian, Gu, Kui, Fan, Qinlei, Chen, Dekun, Ma, Wentao·2019·Frontiers in Genetics
DOI 10.3389/fgene.2018.00691PMC PMC6338032
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  • HDR is most active in the late S and G2 phases of the cell cycle.

    “It is most active in the late S and G2 phases of the cell cycle.”

    From Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing (2021) · cites this paper as [16]

  • NHEJ is active in all phases of the cell cycle.

    “NHEJ facilitates the repair of DSBs by joining DNA fragments through an enzymatic process in the absence of exogenous homologous DNA and is active in all phases of the cell cycle.”

    From Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing (2021) · cites this paper as [16]

  • In CRISPR-gene editing, HDR requires a large amount of donor (exogenous) DNA templates containing a sequence of interest.

    “In CRISPR-gene editing, HDR requires a large amount of donor (exogenous) DNA templates containing a sequence of interest.”

    From Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing (2021) · cites this paper as [16]

  • HDR executes the precise gene insertion or replacement by adding a donor DNA template with sequence homology at the predicted DSB site.

    “HDR executes the precise gene insertion or replacement by adding a donor DNA template with sequence homology at the predicted DSB site.16,17”

    From Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing (2021) · cites this paper as [16]

  • Non-homologous end joining (NHEJ) and homology-directed repair (HDR) pathways are the two mechanisms to repair DSBs created by Cas-9 protein in CRISPR/Cas-9 mechanism.

    “Non-homologous end joining (NHEJ), and homology-directed repair (HDR) pathways are the two mechanisms to repair DSBs created by Cas-9 protein in CRISPR/Cas-9 mechanism.16”

    From Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing (2021) · cites this paper as [16]

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Research works printed but not linked: 103

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Metadata

Authors
Liu, M., Rehman, S., Tang, X., Gu, K., Fan, Q., Chen, D., & Ma, W.
Venue
Frontiers in Genetics
Publisher
Frontiers Media SA
Published
2019-01-07
Volume
9
ISSN
1664-8021
DOI
10.3389/fgene.2018.00691
PMC
PMC6338032
Cited by
323
References
18
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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