Sleep deprivation alters valuation signals in the ventromedial prefrontal cortex
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Even a single night of total sleep deprivation (SD) can have dramatic effects on economic decision making. Here we tested the novel hypothesis that SD influences economic decisions by altering the valuation process. Using functional magnetic resonance imaging we identified value signals related to the anticipation and the experience of monetary and social rewards (attractive female faces). We then derived decision value signals that were predictive of each participant's willingness to exchange money for brief views of attractive faces in an independent market task. Strikingly, SD altered decision value signals in ventromedial prefrontal cortex (VMPFC) in proportion to the corresponding change in economic preferences. These changes in preference were independent of the effects of SD on attention and vigilance. Our results provide novel evidence that signals in VMPFC track the current state of the individual, and thus reflect not static but constructed preferences.
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Sleep deprivation in adults impacts brain function related to reward processing, risk-taking, and cognition.
“Although neuroimaging research in adults has shown that sleep deprivation impacts brain function related to reward processing, risk-taking, and cognition (Chee et al., 2011; Gujar et al., 2011; Libedinsky et al., 2011; Venkatraman et al., 2011), only a few developmental studies have examined how sleep influences reward-related brain function in adolescents (Hasler et al., 2012; Holm et al., 2009)”
From The effects of poor quality sleep on brain function and risk taking in adolescence (2013) · cites this paper as Libedinsky et al., 2011
Sleep deficit, commonly exhibited by individuals with ASD, alters reward receptivity, particularly to social rewards.
“sleep deficit, a problem commonly exhibited by individuals with ASD [216], alters reward receptivity, particularly to social rewards [217-219].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [217]
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- Authors
- Libedinsky, C., Smith, D. V., Teng, C. S., Namburi, P., Chen, V. W., Huettel, S. A., & Chee, M. W. L.
- Affiliations
- National University of Singapore (SG)
- Duke University (US)
- Corresponding author
- Chee, Michael W. L.
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2011
- Volume
- 5
- Pages
- 70-70
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC3199544
- OpenAlex
- W2107133943
- Cited by
- 79
- References
- 55
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 7 · 2014: 6 · 2013: 12 · 2012: 9
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- TUScholarShare (Temple University) (submittedVersion)
- Funders
- National Research Foundation
- Duke Institute for Brain Sciences, Duke University (NIMH RC1-088680)
- National Institute of Mental Health (F31-086248, RC1-088680, F31MH086248)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep deprivation, ventromedial prefrontal cortex, reward valuation, economic decision-making, willingness to pay, monetary rewards, social reward, female faces, preference construction
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