Cited by 1,425Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsIntensive Care Unit Cognitive Disorders

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Behavioral and Psychological Symptoms of Dementia

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Cerejeira, J., Lagarto, L., Mukaetova-Ladinska, E. B.·2012·Frontiers in Neurology

DOI 10.3389/fneur.2012.00073PMC PMC3345875

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Abstract

Behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms and behaviors occurring in subjects with dementia. BPSD constitute a major component of the dementia syndrome irrespective of its subtype. They are as clinically relevant as cognitive symptoms as they strongly correlate with the degree of functional and cognitive impairment. BPSD include agitation, aberrant motor behavior, anxiety, elation, irritability, depression, apathy, disinhibition, delusions, hallucinations, and sleep or appetite changes. It is estimated that BPSD affect up to 90% of all dementia subjects over the course of their illness, and is independently associated with poor outcomes, including distress among patients and caregivers, long-term hospitalization, misuse of medication, and increased health care costs. Although these symptoms can be present individually it is more common that various psychopathological features co-occur simultaneously in the same patient. Thus, categorization of BPSD in clusters taking into account their natural course, prognosis, and treatment response may be useful in the clinical practice. The pathogenesis of BPSD has not been clearly delineated but it is probably the result of a complex interplay of psychological, social, and biological factors. Recent studies have emphasized the role of neurochemical, neuropathological, and genetic factors underlying the clinical manifestations of BPSD. A high degree of clinical expertise is crucial to appropriately recognize and manage the neuropsychiatric symptoms in a patient with dementia. Combination of non-pharmacological and careful use of pharmacological interventions is the recommended therapeutic for managing BPSD. Given the modest efficacy of current strategies, there is an urgent need to identify novel pharmacological targets and develop new non-pharmacological approaches to improve the adverse outcomes associated with BPSD.

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Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,772
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069
Self-citation
The Alzheimer’s disease neuroimaging initiative (ADNI): MRI methods
Jack, C. R., Bernstein, M. A., Fox, N. C., Thompson, P., Alexander, G., Harvey, D., Borowski, B., Britson, P. J., L. Whitwell, J., Ward, C., et al. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21049 · Cited by 4,347
The Neuropsychiatric Inventory
Cummings, J. L. (1997) · Neurology · doi:10.1212/wnl.48.5_suppl_6.10s · Cited by 2,055
Prevalence of Neuropsychiatric Symptoms in Dementia and Mild Cognitive Impairment: Results From the Cardiovascular Health Study
Lyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J., & DeKosky, S. (2002) · JAMA · doi:10.1001/jama.288.12.1475 · Cited by 2,049
Depression in the elderly
Alexopoulos, G. S. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66665-2 · Cited by 2,024
Untitled work
(1987) · PubMed · Cited by 1,147
Mental and Behavioral Disturbances in Dementia: Findings From the Cache County Study on Memory in Aging
Lyketsos, C. G., Steinberg, M., Tschanz, J. T., Norton, M. C., Steffens, D. C., & Breitner, J. C. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.708 · Cited by 1,144
Donepezil and memantine for moderate-to-severe Alzheimer's disease
Howard, R., McShane, R., Lindesay, J., Ritchie, C., Baldwin, A., Barber, R., Burns, A., Dening, T., Findlay, D., Holmes, C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1106668 · Cited by 782
Behavioral and Psychological Signs and Symptoms of Dementia: A Consensus Statement on Current Knowledge and Implications for Research and Treatment
Finkel, S. I., Miller, S., Silva, J. C. E., Cohen, G. D., & Sartorius, N. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297003943 · Cited by 651
Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders
Robert, P. H., Onyike, C. U., Leentjens, A. F. G., Dujardin, K., Aalten, P., STARKSTEIN, S. E., Verhey, F. R. J., Yessavage, J., Clément, J., Drapier, D., et al. (2009) · European Psychiatry · doi:10.1016/j.eurpsy.2008.09.001 · Cited by 618
Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe
Harding, A., Broe, G. A., & Halliday, G. M. (2002) · Brain · doi:10.1093/brain/awf033 · Cited by 609
Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease?
Bozeat, S. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.2.178 · Cited by 603
Systematic Review of Psychological Approaches to the Management of Neuropsychiatric Symptoms of Dementia
Livingston, G., Johnston, K., Katona, C., Paton, J., Lyketsos, C. G., & Old Age Task Force of the World Federation of Biological Psychiatry (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.11.1996 · Cited by 591
Frontotemporal dementia
Neary, D., Snowden, J. S., & Mann, D. M. A. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70223-4 · Cited by 558
Depression in Patients With Mild Cognitive Impairment Increases the Risk of Developing Dementia of Alzheimer Type
Modrego, P. J., & Ferrández, J. (2004) · Archives of Neurology · doi:10.1001/archneur.61.8.1290 · Cited by 539
Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer's disease
Ikeda, M. (2002) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.4.371 · Cited by 499
Neuroanatomical correlates of behavioural disorders in dementia
Rosen, H. J., Allison, S. C., Schauer, G. F., Gorno-Tempini, M. L., Weiner, M. W., & Miller, B. L. (2005) · Brain · doi:10.1093/brain/awh628 · Cited by 497
Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity
Poulin, S. P., Dautoff, R. J., Morris, J. C., Barrett, L. F., & Dickerson, B. C. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.06.014 · Cited by 466
The Behavior Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease. The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease
Tariot, P. N., Mack, J. L., Patterson, M. B., Edland, S. D., Weiner, M., Fillenbaum, G. G., Blazina, L., Teri, L. L., Rubin, E. H., & Mortimer, J. A. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1349 · Cited by 426
Increased Hippocampal Plaques and Tangles in Patients With Alzheimer Disease With a Lifetime History of Major Depression
Rapp, M. A., Beeri, M. S., Grossman, H. T., Sano, M. C., Perl, D. P., Purohit, D. P., Gorman, J. M., & Haroutunian, V. H. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.161 · Cited by 401
Neuropsychiatric Syndromes in Dementia
Aalten, P., Verhey, F. R. J., Boziki, M. K., Bullock, R. A., Byrne, E. J., Camus, V., Caputo, M., Collins, D., Deyn, P. P. D., Elina, K., et al. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000110738 · Cited by 388
Risk of Mortality Among Individual Antipsychotics in Patients With Dementia
Kales, H. C., Kim, H. M., Zivin, K., Valenstein, M., Seyfried, L. S., Chiang, C., Cunningham, F., Schneider, L. S., & Blow, F. C. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11030347 · Cited by 384
Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population
Savva, G. M., ZACCAI, J. H., Matthews, F. E., Davidson, J. E., McKeith, I. G., & Brayne, C. (2009) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.108.049619 · Cited by 382
Management of behavioral problems in Alzheimer's disease
Gauthier, S. G., Cummings, J. L., Ballard, C. G., Brodaty, H., Grossberg, G. T., Robert, P. H., & Lyketsos, C. G. (2010) · International Psychogeriatrics · doi:10.1017/s1041610209991505 · Cited by 379
Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease
Bruen, P. D., McGeown, W. J., Shanks, M. F., & Venneri, A. (2008) · Brain · doi:10.1093/brain/awn151 · Cited by 374
Delusions and Hallucinations Are Associated With Worse Outcome in Alzheimer Disease
Scarmeas, N., Brandt, J., Albert, M., Hadjigeorgiou, G. M., Papadimitriou, A., Dubois, B., Sarazin, M., Devanand, D. P., Honig, L. S., Marder, K. S., et al. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1601 · Cited by 350
The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease
Holmes, C., Wilkinson, D., Dean, C., Vethanayagam, S., Olivieri, S., Langley, A., Pandita-Gunawardena, N. D., Hogg, F., Clare, C., & Damms, J. (2004) · Neurology · doi:10.1212/01.wnl.0000129990.32253.7b · Cited by 339
Depression and Alzheimer's disease: Neurobiological links and common pharmacological targets
Caraci, F., Copani, A., Nicoletti, F., & Drago, F. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.022 · Cited by 325
A Systematic Review of Neuropsychiatric Symptoms in Mild Cognitive Impairment
Monastero, R., Mangialasche, F., Camarda, C., Ercolani, S., & Camarda, R. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1120 · Cited by 305
Antidepressants for agitation and psychosis in dementia
Seitz, D. P., Adunuri, N., Gill, S. S., Gruneir, A., Herrmann, N., & Rochon, P. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008191.pub2 · Cited by 304
Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementia
Bathgate, D., Snowden, J. S., Varma, A. R., Blackshaw, A. J., & Neary, D. (2001) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2001.2000236.x · Cited by 297
Neuropsychiatric Predictors of Progression from Amnestic-Mild Cognitive Impairment to Alzheimer's Disease: The Role of Depression and Apathy
Palmer, K., Iulio, F. D., Varsi, A. E., Gianni, W., Sancesario, G., Caltagirone, C., & Spalletta, G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1352 · Cited by 290
Psychiatric Symptoms Vary With the Severity of Dementia in Probable Alzheimer's Disease
Lopez, O. L., Becker, J. T., Sweet, R. A., Klunk, W., Kaufer, D. I., Saxton, J., Habeych, M., & DeKosky, S. T. (2003) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.15.3.346 · Cited by 286
The cost of behavioral and psychological symptoms of dementia (BPSD) in community dwelling Alzheimer's disease patients
Schnaider Beeri, M., Werner, P., Davidson, M., & Noy, S. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.490 · Cited by 284
Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease
Tekin, S., Mega, M. S., Masterman, D. M., Chow, T. W., Garakian, J., Vinters, H. V., & Cummings, J. L. (2001) · Annals of Neurology · doi:10.1002/ana.72 · Cited by 278
Alzheimer Disease and Frontotemporal Dementias
Levy, M. L. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550070129021 · Cited by 277
Neuropathologic and Neurochemical Correlates of Psychosis in Primary Dementia
Zubenko, G. S., Moossy, J. J., Martinez, A. J., Rao, G., Claassen, D. O., Rosen, J., & Kopp, U. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530180075020 · Cited by 275
Neuropsychiatric disturbance in Alzheimer’s disease clusters into three groups: The Cache County study
Lyketsos, C. G., Sheppard, J. E., Steinberg, M., Tschanz, J. A. T., Norton, M. C., Steffens, D. C., & Breitner, J. C. S. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.448 · Cited by 275
Determinants of burden in those who care for someone with dementia
Campbell, P., Wright, J., Oyebode, J., Job, D., Crome, P., Bentham, P., Jones, L., & Lendon, C. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2071 · Cited by 273
Behavioral Problems in Dementia: A Factor Analysis of the Neuropsychiatric Inventory
Aalten, P., de Vugt, M. E., Lousberg, R. L., Korten, E. C. C. M., Jaspers, N., Senden-Gijsbers, B. L. M. G., Jolles, J., & Verhey, F. R. J. (2003) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000067972 · Cited by 269
Qualitative neuropsychological performance characteristics in frontotemporal dementia and Alzheimer’s disease
Thompson, J. C., Stopford, C. L., Snowden, J., & Neary, D. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.033779 · Cited by 267
Behavioral Syndromes in Alzheimer’s Disease: Description and Correlates
Frisoni, G. B., Rozzini, L., Gozzetti, A., Binetti, G. G., Zanetti, O. O., Bianchetti, A., Trabucchi, M., & Cummings, J. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017113 · Cited by 262
Anxiety, depression and psychosis in vascular dementia: prevalence and associations
Ballard, C., Neill, D., O’Brien, J., McKeith, I. G., Ince, P., & Perry, R. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00057-9 · Cited by 257
Neuropsychiatric symptoms and Quality of Life in patients with very mild and mild Alzheimer's disease
Karttunen, K., Karppi, P., Hiltunen, A., Vanhanen, M., Välimäki, T. H., Martikainen, J. A., Valtonen, H. J., Sivenius, J., Soininen, H. S., Hartikainen, S. A., et al. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2550 · Cited by 252
The course of neuropsychiatric symptoms in dementia. Part I: findings from the two‐year longitudinal Maasbed study
Aalten, P., de Vugt, M. E., Jaspers, N., Jolles, J., & Verhey, F. R. J. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1316 · Cited by 247
Progression of Cognitive, Functional, and Neuropsychiatric Symptom Domains in a Population Cohort With Alzheimer Dementia: The Cache County Dementia Progression Study
Tschanz, J. T., Corcoran, C. D., Schwartz, S., Treiber, K., Green, R. C., Norton, M. C., Mielke, M. M., Piercy, K., Steinberg, M., Rabins, P. V., et al. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181faec23 · Cited by 244
A Cross-Sectional Study of Neuropsychiatric Symptoms in 435 Patients With Alzheimer's Disease
Craig, D., Mirakhur, A., Hart, D. J., McIlroy, S. P., & Passmore, A. P. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.6.460 · Cited by 240
Elderly Patients With Dementia-Related Symptoms of Severe Agitation and Aggression
Salzman, C., Jeste, D. V., Meyer, R. E., Cohen‐Mansfield, J., Cummings, J. L., Grossberg, G. T., Jarvick, L., KRAEMER, H. C., Lebowitz, B. D., Maslow, K., et al. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0602 · Cited by 232
The contribution of neuropsychiatric symptoms to the cost of dementia care
Herrmann, N., Lanctôt, K. L., Sambrook, R., Lesnikova, N., Hébert, R., McCracken, P., Robillard, A., & Nguyen, E. H. L. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1594 · Cited by 232
Caregiver burden associated with behavioral and psychological symptoms of dementia (BPSD) in Taiwanese elderly
Huang, S., Lee, M., Liao, Y., Wang, W., & Lai, T. (2011) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2011.04.009 · Cited by 226
Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease
Tekin, S., Mega, M. S., Masterman, D. M., Chow, T. E., Garakian, J., Vinters, H. V., & Cummings, J. L. (2001) · Annals of Neurology · doi:10.1002/ana.72.abs · Cited by 226
Cerebral Blood Flow Correlates of Apathy in Alzheimer Disease
Craig, A., Cummings, J. L., Fairbanks, L. A., Itti, L., Miller, B. L., Li, J. J., & Mena, I. G. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550110056012 · Cited by 223
Diagnostic criteria for apathy in clinical practice
Mulin, E., Leone, E., Dujardin, K., Delliaux, M., Leentjens, A. F. G., Nobili, F. M., Dessi, B., Tible, O., Agüera-Ortíz, L., Osorio, R. S., et al. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2508 · Cited by 218
Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine
Rodda, J. E., Morgan, S., & Walker, Z. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209990354 · Cited by 218
Do caregiver management strategies influence patient behaviour in dementia?
de Vugt, M. E., Stevens, F., Aalten, P., Lousberg, R., Jaspers, N., Winkens, I., Jolles, J., & Verhey, F. R. J. (2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1044 · Cited by 215
The Quality of Antipsychotic Drug Prescribing in Nursing Homes
Briesacher, B. A., Limcangco, M. R., Simoni, J. M., Doshi, J. A., Levens, S. R., Shea, D. G., & Stuart, B. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.11.1280 · Cited by 215
Noradrenergic changes, aggressive behavior, and cognition in patients with dementia
Matthews, K. L., Chen, C., Esiri, M. M., Keene, J., Minger, S. L., & Francis, P. T. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01235-5 · Cited by 211
Positron emission tomography metabolic correlates of apathy in Alzheimer disease.
Marshall, G., Monserratt, L., Harwood, D., Mandelkern, M., Cummings, J., & Sultzer, D. (2007) · Archives of Neurology · doi:10.1001/archneur.64.7.1015 · Cited by 209
The rate of conversion of mild cognitive impairment to dementia: predictive role of depression
Gabryelewicz, T., Styczyńska, M., Łuczywek, E., Barczak, A. K., Pfeffer, A. Z., Androsiuk, W., Chodakowska-Żebrowska, M., Wasiak, B., Pepłońska, B., & Barcikowska, M. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1716 · Cited by 208
Consistency of Neuropsychiatric Syndromes across Dementias: Results from the European Alzheimer Disease Consortium
Aalten, P., Verhey, F. R. J., Boziki, M. K., Brugnolo, A., Bullock, R. A., Byrne, E. J., Camus, V., Caputo, M., Collins, D., Deyn, P. P. D., et al. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000111082 · Cited by 207
Neuropsychiatric symptoms in dementia-frequency, relationship to dementia severity and comparison in Alzheimer's disease, vascular dementia and frontotemporal dementia
Srikanth, S., Nagaraja, A., & Ratnavalli, E. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.04.014 · Cited by 205
Attention and Fluctuating Attention in Patients With Dementia With Lewy Bodies and Alzheimer Disease
Ballard, C. G., O'Brien, J. T., Gray, A., Cormack, F. K., Ayre, G., Rowan, E., Thompson, P., Bucks, R. S., McKeith, I. G., Walker, M. P., et al. (2001) · Archives of Neurology · doi:10.1001/archneur.58.6.977 · Cited by 201
The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer's disease
Sultzer, D. L., Mahler, M. E., Mandelkern, M. A., Cummings, J. L., van Gorp, W. G., Hinkin, C. H., & Berisford, M. A. (1995) · Journal of Neuropsychiatry · doi:10.1176/jnp.7.4.476 · Cited by 198
Systematic appraisal of dementia guidelines for the management of behavioural and psychological symptoms
Azermai, M., Petrović, M., Elseviers, M. M., Bourgeois, J., Bortel, L. M. V., & Stichele, R. V. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.07.002 · Cited by 197
Structural correlates of apathy in Alzheimer's disease
Apostolova, L. G., Akopyan, G. G., Partiali, N., Steiner, C. A., Dutton, R. A., Hayashi, K. M., Dinov, I. D., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000103914 · Cited by 190
Frontal lobe hypometabolism and depression in Alzheimer's disease
Hirono, N., Mori, E., Ishii, K., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Sasaki, M. (1998) · Neurology · doi:10.1212/wnl.50.2.380 · Cited by 189
Depression and dementia
Korczyn, A. D., & Halperin, I. J. Y. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.346 · Cited by 188
Impact of White Matter Changes on Clinical Manifestation of Alzheimer’s Disease
Hirono, N., Kitagaki, H., Kazui, H., Hashimoto, M., & Mori, E. (2000) · Stroke · doi:10.1161/01.str.31.9.2182 · Cited by 186
Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed, untreated patients with Alzheimer disease.
Spalletta, G., Musicco, M., Padovani, A., Rozzini, L., Perri, R., Fadda, L., Canonico, V., Trequattrini, A., Pettenati, C., Caltagirone, C., et al. (2010) · The American journal of geriatric psychiatry · doi:10.1097/jgp.0b013e3181d6b68d · Cited by 185
Behavioural disturbances in dementia patients and quality of the marital relationship
de Vugt, M. E., Stevens, F. C. J., Aalten, P., Lousberg, R. L., Jaspers, N., Winkens, I., JOLLES, J., & Verhey, F. R. J. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.807 · Cited by 184
Neurotransmitter deficits in behavioural and psychological symptoms of Alzheimer's disease
Lanari, A., Amenta, F., Silvestrelli, G., Tomassoni, D., & Parnetti, L. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.016 · Cited by 182
Depressive Symptoms in Mild Cognitive Impairment Predict Greater Atrophy in Alzheimer's Disease-Related Regions
Lee, G. J., Lu, P. H., Hua, X., Lee, S., Wu, S., Nguyen, K., Teng, E., Leow, A., Jack, C. R., Toga, A. W., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.024 · Cited by 182
Neuropathological correlates of late-life depression in older people
Tsopelas, C., Stewart, R., Savva, G. M., Brayne, C., Ince, P., Thomas, A., & Matthews, F. E. (2011) · British Journal of Psychiatry · doi:10.1192/bjp.bp.110.078816 · Cited by 182
Increased Neurofibrillary Tangles in Patients With Alzheimer Disease With Comorbid Depression
Rapp, M. A., Beeri, M. S., Purohit, D. P., Perl, D. P., Haroutunian, V. H., & Sano, M. C. (2008) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31816029ec · Cited by 181
Caregiver Characteristics Are Associated with Neuropsychiatric Symptoms of Dementia
Sink, K. M., Covinsky, K. E., Barnes, D. E., Newcomer, R. J., & Yaffe, K. S. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00697.x · Cited by 178
Behavioral Syndromes in Alzheimer’s Disease
Devanand, D. P., Brockington, C. D., Moody, B. J., Brown, R. P., Mayeux, R. P., Endicott, J., & Sackeïm, H. A. (1992) · International Psychogeriatrics · doi:10.1017/s104161029200125x · Cited by 178
Delusional Thoughts and Regional Frontal/Temporal Cortex Metabolism in Alzheimer’s Disease
Sultzer, D. L., Brown, C. V., Mandelkern, M. A., Mahler, M. E., Mendez, M. F., Chen, S. T., & Cummings, J. L. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.341 · Cited by 176
Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia
Fuh, J. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.056408 · Cited by 173
Behavioral and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment
Finkel, S. I., Silva, J. C. E., Cohen, G., Miller, S., & Sartorius, N. (1997) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199711)12:11 · Cited by 169
Formal Caregiver Burden in Dementia: Impact of Behavioral and Psychological Symptoms of Dementia and Activities of Daily Living
Miyamoto, Y., Tachimori, H., & Ito, H. (2010) · Geriatric Nursing · doi:10.1016/j.gerinurse.2010.01.002 · Cited by 165
The persistence of neuropsychiatric symptoms in dementia: the Cache County Study
Steinberg, M., Tschanz, J. T., Corcoran, C. D., Steffens, D. C., Norton, M. C., Lyketsos, C. G., & Breitner, J. C. S. (2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1025 · Cited by 164
Increased Neocortical Neurofibrillary Tangle Density in Subjects With Alzheimer Disease and Psychosis
Farber, N. B., Rubin, E. H., Newcomer, J. W., Kinscherf, D. A., Miller, J. P., Morris, J. C., Olney, J. W., & McKeel, D. W. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.12.1165 · Cited by 163
Neuropathological Correlates of Psychotic Phenomena in Confirmed Alzheimer's Disease
Förstl, H., Burns, A. S., Levy, R., & Cairns, N. J. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.165.1.53 · Cited by 161
Course of Neuropsychiatric Symptoms in Residents with Dementia in Nursing Homes Over 2-Year Period
Wetzels, R. B., Zuidema, S. U., de Jonghe, J. F. M., Verhey, F. R. J., & Koopmans, R. T. C. M. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181f60fa1 · Cited by 158
Neuropsychiatric symptoms in dementia: Importance and treatment considerations
Ballard, C. G., Day, S., Sharp, S. I., Wing, G., & Sorensen, S. (2008) · International Review of Psychiatry · doi:10.1080/09540260802099968 · Cited by 157
Neuroanatomy of Apathy and Disinhibition in Frontotemporal Lobar Degeneration
Massimo, L., Powers, C., Moore, P., Vesely, L., Avants, B., Gee, J., Libon, D. J., & Grossman, M. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000194658 · Cited by 156
Frequency and Correlates of Caregiver‐Reported Sleep Disturbances in a Sample of Persons with Early Dementia
Rongve, A., Boeve, B. F., & Aarsland, D. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02733.x · Cited by 154
A study of stereotypic behaviours in Alzheimer’s disease and frontal and temporal variant frontotemporal dementia
Nyatsanza, S., Shetty, T., Gregory, C., Lough, S., Dawson, K., & Hodges, J. R. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.10.1398 · Cited by 152
Four Components Describe Behavioral Symptoms in 1,120 Individuals with Late‐Onset Alzheimer's Disease
Hollingworth, P., Hamshere, M., Moskvina, V., Dowzell, K., Moore, P. J., Foy, C., Archer, N., Lynch, A., Lovestone, S., Brayne, C., et al. (2006) · Journal of The American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00854.x · Cited by 145
Valproate preparations for agitation in dementia
Lonergan, E., & Luxenberg, J. S. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003945.pub3 · Cited by 144
The Role of Dopamine in Symptoms and Treatment of Apathy in Alzheimer's Disease
Mitchell, R. A., Herrmann, N., & Lanctôt, K. L. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00161.x · Cited by 142
Behavioural and psychological syndromes in Alzheimer's disease
Mirakhur, A., Craig, D., Hart, D. J., Mcllroy, S. P., & Passmore, A. P. (2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1203 · Cited by 142
Occurrence of neuropsychiatric symptoms and psychiatric disorders in mild Alzheimer's disease and mild cognitive impairment subtypes
Iulio, F. D., Palmer, K., Blundo, C., Casini, A. R., Gianni, W., Caltagirone, C., & Spalletta, G. (2010) · International Psychogeriatrics · doi:10.1017/s1041610210000281 · Cited by 142
Neuroimaging Correlates of Apathy and Depression in Alzheimer's Disease
STARKSTEIN, S. E., Mizrahi, R., Capizzano, A. A., Ación, L., Brockman, S., & Power, B. (2009) · Journal of Neuropsychiatry · doi:10.1176/jnp.2009.21.3.259 · Cited by 140
The Course of Psychiatric and Behavioral Symptoms and the Use of Psychotropic Medication in Patients With Dementia in Norwegian Nursing Homes—A 12-Month Follow-Up Study
Selbæk, G., Kirkevold, Ø., & Engedal, K. (2008) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318167ae76 · Cited by 139
Serotonergic Function and Treatment of Behavioral and Psychological Symptoms of Frontotemporal Dementia
Herrmann, N., Black, S. E., Chow, T. W., Cappell, J., Tang‐Wai, D. F., & Lanctôt, K. L. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31823033f3 · Cited by 137
Neuropathological Substrates of Psychiatric Symptoms in Prospectively Studied Patients With Autopsy-Confirmed Dementia With Lewy Bodies
Ballard, C. G., Jacoby, R. J., del Ser, T., Khan, M. N., Muñoz, D. G., Holmes, C., Nagy, Z., Perry, E. K., Joachim, C. L., Jaros, E., et al. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.5.843 · Cited by 137
Behavioral and Psychologic Symptoms in Different Types of Dementia
Chiu, M.-J., Chen, T.-F., Yip, P.-K., Hua, M.-S., & Tang, L.-Y. (2006) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(09)60150-9 · Cited by 136
Incidence and subtypes of early-onset dementia in a geographically defined general population
Garre‐Olmo, J., Batlle, D. G., Fernández, M., Daniel, F. M., Huélamo, R. D. E., Casadevall, T., Recio, J. T., Estrada, A. T., & Pousa, S. L. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f5d4c4 · Cited by 134
Behavioral and Psychological Symptoms in Alzheimer’s Disease
Benoît, M., Dygai, I., Migneco, O., Robert, P. H., Bertogliati, C., Darcourt, J., Bénoliel, J., Aubin-Brunet, V., & Pringuey, D. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017198 · Cited by 133
Nonpharmacological intervention for agitation in dementia: A systematic review and meta-analysis
Kong, E.-H., Evans, L. K., & Guevara, J. P. (2009) · Aging & Mental Health · doi:10.1080/13607860902774394 · Cited by 132
Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment : Results from the Cardiovascular Health Study.
Lyketsos, López, Jones, & Fitzpatrick (2002) · JAMA · Cited by 132
SPECT findings on psychosis in Alzheimer's disease
Kotrla, K. J., Chacko, R. C., Harper, R. G., Jhingran, S. G., & Doody, R. S. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.10.1470 · Cited by 127
Behavioural and psychological symptoms in vascular dementia; differences between small- and large-vessel disease
Staekenborg, S. S., Su, T., van Straaten, E. C. W., Lane, R. M., Scheltens, P., Barkhof, F., & van der Flier, W. M. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.187500 · Cited by 127
A SPECT study of apathy in Alzheimer's disease
Lanctôt, K. L., Moosa, S., Herrmann, N., Leibovitch, F. S., Rothenburg, L., Cotter, A., & Black, S. E. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000103633 · Cited by 126
Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review
Konovalov, S., Muralee, S., & Tampi, R. R. (2007) · International Psychogeriatrics · doi:10.1017/s1041610207006540 · Cited by 126
Development of Diagnostic Criteria for Defining Sleep Disturbance in Alzheimer's Disease
Yesavage, J. A., Friedman, L., Ancoli‐Israel, S., Bliwise, D. L., Singer, C. M., Vitiello, M. V., Monjan, A. A., & Lebowitz, B. D. (2003) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988703255684 · Cited by 125
Behavioral Disorders and Caregivers' Reaction in Taiwanese Patients With Alzheimer's Disease
Fuh, J., Liu, C.-K., Mega, M. S., Wang, S., & Cummings, J. L. (2001) · International Psychogeriatrics · doi:10.1017/s1041610201007517 · Cited by 122
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
Wilkins, L. (2005) · Neurology · doi:10.1212/wnl.65.12.1992-a · Cited by 121
Can Agitated Behavior of Nursing Home Residents with Dementia Be Prevented with the Use of Standardized Stimuli?
Cohen‐Mansfield, J., Marx, M. S., Dakheel‐Ali, M., Regier, N. G., Thein, K., & Freedman, L. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02951.x · Cited by 120
Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction
Rosenberg, P. B., Mielke, M. M., Appleby, B. S., Oh, E. S., Leoutsakos, J., & Lyketsos, C. G. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2535 · Cited by 119
Are the Behavioral Symptoms of Alzheimer's Disease Directly Associated with Neurodegeneration?
Serra, L., Perri, R., Cercignani, M., Spanò, B., Fadda, L., Marra, C., Carlesimo, G. A., Caltagirone, C., & Bozzali, M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100048 · Cited by 116
Revisiting the cholinergic hypothesis of behavioral and psychological symptoms in dementia of the Alzheimer's type
Pinto, T., Lanctôt, K. L., & Herrmann, N. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.01.003 · Cited by 113
Pattern of brain atrophy in elderly patients with depression revealed by voxel-based morphometry
Egger, K., Schocke, M., Weiss, E., Auffinger, S., Esterhammer, R., Goebel, G., Walch, T., Mechtcheriakov, S., & Marksteiner, J. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.12.018 · Cited by 113
De novo genesis of neuropsychiatric symptoms in Mild Cognitive Impairment (MCI)
Geda, Y. E., Smith, G. E., Knopman, D. S., Boeve, B. F., Tangalos, E. G., Ivnik, R. J., Mrazek, D. A., Edland, S. D., & Petersen, R. C. (2004) · International Psychogeriatrics · doi:10.1017/s1041610204000067 · Cited by 112
Efficacy and safety of donepezil in patients with more severe Alzheimer's disease: a subgroup analysis from a randomized, placebo‐controlled trial
Feldman, H., Gauthier, S. G., Hecker, J. R., Vellas, B. J., Xu, Y., Ieni, J. R., & Schwam, E. M. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1325 · Cited by 112
Animal-assisted activity and emotional status of patients with Alzheimer's disease in day care
Mossello, E., Ridolfi, A., Mello, A. M., Lorenzini, G., Mugnai, F., Piccini, C., Barone, D., Peruzzi, A., Masotti, G., & Marchionni, N. (2011) · International Psychogeriatrics · doi:10.1017/s1041610211000226 · Cited by 112
Neuropsychiatric Symptoms in Nursing Home Patients: Factor Structure Invariance of the Dutch Nursing Home Version of the Neuropsychiatric Inventory in Different Stages of Dementia
Zuidema, S. U., de Jonghe, J. F. M., Verhey, F. R. J., & Koopmans, R. T. C. M. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000105603 · Cited by 109
Depressive symptoms, clinical AD, and cortical plaques and tangles in older persons
Wilson, R. S., Schneider, J. A., Bienias, J. L., Arnold, S. E., Evans, D. A., & Bennett, D. A. (2003) · Neurology · doi:10.1212/01.wnl.0000092914.04345.97 · Cited by 109
Neuropsychiatric symptoms of Alzheimer's disease differ in Chinese and American patients
Chow, T. W., Liu, C.-K., Fuh, J., Leung, V., Tai, C., Chen, L., Wang, S., Chiu, H. F. K., Lam, L. C. W., Chen, Q. L., et al. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.509 · Cited by 107
Effects of Group Music Intervention on Behavioral and Psychological Symptoms in Patients with Dementia: A Pilot-Controlled Trial
Choi, A., Lee, M. S., Cheong, K.-J., & Lee, J. (2009) · International Journal of Neuroscience · doi:10.1080/00207450802328136 · Cited by 106
Neuropathologic Correlates of Late-Onset Major Depression
Sweet, R. A., Hamilton, R. L., Butters, M. A., Mulsant, B. H., Pollock, B. G., Lewis, D. A., López, O. L., DeKosky, S. T., & Reynolds, C. F. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300554 · Cited by 105
Presence of Behavioral and Psychological Symptoms Predicts Nursing Home Placement in Community-Dwelling Elders With Cognitive Impairment in Univariate But Not Multivariate Analysis
Chan, D., Kasper, J. D., Black, B. S., & Rabins, P. V. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.6.m548 · Cited by 105
The Progression of Cognition, Psychiatric Symptoms, and Functional Abilities in Dementia With Lewy Bodies and Alzheimer Disease
Stavitsky, K., Brickman, A. M., Scarmeas, N., Torgan, R., Tang, M.-X., Albert, M., Brandt, J., Blacker, D., & Stern, Y. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1450 · Cited by 105
Apathy and cortical atrophy in Alzheimer's disease
Tunnard, C., Whitehead, D. L., Hurt, C. S., Wahlund, L., Mecocci, P., Tsolaki, M., Vellas, B. J., Spenger, C., Kłoszewska, I., Soininen, H. S., et al. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2603 · Cited by 102
Predictive Validity of Neuropsychiatric Subgroups on Nursing Home Placement and Survival in Patients With Alzheimer Disease
Tun, S.-M., Murman, D. L., Long, H. L., Colenda, C. C., & von Eye, A. (2007) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000239263.52621.97 · Cited by 102
Behavioral and psychological symptoms of dementia in relation to level of cognitive impairment
Lövheim, H., Sandman, P., Karlsson, S., & Gustafson, Y. (2008) · International Psychogeriatrics · doi:10.1017/s1041610208006777 · Cited by 101
Determinants of the Quality of Life in Alzheimer’s Disease Patients as Assessed by the Japanese Version of the Quality of Life – Alzheimer’s Disease Scale
Matsui, T., Nakaaki, S., Murata, Y., Sato, J., Shinagawa, Y., Tatsumi, H., & Furukawa, T. A. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000090744 · Cited by 100
Stage-Specific Prevalence of Behavioral Symptoms in Alzheimer's Disease in a Multi-Ethnic Community Sample
Chen, J. C., Soo Borson, B., & Scanlan, J. M. (2000) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200005000-00007 · Cited by 99
Dementia associated mental and behavioural disturbances in elderly people in the community: findings from the first Nakayama study.
Ikeda, M., Fukuhara, R., Shigenobu, K., Hokoishi, K., Maki, N., Nebu, A., Komori, K., & Tanabe, H. (2004) · PubMed Central · Cited by 97
A Systematic Evidence Review of Non-pharmacological Interventions for Behavioral Symptoms of Dementia
O'Neil, M. E., Freeman, M., Christensen, V., Telerant, R., Addleman, A., & Kansagara, D. L. (2011) · Cited by 96
Environmental correlates of neuropsychiatric symptoms in nursing home patients with dementia
Zuidema, S. U., de Jonghe, J. F. M., Verhey, F. R. J., & Koopmans, R. T. C. M. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2292 · Cited by 96
Stability of the factor structure of the Neuropsychiatric Inventory in a 31-month follow-up study of a large sample of nursing-home patients with dementia
Selbæk, G., & Engedal, K. (2011) · International Psychogeriatrics · doi:10.1017/s104161021100086x · Cited by 95
Assessment of Agitation in Alzheimer's Disease: The Agitated Behavior in Dementia Scale
Logsdon, R. G., Teri, L. L., Weiner, M., Gibbons, L. E., Raskind, M. A., Peskind, E. R., Grundman, M., Koss, E., Thomas, R. G., Thai, L. J., et al. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb07439.x · Cited by 95
Neuropsychiatric symptoms predict change in quality of life of Alzheimer disease patients: A two‐year follow‐up study
Tatsumi, H., Nakaaki, S., Torii, K., Shinagawa, Y., Watanabe, N., Murata, Y., Sato, J., Mimura, M., & Furukawa, T. A. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2009.01955.x · Cited by 95
Occipital Atrophy Is Associated With Visual Hallucinations in Alzheimer's Disease
Holroyd, S., Shepherd, M. L., & Downs, J. H. (2000) · Journal of Neuropsychiatry · doi:10.1176/jnp.12.1.25 · Cited by 94
Treatment of Alzheimer's disease: current and future therapeutic approaches.
Cummings, J. L. (2004) · PubMed · Cited by 94
An evidence‐based proposal for the classification of neuropsychiatric disturbance in Alzheimer's disease
Lyketsos, C. G., Breitner, J. C. S., & Rabins, P. V. (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.440 · Cited by 94
Efficacy and Tolerability of Antidepressants in the Treatment of Behavioral and Psychological Symptoms of Dementia, A Literature Review of Evidence
Henry, G., Williamson, D. E., & Tampi, R. R. (2011) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317511402051 · Cited by 92
Alzheimer Disease and Frontotemporal Dementia
Rozzini, L., Lussignoli, G., Padovani, A., Bianchetti, A., & Trabucchi, M. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550160005001 · Cited by 92
Special care units for dementia individuals with behavioural problems
Lai, C. K. Y., Yeung, J. H. M., Mok, V., & Chi, I. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006470.pub2 · Cited by 90
Comparison of behavioral and psychological symptoms in early‐onset and late‐onset Alzheimer's disease
Toyota, Y., Ikeda, M., Shinagawa, S., Matsumoto, T., Matsumoto, N., Hokoishi, K., Fukuhara, R., Ishikawa, T., Mori, T., Adachi, H., et al. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1760 · Cited by 90
Genetic correlates of behavioral endophenotypes in Alzheimer disease: role of COMT, 5-HTTLPR and APOE polymorphisms.
Borroni, B., Grassi, M., Agosti, C., Costanzi, C., Archetti, S., Franzoni, S., Caltagirone, C., di Luca, M., Caimi, L., & Padovani, A. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.029 · Cited by 88
The relationship between severity of Alzheimer's disease and prevalence of comorbid depressive symptoms and depression: a systematic review
Verkaik, R., Nuyen, J., Schellevis, F., & Francke, A. L. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1809 · Cited by 86
Neuropsychiatric Symptoms in Amnestic and Nonamnestic Mild Cognitive Impairment
Rozzini, L., Chilovi, B. V., Conti, M. Z., Delrio, I., Borroni, B., Trabucchi, M., & Padovani, A. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000111133 · Cited by 86
Brief Psychosocial Therapy for the Treatment of Agitation in Alzheimer Disease (The CALM-AD Trial)
Ballard, C. G., Brown, R. G., Fossey, J., Douglas, S., Bradley, P., Hancock, J., James, I. A., Juszczak, E., Bentham, P., Burns, A. S., et al. (2009) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181b0f8c0 · Cited by 86
Sex differences in the prevalence of behavioral and psychological symptoms of dementia
Lövheim, H., Sandman, P., Karlsson, S., & Gustafson, Y. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209008497 · Cited by 86
The course of neuropsychiatric symptoms in dementia. Part II: relationships among behavioural sub‐syndromes and the influence of clinical variables
Aalten, P., de Vugt, M. E., Jaspers, N., JOLLES, J., & Verhey, F. R. J. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1317 · Cited by 83
Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease
Berlow, Y. A., Wells, W. M., Ellison, J. M., Sung, Y. H., Renshaw, P. F., & Harper, D. G. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2418 · Cited by 82
Mental and behavioral disturbances in dementia: Findings from the cache county study on memory in aging
Lyketsos, C. G., Steinberg, M., Breitner, J. C. S., Tschanz, J. T., Norton, M. C., & Steffens, D. C. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)83436-3 · Cited by 81
Consequences of Aggressive Behavior in Patients With Dementia
Kunik, M. E., Snow, A. L., Davila, J. A., McNeese, T. D., Steele, A. B., Balasubramanyam, V., Doody, R. S., Schulz, P. E., Kalavar, J. S., Walder, A. M., et al. (2010) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.22.1.40 · Cited by 80
Prevalence of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Alzheimers Disease, and its Relationship with Cognitive Impairment
Martínez, M. F., Molano, A., Castro, J., & Zarranz, J. J. (2010) · Current Alzheimer Research · doi:10.2174/156720510792231748 · Cited by 78
Accuracy of Self‐Reported Depression in Persons with Dementia
Snow, A. L., Kunik, M. E., Molinari, V., Orengo, C. A., Doody, R. S., Graham, D. P., & Norris, M. P. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53154.x · Cited by 77
Neuropsychiatric Symptoms Underlying Caregiver Stress and Insight in Alzheimer’s Disease
Rocca, P., Leotta, D., Liffredo, C., Mingrone, C., Sigaudo, M., Capellero, B., Rocca, G., Simoncini, M., Pirfo, E., & Bogetto, F. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000315513 · Cited by 76
Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment
Chan, W. C., LAM, L. C. W., Tam, C. W. C., Lui, V. W.-C., Leung, G., Lee, A. T. C., Chan, S. S. M., Fung, A. W. T., Chiu, H. F. K., & Chan, W. M. (2010) · Age and Ageing · doi:10.1093/ageing/afq151 · Cited by 76
Clinicopathological correlates of behavioral and psychological symptoms of dementia
Casanova, M. F., STARKSTEIN, S. E., & Jellinger, K. A. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0821-3 · Cited by 75
Prevalence of Neuropsychiatric Symptoms in Alzheimers Disease and Vascular Dementia
Martínez, M. F., Castro, J., Molano, A., Zarranz, J. J., Rodrigo, R., & Ortega, R. (2008) · Current Alzheimer Research · doi:10.2174/156720508783884585 · Cited by 75
Specific psychological and behavioral symptoms of depression in patients with dementia
Prado‐Jean, A., Couratier, P., Druet‐Cabanac, M., Nubukpo, P., Bernard‐Bourzeix, L., Thomas, P., Dechamps, N., Videaud, H., DANTOINE, T. F., & Clément, J. P. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2468 · Cited by 74
Measurement of Inappropriate Behavior Associated With Dementia
Cohen‐Mansfield, J. (1999) · Journal of Gerontological Nursing · doi:10.3928/0098-9134-19990201-08 · Cited by 73
Trajectory of Cognitive Decline as a Predictor of Psychosis in Early Alzheimer Disease in the Cardiovascular Health Study
Emanuel, J. E., López, O. L., Houck, P. R., Becker, J. T., Weamer, E. A., DeMichele‐Sweet, M. A. A., Kuller, L. H., & Sweet, R. A. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181e446c8 · Cited by 73
Behavioral Differences between White Matter Lacunar Dementia and Alzheimer’s Disease: A Comparison on the Neuropsychiatric Inventory
Aharon‐Peretz, J., Kliot, D., & Tomer, R. (2000) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017252 · Cited by 73
International Psychogeriatric Association consensus statement on defining and measuring treatment benefits in dementia
Katona, C., Livingston, G., Cooper, C., Ames, D. J., Brodaty, H., & Chiu, E. Y.-K. (2007) · International Psychogeriatrics · doi:10.1017/s1041610207005145 · Cited by 71
Cognitive and behavioural predictors of survival in Alzheimer disease: results from a sample of treated patients in a tertiary‐referral memory clinic
Russ, T. C., Batty, G. D., & Starr, J. M. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2795 · Cited by 66
The course of neuropsychiatric symptoms in patients with dementia in Norwegian nursing homes
Bergh, S., Engedal, K., Røen, I., & Selbæk, G. (2011) · International Psychogeriatrics · doi:10.1017/s1041610211001177 · Cited by 63
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Ismail, Z., Nguyen, M.-Q., Fischer, C. E., Schweizer, T. A., Mulsant, B. H., & Mamo, D. C. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0195-1 · Cited by 62
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Garre‐Olmo, J., Pousa, S. L., Franch, J. V., Blanco, M. D. G., & Bulbena, A. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101212 · Cited by 61
The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis
Weamer, E. A., Emanuel, J. E., Varón, D., Miyahara, S., Wilkosz, P. A., López, O. L., DeKosky, S. T., & Sweet, R. A. (2008) · International Psychogeriatrics · doi:10.1017/s1041610208007734 · Cited by 60
Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology
Sweet, R. A., Panchalingam, K., Pettegrew, J. W., McClure, R. J., Hamilton, R. L., López, O. L., Kaufer, D., DeKosky, S. T., & Klunk, W. E. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00009-x · Cited by 60
Behavioral and psychological symptoms associated with dementia subtype and severity
Thompson, C. L., Brodaty, H., Trollor, J. N., & Sachdev, P. S. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209991220 · Cited by 60
Depression in Patients With Mild Cognitive Impairment Increases the Risk of Developing Dementia of Alzheimer Type: A Prospective Cohort Study
Ballenger, J. C. (2006) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/s0084-3970(08)70262-7 · Cited by 60
Behavioral correlates of GABAergic disruption in Alzheimer's disease
Lanctôt, K. L., Herrmann, N., Rothenburg, L. S., & Eryavec, G. M. (2006) · International Psychogeriatrics · doi:10.1017/s1041610206003899 · Cited by 59
. Research agenda for DSM-V: diagnostic categories and criteria for neuropsychiatric syndromes in dementia.
Jeste, D. V., Meeks, T. W., Kim, D. S., & Zubenko, G. S. (2006) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988706291087 · Cited by 59
Psychotic Symptoms in Alzheimer's Disease Are Not Associated With More Severe Neuropathologic Features
Sweet, R. A., Hamilton, R. L., López, O. L., Klunk, W. E., Wisniewski, S. R., Kaufer, D., Healy, M. T., & DeKosky, S. T. (2000) · International Psychogeriatrics · doi:10.1017/s1041610200006657 · Cited by 57
Persistence of neuropsychiatric symptoms over six months in mild cognitive impairment in community-dwelling Korean elderly
Ryu, S., Ha, J. H., Park, D., Yu, J., & Livingston, G. (2010) · International Psychogeriatrics · doi:10.1017/s1041610210001766 · Cited by 55
Grouping and Trajectories of Neuropsychiatric Symptoms in Patients with Alzheimer's Disease. Part II: Two-Year Patient Trajectories
Garre‐Olmo, J., Pousa, S. L., Franch, J. V., Blanco, M. D. G., & Bulbena, A. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101215 · Cited by 54
Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia
Proitsi, P., Lupton, M. K., Reeves, S., Hamilton, G., Archer, N. J., Martin, B. M., Iyegbe, C. O., Hollingworth, P., LAWLOR, B. A., Gill, M., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.06.011 · Cited by 54
Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies
Teaktong, T., Piggott, M. A., McKeith, I. G., Perry, R. H., Ballard, C. G., & Perry, E. K. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.02.019 · Cited by 53
Medial Temporal Hypoperfusion and Aggression in Alzheimer Disease
Lanctôt, K. L., Herrmann, N., Nadkarni, N. K., Leibovitch, F. S., Caldwell, C. B., & Black, S. E. (2004) · Archives of Neurology · doi:10.1001/archneur.61.11.1731 · Cited by 51
Antidepressants for agitation and psychosis in dementia
Seitz, D. P., Adunuri, N., Gill, S. S., Gruneir, A., Herrmann, N., & Rochon, P. A. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008191 · Cited by 51
Cerebral perfusion (HMPAO-SPECT) in patients with depression with cognitive impairment versus those with mild cognitive impairment and dementia of Alzheimer’s type: a semiquantitative and automated evaluation
Staffen, W., Bergmann, J., Huber-Schönauer, U., Zauner, H., Kronbichler, M., Golaszewski, S. M., & Ladurner, G. (2009) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-1028-2 · Cited by 49
Caregivers' assessments of preference‐based quality of life in Alzheimer's disease
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HMPAO SPECT imaging of Alzheimer's disease patients with similar content-specific autobiographic delusion: comparison using statistical parametric mapping.
Staff, R. T., Venneri, A., Gemmell, H. G., Shanks, M. F., Pestell, S. J., & Murray, A. D. (2000) · PubMed · Cited by 47
Prevalence of neuropsychiatric syndromes in Alzheimer's disease (AD)
Youn, J. C., Lee, D. Y., Jhoo, J. H., Kim, K. W., Choo, I. H., & Woo, J. I. (2010) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2010.04.015 · Cited by 45
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Components of behavioral pathology in dementia
Schreinzer, D., Ballaban, T., Brannath, W., Lang�, T., Hilger, E., Fasching, P., & Fischer, P. A. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1263 · Cited by 31
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Maria, E. D., Bonvicini, C., Bonomini, C., Alberici, A., Zanetti, O. O., & Gennarelli, M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1194 · Cited by 26
Co‐occurrence of neuropsychiatric syndromes in demented and psychotic institutionalized elderly
Dechamps, A., Jutand, M. A., Onifade, C., Richard‐Harston, S., & Bourdel‐Marchasson, I. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2052 · Cited by 24
Home-based exercise and support programme for people with dementia and their caregivers: study protocol of a randomised controlled trial
Prick, A.-E. J. C., de Lange, J., Scherder, E., & Pot, A. M. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-894 · Cited by 21

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Research works printed but not linked: 4

Aalten P. de Vugt M. E. Jaspers N. Jolles J. Verhey F. R. (2005b). The course of neuropsychiatric symptoms in dementia. Part II: relationships among behavioural sub-syndromes and the influence of clinical variables. Int. J. Geriatr. Psychiatry 20, 531– 536 10.1002/gps.1317 15920706 · DOI
García-Alberca J. M. Lara Muñoz J. P. Berthier Torres M. (2010). Neuropsychiatric and behavioral symptomatology in Alzheimer disease. Actas Esp. Psiquiatr. 38, 212– 222 21104466
Iwata B. A. Volmer T. R. Zarcone J. R. (1993). “The experimental (functional) analysis of behavioral disorders: methodology, application, and limitations,” in Perspectives on the Use of Nonaversive and Aversive Interventions for Persons with Developmental Disabilities, eds Repp A. C. Singh N. N. (Sycamore, IL: Sycamore Press), 301– 330
Mukaetova-Ladinska E. B. Harrington C. R. Xuereb J. Roth M. Wischik C. M. (1995). Biochemical, neuropathological, and clinical correlations of neurofibrillary degeneration in Alzheimer’s disease,” in Treating Alzheimer’s and Other Dementias, eds Bergener M. Finkel S. I. (New York: Springer), 57– 80

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See all 1,425

Authors: Cerejeira, J., Lagarto, L., & Mukaetova-Ladinska, E. B.
Affiliations: Unidade Local de Saúde de Coimbra (PT)
ORCID: Cerejeira, J.
Venue: Frontiers in Neurology
Publisher: Frontiers Media SA
Published: 2012
Volume: 3
Pages: 73-73
ISSN: 1664-2295 (ISSN-L)
DOI: 10.3389/fneur.2012.00073
PMC: PMC3345875
OpenAlex: W2120296399
Cited by: 1,425
References: 214
Citations by year: 2026: 111 · 2025: 138 · 2024: 144 · 2023: 188 · 2022: 129 · 2021: 150 · 2020: 122 · 2019: 92 · 2018: 90 · 2017: 78 · 2016: 59 · 2015: 38 · 2014: 32 · 2013: 27 · 2012: 13
FWCI: 25.13
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
Locations: Frontiers in Neurology (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Newcastle University ePrints (Newcastle Univesity) (cc-by-nc)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords: behavioral and psychological symptoms of dementia, neuropsychiatric symptoms, dementia, agitation, anxiety, depression, apathy, delusions, hallucinations, sleep disorders, non-pharmacological treatment, pharmacotherapy, pathogenesis, genetic factors, neuropathology, caregiver burden

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