Signaling pathways regulating neuron–glia interaction and their implications in Alzheimer's disease

Lian, Hong; Zheng, Hui

doi:10.1111/jnc.13424

Cited by 77

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Signaling pathways regulating neuron–glia interaction and their implications in Alzheimer's disease

Lian, Hong, Zheng, Hui·2016·Journal of Neurochemistry

DOI 10.1111/jnc.13424PMC PMC4720533

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Abstract

Astrocytes are the most abundant cells in the central nervous system. They play critical roles in neuronal homeostasis through their physical properties and neuron–glia signaling pathways. Astrocytes become reactive in response to neuronal injury and this process, referred to as reactive astrogliosis, is a common feature accompanying neurodegenerative conditions, particularly Alzheimer's disease. Reactive astrogliosis represents a continuum of pathobiological processes and is associated with morphological, functional, and gene expression changes of varying degrees. There has been a substantial growth of knowledge regarding the signaling pathways regulating glial biology and pathophysiology in recent years. Here, we attempt to provide an unbiased review of some of the well‐known players, namely calcium, proteoglycan, transforming growth factor β, NF κB, and complement, in mediating neuron–glia interaction under physiological conditions as well as in Alzheimer's disease. image This review discusses the role of astrocytic NFκB and calcium as well as astroglial secreted factors, including proteoglycans, TGFβ, and complement in mediating neuronal function and AD pathogenesis through direct interaction with neurons and through cooperation with microglia.

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Many signaling molecules secreted by reactive glia have been proposed to mediate neuron-glia interactions in AD pathogenesis.
“Many signaling molecules secreted by reactive glia have been proposed to mediate neuron-glia interactions in AD pathogenesis (10).”
From Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia (2017) · cites this paper as [10]

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The Many Faces of Astrocytes in Alzheimer's Disease
Monterey, M. D., Wei, H., Wu, X., & Wu, J. Q. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.619626 · Cited by 117
Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia
Yang, C.-N., Wu, M.-F., Liu, C.-C., Jung, W.-H., Chang, Y.-C., Lee, W.-P., Shiao, Y.-J., Wu, C.-L., Liou, H.-H., Lin, S.-K., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx278 · Cited by 27

Authors: Lian, H., & Zheng, H.
Affiliations: Huffington Center on Aging Baylor College of Medicine Houston Texas USA
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2015-11-30
Volume: 136
Issue: 3
Pages: 475-491
ISSN: 0022-3042
1471-4159
DOI: 10.1111/jnc.13424
PMC: PMC4720533
Cited by: 77
References: 39
Language: en
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders: National Institutes of Health (AG032051, AG020670, NS076117)

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Signaling pathways regulating neuron–glia interaction and their implications in Alzheimer's disease

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