Factors affecting two-point discrimination in argus II patients
Open accessAbstract
Two of the main obstacles to the development of epiretinal prosthesis technology are electrodes that require current amplitudes above safety limits to reliably elicit percepts, and a failure to consistently elicit pattern vision. Here, we explored the causes of high current amplitude thresholds and poor spatial resolution within the Argus II epiretinal implant. We measured current amplitude thresholds and two-point discrimination (the ability to determine whether one or two electrodes had been stimulated) in 3 blind participants implanted with Argus II devices. Our data and simulations show that axonal stimulation, lift and retinal damage all play a role in reducing performance in the Argus 2, by either limiting sensitivity and/or reducing spatial resolution. Understanding the relative role of these various factors will be critical for developing and surgically implanting devices that can successfully subserve pattern vision.
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Several factors might limit the spatial resolution of prosthetic vision, including retinal damage, electrode-retina distance, and inadvertent stimulation of nerve fiber bundles.
“Most recently, Yücel et al (2022) identified several factors that might limit the spatial resolution of prosthetic vision, which included retinal damage, electrode-retina distance, and the inadvertent stimulation of nerve fiber bundles.”
From Axonal stimulation affects the linear summation of single-point perception in three Argus II users (2024) · cites this paper as Yücel et al 2022
Phosphenes tended to appear larger and rounder as stimulus amplitude increased.
“We found that phosphenes tended to appear larger and rounder as stimulus amplitude increased (table 4), which is consistent with previous considerations about the current spread in the retina (de Balthasar et al 2008, Granley and Beyeler 2021, Yücel et al 2022).”
From Axonal stimulation affects the linear summation of single-point perception in three Argus II users (2024) · cites this paper as Yücel et al 2022
The probability of perceiving two distinct phosphenes increases with inter-electrode distance.
“Yücel et al (2022) previously demonstrated that the probability of perceiving two distinct phosphenes increases with inter-electrode distance.”
From Axonal stimulation affects the linear summation of single-point perception in three Argus II users (2024) · cites this paper as Yücel et al (2022)
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Axonal stimulation affects the linear summation of single-point perception in three Argus II users
Hou, Y., Nanduri, D., Granley, J., Weiland, J. D., & Beyeler, M. (2024) · Journal of Neural Engineering · doi:10.1088/1741-2552/ad31c4 · Cited by 14 · see citing works
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- Authors
- Yücel, E. I., Sadeghi, R., Kartha, A., Montezuma, S. R., Dagnelie, G., Rokem, A., Boynton, G. M., Fine, I., & Beyeler, M.
- Affiliations
- Johns Hopkins University (US)
- University of Minnesota (US)
- University of Washington (US)
- University of California, Santa Barbara (US)
- Corresponding author
- Fine, Ione
- ORCID
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2022-08-24
- Volume
- 16
- Pages
- 901337-901337
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC9448992
- OpenAlex
- W4292860335
- Cited by
- 13
- References
- 50
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Eye Institute (R01-62-5032, R00 EY02932)
- Washington Research Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- Argus II, epiretinal prosthesis, two-point discrimination, spatial resolution, retinal damage, pattern vision, visual prosthesis, blind patients
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