The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting
Open accessAbstract
The influence of meal frequency and timing on health and disease has been a topic of interest for many years. While epidemiological evidence indicates an association between higher meal frequencies and lower disease risk, experimental trials have shown conflicting results. Furthermore, recent prospective research has demonstrated a significant increase in disease risk with a high meal frequency (≥6 meals/day) as compared to a low meal frequency (1–2 meals/day). Apart from meal frequency and timing we also have to consider breakfast consumption and the distribution of daily energy intake, caloric restriction, and night-time eating. A central role in this complex scenario is played by the fasting period length between two meals. The physiological underpinning of these interconnected variables may be through internal circadian clocks, and food consumption that is asynchronous with natural circadian rhythms may exert adverse health effects and increase disease risk. Additionally, alterations in meal frequency and meal timing have the potential to influence energy and macronutrient intake.A regular meal pattern including breakfast consumption, consuming a higher proportion of energy early in the day, reduced meal frequency (i.e., 2–3 meals/day), and regular fasting periods may provide physiological benefits such as reduced inflammation, improved circadian rhythmicity, increased autophagy and stress resistance, and modulation of the gut microbiota
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Cites
Spiegel, K., Tasali, E., Penev, P., & Cauter, E. V. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00008 · Cited by 2,459
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986
Circadian clocks and insulin resistance
Stenvers, D. J., Scheer, F. A. J. L., Schrauwen, P., la Fleur, S. E., & Kalsbeek, A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0122-1 · Cited by 733
Moro, T., Tinsley, G., Bianco, A., Marcolin, G., Pacelli, Q. F., Battaglia, G., Palma, A., Gentil, P., Neri, M., & Paoli, A. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1044-0 · Cited by 732
Self-citationAssociation between Eating Patterns and Obesity in a Free-living US Adult Population
Ma, Y. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg117 · Cited by 725 · cited 1×
“Again, a recently published cross-sectional analysis within the prospective Seasonal Variation of Blood Cholesterol Study in Worcester County, Massachusetts (SEASONS) showed that a frequency higher than four times per day leads to a lower risk of obesity compared to a frequency lower than three times per day, even aft…”
BackgroundDiet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease
Albenberg, L. G., & Wu, G. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.058 · Cited by 606 · cited 2×
“M reover, the gut microbiota has been associated to many metabolic diseases such as obesity, diabetes, chronic low-grade inflammation and, last but not least, cardiovascular disease [110].”
BackgroundJakubowicz, D., Barnea, M., Wainstein, J., & Froy, O. (2013) · Obesity · doi:10.1002/oby.20460 · Cited by 593
Nibbling versus gorging: metabolic advantages of increased meal frequency
Jenkins, D. J. A., Wolever, T. M. S., Vuksan, V., Brighenti, F., Cunnane, S. C., Rao, A. V., Jenkins, A. L., Buckley, G., Patten, R., Singer, W., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198910053211403 · Cited by 467
Circadian disorganization alters intestinal microbiota
Voigt, R. M., Forsyth, C. B., Green, S. J., Mutlu, E., Engen, P., Vitaterna, M. H., Turek, F. W., & Keshavarzian, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097500 · Cited by 439
Later circadian timing of food intake is associated with increased body fat
McHill, A. W., Phillips, A. J., Czeisler, C. A., Keating, L., Yee, K., Barger, L. K., Garaulet, M., Scheer, F. A., & Klerman, E. B. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.161588 · Cited by 414
Fábry, P., Hejl, Z., Fodor, J., Braun, T., & Zvolánková, K. (1964) · The Lancet · doi:10.1016/s0140-6736(64)90510-0 · Cited by 389
Effects of intermittent fasting on body composition and clinical health markers in humans
Tinsley, G. M., & La Bounty, P. M. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv041 · Cited by 382
Self-citationGut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Karbach, S. H., Schönfelder, T., Brandão, I., Wilms, E., Hörmann, N., Jäckel, S., Schüler, R., Finger, S., Knorr, M., Lagrange, J., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003698 · Cited by 378
Cahill, L. E., Chiuve, S. E., Mekary, R. A., Jensen, M. K., Flint, A. J., Hu, F. B., & Rimm, E. B. (2013) · Circulation · doi:10.1161/circulationaha.113.001474 · Cited by 317
Chowdhury, E. A., Richardson, J. D., Holman, G. D., Tsintzas, K., Thompson, D., & Betts, J. A. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.122044 · Cited by 255
Eating patterns and dietary composition in relation to BMI in younger and older adults
Howarth, N. C., Huang, T. T.-K., Roberts, S. B., Lin, B.-H., & McCrory, M. A. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803456 · Cited by 249 · cited 1×
“These data suggest that 1–2 meals are better than three or more, but how can we integrate these results with previous, older research? Both older studies [9,10,12,29,30] and more recent research [31] seem to suggest that a higher meal frequency can reduce weight gain risk; however, recent large prospective studies see…”
ResultTime-restricted feeding and risk of metabolic disease: A review of human and animal studies
Rothschild, J., Hoddy, K. K., Jambazian, P., & Varady, K. A. (2014) · Nutrition Reviews · doi:10.1111/nure.12104 · Cited by 241
Nutrients, Clock Genes, and Chrononutrition
Oike, H., Oishi, K., & Kobori, M. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0082-6 · Cited by 198
Dietary cholesterol: from physiology to cardiovascular risk
Lecerf, J.-M., & de Lorgeril, M. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511000237 · Cited by 182
Morris, C. J., Garcia, J. I., Myers, S., Yang, J. N., Trienekens, N., & Scheer, F. A. J. L. (2015) · Obesity · doi:10.1002/oby.21189 · Cited by 167
Maukonen, M., Kanerva, N., Partonen, T., Kronholm, E., Tapanainen, H., Kontto, J., & Männistö, S. (2017) · Obesity · doi:10.1002/oby.21747 · Cited by 145
The Role of Snacking in Energy Balance: a Biobehavioral Approach,
Chapelot, D. (2011) · The Journal of Nutrition · doi:10.3945/jn.109.114330 · Cited by 126
Holmbäck, I., Ericson, U., Gullberg, B., & Wirfält, E. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510001753 · Cited by 120
Paoli, A., Moro, T., Marcolin, G., Neri, M., Bianco, A., Palma, A., & Grimaldi, K. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-237 · Cited by 116 · cited 1×
“As a part of the strategies proposed for reducing energy intake (diets, drugs, and bariatric surgery) [24] and for increasing energy output (exercise and non-exercise movement) [25], meal timing and frequency could exert a significant influence on weight control and weight loss.”
BackgroundSelf-citationGaraulet, M., Esteban Tardido, A., Lee, Y.-C., Smith, C. E., Parnell, L. D., & Ordovás, J. M. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.270 · Cited by 98
Paoli, A., Moro, T., Bosco, G., Bianco, A., Grimaldi, K., Camporesi, E., & Mangar, D. (2015) · Marine Drugs · doi:10.3390/md13020996 · Cited by 81
Self-citationTaylor, M., & Garrow, J. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801572 · Cited by 79
Garaulet, M., Vera, B., Bonnet-Rubio, G., Gómez-Abellán, P., Lee, Y.-C., & Ordovás, J. M. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.134528 · Cited by 53
Feeding Time Entrains the Olfactory Bulb Circadian Clock in Anosmic PER2:LUC Mice
Pavlovski, I., Evans, J. A., & Mistlberger, R. E. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.10.009 · Cited by 20
Cited by
Stekovic, S., Hofer, S. J., Tripolt, N., Aon, M. A., Royer, P., Pein, L., Stadler, J. T., Pendl, T., Prietl, B., Url, J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.016 · Cited by 412
Precision nutrition: A systematic literature review
Kirk, D., Catal, C., & Tekinerdogan, B. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104365 · Cited by 238
Papakonstantinou, E., Oikonomou, C., Nychas, G., & Dimitriadis, G. D. (2022) · Nutrients · doi:10.3390/nu14040823 · Cited by 199
Cardiometabolic Benefits of Intermittent Fasting
Varady, K. A., Cienfuegos, S., Ezpeleta, M., & Gabel, K. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-052020-041327 · Cited by 186
MORO, T., TINSLEY, G., PACELLI, F. Q., MARCOLIN, G., BIANCO, A., & PAOLI, A. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002738 · Cited by 134
Self-citation
Metadata
- Authors
- Paoli, A., Tinsley, G., Bianco, A., & Moro, T.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-03-28
- Volume
- 11
- Issue
- 4
- Pages
- 719
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2923351390
- Cited by
- 377
- References
- 29
- FWCI
- 22.57
- Type
- journal article
- Language
- en
- Open access
- gold
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