Cited by 266Gastrointestinal motility and disordersInfant Health and DevelopmentGut microbiota and health

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Irritable bowel syndrome: A clinical review

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Soares, Rosa LS·2014·World Journal of Gastroenterology

DOI 10.3748/wjg.v20.i34.12144PMC PMC4161800

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Abstract

Irritable bowel syndrome (IBS) remains a clinical challenge in the 21(st) century. It's the most commonly diagnosed gastrointestinal condition and also the most common reason for referral to gastroenterology clinics. Its can affect up to one in five people at some point in their lives, and has a significantly impact of life quality and health care utilization. The prevalence varies according to country and criteria used to define IBS. Various mechanisms and theories have been proposed about its etiology, but the biopsychosocial model is the most currently accepted for IBS. The complex of symptoms would be the result of the interaction between psychological, behavioral, psychosocial and environmental factors. The diagnosis of IBS is not confirmed by a specific test or structural abnormality. It is made using criteria based on clinical symptoms such as Rome criteria, unless the symptoms are thought to be atypical. Today the Rome Criteria III is the current gold-standard for the diagnoses of IBS. Secure positive evidence of IBS by means of specific disease marker is currently not possible and cannot be currently recommended for routine diagnosis. There is still no clinical evidence to recommend the use of biomarkers in blood to diagnose IBS. However, a number of different changes in IBS patients were demonstrated in recent years, some of which can be used in the future as a diagnostic support. IBS has no definitive treatment but could be controlled by non-pharmacologic management eliminating of some exacerbating factors such certain drugs, stressor conditions and changes in dietary habits.The traditional pharmacologic management of IBS has been symptom based and several drugs have been used. However, the cornerstone of its therapy is a solid patient physician relationship. This review will provide a summary of pathophysiology, diagnostic criteria and current and emerging therapies for IBS.

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The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
Functional Bowel Disorders
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
The functional gastrointestinal disorders and the Rome III process
Drossman, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.008 · Cited by 2,416
U. S. Householder survey of functional gastrointestinal disorders: Prevalence, sociodemography, and health impact
Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198
Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis
Lovell, R. M., & Ford, A. C. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.02.029 · Cited by 2,155
Gut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475
Towards positive diagnosis of the irritable bowel.
Manning, A. P., Thompson, W., Heaton, K. W., & Morris, A. F. (1978) · BMJ · doi:10.1136/bmj.2.6138.653 · Cited by 1,404
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384
Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome
Kaptchuk, T. J., Kelley, J. M., Conboy, L. A., Davis, R. B., Kerr, C. E., Jacobson, E. E., Kirsch, I., Schyner, R. N., Nam, B. H., Nguyen, L. T., et al. (2008) · BMJ · doi:10.1136/bmj.39524.439618.25 · Cited by 1,196
Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Global and Deep Molecular Analysis of Microbiota Signatures in Fecal Samples From Patients With Irritable Bowel Syndrome
Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.043 · Cited by 1,041
Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation
Pimentel, M., Lembo, A., Chey, W. D., Zakko, S., Ringel, Y., Yu, J., Mareya, S. M., Shaw, A. L., Bortey, E., & Forbes, W. P. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1004409 · Cited by 1,036
The Fecal Microbiota of Irritable Bowel Syndrome Patients Differs Significantly From That of Healthy Subjects
Kassinen, A., Krogius-Kurikka, L., Mäkivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J., & Palva, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.005 · Cited by 1,002
Altered rectal perception is a biological marker of patients with irritable bowel syndrome
Mertz, H., Naliboff, B. D., Munakata, J., Niazi, N., & Mayer, E. A. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90267-8 · Cited by 976
Prevalence of, and Risk Factors for, Chronic Idiopathic Constipation in the Community: Systematic Review and Meta-analysis
Suares, N. C., & Ford, A. C. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.164 · Cited by 919
Sexual and physical abuse in women with functional or organic gastrointestinal disorders
Drossman, D. A., Leserman, J., Nachman, G., Li, Z., Gluck, H., Toomey, T. C., & Mitchell, C. M. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-11-828 · Cited by 898
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833
The impact of irritable bowel syndrome on health-related quality of life
Gralnek, I. M., Hays, R. D., Kilbourne, A., Naliboff, B., & Mayer, E. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.16484 · Cited by 781
Eradication of Small Intestinal Bacterial Overgrowth Reduces Symptoms of Irritable Bowel Syndrome
Pimentel, M., Chow, E. J., & Lin, H. C. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03368.x · Cited by 780
The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40 000 subjects
Hungin, A. P. S., Whorwell, P. J., Tack, J. F., & Mearin, F. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01456.x · Cited by 774
The role of psychological and biological factors in postinfective gut dysfunction
Gwee, K.-A., Leong, Y.-L., Graham, C., McKendrick, M. W., Collins, S. M., Walters, S. J., Underwood, J. E., & Read, N. W. (1999) · Gut · doi:10.1136/gut.44.3.400 · Cited by 764
Why do people sue doctors? A study of patients and relatives taking legal action
Vincent, C. A., Phillips, A., & Young, M. (1994) · The Lancet · doi:10.1016/s0140-6736(94)93062-7 · Cited by 699
Analysis of the Fecal Microbiota of Irritable Bowel Syndrome Patients and Healthy Controls with Real-Time PCR
Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699
An Evidence-Based Position Statement on the Management of Irritable Bowel Syndrome
American College of Gastroenterology IBS Task Force (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.122 · Cited by 694
Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome
Saulnier, D. M., Riehle, K., Mistretta, T., Diaz, M., Mandal, D., Raza, S., Weidler, E. M., Qin, X., Coarfa, C., Milosavljevic, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.072 · Cited by 672
Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome a double-blind, randomized, placebo-controlled study
Pimentel, M., Chow, E. J., & Lin, H. C. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07234.x · Cited by 670
Irritable bowel syndrome in the general population.
Jones, R. H., & LYDEARD, S. (1992) · BMJ · doi:10.1136/bmj.304.6819.87 · Cited by 636
Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?
Dinan, T. G., Quigley, E. M. M., Ahmed, S. M. M., Scully, P., O’Brien, S., O’Mahony, L., O’Mahony, S., Shanahan, F., & Keeling, P. W. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.033 · Cited by 636
The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612
Tolerance for Rectosigmoid Distention in Irritable Bowel Syndrome
Whitehead, W. E., Holtkötter, B., Enck, P., Hoelzl, R., Holmes, K. D., Anthony, J. C., Shabsin, H. S., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90332-u · Cited by 592
Noninvasive Markers in the Assessment of Intestinal Inflammation in Inflammatory Bowel Diseases: Performance of Fecal Lactoferrin, Calprotectin, and PMN-Elastase, CRP, and Clinical Indices
Langhorst, J., Elsenbruch, S., Koelzer, J., Rueffer, A., Michalsen, A., & Dobos, G. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01556.x · Cited by 588
Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention
Mertz, H., Morgan, V. L., Tanner, G., Pickens, D. R., Price, R. R., Shyr, Y., & KESSLER, R. M. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70170-3 · Cited by 585
Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS
Dunlop, S. P., Jenkins, D., Neal, K. R., & Spiller, R. C. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.028 · Cited by 583
Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis
Ford, A. C., Talley, N. J., Schoenfeld, P. S., Quigley, E. M. M., & Moayyedi, P. (2009) · Gut · doi:10.1136/gut.2008.163162 · Cited by 582
Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis
Ford, A. C., Talley, N. J., Spiegel, B. M. R., Foxx-Orenstein, A. E., Schiller, L., Quigley, E. M. M., & Moayyedi, P. (2008) · BMJ · doi:10.1136/bmj.a2313 · Cited by 565
Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators
Piche, T., Barbara, G., Aubert, P., Bruley des Varannes, S., Dainese, R., Nano, J. L., Cremon, C., Stanghellini, V, De Giorgio, R., Galmiche, J. P., et al. (2009) · Gut · doi:10.1136/gut.2007.140806 · Cited by 540
Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial
Atkinson, W., Sheldon, T. A., Shaath, N., & Whorwell, P. J. (2004) · Gut · doi:10.1136/gut.2003.037697 · Cited by 534
Food-Related gastrointestinal symptoms in the irritable bowel syndrome
Simrén, M., Månsson, A., Langkilde, A. M., Svedlund, J., Abrahamsson, H., Bengtsson, U., & Björnsson, E. S. (2001) · Digestion · doi:10.1159/000051878 · Cited by 529
Irritable Bowel Syndrome
Lagattolla, N. (2002) · CRC Press eBooks · doi:10.1201/b14719-46 · Cited by 522
Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome
Törnblom, H., Lindberg, G., Nyberg, B., & Veress, B. (2002) · Gastroenterology · doi:10.1053/gast.2002.37059 · Cited by 516
Methane, a Gas Produced by Enteric Bacteria, Slows Intestinal Transit and Augments Small Intestinal Contractile Activity
Pimentel, M., Lin, H. C., Enayati, P., van den Burg, B., Lee, H.-R., Chen, J. H., Park, S., Kong, Y., & Conklin, J. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00574.2004 · Cited by 508
Frequency of Symptoms of Ovarian Cancer in Women Presenting to Primary Care Clinics
Goff, B. A. (2004) · JAMA · doi:10.1001/jama.291.22.2705 · Cited by 503
Small intestinal bacterial overgrowth in patients with irritable bowel syndrome
Posserud, I., Stotzer, P.-O., Björnsson, E. S., Abrahamsson, H., & Simrén, M. (2007) · Gut · doi:10.1136/gut.2006.108712 · Cited by 499
Increased mast cells in the irritable bowel syndrome
O’Sullivan, Clayton, Breslin, Harman, Bountra, Mclaren, & O’Morain (2000) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2000.00221.x · Cited by 480
Abnormal Intestinal Permeability in Subgroups of Diarrhea-Predominant Irritable Bowel Syndromes
Dunlop, S. P., Hebden, J., Campbell, E., Naesdal, J., Olbe, L., Perkins, A. C., & Spiller, R. C. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00672.x · Cited by 476
Rectal distention testing in patients with irritable bowel syndrome: Sensitivity, specificity, and predictive values of pain sensory thresholds
Bouin, M., Plourde, V., Boivin, M., Riberdy, M., Lupien, F., Laganière, M., Verrier, P., & Poitras, P. (2002) · Gastroenterology · doi:10.1053/gast.2002.33601 · Cited by 470
Systematic review and meta-analysis: the incidence and prognosis of post-infectious irritable bowel syndrome
THABANE, M., KOTTACHCHI, D. T., & MARSHALL, J. K. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03399.x · Cited by 466
Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety
Chey, W. D., Lembo, A. J., Lavins, B. J., Shiff, S. J., Kurtz, C. B., Currie, M. G., MacDougall, J. E., Jia, X. D., Shao, J. Z., Fitch, D. A., et al. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.254 · Cited by 463
Irritable bowel syndrome in twins: Heredity and social learning both contribute to etiology
Levy, R. L., Jones, K. R., Whitehead, W. E., Feld, S. I., Talley, N. J., & Corey, L. A. (2001) · Gastroenterology · doi:10.1053/gast.2001.27995 · Cited by 458
Melancholic microbes: a link between gut microbiota and depression
Dinan, T. G., & Cryan, J. F. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12198 · Cited by 424
Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome
Camilleri, M., Lasch, K. L., & Zhou, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00155.2012 · Cited by 412
Quantitative Meta-analysis Identifies Brain Regions Activated During Rectal Distension in Irritable Bowel Syndrome
Tillisch, K., Mayer, E. A., & Labus, J. S. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.07.053 · Cited by 412
Meta‐analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome
Poynard, T., Regimbeau, C., & Benhamou, Y. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.00937.x · Cited by 406
Clinical trial: lubiprostone in patients with constipation‐associated irritable bowel syndrome – results of two randomized, placebo‐controlled studies
DROSSMAN, D. A., CHEY, W. D., JOHANSON, J. F., FASS, R., SCOTT, C., PANAS, R., & UENO, R. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03881.x · Cited by 399
A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation
Rao, S. S. C., Lembo, A., Shiff, S., Lavins, B., Currie, M., Jia, X., Shi, K., Macdougall, J. E., Shao, J. Z., Eng, P., et al. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.255 · Cited by 394
Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care
Sanders, D. S., Carter, M. J., Hurlstone, D. P., Pearce, A., Ward, A. M., McAlindon, M. E., & Lobo, A. J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06581-3 · Cited by 390
Gastrointestinal Illness and the Biopsychosocial Model
Drossman, D. A. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199805000-00007 · Cited by 388
Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis
Wang, L.-H., Fang, X.-C., & Pan, G.-Z. (2004) · Gut · doi:10.1136/gut.2003.021154 · Cited by 387
Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
Guilarte, M., Santos, J., de Torres, I., Alonso, C., Vicario, M., Ramos, L., Martinez, C., Casellas, F., Saperas, E., & Malagelada, J. R. (2007) · Gut · doi:10.1136/gut.2006.100594 · Cited by 385
Symptoms of irritable bowel syndrome in a British urban community: Consulters and nonconsulters
Heaton, K. W., O'Donnell, L. J. D., Braddon, F., Mountford, R. A., Hughes, A., & Cripps, P. J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90320-x · Cited by 382
Pharmacologic Treatment of the Irritable Bowel Syndrome
Jailwala, J., Imperiale, T. F., & Kroenke, K. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-2-200007180-00013 · Cited by 374
Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns.
Cann, P. A., Read, N. W., Brown, C., Hobson, N., & Holdsworth, C. D. (1983) · Gut · doi:10.1136/gut.24.5.405 · Cited by 365
Perceived food intolerance in subjects with irritable bowel syndrome--etiology, prevalence and consequences
Monsbakken, K. W., Vandvik, P. O., & Farup, P. G. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602367 · Cited by 364
The Utility of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review
Brenner, D. M., Moeller, M. J., Chey, W. D., & Schoenfeld, P. S. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.25 · Cited by 362
Postinfectious Irritable Bowel Syndrome-A Meta-Analysis
Halvorson, H. A., Schlett, C. D., & Riddle, M. S. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00654.x · Cited by 352
The Irritable Bowel Syndrome: Long-Term Prognosis and the Physician-Patient Interaction
Owens, D. M., Nelson, D. K., & Talley, N. J. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-2-199501150-00005 · Cited by 349
Influences of Dietary and Environmental Stress on Microbial Populations in the Murine Gastrointestinal Tract
Tannock, G. W., & Savage, D. C. (1974) · Infection and Immunity · doi:10.1128/iai.9.3.591-598.1974 · Cited by 349
Colonic Motility Abnormality in Patients With Irritable Bowel Syndrome Exhibiting Abdominal Pain and Diarrhea
Chey, W. Y., Jin, H. O., Lee, M. H., Sun, S. W., & Lee, K. Y. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03804.x · Cited by 347
Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives
Tack, J., van Outryve, M., Beyens, G., Kerstens, R., & Vandeplassche, L. (2009) · Gut · doi:10.1136/gut.2008.162404 · Cited by 347
Clinical trial: The efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation: A 12-week, randomized, double-blind, placebo-controlled study
QUIGLEY, E. M. M., VANDEPLASSCHE, L., KERSTENS, R., & AUSMA, J. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03884.x · Cited by 344
A Randomized Double-Blind Placebo-Controlled Trial of Rifaximin in Patients with Abdominal Bloating and Flatulence
Sharara, A. I., Aoun, E., Abdul-Baki, H., Mounzer, R., Sidani, S., & ElHajj, I. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00458.x · Cited by 344
Mucosal Immune Activation in Irritable Bowel Syndrome: Gender-Dependence and Association With Digestive Symptoms
Cremon, C., Gargano, L., Morselli-Labate, A. M., Santini, D., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Corinaldesi, R., & Barbara, G. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.94 · Cited by 342
Impaired transit and tolerance of intestinal gas in the irritable bowel syndrome
Serra, J. (2001) · Gut · doi:10.1136/gut.48.1.14 · Cited by 340
The Role of Intestinal Gas in Functional Abdominal Pain
Lasser, R. B., Bond, J. H., & Levitt, M. D. (1975) · New England Journal of Medicine · doi:10.1056/nejm197509112931103 · Cited by 323
Bran and irritable bowel syndrome: time for reappraisal
Francis, C. Y. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91055-3 · Cited by 315
Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity
Gecse, K., Róka, R., Ferrier, L., Leveque, M., Eutamene, H., Cartier, C., Ait-Belgnaoui, A., Rosztóczy, A., Izbéki, F., Fioramonti, J., et al. (2008) · Gut · doi:10.1136/gut.2007.140210 · Cited by 314
Gastrointestinal food hypersensitivity: Basic mechanisms of pathophysiology
Crowe, S. E., & Perdue, M. H. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90047-3 · Cited by 310
Functional gastrointestinal disorders and mood disorders in patients with inactive inflammatory bowel disease: Prevalence and impact on health
Farrokhyar, F., Marshall, J. K., Easterbrook, B., & Irvine, J. E. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000195391.49762.89 · Cited by 310
The Irritable Bowel Syndrome: Review and a Graduated Multicomponent Treatment Approach
Drossman, D. A., & Thompson, W. G. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-12-1009 · Cited by 309
Natural History of Functional Gastrointestinal Disorders: A 12-year Longitudinal Population-Based Study
Halder, S. L. S., Locke, G. R., Schleck, C. D., Zinsmeister, A. R., Melton, L. J., & Talley, N. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.010 · Cited by 309
Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery.
Marshall, J. K., Thabane, M., Garg, A. X., Clark, W., Salvadori, M., & Collins, S. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.053 · Cited by 304
Irritable Bowel Syndrome, Health Care Use, and Costs: A U.S. Managed Care Perspective
Longstreth, G. F., Wilson, A., Knight, K., Wong, J. B., Chiou, C. F., Barghout, V. E., Frech, F. H., & Ofman, J. J. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07296.x · Cited by 294
The placebo effect in irritable bowel syndrome trials: a meta‐analysis1
Patel, S. M., Stason, W. B., Legedza, A., Ock, S. M., Kaptchuk, T. J., Conboy, L., Canenguez, K., Park, J. K., Kelly, E., Jacobson, E., et al. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00650.x · Cited by 285
Evidence of a Genetic Contribution to Functional Bowel Disorder
Morris‐Yates, A. D., Talley, N. J., Boyce, P. M., Nandurkar, S., & Andrews, G. (1998) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(98)00321-9 · Cited by 285
The Expression and the Cellular Distribution of the Tight Junction Proteins Are Altered in Irritable Bowel Syndrome Patients With Differences According to the Disease Subtype
Bertiaux-Vandaële, N., Youmba, S. B., Belmonte, L., Lecleire, S., Antonietti, M., Gourcerol, G., Leroi, A., Déchelotte, P., Ménard, J., Ducrotte, P., et al. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.257 · Cited by 285
Combined oro-caecal scintigraphy and lactulose hydrogen breath testing demonstrate that breath testing detects oro-caecal transit, not small intestinal bacterial overgrowth in patients with IBS
Yu, D., Cheeseman, F., & Vanner, S. (2011) · Gut · doi:10.1136/gut.2009.205476 · Cited by 284
The Efficacy and Safety of Rifaximin for the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
Menees, S. B., Maneerattannaporn, M., Kim, H. M., & Chey, W. D. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.355 · Cited by 283
The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota
Crouzet, L., Gaultier, E., Del'Homme, C., Cartier, C., Delmas, E., Dapoigny, M., Fioramonti, J., & Bernalier‐Donadille, A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12103 · Cited by 280
Psychosocial Factors are Linked to Functional Gastrointestinal Disorders: A Population Based Nested Case-Control Study
Richard Locke, G., Weaver, A. L., Joseph Melton, L., & Talley, N. J. (2004) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04043.x · Cited by 278
Functional dyspepsia—symptoms, definitions and validity of the Rome III criteria
Tack, J. F., & Talley, N. J. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.14 · Cited by 276
Prevalence of irritable bowel syndrome: a community survey.
Wilson, S., Roberts, L. M., Roalfe, A. K., Bridge, P., & Singh, S. (2004) · Europe PMC (PubMed Central) · Cited by 276
Somatic comorbidities of irritable bowel syndrome: A systematic analysis
Riedl, A., Schmidtmann, M., Stengel, A., Goebel, M., Wisser, A.-S., Klapp, B. F., & Mönnikes, H. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.02.021 · Cited by 274
Systematic review on the management of irritable bowel syndrome in North America
Brandt, L. J., Bjorkman, D. J., Fennerty, M. B., Locke, G. R., Olden, K. W., Peterson, W., Quigley, E. M. M., Schoenfeld, P., Schuster, M. M., & Talley, N. J. (2002) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(02)05657-5 · Cited by 271
Abdominal Pain, Bloating, and Diarrheain the United States:
Sandler, R. S., Stewart, W. F., Liberman, J. N., Ricci, J. A., & Zorich, N. L. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005554103531 · Cited by 268
A role for inflammation in irritable bowel syndrome?
Barbara, G., GIORGIO, R. D., Stanghellini, V., Cremon, C., & Corinaldesi, R. (2002) · Gut · doi:10.1136/gut.51.suppl_1.i41 · Cited by 266
Efficacy of 5-HT3 Antagonists and 5-HT4 Agonists in Irritable Bowel Syndrome: Systematic Review and Meta-Analysis
Ford, A. C., Brandt, L. J., Young, C., Chey, W. D., Foxx-Orenstein, A. E., & Moayyedi, P. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.223 · Cited by 261
Irritable bowel syndrome and surgery: A multivariable analysis☆
Longstreth, G. F., & Yao, J. F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.020 · Cited by 248
IBS-Like Symptoms in Patients with Inflammatory Bowel Disease in Remission; Relationships with Quality of Life and Coping Behavior
Minderhoud, I. M., Oldenburg, B., Wismeijer, J. A., Henegouwen, G. P. V. B., & Smout, A. J. P. M. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000020506.84248.f9 · Cited by 243
The utility of diagnostic tests in irritable bowel syndrome patients: a systematic review
Cash, B. D., Schoenfeld, P., & Chey, W. D. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07027.x · Cited by 242
The Irritable Bowel Syndrome
Horwitz, B. J., & Fisher, R. S. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106143442407 · Cited by 235
Irritable Bowel Syndrome: A 10-Yr Natural History of Symptoms and Factors That Influence Consultation Behavior
Ford, A. C., Forman, D., Bailey, A. G., Axon, A. T. R., & Moayyedi, P. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01740.x · Cited by 233
The Degree of Breath Methane Production in IBS Correlates With the Severity of Constipation
Chatterjee, S., Park, S., Low, K., Kong, Y., & Pimentel, M. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01072.x · Cited by 231
A Comparison of The Rome and Manning Criteria for Case Identification in Epidemiological Investigations of Irritable Bowel Syndrome
Saito, Y. A., Locke, R. G., Talley, N. J., Zinsmeister, A. R., Fett, S. L., & Melton, J. L. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03192.x · Cited by 227
Severity in Irritable Bowel Syndrome: A Rome Foundation Working Team Report
Drossman, D. A., Chang, L., Bellamy, N., Gallo-Torres, H. E., Lembo, A., Mearin, F., Norton, N. J., & Whorwell, P. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.201 · Cited by 226
Evidence of a Genetic Contribution to Functional Bowel Disorder
Morris‐Yates, A. D., Talley, N. J., Boyce, P. M., Nandurkar, S., & Andrews, G. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.440_j.x · Cited by 225
Irritable bowel syndrome according to varying diagnostic criteria: are the new Rome II criteria unnecessarily restrictive for research and practice?
Boyce, P. M., Koloski, N. A., & Talley, N. J. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03197.x · Cited by 225
Meta‐analysis: the treatment of irritable bowel syndrome
Pantoflickova, D., Michetti, P., Fried, M., Beglinger, C., & Blum, A. L. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02267.x · Cited by 223
Intestinal Serotonin Release, Sensory Neuron Activation, and Abdominal Pain in Irritable Bowel Syndrome
Cremon, C., Carini, G., Wang, B., Vasina, V., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Grundy, D., Tonini, M., De Ponti, F., et al. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.86 · Cited by 223
Irritable bowel syndrome: Diagnosis and pathogenesis
El‐Salhy, M. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i37.5151 · Cited by 222
Fibromyalgia in The Irritable Bowel Syndrome: Studies of Prevalence and Clinical Implications
Sperber, A. D., Atzmon, Y., Neumann, L., Weisberg, I., Shalit, Y., Abu-Shakrah, M., Fich, A., & Buskila, D. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01643.x · Cited by 220
Acupuncture for treatment of irritable bowel syndrome
Manheimer, E. W., Cheng, K., Wieland, L. S., Min, L. S., Shen, X., Berman, B., & Lao, L. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005111.pub3 · Cited by 219
The Jejunum of Diarrhea-Predominant Irritable Bowel Syndrome Shows Molecular Alterations in the Tight Junction Signaling Pathway That Are Associated With Mucosal Pathobiology and Clinical Manifestations
Martínez, C., Vicario, M., Ramos, L., Lobo, B., Mosquera, J. L., Alonso, C., Sánchez, A., Guilarte, M., Antolín, M., de Torres, I., et al. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.472 · Cited by 214
PROGNOSIS IN THE IRRITABLE BOWEL SYNDROME: A 5-YEAR PROSPECTIVE STUDY
Harvey, R. F., Mauad, E. C., & Brown, A. M. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90304-7 · Cited by 212
Irritable bowel syndrome in twins: genes and environment
Bengtson, M.-B., Ronning, T., Vatn, M. H., & Harris, J. R. (2006) · Gut · doi:10.1136/gut.2006.097287 · Cited by 212
Effects of 5-Hydroxytryptamine (Serotonin) Type 3 Antagonists on Symptom Relief and Constipation in Nonconstipated Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Andresen, V., Montori, V. M., Keller, J., West, C. P., Layer, P., & Camilleri, M. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.12.015 · Cited by 212
Current Understanding of Gastrointestinal Immunoregulation and Its Relation to Food Allergy
Brandtzæg, P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04131.x · Cited by 208
A Double-Blind Placebo-Controlled Trial with Loperamide in Irritable Bowel Syndrome
Efskind, P., Bernklev, T., & Vatn, M. H. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609006766 · Cited by 206
Is Irritable Bowel Syndrome a Diagnosis of Exclusion? A Survey of Primary Care Providers, Gastroenterologists, and IBS Experts
Spiegel, B. M. R., Farid, M., Esrailian, E., Talley, J., & Chang, L. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.47 · Cited by 206
The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-d-aspartate receptor
Willert, R. P., Woolf, C. J., Hobson, A. R., Delaney, C. M., Thompson, D. G., & Aziz, Q. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.047 · Cited by 202
Physical and Psychological Stress in Rats Enhances Colonic Epithelial Permeability via Peripheral CRH
Saunders, P. R., Santos, J., Hanssen, N. P. M., Yates, D. A., Groot, J. A., & Perdue, M. H. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1013204612762 · Cited by 198
Cognitive behaviour therapy in addition to antispasmodic treatment for irritable bowel syndrome in primary care: randomised controlled trial
Kennedy, T., Jones, R. H., Darnley, S., Seed, P. T., Wessely, S. C., & Chalder, T. (2005) · BMJ · doi:10.1136/bmj.38545.505764.06 · Cited by 191
Increased colonic pain sensitivity in irritable bowel syndrome is the result of an increased tendency to report pain rather than increased neurosensory sensitivity
Dorn, S. D., Palsson, O. S., Thiwan, S., Kanazawa, M., Clark, W. C., van Tilburg, M. A. L., Drossman, D. A., Scarlett, Y. V., Levy, R. L., Ringel, Y., et al. (2007) · Gut · doi:10.1136/gut.2006.117390 · Cited by 191
Double-blind Placebo-Controlled Trial of Amitriptyline for the Treatment of Irritable Bowel Syndrome in Adolescents
Bahar, R., Collins, B. S., Steinmetz, B. A., & Ament, M. E. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.10.012 · Cited by 186
Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case–control study in irritable bowel syndrome
Lupascu, A., Gabrielli, M., Lauritano, E. C., Scarpellini, E., Santoliquido, A., Cammarota, G., Flore, R. A., Tondi, P., POLA, P., Gasbarrini, G. B., et al. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02690.x · Cited by 186
Incidence of Post-Infectious Irritable Bowel Syndrome and Functional Intestinal Disorders Following a Water-Borne Viral Gastroenteritis Outbreak
Zanini, B., Ricci, C., Bandera, F., Caselani, F., Magni, A., Laronga, A. M., & Lanzini, A. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.102 · Cited by 185
Lipid-induced intestinal gas retention in irritable bowel syndrome
Serra, J., Salvioli, B., Azpiroz, F., & Malagelada, J. (2002) · Gastroenterology · doi:10.1053/gast.2002.35394 · Cited by 184
Psychological treatments for the management of irritable bowel syndrome
Zijdenbos, I. L., de Wit, N. J., van der Heijden, G. J., Rubin, G., & Quartero, A. O. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006442.pub2 · Cited by 180
Randomized, double‐blind, placebo‐controlled trial of prednisolone in post‐infectious irritable bowel syndrome
Dunlop, S., Jenkins, D., Neal, K. R., Næsdal, J., Borgaonker, M., Collins, S. M., & Spiller, R. E. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01640.x · Cited by 178
Association of distinct α 2 adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders
Kim, H. J., Camilleri, M., Carlson, P. J., Cremonini, F., Ferber, I., Stephens, D. A., McKinzie, S., Zinsmeister, A. R., & Urrutia, R. A. (2004) · Gut · doi:10.1136/gut.2003.030882 · Cited by 176
Antibiotics increase functional abdominal symptoms
Maxwell, P., Rink, E., Kumar, D., & Mendall, M. A. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05428.x · Cited by 176
Loperamide in Treatment of Irritable Bowel Syndrome—A Double-Blind Placebo Controlled Study
Lavö, B., Stenstam, M., & Nielsen, A.-L. (1987) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528709091003 · Cited by 175
Epidemiology of IBS
Choung, R. S., & Locke, G. R. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.006 · Cited by 175
Cortical effects of anticipation and endogenous modulation of visceral pain assessed by functional brain MRI in irritable bowel syndrome patients and healthy controls
Song, G. H., Venkatraman, V., Ho, K. Y., Chee, M. W. L., Yeoh, K. G., & Wilder‐Smith, C. H. (2006) · Pain · doi:10.1016/j.pain.2006.06.017 · Cited by 175
Detection of Bacterial Overgrowth in IBS Using the Lactulose H2 Breath Test: Comparison with 14C-d-Xylose and Healthy Controls
Walters, B., & Vanner, S. J. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40795.x · Cited by 172
Lactulose Breath Testing Does Not Discriminate Patients With Irritable Bowel Syndrome From Healthy Controls
Bratten, J. R., Spanier, J., & Jones, M. P. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01785.x · Cited by 172
The Prevalence of Fibromyalgia in Other Chronic Pain Conditions
Yunus, M. B. (2011) · Pain Research and Treatment · doi:10.1155/2012/584573 · Cited by 171
Symptomatic overlap between irritable bowel syndrome and microscopic colitis
Limsui, D., Pardi, D. S., Camilleri, M., Loftus, E. V., Kammer, P. P., Tremaine, W. J., & Sandborn, W. J. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20059 · Cited by 167
Gastrointestinal Microbiota in Irritable Bowel Syndrome: Their Role in Its Pathogenesis and Treatment
Parkes, G. C., Brostoff, J., Whelan, K., & Sanderson, J. D. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01869.x · Cited by 167
Phenotypic changes in colonocytes following acute stress or activation of mast cells in mice: implications for delayed epithelial barrier dysfunction
Demaude, J. (2006) · Gut · doi:10.1136/gut.2005.078675 · Cited by 167
Treatment of irritable bowel syndrome: a review of randomised controlled trials
Akehurst, R. L., & KALTENTHALER, E. (2001) · Gut · doi:10.1136/gut.48.2.272 · Cited by 165
Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5‐HT signalling and metabolism in human disease
Spiller, R. E. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00965.x · Cited by 164
A Systematic Review of Alternative Therapies in the Irritable Bowel Syndrome
Spanier, J., Howden, C. W., & Jones, M. P. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.3.265 · Cited by 162
Efficacy of tricyclic antidepressants in irritable bowel syndrome: A meta-analysis
Rahimi, R., Nikfar, S., Rezaie, A. R., & Abdollahi, M. R. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.1548 · Cited by 156
Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome
Wilder‐Smith, C. H. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i27.3699 · Cited by 156
Is the association between irritable bowel syndrome and abuse explained by neuroticism? A population based study
Talley, N. J., Boyce, P. M., & Jones, M. (1998) · Gut · doi:10.1136/gut.42.1.47 · Cited by 154
Serotonin Signaling Is Altered in Irritable Bowel Syndrome With Diarrhea but Not in Functional Dyspepsia in Pediatric Age Patients
Faure, C. C., Patey, N., Gauthier, C., Brooks, E. M., & Mawe, G. M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.032 · Cited by 154
Visceral perception in irritable bowel syndrome
Zighelboim, J., Talley, N. J., Phillips, S. F., Harmsen, W. S., & Zinsmeister, A. R. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02064986 · Cited by 152
Untitled work
(1996) · PubMed · Cited by 150
Neonatal maternal separation of rat pups results in abnormal cholinergic regulation of epithelial permeability
Gareau, M. G., Jury, J., & Perdue, M. H. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00392.2006 · Cited by 147
Serotonin Transporter Gene Polymorphism in Irritable Bowel Syndrome
Pata, C., Erdal, E. M., Derici, E., Yazar, A., Kanık, A., & Ulu, O. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05841.x · Cited by 146
Brain-Gut Interactions in IBS
Fichna, J., & Storr, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00127 · Cited by 146
Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: A cost-effectiveness analysis☆
Spiegel, B. M. R., DeRosa, V. P., Gralnek, I. M., Wang, V. C., & Dulai, G. S. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.012 · Cited by 146
Intestinal permeability and irritable bowel syndrome
Camilleri, M., & Gorman, H. (2007) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2007.00925.x · Cited by 145
Influence of genetics on irritable bowel syndrome, gastro‐oesophageal reflux and dyspepsia: a twin study
LEMBO, A., ZAMAN, M., Jones, M., & Talley, N. J. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03326.x · Cited by 144
Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin‐releasing factor and nerve growth factor interplay
Barreau, F., Cartier, C., Leveque, M., Ferrier, L., Moriez, R., Laroute, V., Rosztoczy, A. I., Fioramonti, J., & Bueno, L. P. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120907 · Cited by 144
Prokinetic effects in patients with intestinal gas retention
Caldarella, M. P., Serra, J., Azpiroz, F., & Malagelada, J. (2002) · Gastroenterology · doi:10.1053/gast.2002.33658 · Cited by 143
Long-Term Success of GUT-Directed Group Hypnosis for Patients With Refractory Irritable Bowel Syndrome: A Randomized Controlled Trial
Moser, G., Trägner, S., Gajowniczek, E. E., Mikulits, A., Michalski, M., Kazemi-Shirazi, L., Kulnigg-Dabsch, S., Führer, M., Ponocny-Seliger, E., Dejaco, C., et al. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.19 · Cited by 139
Relationship of Abdominal Bloating to Distention in Irritable Bowel Syndrome and Effect of Bowel Habit
Houghton, L. A., Lea, R., Agrawal, A., Reilly, B., & Whorwell, P. J. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.015 · Cited by 138
Mucosal Barrier Defects in Irritable Bowel Syndrome. Who Left the Door Open?
Barbara, G. (2006) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00667.x · Cited by 136
Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome
Zar, S., Mincher, L., Benson, M. J., & Kumar, D. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510015593 · Cited by 134
Long-term alterations of colonic nerve–mast cell interactions induced by neonatal maternal deprivation in rats
Barreau, F., Salvador‐Cartier, C., Houdeau, E., Bueno, L., & Fioramonti, J. (2008) · Gut · doi:10.1136/gut.2007.126680 · Cited by 133
Prevalence, Characteristics, and Impact of Bloating Symptoms in Patients With Irritable Bowel Syndrome
Ringel, Y., Williams, R. E., Kalilani, L., & Cook, S. F. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.07.008 · Cited by 133
The Prevalence of Celiac Disease Among Patients With Nonconstipated Irritable Bowel Syndrome Is Similar to Controls
Cash, B. D., Rubenstein, J. H., Young, P. E., Gentry, A., Nojkov, B., Lee, D. K., Andrews, A. H., Dobhan, R. R., & Chey, W. D. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.084 · Cited by 131
Chronic abdominal wall pain: Clinical features, health care costs, and long-term outcome
Costanza, C. D., Longstreth, G. F., & Liu, A. L. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00124-7 · Cited by 131
Yogic Versus Conventional Treatment in Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized Control Study
Taneja, I., Deepak, K. K., Poojary, G., Acharya, I. N., Pandey, R. M., & Sharma, M. (2004) · Applied Psychophysiology and Biofeedback · doi:10.1023/b:apbi.0000017861.60439.95 · Cited by 129
Cortagine, a CRF 1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways
Larauche, M. H., Gourcerol, G., Wang, L., Pambukchian, K., Brunnhuber, S., Adelson, D. W., Rivier, J., Million, M., & Taché, Y. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00072.2009 · Cited by 129
Characterization of the Alternating Bowel Habit Subtype in Patients with Irritable Bowel Syndrome
Tillisch, K., Labus, J. S., Naliboff, B. D., Bolus, R. R., Shetzline, M. A., Mayer, E. A., & Chang, L. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41211.x · Cited by 126
Increased prevalence of irritable bowel syndrome in patients with bronchial asthma
Roussos, A., Koursarakos, P., PATSOPOULOS, D., Gerogianni, I., & Philippou, N. (2003) · Respiratory Medicine · doi:10.1053/rmed.2001.1409 · Cited by 124
Intestinal motility in irritable bowel syndrome: Is IBS a motility disorder?
McKee, D. P., & Quigley, E. M. M. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01296097 · Cited by 122
Presentations of Adult Celiac Disease in a Nationwide Patient Support Group
Zipser, R. D., Patel, S. A., Yahya, K. Z., Baisch, D., & Monarch, E. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1022897028030 · Cited by 122
Initial validation of a bowel symptom questionnaire* and measurement of chronic gastrointestinal symptoms in Australians
Talley, N. J., Newman, P., Boyce, P. M., Paterson, K. J., & Owen, B. (1995) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1995.tb01894.x · Cited by 121
A meta‐analysis of the placebo response in complementary and alternative medicine trials of irritable bowel syndrome
Dorn, S. D., Kaptchuk, T. J., Park, J. B., Nguyen, L. T., Canenguez, K., Nam, B. H., Woods, K. B., Conboy, L. A., Stason, W. B., & Lembo, A. J. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00937.x · Cited by 119
Visceral perception: inflammatory and non-inflammatory mediators
Bueno, L. P., & Fioramonti, J. (2002) · Gut · doi:10.1136/gut.51.suppl_1.i19 · Cited by 118
Genetic Influences in Irritable Bowel Syndrome: A Twin Study
Mohammed, I., Cherkas, L. F., Riley, S. A., Spector, T. D., & Trudgill, N. J. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41700.x · Cited by 118
Utility of red flag symptom exclusions in the diagnosis of irritable bowel syndrome
WHITEHEAD, W. E., PALSSON, O. S., FELD, A. D., LEVY, R. L., VON KORFF, M., TURNER, M. J., & DROSSMAN, D. A. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02956.x · Cited by 118
Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling
Aizawa, E., Sato, Y., Kochiyama, T., Saito, N., Izumiyama, M., Morishita, J., Kanazawa, M., Shima, K., Mushiake, H., Hongo, M., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.104 · Cited by 116
THE EPIDEMIOLOGY OF FUNCTIONAL GASTROINTESTINAL DISORDERS IN NORTH AMERICA
Locke, G. R. (1996) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70362-9 · Cited by 113
Defining the predictors of the placebo response in irritable bowel syndrome
Pitz, M., Cheang, M., & Bernstein, C. N. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00626-3 · Cited by 111
Systematic review: the influence of geography and ethnicity in irritable bowel syndrome
Kang, J. Y. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02396.x · Cited by 110
Irritable bowel syndrome: The burden and unmet needs in Europe
Quigley, E. M. M., Bytzer, P. M., Jones, R. H., & Mearin, F. (2006) · Digestive and Liver Disease · doi:10.1016/j.dld.2006.05.009 · Cited by 110
Small Intestinal Bacterial Overgrowth
Quigley, E. M. M., & Abu-Shanab, A. (2010) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2010.07.007 · Cited by 108
Functional Gastrointestinal Disorders
Banoub, H., Nazer, H. M., & Chong, S. K. F. (2012) · Springer eBooks · doi:10.1007/978-3-642-02202-9_185 · Cited by 107
Sensitization of Peripheral Sensory Nerves by Mediators From Colonic Biopsies of Diarrhea-Predominant Irritable Bowel Syndrome Patients: A Role for PAR2
Valdez-Morales, E. E., Overington, J., Guerrero-Alba, R., Ochoa-Cortes, F., Ibeakanma, C. O., Spreadbury, I., Bunnett, N. W., Beyak, M., & Vanner, S. J. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.241 · Cited by 107
III. Visceral afferent pathways: a source of new therapeutic targets for abdominal pain
Bueno, L. P., Fioramonti, J., & Villar, R. G. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.5.g670 · Cited by 105
Bloating and Distension in Irritable Bowel Syndrome: The Role of Gastrointestinal Transit
Agrawal, A., Houghton, L. A., Reilly, B., Morris, J., & Whorwell, P. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.251 · Cited by 104
A Population Study on Irritable Bowel Syndrome and Mental Health
E. Österberg, L. B. (2000) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655200750024128 · Cited by 104
Abnormal Propagation Pattern of Duodenal Pressure Waves in the Irritable Bowel Syndrome (IBS)
Simrén, M., Castedal, M., Svedlund, J., Abrahamsson, H., & Björnsson, E. S. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1010770302403 · Cited by 101
Systematic review: accuracy of symptom‐based criteria for diagnosis of irritable bowel syndrome in primary care
Jellema, P., van der Windt, D., Schellevis, F., & van der Horst, H. E. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04087.x · Cited by 101
Irritable bowel syndrome and hypersensitivity to food.
Petitpierre, M., Gumowski, P. I., & Girard, J. P. (1985) · PubMed · Cited by 99
Irritable Bowel Syndrome: A Review and Update
Occhipinti, K. E., & Smith, J. (2012) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-0032-1301759 · Cited by 99
Chronic gastrointestinal symptoms and quality of life in the Korean population
Jeong, J., Choi, M., Cho, Y., Lee, S., Oh, J. H., Park, J. M., Cho, Y.-K., Lee, I. S., Kim, S., Han, S.-W., et al. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6388 · Cited by 99
Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome
Stanghellini, V., Tosetti, C., Barbara, G., GIORGIO, R. D., Cogliandro, L., Cogliandro, R. F., & Corinaldesi, R. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07062.x · Cited by 98
Sugar malabsorption in functional abdominal bloating: A pilot study on the long-term effect of dietary treatment
Fernández‐Bañares, F., Rosinach, M., Esteve, M., Forné, M., Espinós, J. C., & Viver, J. M. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2005.11.010 · Cited by 96
Prevalence of Gastro-Esophageal Reflux-Type Symptoms in Individuals With Irritable Bowel Syndrome in the Community: A Meta-Analysis
Lovell, R. M., & Ford, A. C. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.336 · Cited by 95
Citalopram Provides Little or No Benefit in Nondepressed Patients With Irritable Bowel Syndrome
Ladabaum, U., Sharabidze, A., Levin, T. R., Zhao, W. K., Chung, E. H., Bacchetti, P., Jin, C., Grimes, B. A., & Pepin, C. J. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2009.09.008 · Cited by 95
A randomised controlled trial of self-help interventions in patients with a primary care diagnosis of irritable bowel syndrome
Robinson, A., Lee, V., Kennedy, A. P., Middleton, L., Rogers, A. E., Thompson, D. G., & Reeves, D. (2005) · Gut · doi:10.1136/gut.2004.062901 · Cited by 94
Giardia lamblia infection in patients with irritable bowel syndrome and dyspepsia: A prospective study
Grazioli, B. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i12.1941 · Cited by 89
Pharmacologic therapy for the irritable bowel syndrome
Talley, N. J. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07306.x · Cited by 89

Research works printed but not linked: 4

Cumming W. Electrogalvinism in a particular affliction of mucous membrane of the bowels. London Med Gaz 1948;59:969-973.
10.1111/j.1365-2982.2008.0114x · DOI
10.5056/jnm.2011.17.2.13 · DOI
10.1111/j.1365-2036.2009.04081 · DOI

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See all 266

Authors: Soares, R. L.
Venue: World Journal of Gastroenterology
Publisher: Baishideng Publishing Group Inc.
Published: 2014
Volume: 20
Issue: 34
Pages: 12144
ISSN: 1007-9327 (ISSN-L)
DOI: 10.3748/wjg.v20.i34.12144
PMC: PMC4161800
OpenAlex: W2040223383
Cited by: 266
References: 271
Citations by year: 2026: 12 · 2025: 15 · 2024: 16 · 2023: 38 · 2022: 26 · 2021: 28 · 2020: 24 · 2019: 23 · 2018: 21 · 2017: 22 · 2016: 24 · 2015: 16 · 2014: 1
FWCI: 3.49
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Gastroenterology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: irritable bowel syndrome, Rome criteria, biopsychosocial model, IBS pathophysiology, IBS diagnosis, non-pharmacological treatment, pharmacotherapy, physician-patient relationship, quality of life, prevalence
MeSH terms: Combined Modality Therapy, Humans, Predictive Value of Tests, Risk Factors, Prevalence, Treatment Outcome, Irritable Bowel Syndrome

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