Cited by 167Muscle metabolism and nutritionNutrition and Health in AgingClinical Nutrition and Gastroenterology

The DOI matches its Crossref record; 34 of the 36 references it cites were found in a registry or an index.

Dietary Protein Digestion and Absorption Rates and the Subsequent Postprandial Muscle Protein Synthetic Response Do Not Differ between Young and Elderly Men ,

Open access

Koopman, René, Walrand, Stéphane, Beelen, Milou, Gijsen, Annemie P., Kies, Arie K., Boirie, Yves, Saris, Wim H.M., van Loon, Luc J.C.·2009·The Journal of Nutrition

DOI 10.3945/jn.109.109173

Open this paper in CoChat — free account

Abstract

Impaired digestion and/or absorption of dietary protein lowers postprandial plasma amino acid availability and, as such, could reduce the postprandial muscle protein synthetic response in the elderly. We aimed to compare in vivo dietary protein digestion and absorption and the subsequent postprandial muscle protein synthetic response between young and elderly men. Ten elderly (64 +/- 1 y) and 10 young (23 +/- 1 y) healthy males consumed a single bolus of 35 g specifically produced, intrinsically l-[1-(13)C]phenylalanine-labeled micellar casein (CAS) protein. Furthermore, primed continuous infusions with l-[ring-(2)H(5)]phenylalanine, l-[1-(13)C]leucine, and l-[ring-(2)H(2)]tyrosine were applied and blood and muscle tissue samples were collected to assess the appearance rate of dietary protein-derived phenylalanine in the circulation and the subsequent muscle protein fractional synthetic rate over a 6-h postprandial period. Protein ingestion resulted in a rapid increase in exogenous phenylalanine appearance in both the young and elderly men. Total exogenous phenylalanine appearance rates (expressed as area under the curve) were 39 +/- 3 mumol.6 h.kg(-1) in the young men and 38 +/- 2 mumol.6 h.kg(-1) in the elderly men (P = 0.73). In accordance, splanchnic amino acid extraction did not differ between young (72 +/- 2%) and elderly (73 +/- 1%) volunteers (P = 0.74). Muscle protein synthesis rates, calculated from the oral tracer, were 0.063 +/- 0.006 and 0.054 +/- 0.004%/h in the young and elderly men, respectively, and did not differ between groups (P = 0.27). We conclude that protein digestion and absorption kinetics and the subsequent muscle protein synthetic response following the ingestion of a large bolus of intact CAS are not substantially impaired in healthy, elderly men.

Integrity signals

Registry

Crossref · 10.3945/jn.109.109173

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211 · cited 6×
“Interestingly, data from recent studies suggest that the muscle protein synthetic response to the ingestion of a small amount of amino acids with (6,10) or without (11,12) carbohydrate is reduced in the elderly compared with young controls.”
BackgroundResultInfluential
Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research
Bergström, J. P. (1975) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517509095787 · Cited by 1,173
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2006) · Diabetes Care · doi:10.2337/diacare.29.s1.06.s43 · Cited by 924
A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923
Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis
Wolfe, R. R. (1992) · Medical Entomology and Zoology · Cited by 610
What Is Sarcopenia?
Evans, W. J. (1995) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/50a.special_issue.5 · Cited by 606
Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids
Katsanos, C. S., Kobayashi, H., Sheffield‐Moore, M., Aarsland, A. A., & Wolfe, R. R. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.1065 · Cited by 515
Age and aerobic exercise training effects on whole body and muscle protein metabolism
Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., & Nair, K. S. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00366.2003 · Cited by 470
Amino acid ingestion improves muscle protein synthesis in the young and elderly
Paddon-Jones, D., Sheffield-Moore, M., Zhang, X.-J., Volpi, E., Wolf, S. E., Aarsland, A., Ferrando, A. A., & Wolfe, R. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00368.2003 · Cited by 467 · cited 4×
“The apparent discrepancy between our findings and some (11,12), but not all, studies (5,7,33) may be attributed to differences in the mode of amino acid administration, i.”
BackgroundResultInfluential
The Response of Muscle Protein Anabolism to Combined Hyperaminoacidemia and Glucose-Induced Hyperinsulinemia Is Impaired in the Elderly1
Volpi, E., Mittendorfer, B., Rasmussen, B. B., & Wolfe, R. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7021 · Cited by 464

Show all 36 references

Sorted by citations

Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553
Self-citation
Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group
Deutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.04.007 · Cited by 1,738
Self-citation
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population
Levine, M. E., Suarez, J. A., Brandhorst, S., Balasubramanian, P., Cheng, C.-W., Madia, F., Fontana, L., Mirisola, M. G., Guevara-Aguirre, J., Wan, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.006 · Cited by 910
The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans
Wilkinson, D. J., Piasecki, M., & Atherton, P. J. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.005 · Cited by 950
Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men
Pennings, B., Boirie, Y., Senden, J. M., Gijsen, A. P., Kuipers, H., & van Loon, L. J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.008102 · Cited by 656
Self-citation
The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption
van Vliet, S., Burd, N. A., & van Loon, L. J. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.204305 · Cited by 651
Anabolic Resistance of Muscle Protein Synthesis with Aging
Burd, N. A., Gorissen, S. H., & van Loon, L. J. C. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e318292f3d5 · Cited by 384
Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion
Wall, B. T., Gorissen, S. H., Pennings, B., Koopman, R., Groen, B. B. L., Verdijk, L. B., & van Loon, L. J. C. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140903 · Cited by 352
Self-citation
Exercising before protein intake allows for greater use of dietary protein–derived amino acids for de novo muscle protein synthesis in both young and elderly men
Pennings, B., Koopman, R., Beelen, M., Senden, J. M., Saris, W. H., & van Loon, L. J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29649 · Cited by 311
Self-citation
Dietary protein intake in community-dwelling, frail, and institutionalized elderly people: scope for improvement
Tieland, M., Borgonjen-Van den Berg, K. J., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2012) · European Journal of Nutrition · doi:10.1007/s00394-011-0203-6 · Cited by 297
Protein and healthy aging
Paddon‐Jones, D., Campbell, W. W., Jacques, P. F., Kritchevsky, S. B., Moore, L. L., Rodriguez, N. R., & van Loon, L. J. C. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.084061 · Cited by 284
Effect of protein/essential amino acids and resistance training on skeletal muscle hypertrophy: A case for whey protein
Hulmi, J. J., Lockwood, C. M., & Stout, J. R. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-51 · Cited by 238
Protein Ingestion before Sleep Improves Postexercise Overnight Recovery
RES, P. T., GROEN, B., PENNINGS, B., BEELEN, M., WALLIS, G. A., GIJSEN, A. P., SENDEN, J. M. G., & VAN LOON, L. J. C. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31824cc363 · Cited by 226
Self-citation
Ingestion of wheat protein increases in vivo muscle protein synthesis rates in healthy older men in a randomized trial
Gorissen, S. H., Horstman, A. M., Franssen, R., Crombag, J. J., Langer, H., Bierau, J., Respondek, F., & van Loon, L. J. (2016) · The Journal of Nutrition · doi:10.3945/jn.116.231340 · Cited by 221
Regulation of muscle protein synthesis and the effects of catabolic states
Gordon, B. S., Kelleher, A. R., & Kimball, S. R. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.039 · Cited by 219
Age-related changes in skeletal muscle: changes to life-style as a therapy
McCormick, R., & Vasilaki, A. (2018) · Biogerontology · doi:10.1007/s10522-018-9775-3 · Cited by 227
Protein Ingestion before Sleep Increases Muscle Mass and Strength Gains during Prolonged Resistance-Type Exercise Training in Healthy Young MenNitrogen1–3
Snijders, T., Res, P. T., Smeets, J. S., van Vliet, S., van Kranenburg, J., Maase, K., Kies, A. K., Verdijk, L. B., & van Loon, L. J. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.208371 · Cited by 175
Self-citation
The anabolic response to plant-based protein ingestion
Pinckaers, P. J. M., Trommelen, J., Snijders, T., & van Loon, L. J. C. (2021) · Sports Medicine · doi:10.1007/s40279-021-01540-8 · Cited by 170
Effects of leucine-rich protein supplements on anthropometric parameter and muscle strength in the elderly: A systematic review and meta-analysis
Komar, B., Schwingshackl, L., & Hoffmann, G. (2015) · The Journal of nutrition, health and aging · doi:10.1007/s12603-014-0559-4 · Cited by 161
Post-Prandial Protein Handling: You Are What You Just Ate
Groen, B. B. L., Horstman, A. M. H., Hamer, H. M., de Haan, M. W., van Kranenburg, J. M. X., Bierau, J., Poeze, M., Wodzig, W. K. W. H., Rasmussen, B. B., & van Loon, L. J. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141582 · Cited by 165
Carbohydrate Coingestion Delays Dietary Protein Digestion and Absorption but Does Not Modulate Postprandial Muscle Protein Accretion
Gorissen, S. H. M., Burd, N. A., Hamer, H. M., Gijsen, A. P., Groen, B. B. L., & van Loon, L. J. C. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3970 · Cited by 147
Self-citation
Consumption of whole eggs promotes greater stimulation of postexercise muscle protein synthesis than consumption of isonitrogenous amounts of egg whites in young men
van Vliet, S., Shy, E. L., Abou Sawan, S., Beals, J. W., West, D. W., Skinner, S. K., Ulanov, A. V., Li, Z., Paluska, S. A., Parsons, C. M., et al. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.159855 · Cited by 141
Exercise, Amino Acids, and Aging in the Control of Human Muscle Protein Synthesis
Walker, D. K., Dickinson, J. M., Timmerman, K. L., Drummond, M. J., Reidy, P. T., Fry, C. S., Gundermann, D. M., & Rasmussen, B. B. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318223b037 · Cited by 143
Exercise and Protein Intake: A Synergistic Approach against Sarcopenia
Martone, A. M., Marzetti, E., Calvani, R., Picca, A., Tosato, M., Santoro, L., Giorgio, A. D., Nesci, A., Sisto, A., Santoliquido, A., et al. (2017) · BioMed Research International · doi:10.1155/2017/2672435 · Cited by 143
Protein type, protein dose, and age modulate dietary protein digestion and phenylalanine absorption kinetics and plasma phenylalanine availability in humans
Gorissen, S. H., Trommelen, J., Kouw, I. W., Kouw, I. W., Pennings, B., Pennings, B., Wall, B. T., Churchward-Venne, T. A., Horstman, A. M., Koopman, R., et al. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxaa024 · Cited by 131
Self-citation
Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise–Induced Muscle Protein Anabolism
Reidy, P. T., & Rasmussen, B. B. (2016) · The Journal of Nutrition · doi:10.3945/jn.114.203208 · Cited by 128
Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies
Kubat, G. B., Bouhamida, E., Ülger, Ö., Türkel, İ., Pedriali, G., Ramaccini, D., Ekinci, Ö., Özerkliğ, B., Atalay, Ö., Patergnani, S., et al. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.07.003 · Cited by 134
Does the muscle protein synthetic response to exercise and amino acid-based nutrition diminish with advancing age? A systematic review
Shad, B. J., Thompson, J. L., & Breen, L. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00213.2016 · Cited by 131
Effects of adequate dietary protein with whey protein, leucine, and vitamin D supplementation on sarcopenia in older adults: An open-label, parallel-group study
Lin, C.-C., Shih, M.-H., Chen, C.-D., & Yeh, S.-L. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.08.017 · Cited by 123
Alterations in human muscle protein metabolism with aging: Protein and exercise as countermeasures to offset sarcopenia
Churchward‐Venne, T. A., Breen, L., & Phillips, S. M. (2013) · BioFactors · doi:10.1002/biof.1138 · Cited by 122
Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men
Groen, B. B. L., Res, P. T., Pennings, B., Hertle, E., Senden, J. M. G., Saris, W. H. M., & van Loon, L. J. C. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00321.2011 · Cited by 117
Self-citation
Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes
Leenders, M., & van Loon, L. J. C. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00443.x · Cited by 115
Influence of Amino Acids, Dietary Protein, and Physical Activity on Muscle Mass Development in Humans
Dideriksen, K., Reitelseder, S., & Holm, L. (2013) · Nutrients · doi:10.3390/nu5030852 · Cited by 110
Insects are a viable protein source for human consumption: from insect protein digestion to postprandial muscle protein synthesis in vivo in humans: a double-blind randomized trial
Hermans, W. J. H., Senden, J. M., Churchward‐Venne, T. A., Paulussen, K. J. M., Fuchs, C. J., Smeets, J. S. J., van Loon, J. J. A., Verdijk, L. B., & van Loon, L. J. C. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab115 · Cited by 109
Dietary protein digestion and absorption are impaired during acute postexercise recovery in young men
van Wijck, K., Pennings, B., van Bijnen, A. A. J. H. M., Senden, J. M., Buurman, W. A., Dejong, C. H. C., van Loon, L. J. C., & Lenaerts, K. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00294.2012 · Cited by 100
Keeping Older Muscle “Young” through Dietary Protein and Physical Activity
Moore, D. R. (2014) · Advances in Nutrition · doi:10.3945/an.113.005405 · Cited by 94
Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition
Mitchell, W. K., Wilkinson, D. J., Phillips, B. E., Lund, J. N., Smith, K., & Atherton, P. J. (2016) · Advances in Nutrition · doi:10.3945/an.115.011650 · Cited by 100
Impact of specialized oral nutritional supplement on clinical, nutritional, and functional outcomes: A randomized, placebo-controlled trial in community-dwelling older adults at risk of malnutrition
Chew, S. T. H., Tan, N. C., Cheong, M., Oliver, J. S., Baggs, G. E., Choe, Y. S., How, C. H., Chow, W. L., Tan, C. Y. L., Kwan, S. C., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.10.015 · Cited by 105
The muscle protein synthetic response to food ingestion
Gorissen, S. H. M., Rémond, D., & van Loon, L. J. C. (2015) · Meat Science · doi:10.1016/j.meatsci.2015.05.009 · Cited by 92
Mechanistic Links Underlying the Impact of C-Reactive Protein on Muscle Mass in Elderly
Wåhlin‐Larsson, B., Wilkinson, D. J., Strandberg, E., Hosford-Donovan, A., Atherton, P. J., & Kadi, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484679 · Cited by 81
Isolated Leucine and Branched-Chain Amino Acid Supplementation for Enhancing Muscular Strength and Hypertrophy: A Narrative Review
Plotkin, D. L., Delcastillo, K., Van Every, D. W., Tipton, K. D., Aragon, A. A., & Schoenfeld, B. J. (2021) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2020-0356 · Cited by 80
No differences in muscle protein synthesis rates following ingestion of wheat protein, milk protein, and their protein blend in healthy, young males
Pinckaers, P. J. M., Kouw, I. W. K., Hendriks, F. K., van Kranenburg, J. M. X., de Groot, L. C. P. G. M., Verdijk, L. B., Snijders, T., & van Loon, L. J. C. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521000635 · Cited by 76
Presleep dietary protein-derived amino acids are incorporated in myofibrillar protein during postexercise overnight recovery
Trommelen, J., Kouw, I. W. K., Holwerda, A. M., Snijders, T., Halson, S. L., Rollo, I., Verdijk, L. B., & van Loon, L. J. C. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00273.2016 · Cited by 76
The importance of protein sources to support muscle anabolism in cancer: An expert group opinion
Ford, K. L., Arends, J., Atherton, P. J., ENGELEN, M. P. K. J., Gonçalves, T. J. M., Laviano, A., Lobo, D. N., Phillips, S. M., Ravasco, P., Deutz, N. E. P., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.11.032 · Cited by 81
Evaluating the Leucine Trigger Hypothesis to Explain the Post-prandial Regulation of Muscle Protein Synthesis in Young and Older Adults: A Systematic Review
Zaromskyte, G., Prokopidis, K., Ioannidis, T., Tipton, K. D., & Witard, O. C. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.685165 · Cited by 81
Ingestion of Free Amino Acids Compared with an Equivalent Amount of Intact Protein Results in More Rapid Amino Acid Absorption and Greater Postprandial Plasma Amino Acid Availability Without Affecting Muscle Protein Synthesis Rates in Young Adults in a Double-Blind Randomized Trial
Weijzen, M. E. G., van Gassel, R. J. J., Kouw, I. W. K., Trommelen, J., Gorissen, S. H. M., van Kranenburg, J. M. X., Goessens, J. P. B., van de Poll, M. C. G., Verdijk, L. B., & van Loon, L. J. C. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab305 · Cited by 77
Fast-digestive protein supplement for ten days overcomes muscle anabolic resistance in healthy elderly men
Walrand, S., Gryson, C., Salles, J., Giraudet, C., Migné, C., Bonhomme, C., Ruyet, P. L., & Boirie‌, Y. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.04.020 · Cited by 76
Self-citation
Nutrition in the Very Old
Granic, A., Mendonça, N., Hill, T. R., Jagger, C., Stevenson, E., Mathers, J. C., & Sayer, A. A. (2018) · Nutrients · doi:10.3390/nu10030269 · Cited by 85
Older adults have delayed amino acid absorption after a high protein mixed breakfast meal
Milan, A., D'Souza, R., Pundir, S., Pileggi, C. A., Thorstensen, E., Barnett, M., Markworth, J. F., Cameron-Smith, D., & Mitchell, C. (2015) · The Journal of Nutrition, Health & Aging · doi:10.1007/s12603-015-0500-5 · Cited by 67
Role of specific dietary amino acids in clinical conditions
Jonker, R., ENGELEN, M. P. K. J., & Deutz, N. E. P. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002358 · Cited by 73
Muscle Protein Anabolic Resistance to Essential Amino Acids Does Not Occur in Healthy Older Adults Before or After Resistance Exercise Training
Moro, T., Brightwell, C. R., Deer, R., Graber, T. G., Galvan, E., Fry, C. S., Volpi, E., & Rasmussen, B. B. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy064 · Cited by 72
The muscle protein synthetic response to the ingestion of a plant-derived protein blend does not differ from an equivalent amount of milk protein in healthy, young males
Pinckaers, P. J., Kouw, I. W., Gorissen, S. H., Houben, L. H., Senden, J. M., Wodzig, W. K., de Groot, L. C., Verdijk, L. B., Snijders, T., & van Loon, L. J. (2022) · The Journal of Nutrition · doi:10.1093/jn/nxac222 · Cited by 70
Resistance Exercise Augments Postprandial Overnight Muscle Protein Synthesis Rates
TROMMELEN, J., HOLWERDA, A. M., KOUW, I. W. K., LANGER, H., HALSON, S. L., ROLLO, I., VERDIJK, L. B., & VAN LOON, L. J. C. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001045 · Cited by 69
Muscle protein turnover in the elderly and its potential contribution to the development of sarcopenia
Murton, A. J. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115000130 · Cited by 66
Gut amino acid absorption in humans: Concepts and relevance for postprandial metabolism
Trommelen, J., Tomé, D., & van Loon, L. J. C. (2021) · Clinical Nutrition Open Science · doi:10.1016/j.nutos.2020.12.006 · Cited by 78
Accelerated protein digestion and amino acid absorption after Roux-en-Y gastric bypass
Bojsen-Møller, K. N., Jacobsen, S. H., Dirksen, C., Jørgensen, N. B., Reitelseder, S., Jensen, J. B., Kristiansen, V. B., Holst, J. J., van Hall, G., & Madsbad, S. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.109298 · Cited by 68
Nutritionally essential amino acids and metabolic signaling in aging
Dillon, E. L. (2012) · Amino Acids · doi:10.1007/s00726-012-1438-0 · Cited by 69
Nutritional and lifestyle management of the aging journey: A narrative review
Kassis, A. N., Fichot, M., Horcajada, M.-N., Horstman, A. M. H., Duncan, P. I., Bergonzelli, G. E., Preitner, N., Zimmermann, D., Bosco, N., Vidal, K., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1087505 · Cited by 81
Efficacy of Nutritional Interventions as Stand-Alone or Synergistic Treatments with Exercise for the Management of Sarcopenia
Damanti, S., Azzolino, D., Roncaglione, C., Arosio, B., Rossi, P. D., & Cesari, M. (2019) · Nutrients · doi:10.3390/nu11091991 · Cited by 72
A focus on leucine in the nutritional regulation of human skeletal muscle metabolism in ageing, exercise and unloading states
Ely, I. A., Phillips, B. E., Smith, K., Wilkinson, D. J., Piasecki, M., Breen, L., Larsen, M. S., & Atherton, P. J. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.08.010 · Cited by 64
Metabolic phenotyping using kinetic measurements in young and older healthy adults
Deutz, N. E. P., Thaden, J. J., Have, G. A. M. T., Walker, D. K., & ENGELEN, M. P. K. J. (2017) · Metabolism · doi:10.1016/j.metabol.2017.09.015 · Cited by 64
The glycation level of milk protein strongly modulates post-prandial lysine availability in humans
Nyakayiru, J., van Lieshout, G. A. A., Trommelen, J., van Kranenburg, J. M. X., Verdijk, L. B., Bragt, M. C. E., & van Loon, L. J. C. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519002927 · Cited by 60
Night-time consumption of protein or carbohydrate results in increased morning resting energy expenditure in active college-aged men
Madzima, T. A., Panton, L. B., Fretti, S. K., Kinsey, A. W., & Ormsbee, M. J. (2014) · British Journal of Nutrition · doi:10.1017/s000711451300192x · Cited by 58
Potato Protein Ingestion Increases Muscle Protein Synthesis Rates at Rest and during Recovery from Exercise in Humans
Pinckaers, P. J., Hendriks, F. K., Hermans, W. J. H., Goessens, J. P. B., Senden, J. M., van Kranenburg, J. M. X., Wodzig, W. K. W. H., Snijders, T., & van Loon, L. J. C. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002937 · Cited by 65
Higher Muscle Protein Synthesis Rates Following Ingestion of an Omnivorous Meal Compared with an Isocaloric and Isonitrogenous Vegan Meal in Healthy, Older Adults
Pinckaers, P. J., Domić, J., Petrick, H. L., Holwerda, A. M., Trommelen, J., Hendriks, F. K., Houben, L. H. P., Goessens, J. P. B., van Kranenburg, J. M. X., Senden, J. M., et al. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.11.004 · Cited by 63
Lesser suppression of energy intake by orally ingested whey protein in healthy older men compared with young controls
Giezenaar, C., Trahair, L. G., Rigda, R. S., Hutchison, A. T., Feinle‐Bisset, C., Luscombe‐Marsh, N. D., Hausken, T., Jones, K. L., Horowitz, M., Chapman, I., et al. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00213.2015 · Cited by 57
Dietary protein considerations to support active aging
Wall, B. T., Cermak, N. M., & van Loon, L. J. C. (2014) · Sports Medicine · doi:10.1007/s40279-014-0258-7 · Cited by 56
Endothelial function and the regulation of muscle protein anabolism in older adults
Timmerman, K. L., & Volpi, E. (2013) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.03.013 · Cited by 53
The production of intrinsically labeled milk and meat protein is feasible and provides functional tools for human nutrition research
Pennings, B., Pellikaan, W. F., Senden, J. M., van Vuuren, A. M., Sikkema, J., & van Loon, L. J. C. (2011) · Journal of Dairy Science · doi:10.3168/jds.2011-4451 · Cited by 53
Habituation to low or high protein intake does not modulate basal or postprandial muscle protein synthesis rates: a randomized trial
Gorissen, S. H., Horstman, A. M., Franssen, R., Kouw, I. W., Wall, B. T., Burd, N. A., de Groot, L. C., & van Loon, L. J. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.129924 · Cited by 53
Dietary protein and exercise training in ageing
Koopman, R. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110003927 · Cited by 50
Self-citation
Early rehabilitation in critical care (eRiCC): functional electrical stimulation with cycling protocol for a randomised controlled trial
Parry, S. M., Berney, S., Koopman, R., Bryant, A., El-Ansary, D., Puthucheary, Z., Hart, N., Warrillow, S., & Denehy, L. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-001891 · Cited by 50
Self-citation
Impact of elderly gastrointestinal alterations on gastric emptying and enzymatic hydrolysis of skim milk: An in vitro study using a dynamic stomach system
Zhang, P., Iqbal, S., Deng, R., Duan, X., Han, H., Chen, X. D., & Wu, P. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134365 · Cited by 48
Whey Protein Hydrolysate Increases Amino Acid Uptake, mTORC1 Signaling, and Protein Synthesis in Skeletal Muscle of Healthy Young Men in a Randomized Crossover Trial
Moro, T., Brightwell, C. R., Velarde, B., Fry, C. S., Nakayama, K., Sanbongi, C., Volpi, E., & Rasmussen, B. B. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz053 · Cited by 77
Protein Co-Ingestion Strongly Increases Postprandial Insulin Secretion in Type 2 Diabetes Patients
MANDERS, R. J. F., Hansen, D., Zorenc, A. H. G., Dendale, P., Kloek, J., Saris, W. H. M., & van Loon, L. J. C. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0294 · Cited by 44
Self-citation
Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes
Deane, C. S., Bass, J. J., Crossland, H., Phillips, B. E., & Atherton, P. J. (2020) · Nutrients · doi:10.3390/nu12092670 · Cited by 48
Influence of Aging on Nitrogen Accretion During Critical Illness
Dickerson, R. N., Maish, G. O., Croce, M. A., Minard, G., & Brown, R. O. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113506939 · Cited by 43
The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans
Burd, N. A., Cermak, N. M., Kouw, I. W. K., Gorissen, S. H. M., Gijsen, A. P., & van Loon, L. J. C. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00411.2014 · Cited by 42
Self-citation
Fighting Sarcopenia in Older Frail Subjects: Protein Fuel for Strength, Exercise for Mass
Boirie‌, Y. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.10.017 · Cited by 45
Self-citation
In vitro gastric digestion and emptying of tsampa under simulated elderly and young adult digestive conditions using a dynamic stomach system
Li, L., Baima, C., Jiang, J., Liu, Z., Wang, J., Chen, X. D., & Wu, P. (2022) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2022.111054 · Cited by 40
Evidence for the Contribution of Gut Microbiota to Age-Related Anabolic Resistance
Watson, M. D., Cross, B. L., & Grosicki, G. J. (2021) · Nutrients · doi:10.3390/nu13020706 · Cited by 41
Cheese Ingestion Increases Muscle Protein Synthesis Rates Both at Rest and During Recovery from Exercise in Healthy, Young Males: A Randomized Parallel-Group Trial
Hermans, W. J. H., Fuchs, C. J., Hendriks, F. K., Houben, L. H. P., Senden, J. M., Verdijk, L. B., & van Loon, L. J. C. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac007 · Cited by 39
Muscle Performance, Size, and Safety Responses After Eight Weeks of Resistance Training and Protein Supplementation: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
Herda, A. A., Herda, T. J., Costa, P. B., Ryan, E. D., Stout, J. R., & Cramer, J. T. (2013) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31828c289f · Cited by 39
Effects of intraduodenal protein on appetite, energy intake, and antropyloroduodenal motility in healthy older compared with young men in a randomized trial
Soenen, S., Giezenaar, C., Hutchison, A. T., Horowitz, M., Chapman, I. M., & Luscombe‐Marsh, N. D. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.087981 · Cited by 41
Dietary protein considerations for muscle protein synthesis and muscle mass preservation in older adults
Olaniyan, E. T., O’Halloran, F., & McCarthy, A. L. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422420000219 · Cited by 39
Modulation of Amino Acid Metabolic Signatures by Supplemented Isoenergetic Diets Differing in Protein and Cereal Fiber Content
Hattersley, J. G., Pfeiffer, A. F. H., Roden, M., Petzke, K., Hoffmann, D., Rudovich, N. N., Randeva, H. S., Vatish, M., Osterhoff, M. A., Gögebakan, Ö., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2302 · Cited by 40
Effects of Substitution, and Adding of Carbohydrate and Fat to Whey-Protein on Energy Intake, Appetite, Gastric Emptying, Glucose, Insulin, Ghrelin, CCK and GLP-1 in Healthy Older Men—A Randomized Controlled Trial
Giezenaar, C., van der Burgh, Y., Lange, K. M., Hatzinikolas, S., Hausken, T., Jones, K. L., Horowitz, M., Chapman, I., & Soenen, S. (2018) · Nutrients · doi:10.3390/nu10020113 · Cited by 35
Effects of the daily consumption of protein enriched bread and protein enriched drinking yoghurt on the total protein intake in older adults in a rehabilitation centre: A single blind randomised controlled trial
van Til, A. J., Naumann, E., Cox-Claessens, I. J. H. M., Kremer, S., Boelsma, E., & de van der Schueren, M. A. E. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0471-6 · Cited by 34
'The Rate at Which Digested Protein Enters the Small Intestine Modulates the Rate of Amino Acid Digestibility throughout the Small Intestine of Growing Pigs
Montoya, C. A., Cabrera, D. L., Zou, M. L., Boland, M., & Moughan, P. J. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy193 · Cited by 30
The Regulation and Secretion of Glucagon in Response to Nutrient Composition: Unraveling Their Intricate Mechanisms
Zhang, J., Zheng, Y., Martens, L., & Pfeiffer, A. F. H. (2023) · Nutrients · doi:10.3390/nu15183913 · Cited by 34
Post-prandial muscle protein synthesis rates following the ingestion of pea-derived protein do not differ from ingesting an equivalent amount of milk-derived protein in healthy, young males
Pinckaers, P. J., Smeets, J. S. J., Kouw, I. W. K., Goessens, J. P. B., Gijsen, A. P., de Groot, C. P. G. M., Verdijk, L. B., van Loon, L. J. C., & Snijders, T. (2024) · European Journal of Nutrition · doi:10.1007/s00394-023-03295-6 · Cited by 30
Self-citation
Age effect on myocellular remodeling: Response to exercise and nutrition in humans
Irving, B. A., Robinson, M. M., & Nair, K. S. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.11.001 · Cited by 31
Slow and fast dietary proteins differentially modulate postprandial metabolism
He, T., & Giuseppin, M. L. F. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.866639 · Cited by 28
Effect of fast dietary proteins on muscle protein synthesis rate and muscle strength in ad libitum-fed and energy-restricted old rats
Walrand, S., Zangarelli‌, A., Guillet, C., Salles, J., Soulier, K., Giraudet, C., Patrac, V., & Boirie‌, Y. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002182 · Cited by 31
Self-citation
Review of protein intake and suitability of foods for protein-fortification in older adults in the UK
Smith, R., Clegg, M., & Methven, L. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2137777 · Cited by 28
Dementia risk by combinations of metabolic diseases and body mass index: Japan Gerontological Evaluation Study Cohort Study
Yokomichi, H., Kondo, K., Nagamine, Y., Yamagata, Z., & Kondo, N. (2019) · Journal of Diabetes Investigation · doi:10.1111/jdi.13103 · Cited by 24
Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations—A Randomized Controlled Trial
Giezenaar, C., Lange, K. M., Hausken, T., Jones, K. L., Horowitz, M., Chapman, I. M., & Soenen, S. (2020) · Nutrients · doi:10.3390/nu12041008 · Cited by 29
Age-Related Anabolic Resistance: Nutritional and Exercise Strategies, and Potential Relevance to Life-Long Exercisers
Pérez-Castillo, Í. M., Rueda, R., Pereira, S. L., Bouzamondo, H., Chicharro, J. L., Segura-Ortiz, F., & Atherton, P. J. (2025) · Nutrients · doi:10.3390/nu17223503 · Cited by 25
The Role of Amino Acids in Skeletal Muscle Adaptation to Exercise
Aguirre, N., van Loon, L. J. C., & Baar, K. (2013) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000350261 · Cited by 25
The influence of a tomato food matrix on the bioavailability and plasma kinetics of oral gamma-aminobutyric acid (GABA) and its precursor glutamate in healthy men
de Bie, T. H., Balvers, M. G. J., de Vos, R. C. H., Witkamp, R. F., & Jongsma, M. A. (2022) · Food & Function · doi:10.1039/d2fo01358d · Cited by 21

Authors: Koopman, R., Walrand, S., Beelen, M., Gijsen, A. P., Kies, A. K., Boirie, Y., Saris, W. H. M., & van Loon, L. J. C.
Affiliations: Maastricht University (NL)
Université Clermont Auvergne (FR)
DSM (Netherlands) (NL)
Corresponding author: van Loon, Luc J.C.
ORCID: Koopman, René
Walrand, Stéphane
Beelen, Milou
Kies, Arie K.
Saris, Wim H.M.
van Loon, Luc J.C.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2009-09
Volume: 139
Issue: 9
Pages: 1707-1713
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.109.109173
OpenAlex: W2109595244
Cited by: 167
References: 36
Citations by year: 2026: 4 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 9 · 2019: 6 · 2018: 11 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 14 · 2013: 16 · 2012: 12
FWCI: 4.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4908 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords: dietary protein digestion, protein absorption, aging, older men, micellar casein, amino acid availability
MeSH terms: Aged, Aging, Amino Acids, Caseins, Dietary Proteins, Digestion, Humans, Insulin, Intestinal Absorption, Male, Middle Aged, Muscle Proteins, Postprandial Period, Area Under Curve, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dietary Protein Digestion and Absorption Rates and the Subsequent Postprandial Muscle Protein Synthetic Response Do Not Differ between Young and Elderly Men ,

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks