Cited by 615Child and Adolescent Psychosocial and Emotional DevelopmentAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and Applications

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A Randomized Trial of a Group Cognitive Intervention for Preventing Depression in Adolescent Offspring of Depressed Parents

Clarke, Gregory N., Hornbrook, Mark, Lynch, Frances, Polen, Michael, Gale, John, Beardslee, William, O'Connor, Elizabeth, Seeley, John·2001·Archives of General Psychiatry

DOI 10.1001/archpsyc.58.12.1127

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Abstract

BACKGROUND: Adolescent offspring of depressed parents are at high risk for development of depression. Cognitive restructuring therapy holds promise for preventing progression to depressive episodes. METHODS: A randomized, controlled trial was conducted to prevent depressive episodes in at-risk offspring (aged 13-18 years) of adults treated for depression in a health maintenance organization (HMO). Potential adult cases were found by reviewing the HMO pharmacy records for dispensation of antidepressant medication and the mental health appointment system. Medical charts were reviewed for a depression diagnosis. Recruitment letters signed by treating physicians were mailed to adults. Eligible offspring had subdiagnostic depressive symptoms insufficient to meet full DSM-III-R criteria for affective disorder and/or a past mood disorder. These youth were randomized to usual HMO care (n = 49) or usual care plus a 15-session group cognitive therapy prevention program (n = 45). RESULTS: We detected significant treatment-by-time (program) effects for the Center for Epidemiological Studies Depression Scale (P=.005) and the Global Assessment of Functioning scores (P =.04). Survival analysis of incident major depressive episodes during a median 15-month follow-up found a significant advantage (P =.003) for the experimental condition (9.3% cumulative major depression incidence) compared with the usual-care control condition (28.8%). CONCLUSION: A brief, group cognitive therapy prevention program can reduce the risk for depression in the adolescent offspring of parents with a history of depression.

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Authors: Clarke, G. N., Hornbrook, M., Lynch, F., Polen, M., Gale, J., Beardslee, W., O'Connor, E., & Seeley, J.
Affiliations: Kaiser Permanente Center for Health Research (US)
Corresponding author: Clarke, Gregory N.
ORCID: Clarke, Gregory N.
Hornbrook, Mark
Lynch, Frances
Beardslee, William
Seeley, John
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2001-12-01
Volume: 58
Issue: 12
Pages: 1127
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.58.12.1127
OpenAlex: W2122338294
Cited by: 615
References: 40
Citations by year: 2026: 6 · 2025: 9 · 2024: 12 · 2023: 12 · 2022: 7 · 2021: 15 · 2020: 3 · 2019: 16 · 2018: 17 · 2017: 21 · 2016: 35 · 2015: 34 · 2014: 29 · 2013: 36 · 2012: 46
FWCI: 27.52
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01mh051318-05)
National Institute of Mental Health (1R01 MH 51318-01A1)
Topics: Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords: depression prevention, offspring of depressed parents, adolescent depression, group cognitive therapy, family history of depression, health maintenance organizations
MeSH terms: Adolescent, Depressive Disorder, Female, Health Maintenance Organizations, Humans, Male, Personality Assessment, Psychotherapy, Brief, Psychotherapy, Group, Comorbidity, Cognitive Behavioral Therapy, Child of Impaired Parents, Treatment Outcome

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A Randomized Trial of a Group Cognitive Intervention for Preventing Depression in Adolescent Offspring of Depressed Parents

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