Prevention of major depression

Muñoz, Ricardo F.; Cuijpers, Pim; Smit, Filip; Barrera, Alinne Z.; Leykin, Yan

doi:10.1146/annurev-clinpsy-033109-132040

Cited by 326Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and AccessDigital Mental Health Interventions

Prevention of major depression

Muñoz, Ricardo F., Cuijpers, Pim, Smit, Filip, Barrera, Alinne Z., Leykin, Yan·2010·Annual Review of Clinical Psychology

DOI 10.1146/annurev-clinpsy-033109-132040

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Abstract

Before the 1980s, no randomized controlled trials had been carried out to test whether major depressive episodes could be prevented. In the past 30 years, several trials have reported success in reducing the incidence (the number of new cases) of major depressive episodes. These studies suggest that major depression can be prevented. Given the large burden of disease caused by major depression, it is time for substantial systematic efforts to replicate these studies, carry out multisite trials, and widely disseminate prevention interventions found to be effective. The present review examines the conceptual and practical differences between treatment and prevention trials and the importance of identifying groups at high short-term risk for major depressive episodes to make prevention trials feasible. We also list the randomized controlled prevention trials that have been carried out to date and discuss the need for prevention interventions that go beyond the limits of traditional face-to-face interventions.

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The most efficient means for population-level intervention is to target those at increased risk.
“However, it has been demonstrated that the most efficient means for population-level intervention is to target those at increased risk [13].”
From A pilot evaluation of a smartphone application for workplace depression (2020) · cites this paper as [13]
Over 30,000 participants are needed to adequately power a prevention program evaluation study.
“it has been estimated that over 30,000 participants are needed to adequately power a prevention program evaluation study [40].”
From Acceptance and commitment therapy universal prevention program for adolescents: a feasibility study. (2017) · cites this paper as [40]
Many universal interventions may not be appropriately powered to find effects because the sample size required for universal prevention can be overwhelming.
“Furthermore, many universal interventions may not be appropriately powered to find such effects as the sample size required for universal prevention can be overwhelming [66, 67].”
From eHealth interventions for the prevention of depression and anxiety in the general population: a systematic review and meta-analysis (2017) · cites this paper as [66]

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Poverty, Race/Ethnicity, and Psychiatric Disorder: A Study of Rural Children
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Opportunities for Cost-effective Prevention of Late-Life Depression
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Infants of postpartum depressed mothers: Temperament and cognitive status.
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Promoting mental health after childbirth: A controlled trial of primary prevention of postnatal depression
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Prevalence of child and adolescent psychiatric disorders: the Zürich Epidemiological Study
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Pragmatic randomized trial of antenatal intervention to prevent post-natal depression by reducing psychosocial risk factors
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Group prevention of depression and anxiety symptoms
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Hands-on Help: computer-aided Psychotherapy
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Brief cognitive-behavioral depression prevention program for high-risk adolescents outperforms two alternative interventions: a randomized efficacy trial
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Newborn screening for cystic fibrosis
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Preventing Depression in Age-Related Macular Degeneration
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Evaluation of universal, indicated, and combined cognitive-behavioral approaches to the prevention of depression among adolescents.
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Management of Depression After Stroke
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Hands-on Help
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Prevention of Late-Life Depression in Primary Care: Do We Know Where to Begin?
Schoevers, R. A., Smit, F., Deeg, D. J. H., Cuijpers, P. J., Dekker, J., van Tilburg, W., & Beekman, A. T. F. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1611 · Cited by 158 · see citing works
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The prevention of depression using the Internet
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Preventing depression: A review of cognitive-behavioral and family interventions
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Children of Currently Depressed Mothers
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The Prevention of Depression: Research and Practice
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Minimal-contact psychotherapy for sub-threshold depression in primary care
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Increased mortality in depressive disorders: A review
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Outcome results of a psycho-educational intervention in pregnancy to prevent PPD: A randomized control trial
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Social and Psychological Research in Community Settings
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Stress debriefing after childbirth: a randomised controlled trial
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Research to Address Racial and Ethnic Disparities in Mental Health: Some Lessons Learned
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Preventing depression in adolescents with epilepsy
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Depressive Disorders in the Medically Ill
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Intervention for minor depression in primary care patients.
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Rates of Depression at 3 and 15 Months Poststroke and Their Relationship With Cognitive Decline: the Sydney Stroke Study
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Depression Prevention: Research Directions
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Interpersonal Psychotherapy for Elderly Patients in Primary Care
van Schaik, A., van Marwijk, H., Adèr, H. J., van Dyck, R., de Haan, M., Penninx, B. W. J. H., van der Kooy, K. G., van Hout, H. P. J., & Beekman, A. T. F. (2006) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000199341.25431.4b · Cited by 102 · see citing works
Childhood Abuse, Postpartum Depression and Parenting Difficulties: A Literature Review of Associations
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Acute psychiatric disturbance in pregnancy and the puerperium
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Depression and multiple sclerosis: Review of a lethal combination
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The San Francisco mood survey project: Preliminary work toward the prevention of depression
Muñoz, R. F., Glish, M. A., Soo-Hoo, T., & Robertson, J. (1982) · American Journal of Community Psychology · doi:10.1007/bf00896498 · Cited by 100 · see citing works
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Persistent comorbid symptoms of depression and anxiety predict mortality in heart disease
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Postnatal Depression: Its Nature, Effects, and Identification Using the Edinburgh Postnatal Depression Scale
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The Spectrum of Quality-of-Life Impairments in Recurrent Geriatric Depression
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Associations between Major Depression, Bipolar Disorders, Dysthymia and Cardiovascular Diseases in the General Adult Population
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The prevention of depression in nursing home residents: A randomized clinical trial of cognitive–behavioral therapy
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Preventing postnatal depression in mothers of very preterm infants: a randomised controlled trial
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Pharmacotherapy of Mood Disorders
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Prevention of depression in subclinically depressed adults: Follow-up effects on the ‘Coping with Depression’ course
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Preventing Postpartum Depression Part II: A Critical Review of Nonbiological Interventions
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An Epidemiological Approach to Depression Prevention in Old Age
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The comparison of burden between caregiving spouses of depressive and demented patients
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Difficulties and Rewards in Family Care of the Depressed Older Adult
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Treatment and Prevention of Depression After Surgery for Hip Fracture in Older People: Randomized, Controlled Trials
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The prevention of depression: Current research and practice
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Target groups for the prevention of late-life anxiety
Smit, F., Comijs, H., Schoevers, R., Cuijpers, P., Deeg, D., & Beekman, A. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.023127 · Cited by 65 · see citing works
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Depression in neurological disorders: an update
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Prevention of depression among Icelandic adolescents
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A Preventive Intervention for Pregnant Women on Public Assistance at Risk for Postpartum Depression
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Social and Community Interventions
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Cigarette Smoking, Stages of Change, and Major Depression in the Canadian Population
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Prevention of Late-Life Depression in Primary Care: Do We Know Where to Begin?
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Depressive Symptoms and Sexual Risk Behavior in Young, Chlamydia-Infected, Heterosexual Dyads
Shrier, L. A., Schillinger, J. A., Aneja, P., Rice, P. A., Batteiger, B. E., Braslins, P. G., Orr, D. P., & Fortenberry, J. D. (2009) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2008.11.016 · Cited by 41 · see citing works
Preventing Postpartum Depression Part I: A Review of Biological Interventions
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The prevention of mental disorders
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Relationships among Depressive Symptoms, Sexually Transmitted Infections, and Pregnancy in African-American Adolescent Girls
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Prevention of major depression: Early detection and early intervention in the general population.
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Conquering Depression
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Assessing the preventive effects of cognitive therapy following relief of depression: A methodological innovation
Kashner, T. M., Henley, S. S., Golden, R. M., Rush, A. J., & Jarrett, R. B. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.04.004 · Cited by 17 · see citing works
The Life Satisfaction Course: An Intervention for the Elderly
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Prevention of mental disorders.
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The Relationships Among Depressive Symptoms, Sexually Transmitted Infections, and Pregnancy in African-American Adolescent Girls
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Gender Differences in Depression in Representative National Samples: Meta-Analyses of Diagnoses and Symptoms
Salk, R. H., Hyde, J. S., & Abramson, L. Y. (2017) · Psychological Bulletin · doi:10.1037/bul0000102 · Cited by 2,622 · see citing works
“Research to identify preventive interventions is even more important (Muñoz et al., 2010).”
Postpartum depression: current status and future directions
O'Hara, M. W., & McCabe, J. E. (2013) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185612 · Cited by 1,750 · see citing works
Personality and depression: explanatory models and review of the evidence
Klein, D. N., Kotov, R., & Bufferd, S. J. (2011) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032210-104540 · Cited by 886 · see citing works
School-based depression and anxiety prevention programs for young people: A systematic review and meta-analysis
Werner-Seidler, A., Perry, Y., Calear, A. L., Newby, J. M., & Christensen, H. (2017) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.10.005 · Cited by 773 · see citing works
“…be prevented, prevention programs can delay the onset of clinically significant symptoms AC C EP TE D M AN U SC R IP T (Bienvenu & Ginsburg, 2007; Merry et al., 2011), which confers considerable benefit, including reduced disability and service use (Donovan & Spence, 2000; Muñoz et al., 2010).”
Background
Preventing the onset of major depressive disorder: A meta-analytic review of psychological interventions
van Zoonen, K., Buntrock, C., Ebert, D. D., Smit, F., Reynolds, C. F., Beekman, A. T., & Cuijpers, P. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyt175 · Cited by 425 · see citing works
Self-citation
Preventing Depression: A Global Priority
Cuijpers, P., Beekman, A. T. F., & Reynolds, C. F. (2012) · JAMA · doi:10.1001/jama.2012.271 · Cited by 368 · see citing works
Self-citation
Interpersonal emotion regulation as a mechanism of social support in depression
Marroquín, B. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.09.005 · Cited by 414 · see citing works
Cytokine Research in Depression: Principles, Challenges, and Open Questions
Himmerich, H., Patsalos, O., Lichtblau, N., Ibrahim, M. A. A., & Dalton, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00030 · Cited by 313 · see citing works
Mapping risk factors for depression across the lifespan: An umbrella review of evidence from meta-analyses and Mendelian randomization studies
Köhler, C. A., Evangelou, E., Stubbs, B., Solmi, M., Veronese, N., Belbasis, L., Bortolato, B., Melo, M. C. A., Coelho, C. A., Fernandes, B. S., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.05.020 · Cited by 302 · see citing works
School-based depression and anxiety prevention programs: An updated systematic review and meta-analysis
Werner‐Seidler, A., Spanos, S., Calear, A. L., Perry, Y., Torok, M. H., O’Dea, B., Christensen, H. M., & Newby, J. M. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102079 · Cited by 317 · see citing works
Prevention of mental health disorders using internet and mobile-based interventions: a narrative review and recommendations for future research.
Ebert, D. D., Cuijpers, P., Muñoz, R. F., & Baumeister, H. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00116 · Cited by 244 · see citing works
Self-citation
Transmission and Prevention of Mood Disorders Among Children of Affectively Ill Parents: A Review
Beardslee, W. R., Gladstone, T. R. G., & O’Connor, E. (2011) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2011.07.020 · Cited by 266 · see citing works
Using evidence-based internet interventions to reduce health disparities worldwide.
Muñoz, R. F. (2010) · Journal of Medical Internet Research · doi:10.2196/jmir.1463 · Cited by 242 · see citing works
Self-citation
eHealth interventions for the prevention of depression and anxiety in the general population: a systematic review and meta-analysis
Deady, M., Choi, I., Calvo, R. A., Glozier, N., Christensen, H., & Harvey, S. B. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1473-1 · Cited by 222 · see citing works
On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?
Roohi, E., Jaafari, N., & Hashemian, F. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02100-7 · Cited by 236 · see citing works
Effectiveness of Internet-based interventions for the prevention of mental disorders: a systematic review and meta-analysis
Sander, L., Rausch, L., & Baumeister, H. (2016) · JMIR Mental Health · doi:10.2196/mental.6061 · Cited by 218 · see citing works
Subthreshold depression in children and adolescents – a systematic review
Wesselhoeft, R. T., Sørensen, M. J., Heiervang, E. R., & Bilenberg, N. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.010 · Cited by 215 · see citing works
Preventing the development of depression at work: a systematic review and meta-analysis of universal interventions in the workplace
Tan, L., Wang, M.-J., Modini, M., Joyce, S., Mykletun, A., Christensen, H., & Harvey, S. B. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-74 · Cited by 208 · see citing works
A penny for your thoughts: dimensions of self-generated thought content and relationships with individual differences in emotional wellbeing
Andrews-Hanna, J. R., Kaiser, R. H., Turner, A. E. J., Reineberg, A. E., Godinez, D., Dimidjian, S., & Banich, M. T. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00900 · Cited by 184 · see citing works
“Biases in thought content may emerge prior to the onset of a major depressive episode, perhaps providing a marker of clinical risk and a target for preventive therapies (Muñoz et al., 2010; Beshai et al., 2011).”
Background
Racism and Health II: A Needed Research Agenda for Effective Interventions
Williams, D. R., & Mohammed, S. A. (2013) · American Behavioral Scientist · doi:10.1177/0002764213487341 · Cited by 189 · see citing works
Major depression can be prevented.
Muñoz, R. F., Beardslee, W. R., & Leykin, Y. (2012) · American Psychologist · doi:10.1037/a0027666 · Cited by 174 · see citing works
Self-citation
Lipids in Psychiatric Disorders and Preventive Medicine
Schneider, M., Levant, B., Reichel, M., Gulbins, E., Kornhuber, J., & Müller, C. P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.002 · Cited by 175 · see citing works
How financial hardship is associated with the onset of mental health problems over time
Kiely, K. M., Leach, L., Olesen, S. C., & Butterworth, P. (2015) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-015-1027-0 · Cited by 178 · see citing works
Sleep disturbance, inflammation and depression risk in cancer survivors
Irwin, M. R., Olmstead, R. E., Ganz, P. A., & Haque, R. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.05.002 · Cited by 173 · see citing works
Early Intervention to Reduce the Global Health and Economic Burden of Major Depression in Older Adults
Reynolds, C. F., Cuijpers, P., Patel, V., Cohen, A., Dias, A., Chowdhary, N., Okereke, O. I., Amanda Dew, M., Anderson, S. J., Mazumdar, S., et al. (2012) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031811-124544 · Cited by 163 · see citing works
Self-citation
Preventing Symptoms of Depression by Teaching Adolescents That People Can Change: Effects of a Brief Incremental Theory of Personality Intervention at 9-Month Follow-Up
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Web-Based Cognitive Behavioral Therapy Intervention for the Prevention of Suicidal Ideation in Medical Interns
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“However, it has been demonstrated that the most efficient means for population-level intervention is to target those at increased risk [13].”
Background
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Authors: Muñoz, R. F., Cuijpers, P., Smit, F., Barrera, A. Z., & Leykin, Y.
Affiliations: San Francisco General Hospital (US)
Amsterdam Public Health (NL)
Palo Alto University (US)
ORCID: Muñoz, Ricardo F.
Cuijpers, Pim
Smit, Filip
Barrera, Alinne Z.
Leykin, Yan
Venue: Annual Review of Clinical Psychology
Publisher: Annual Reviews
Published: 2010-03-01
Volume: 6
Issue: 1
Pages: 181-212
ISSN: 1548-5943 (ISSN-L)
1548-5951
DOI: 10.1146/annurev-clinpsy-033109-132040
OpenAlex: W2120806935
Cited by: 326
References: 163
Citations by year: 2026: 8 · 2025: 7 · 2024: 18 · 2023: 17 · 2022: 15 · 2021: 29 · 2020: 21 · 2019: 17 · 2018: 17 · 2017: 19 · 2016: 21 · 2015: 25 · 2014: 36 · 2013: 28 · 2012: 26
FWCI: 2.95
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Clinical Psychology (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
VU Research Portal (publishedVersion)
Pure Amsterdam UMC (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: National Institute of Mental Health (T32MH019391, F32 MH07771)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
Keywords: major depressive disorder, depression prevention, randomized controlled trials, prevention trials, treatment trials, high-risk groups, replication, multisite trials, intervention dissemination, face-to-face intervention
MeSH terms: Major Depressive Disorder, Health Promotion, Humans, Incidence, Prevalence

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