Cited by 584Functional Brain Connectivity StudiesAdvanced MRI Techniques and ApplicationsNeural dynamics and brain function

Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest

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Shmuel, Amir, Leopold, David A.·2008·Human Brain Mapping

Abstract

Recent studies have demonstrated large amplitude spontaneous fluctuations in functional‐MRI (fMRI) signals in humans in the resting state. Importantly, these spontaneous fluctuations in blood‐oxygenation‐level‐dependent (BOLD) signal are often synchronized over distant parts of the brain, a phenomenon termed functional‐connectivity. Functional‐connectivity is widely assumed to reflect interregional coherence of fluctuations in activity of the underlying neuronal networks. Despite the large body of human imaging literature on spontaneous activity and functional‐connectivity in the resting state, the link to underlying neural activity remains tenuous. Through simultaneous fMRI and intracortical neurophysiological recording, we demonstrate correlation between slow fluctuations in BOLD signals and concurrent fluctuations in the underlying locally measured neuronal activity. This correlation varied with time‐lag of BOLD relative to neuronal activity, resembling a traditional hemodynamic response function with peaks at ∼6 s lag of BOLD signal. The correlations were reliably detected when the neuronal signal consisted of either the spiking rate of a small group of neurons, or relative power changes in the multi‐unit activity band, and particularly in the local field potential gamma band. Analysis of correlation between the voxel‐by‐voxel fMRI time‐series and the neuronal activity measured within one cortical site showed patterns of correlation that slowly traversed cortex. BOLD fluctuations in widespread areas in visual cortex of both hemispheres were significantly correlated with neuronal activity from a single recording site in V1. To the extent that our V1 findings can be generalized to other cortical areas, fMRI‐based functional‐connectivity between remote regions in the resting state can be linked to synchronization of slow fluctuations in the underlying neuronal signals. Hum Brain Mapp 2008. © 2008 Wiley‐Liss, Inc.

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  • Without sensory input, spontaneous BOLD fluctuations still correlate with underlying synaptic activity measured by LFP, ECoG, and EEG.

    “In the absence of any sensory input, spontaneous BOLD fluctuations are still correlated with underlying synaptic activity observed with LFP (136, 137), ECoG (138), and EEG (139, 140).”
  • Functional pathways critical to vision, motor function, audition, language, reading, and attention are detectable as enhanced FC computed from at rest inter-region oscillatory synchronization determined via fMRI.

    “Functional pathways critical to vision, motor function, audition, language, reading, and attention are detectable as enhanced FC computed from at rest inter-region oscillatory synchronization determined via functional magnetic resonance imaging (34–42).”

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Authors
Shmuel, A., & Leopold, D. A.
Affiliations
Montreal Neurological Institute and Hospital (CA)
Venue
Human Brain Mapping
Publisher
Wiley
Published
2008-05-08
Volume
29
Issue
7
Pages
751-761
ISSN
  • 1065-9471 (ISSN-L)
  • 1097-0193
OpenAlex
W2136838610
Cited by
584
References
36
Citations by year
2026: 7 · 2025: 16 · 2024: 29 · 2023: 17 · 2022: 24 · 2021: 26 · 2020: 25 · 2019: 58 · 2018: 29 · 2017: 33 · 2016: 29 · 2015: 43 · 2014: 46 · 2013: 44 · 2012: 45
FWCI
19.35
Type
journal article
Language
en
Open access
Locations
  • Human Brain Mapping (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • European Molecular Biology Organization
  • Max-Planck-Gesellschaft
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
spontaneous fluctuations, resting-state functional connectivity, BOLD signal, neuronal activity, visual cortex, primary visual cortex, hemodynamic response function, local field potentials, gamma band, multi-unit activity, intracortical recording, neuronal synchronization
MeSH terms
Animals, Brain, Brain Mapping, Macaca mulatta, Magnetic Resonance Imaging, Neural Pathways, Neurons, Rest, Visual Cortex

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