UCSF Chimera—A visualization system for exploratory research and analysis

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Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

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Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d

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Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution

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A wheat resistosome defines common principles of immune receptor channels

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NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation

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Structure of the Decorated Ciliary Doublet Microtubule

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In-cell architecture of an actively transcribing-translating expressome

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Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation

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Cryo-electron microscopy--a primer for the non-microscopist

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Benchmarking AlphaFold‐enabled molecular docking predictions for antibiotic discovery

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Structural mechanism of cGAS inhibition by the nucleosome

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NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

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Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function

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Structure of the bacterial ribosome at 2 Å resolution

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Structural basis for iron piracy by pathogenic Neisseria

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Structure of a yeast activated spliceosome at 3.5 Å resolution

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Structural basis for sequestration and autoinhibition of cGAS by chromatin

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Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype

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Structure and dynamics of the active human parathyroid hormone receptor-1

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Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

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Structure of a 14-3-3 Coordinated Hexamer of the Plant Plasma Membrane H+-ATPase by Combining X-Ray Crystallography and Electron Cryomicroscopy

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Proteins evolve on the edge of supramolecular self-assembly

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Structure of a Pancreatic ATP-Sensitive Potassium Channel

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A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

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Structure of the membrane-assembled retromer coat determined by cryo-electron tomography

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Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools

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Structural basis for the inhibition of cGAS by nucleosomes

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Regulated protein turnover: snapshots of the proteasome in action

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Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

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Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

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Multi‐state modeling of G‐protein coupled receptors at experimental accuracy

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Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

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Structure and conformational dynamics of the human spliceosomal Bact complex

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Structural basis for regulation of human acetyl-CoA carboxylase

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Structural insight into the unique properties of adeno-associated virus serotype 9

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Atomic model for the dimeric F O region of mitochondrial ATP synthase

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A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

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Structural basis of ketamine action on human NMDA receptors

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Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex

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Structural basis for TetM-mediated tetracycline resistance

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Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline

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Structural basis for the recognition of Sonic Hedgehog by human Patched1

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Structures of the σ2 receptor enable docking for bioactive ligand discovery

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Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

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Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1

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Differentiation and Characterization of Excitatory and Inhibitory Synapses by Cryo-electron Tomography and Correlative Microscopy

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The SARS-CoV-2 Spike variant D614G favors an open conformational state

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Structurally mapping the diverse phenotype of adeno-associated virus serotype 4

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Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action

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MCART1/SLC25A51 is required for mitochondrial NAD transport

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The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia

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Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

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Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8

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ABCG2 transports anticancer drugs via a closed-to-open switch

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Twenty-Five Years of Structural Parvovirology

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Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness

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Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex

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Structures of human Patched and its complex with native palmitoylated sonic hedgehog

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Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase

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Structural basis of γ-secretase inhibition and modulation by small molecule drugs

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Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome

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Selective PP2A enhancement through biased heterotrimer stabilization

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Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

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Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures

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The Assembly-Activating Protein Promotes Capsid Assembly of Different Adeno-Associated Virus Serotypes

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Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure

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Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

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Key enzymes of the retinoid (visual) cycle in vertebrate retina

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Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins

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Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1

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A marine microbiome antifungal targets urgent-threat drug-resistant fungi

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Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation

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Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

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Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127

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Structural basis of splicing modulation by antitumor macrolide compounds

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A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor

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Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

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Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

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Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency

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Structural and functional characterization of G protein–coupled receptors with deep mutational scanning

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Structure of a CLC chloride ion channel by cryo-electron microscopy

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