Modeling the mindfulness‐to‐meaning theory's mindful reappraisal hypothesis: Replication with longitudinal data from a randomized controlled study
Abstract
The Mindfulness to Meaning Theory provides a detailed process model of the mechanisms by which mindfulness may promote well‐being. Central to the Mindfulness to Meaning Theory is the mindful reappraisal hypothesis (MRH), which suggests mindfulness training promotes well‐being by facilitating positive reappraisal. Emerging evidence from interconnected domains of research supports the MRH. However, it remains unclear whether mindful reappraisal continues to develop after a mindfulness training course and whether this continued development encourages well‐being over time. As such, this randomized controlled study compared participants receiving a mindfulness‐based stress reduction (MBSR) course with participants receiving no mindfulness training on positive reappraisal use and well‐being over the course of 6 years. Latent growth curve modeling revealed that mindfulness training increased well‐being by significantly increasing the trajectory of positive reappraisal over time. The MRH was then unpacked by examining whether MBSR also stimulated decentering and broadened awareness, core components of the MRH. Multivariate path analysis revealed that mindfulness training increased decentering, which in turn broadened awareness, which was then associated with positive reappraisal, ultimately promoting well‐being. Taken together, these findings suggest that MBSR cultivates a downstream cascade of adaptive psychological processes that continue to promote quality of life 6‐years after mindfulness training.
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This heightened self-awareness helps identify stress triggers and patterns, allowing for proactive stress management through positive reappraisal, emotion regulation, or other strategies, thereby modulating cortisol and testosterone profiles effectively.
“this heightened self-awareness helps identify stress triggers and patterns, allowing for proactive stress management through positive reappraisal, emotion regulation, or other strategies, thereby modulating cortisol and testosterone profiles effectively (Goldin et al., 2021;González-Palau & Medrano, 2022;hanley et al., 2021;tang, tang, & Posner, 2016;terburg et al., 2009).”
From Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males (2024) · cites this paper as hanley et al., 2021
A growing body of theoretical articles and empirical studies suggests a connection between mindfulness training and the enhancement of emotion regulation strategies.
“A growing body of theoretical articles and empirical studies suggests a connection between mindfulness training and the enhancement of emotion regulation strategies [30–34].”
From Emotion Regulation as a Mechanism of Mindfulness in Individual Cognitive-Behavioral Therapy for Depression and Anxiety Disorders (2024) · cites this paper as [34]
Cultivating a more accepting and flexible emotion regulation approach may protect against depression and anxiety through reappraisal, acceptance, and problem-solving.
“The second pathway includes cultivating a more accepting and flexible emotion regulation approach that may protect against depression and anxiety through reappraisal, acceptance, and problem-solving [23, 34, 75–78].”
From Emotion Regulation as a Mechanism of Mindfulness in Individual Cognitive-Behavioral Therapy for Depression and Anxiety Disorders (2024) · cites this paper as [34]
According to mindfulness-to-meaning theory, the observational stance fostered by mindfulness facilitates reframing situations from novel perspectives through reappraisal.
“According to the mindfulness-to-meaning theory [81, 82], this observational stance fosters an expanded attentional space, facilitating reframing situations from novel perspectives through reappraisal [34].”
From Emotion Regulation as a Mechanism of Mindfulness in Individual Cognitive-Behavioral Therapy for Depression and Anxiety Disorders (2024) · cites this paper as [34]
Adapting psychotherapies to patients' cultural worldview, cultural humility, and matching between patient and provider cultural identities improve treatment outcomes.
“For example, adapting psychotherapies to patients’ cultural worldview147, cultural humility (that is, a lack of superiority and openness to patients’ cultural perspectives)148, and matching between patient and provider cultural identities improve treatment outcomes149.”
From A common factors perspective on mindfulness-based interventions (2022) · cites this paper as [149]
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“At least two major categories of coping skills have been implicated in efficacious mental health interventions: decentering and positive reappraisal (Hanley et al., 2021; O’Toole et al., 2019).”
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“Speci fi cally, during a stressful situation, attention may be reduced and biased towards negative content, thus limiting one ’ s cognitive resources necessary for monitoring the variety of internal and external cues that inform self-awareness (Hanley et al., 2021; Villemonteix et al., 2017).”
Segal, O., Sher, H., Aderka, I. M., & Weinbach, N. (2023) · Behaviour Research and Therapy · doi:10.1016/j.brat.2023.104303 · Cited by 13 · see citing works
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Self-citationThe Effects of Mindfulness-Based Intervention on Emotion-Related Impulsivity in Addictive Disorders
Parisi, A. B., Hudak, J., & Garland, E. L. (2023) · Current Addiction Reports · doi:10.1007/s40429-023-00501-7 · Cited by 10 · see citing works
Self-citationThe benefits of radical acceptance of reality as a standalone strategy for emotion regulation
Segal, O., Bronshtein, K., & Weinbach, N. (2025) · Current Psychology · doi:10.1007/s12144-025-07286-0 · Cited by 8 · see citing works
“Similar findings were reported in studies showing that mindfulness practice, which incorporates the willingness and nonjudgment components of acceptance (Lindsay & Creswell, 2017), can enhance cognitive reappraisal’s success and efficacy (e.g., Garland et al., 2017; Hanley et al., 2021).”
Parisi, A. B., Hudak, J., Froeliger, B., & Garland, E. L. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00084-2 · Cited by 8 · see citing works
Self-citationErgüler, H., Ferreira, N. B., Adonis, M. N., & Koushiou, M. (2023) · Mindfulness · doi:10.1007/s12671-023-02225-1 · Cited by 8 · see citing works
“Evidence suggests that mindfulness can have a positive influence on psychological well-being via an enhanced regulation of negative emotions (Fisher et al., 2022; Hanley et al., 2021; Roemer et al., 2015).”
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Qi, H., Liu, X., & Jiang, F. (2024) · The Journal of Psychology · doi:10.1080/00223980.2024.2431198 · Cited by 6 · see citing works
“For example, self-compassion (Zheng et al., 2022), emotion regulation (Hanley et al., 2021), and selflessness (Hanley et al., 2017) mediate the relationship between mindfulness and eudaimonic well-being.”
The effects of mindfulness on eudaimonic well-being and its theoretical explanation
Qi, H. E., & Xiaoming, L. I. U. (2023) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2023.01937 · Cited by 5 · see citing works
The role of mind-body bridging-based university psychology course for students’ well-being
Siira, V., Petäjäniemi, M., Lutovac, S., & Kaasila, R. (2022) · Nordic Psychology · doi:10.1080/19012276.2022.2159867 · Cited by 4 · see citing works
“Mindfulness research has found that positive reappraisal, followed by increased decentering and broadened awareness, promotes well-being (Hanley et al., 2021).”
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Cebolla, A., Navarro-Siurana, J., Galante, J., Sarrión, P., Vidal, J., Fernández-Castilla, B., Lecuona, Ó., Vázquez, C., & Baños, R. M. (2025) · Applied Psychology: Health and Well-Being · doi:10.1111/aphw.70069 · Cited by 5 · see citing works
Mindfulness-Based Interventions for Clinical Anxiety and Depression
Hazlett‐Stevens, H. (2021) · Springer eBooks · doi:10.1007/978-3-030-81245-4_9 · Cited by 2 · see citing works
Potential Mechanisms Underlying Reappraisal Strategies: An Exploratory Study
Wild, K. J., Macavei, B., & Opre, A. N. (2024) · Journal of Evidence-Based Psychotherapies · doi:10.24193/jebp.2024.2.17 · Cited by 2 · see citing works
Ayele, F. A., & Barchard, K. A. (2024) · Discover Psychology · doi:10.1007/s44202-024-00229-z · Cited by 2 · see citing works
“The mindfulness-to-meaning theory (MMT) outlines a set of psychological processes that lead to enduring well-being and positive psychological states [35, 36].”
Influentialde Zavala, A. G., Förster, C. A., Ziegler, M. D., Nalberczak‐Skóra, M., Ciesielski, P., & Mazurkiewicz, M. (2024) · Applied Psychology Health and Well-Being · doi:10.1111/aphw.12518 · Cited by 4 · see citing works
“Refined management of positive and prosocial emotions (e.g., Lindsay et al., 2018; Singer & Engert, 2019), positive reappraisal, and broadened self-awareness (Garland & Fredrickson, 2019; Hanley et al., 2021) underlie the positive effects of mindfulness practice on psychological well-being.”
BackgroundChanging the emotion process: The role of emotion regulation
Bjureberg, J., & Gross, J. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95604-8.00015-0 · Cited by 2 · see citing works
Self-citationTheories in Mindfulness Studies: A Narrative Review
Kar, B., & Kar, N. (2025) · Advances in mental health and addiction · doi:10.1007/978-3-031-98979-7_2 · Cited by 1 · see citing works
Embracing Mindfulness During Interpersonal Conflict
Lee, L. W. Y., Snell, R. S., Lei, H. W. L., & Wu, C. X. (2026) · Mindfulness · doi:10.1007/s12671-026-02810-0 · Cited by 1 · see citing works
Mindfulness-to-meaning processes in host empowerment through co-creation for responsible tourism
Chen, L. I.-L. (2025) · Journal of Responsible Tourism Management · doi:10.1108/jrtm-10-2025-0007 · Cited by 1 · see citing works
Enhancing mindfulness interventions for test anxiety: A perspective based on the NIH stage model
Shaoqing, X. U., Xinhua, L. I. U., Zhang, H., Ли, Б., Xinfeng, T. A. N. G., Gaiping, Q. U., Yuqin, B. A. O., Junping, Z. H. A. O., & Fu, Z. (2023) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2023.02380 · Cited by 1 · see citing works
Emotion Regulation Reduces Negativity Bias and Enhances Mnemonic Discrimination in DepressionPreprint
Hayes, B. K., Harikumar, A., Ferguson, L. A., Dicker, E. E., Denny, B. T., & Leal, S. L. (2022) · doi:10.31234/osf.io/6jn5w · Cited by 1 · see citing works
App-based Mindfulness Training Supported Eudaimonic Wellbeing during the COVID19 pandemicPreprint
de Zavala, A. G. (2023) · doi:10.31234/osf.io/sqkf5 · Cited by 1 · see citing works
de Zavala, A. G., Förster, C. A., Ziegler, M. D., & Mazurkiewicz, M. (2023) · doi:10.31234/osf.io/rz8te · Cited by 1 · see citing works
Abbott, P., D’Ambruoso, L., Shanks, R., Engdawork, K., & Mihretu, A. (2025) · Qeios · doi:10.32388/up1vr6 · Cited by 1 · see citing works
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Research Advances in Mindfulness Interventions in Therapy of Post-Traumatic Growth
赵, 卓. (2021) · Advances in Psychology · doi:10.12677/ap.2021.1111276
Life Satisfaction in Motherhood: The Influence of Mindfulness on Life Stressors
Schumacher, S., & Schumacher, S. M. (2024) · doi:10.58809/exxh7090
The effect of focused reappraisal strategies on emotional intensity
Wild, K. J., Costea, A. R., Pintea, S., Macavei, B., Fodor, O. C., & Opre, A. N. (2024) · Studia Universitatis Babeș-Bolyai Psychologia-Paedagogia · doi:10.24193/subbpsyped.2024.2.04
Mechanisms of Mindfulness Interventions: Perspectives from Monitor and Acceptance Theory (MAT)
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Emotion polyregulation and daily negative affect: predictors of use and strategy-level effectiveness
Dicker, E. E., Leal, S. L., & Denny, B. T. (2026) · Anxiety Stress & Coping · doi:10.1080/10615806.2026.2640041
“Thus, cognitive reappraisal, or particular tactics involving active engagement and emotional decentering, such as psychological distancing, may prove to be key drivers of successful polyregulation sequences or combinations (Denny & Ochsner, 2014; Dicker et al., 2022; Hanley et al., 2021).”
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Promoting Nature Connectedness: Insights into the Roles of Mindfulness and Nonattachment
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How AI Can Enhance Psychological Resilience
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“Longitudinal research has provided support for the proposed relationships among attentional control, decentering, broadened awareness, and reappraisal (Garland et al., 2017; Hanley et al., 2021).”
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- Authors
- Hanley, A. W., de Vibe, M., Solhaug, I., Farb, N., Goldin, P. R., Gross, J. J., & Garland, E. L.
- Affiliations
- University of Utah (US)
- Norwegian Knowledge Centre for the Health Services Oslo Norway
- UiT The Arctic University of Norway (NO)
- University of Toronto (CA)
- University of California, Davis (US)
- Stanford University (US)
- Corresponding author
- Garland, Eric L.
- Venue
- Stress and Health
- Publisher
- Wiley
- Published
- 2021-03-09
- Volume
- 37
- Issue
- 4
- Pages
- 778-789
- ISSN
- 1532-2998 (ISSN-L)
- 1532-3005
- OpenAlex
- W3131735914
- Semantic Scholar
- 441393eb474d85f500bd8fac362b2fb7012b05dc
- Cited by
- 56
- References
- 78
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 10 · 2023: 14 · 2022: 11 · 2021: 4
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stress and Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Social Sciences › Psychology › Social Psychology › Psychological Well-being and Life Satisfaction
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Keywords
- positive reappraisal, mindfulness training, mindfulness-based stress reduction, decentering, well-being, quality of life, latent growth curve models
- MeSH terms
- Humans, Quality of Life, Research Design, Stress, Psychological, Multivariate Analysis, Mindfulness
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