Cited by 144Gut microbiota and healthNutritional Studies and DietGastrointestinal motility and disorders

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Diet, gut microbiota and cognition

Proctor, Cicely, Thiennimitr, Parameth, Chattipakorn, Nipon, Chattipakorn, Siriporn C·2017·Metabolic Brain Disease

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Abstract

The consumption of a diet high in fat and sugar can lead to the development of obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease and cognitive decline. In the human gut, the trillions of harmless microorganisms harboured in the host's gastrointestinal tract are called the 'gut microbiota'. Consumption of a diet high in fat and sugar changes the healthy microbiota composition which leads to an imbalanced microbial population in the gut, a phenomenon known as "gut dysbiosis". It has been shown that certain types of gut microbiota are linked to the pathogenesis of obesity. In addition, long-term consumption of a high fat diet is associated with cognitive decline. It has recently been proposed that the gut microbiota is part of a mechanistic link between the consumption of a high fat diet and the impaired cognition of an individual, termed "microbiota-gut-brain axis". In this complex relationship between the gut, the brain and the gut microbiota, there are several types of gut microbiota and host mechanisms involved. Most of these mechanisms are still poorly understood. Therefore, this review comprehensively summarizes the current evidence from mainly in vivo (rodent and human) studies of the relationship between diet, gut microbiota and cognition. The possible mechanisms that the diet and the gut microbiota have on cognition are also presented and discussed.

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Authors: Proctor, C., Thiennimitr, P., Chattipakorn, N., & Chattipakorn, S. C.
Affiliations: University of Manchester (GB)
Chiang Mai University (TH)
Corresponding author: Chattipakorn, Siriporn C
ORCID: Thiennimitr, Parameth
Chattipakorn, Nipon
Chattipakorn, Siriporn C
Venue: Metabolic Brain Disease
Publisher: Springer Science and Business Media LLC
Published: 2016-10-05
Volume: 32
Issue: 1
Pages: 1-17
ISSN: 0885-7490 (ISSN-L)
1573-7365
DOI: 10.1007/s11011-016-9917-8
OpenAlex: W2528793084
Cited by: 144
References: 120
Citations by year: 2026: 3 · 2025: 7 · 2024: 16 · 2023: 21 · 2022: 29 · 2021: 17 · 2020: 19 · 2019: 16 · 2018: 7 · 2017: 9
FWCI: 0.96
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Metabolic Brain Disease (publishedVersion)
PubMed (publishedVersion)
Funders: Thailand Research Fund (BRG5780016, TRG5880041)
National Research Council of Thailand (SC)
a NSTDA Research Chair Grant from the National Science and Technology Development Agency Thailand (NC)
Chiang Mai University Center of Excellence Award (NC)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, diet, cognitive decline, high-fat diet, sugar consumption, gut dysbiosis, obesity, type 2 diabetes, cardiovascular disease, microbiota-gut-brain axis, host-microbe interactions
MeSH terms: Gastrointestinal Microbiome, Cognition, Diabetes Mellitus, Type 2, Diet, Humans, Obesity, Gastrointestinal Tract

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