LIGAND: A versatile computerized approach for characterization of ligand-binding systems

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501

Determination and characterization of a cannabinoid receptor in rat brain

Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443

Negative regulation of transforming growth factor-β by the proteoglycan decorin

Yamaguchi, Y., Mann, D. M., & Ruoslahti, E. (1990) · Nature · doi:10.1038/346281a0 · Cited by 1,516

Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

Reppert, S. M., Weaver, D. R., & Ebisawa, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90055-8 · Cited by 1,096

Pharmacological profile of antidepressants and related compounds at human monoamine transporters

Tatsumi, M., Groshan, K., Blakely, R. D., & Richelson, E. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01393-9 · Cited by 939

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

Puel, A., Ziegler, S. F., Buckley, R. H., & Leonard., W. J. (1998) · Nature Genetics · doi:10.1038/3877 · Cited by 813

Neurotransmitter Receptor and Transporter Binding Profile of Antidepressants and Their Metabolites

Owens, M. J., Morgan, W. N., Plott, S. J., & Nemeroff, C. B. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37161-7 · Cited by 676

Localization, Quantitation, and In Situ Detection of Specific Peptide–MHC Class I Complexes Using a Monoclonal Antibody

Porgador, A., Yewdell, J. W., Deng, Y., Bennink, J. R., & Germain, R. N. (1997) · Immunity · doi:10.1016/s1074-7613(00)80447-1 · Cited by 669

Allelic Association of the D2 Dopamine Receptor Gene With Receptor-Binding Characteristics in Alcoholism or Gene ism

Noble, E. P. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310066012 · Cited by 655

The binding cascade of SecB to SecA to SecYE mediates preprotein targeting to the E. coli plasma membrane

Hartl, F.-U., Lecker, S., Schiebel, E., Hendrick, J. P., & Wickner, W. (1990) · Cell · doi:10.1016/0092-8674(90)90160-g · Cited by 562

Evidence that Tobacco Smoking Increases the Density of (−)‐[3H]Nicotine Binding Sites in Human Brain

Benwell, M. E. M., Balfour, D. J. K., & Anderson, J. M. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb10600.x · Cited by 551

Evidence for dopamine receptor pruning between adolescence and adulthood in striatum but not nucleus accumbens

Teicher, M. H., Andersen, S. L., & Hostetter, J. C. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(95)00109-q · Cited by 505

Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease

Masliah, E., Hansen, L., Alford, M., Deteresa, R., & Mallory, M. (1996) · Annals of Neurology · doi:10.1002/ana.410400512 · Cited by 476

The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor

Majewska, M. D., Demirgo¨ren, S., Spivak, C. E., & London, E. D. (1990) · Brain Research · doi:10.1016/0006-8993(90)90261-9 · Cited by 433

Identification of the Nicotinic Receptor Subtypes Expressed on Dopaminergic Terminals in the Rat Striatum

Zoli, M., Moretti, M., Zanardi, A., McIntosh, J. M., Clementi, F., & Gotti, C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-08785.2002 · Cited by 407

Alzheimer's β-Amyloid Peptides Compete for Insulin Binding to the Insulin Receptor

Xie, L., Helmerhorst, E., Taddei, K., Plewright, B., van Bronswijk, W., & Martins, R. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-10-j0001.2002 · Cited by 291

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein.

Williams, S. E., Ashcom, J. D., Argraves, W. S., & Strickland, D. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50384-2 · Cited by 285

The Binding Site of Neuropeptide Vasopressin V1a Receptor

Mouillac, B., Chini, B., Balestre, M.-N., Elands, J., Trumpp-Kallmeyer, S., Hoflack, J., Hibert, M., Jard, S., & Barberis, C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25771 · Cited by 262

Interaction of the Chiral Forms of Ketamine with Opioid, Phencyclidine, σ and Muscarinic Receptors

Hustveit, O., Maurset, A., & Øye, I. (1995) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1995.tb01041.x · Cited by 246

125I-labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT: a selective oxytocin receptor ligand

Elands, J., Barberis, C., Jard, S., Tribollet, E., Dreifuss, J.-J., Bankowski, K., Manning, M., & Sawyer, W. H. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90778-9 · Cited by 245

In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.

Dolwick, K. M., Swanson, H. I., & Bradfield, C. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8566 · Cited by 239

Nicotinic Acetylcholine Receptors in the Mesolimbic Pathway: Primary Role of Ventral Tegmental Area α6β2* Receptors in Mediating Systemic Nicotine Effects on Dopamine Release, Locomotion, and Reinforcement

Gotti, C., Guiducci, S., Tedesco, V., Corbioli, S., Zanetti, L., Moretti, M., Zanardi, A., Rimondini, R., Mugnaini, M., Clementi, F., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5095-09.2010 · Cited by 226

Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.

Wheeler, M. B., Lu, M., Dillon, J. S., Leng, X. H., Chen, C., & Boyd, A. E. (1993) · Endocrinology · doi:10.1210/endo.133.1.8391428 · Cited by 225

Glycosphingolipid receptor function is modified by fatty acid content. Verotoxin 1 and verotoxin 2c preferentially recognize different globotriaosyl ceramide fatty acid homologues

Kiarash, A., Boyd, B., & Lingwood, C. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78102-2 · Cited by 206

The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors

Dyson, S., & Gurdon, J. B. (1998) · Cell · doi:10.1016/s0092-8674(00)81185-x · Cited by 204

Glucocorticoid hormone resistance during primate evolution: receptor-mediated mechanisms

Chrousos, G. P., Renquist, D., Brandon, D., Eil, C., Pugeat, M., Vigersky, R., Cutler, G. B., Loriaux, D. L., & Lipsett, M. B. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.6.2036 · Cited by 179

Variability in D2‐dopamine receptor density and affinity: A PET study with [11C]raclopride in man

Farde, L., Hall, H., Pauli, S., & Halldin, C. (1995) · Synapse · doi:10.1002/syn.890200303 · Cited by 175

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.

Kounnas, M. Z., Argraves, W. S., & Strickland, D. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36811-5 · Cited by 151

Glycoprotein G isoforms from some alphaherpesviruses function as broad-spectrum chemokine binding proteins.

Bryant, N. A., Davis‐Poynter, N., Vanderplasschen, A., & Alcami, A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg092 · Cited by 141

Different effects on the responses of functional pre-and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT

Larsson, L.-G., Rényi, L., Ross, S. B., Svensson, B., & Ängeby-Möller, K. (1990) · Neuropharmacology · doi:10.1016/0028-3908(90)90047-u · Cited by 137

Identification of brain isoforms of the rat calcitonin receptor.

Sexton, P. M., Houssami, S., Hilton, J. M., O'Keeffe, L. M., Center, R. J., Gillespie, M. T., Darcy, P., & Findlay, D. M. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.6.8395656 · Cited by 134

Human 5-HT5 receptors: the 5-HT5A receptor is functional but the 5-HT5B receptor was lost during mammalian evolution

Grailhe, R., Grabtree, G. W., & Hen, R. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00933-5 · Cited by 130

Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and β-amyloid pathologies

Kelliher, M., Fastbom, J., Cowburn, R. F., Bonkale, W., Ohm, T. G., Ravid, R., Sorrentino, V., & O'Neill, C. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00042-1 · Cited by 129

Localization of Vasopressin Binding Sites in Rat Tissues Using Specific Vi and V2 Selective Ligands*

PHILLIPS, P. A., ABRAHAMS, J. M., KELLY, J. M., MOOSER, V., TRINDER, D., & JOHNSTON, C. I. (1990) · Endocrinology · doi:10.1210/endo-126-3-1478 · Cited by 127

Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women

Åkerlund, M., Bossmar, T., Brouard, R., Kostrzewska, A., Laudanski, T., Lemancewicz, A., Gal, C. S., & Steinwall, M. (1999) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1999.tb08112.x · Cited by 123

SecYEG and SecA are the stoichiometric components of preprotein translocase.

Douville, K., Price, A., Eichler, J., Economou, A., & Wickner, W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.20106 · Cited by 123

Two aromatic residues regulate the response of the human oxytocin receptor to the partial agonist arginine vasopressin

Chini, B., Mouillac, B., Balestre, M.-N., Trumpp-Kallmeyer, S., Hoflack, J., Hibert, M., Andriolo, M., Pupier, S., Jard, S., & Barberis, C. (1996) · FEBS Letters · doi:10.1016/s0014-5793(96)01135-0 · Cited by 117

Broad immunocytochemical localization of the formylpeptide receptor in human organs, tissues, and cells

Becker, E. L., Forouhar, F. A., Grunnet, M. L., Boulay, F., Tardif, M., Bormann, B.-J., Sodja, D., Ye, R. D., Woska Jr, J. R., & Murphy, P. M. (1998) · Cell and Tissue Research · doi:10.1007/s004410051042 · Cited by 119

The identification of a human myometrial corticotropin-releasing hormone receptor that increases in affinity during pregnancy.

Hillhouse, E. W., Grammatopoulos, D., Milton, N. G., & Quartero, H. W. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.3.8383145 · Cited by 110

Vasopressin stimulates insulin release from islet cells through V1b receptors: a combined pharmacological/knockout approach

Oshikawa, S., Tanoue, A., Koshimizu, T.-A., Kitagawa, Y., & Tsujimoto, G. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.3.623 · Cited by 105

The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and mediates binding of normal very low density lipoproteins to LRP

Williams, S. E., Inoue, I., Tran, H., Fry, G. L., Pladet, M. W., Iverius, P. H., Lalouel, J. M., Chappell, D. A., & Strickland, D. K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37017-5 · Cited by 103

Pharmacological characterization of two novel and potent 5‐HT4receptor agonists, RS 67333 and RS 67506,in vitro and in vivo

Eglen, R. M., Bonhaus, D. W., Johnson, L. G., Leung, E., & Clark, R. D. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16628.x · Cited by 102

Three classes of epidermal growth factor receptors on HeLa cells.

Berkers, J. A., van Bergen en Henegouwen, P. M., & Boonstra, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35261-4 · Cited by 98

α Melanocyte stimulating hormone (αmsh) stimulates normal human melanocyte growth by binding to high-affinity receptors

Luca, M. D., Siegrist, W., Bondanza, S., Mathor, M., Cancedda, R., & Eberle, A. N. (1993) · Journal of Cell Science · doi:10.1242/jcs.105.4.1079 · Cited by 98

Regional Sex Differences in Cell Nuclear Estrogen-Binding Capacity in the Rat Hypothalamus and Preoptic Area*

BROWN, T. J., HOCHBERG, R. B., ZIELINSKI, J. E., & MACLUSKY, N. J. (1988) · Endocrinology · doi:10.1210/endo-123-4-1761 · Cited by 92

Regulation of Pituitary Vasopressin V1b Receptor mRNA during Stress in the Rat

Rabadan‐Diehl, C., Lolait, S. J., & Aguilera, G. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00734.x · Cited by 86

Regulation of thyrotropin receptor gene expression in rat FRTL-5 thyroid cells

Saji, M., Akamizu, T., Sanchez, M., Obici, S., Avvedimento, E., Gottesman, M. E., & Kohn, L. D. (1992) · Endocrinology · doi:10.1210/endo.130.1.1309347 · Cited by 84

Changes in the second messenger cyclic AMP during development may underlie motoric symptoms in attention deficit/hyperactivity disorder (ADHD)

Andersen, S. L. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00417-x · Cited by 80

Glucocorticoids Increase Vasopressin V1b Receptor Coupling to Phospholipase C

Rabadan-Diehl, C., & Aguilera, G. (1998) · Endocrinology · doi:10.1210/endo.139.7.6121 · Cited by 78

Oxytocin-stimulated release of adrenocorticotropin from the rat pituitary is mediated by arginine vasopressin receptors of the V1b type

Schlosser, S. F., Almeida, O. F., Patchev, V. K., Yassouridis, A., & Elands, J. (1994) · Endocrinology · doi:10.1210/endo.135.5.7956927 · Cited by 75

Expression and localization of estrogen receptor α in the C2C12 murine skeletal muscle cell line

Milanesi, L., de Boland, A. R., & Boland, R. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21706 · Cited by 64

Pancreatic vasopressin V 1b receptors: characterization in In-R1-G9 cells and localization in human pancreas

Folny, V., Raufaste, D., Lukovic, L., Pouzet, B., Rochard, P., Pascal, M., & Serradeil-Le Gal, C. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00148.2003 · Cited by 61

Regulation of nicotinic receptors in rat brain following quasi‐irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine

El‐Bizri, H., & Clarke, P. B. S. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb17080.x · Cited by 51

Mouse strain differences in the behavioral effects of Corticotropin-Releasing Factor (CRF) and the CRF antagonist α-helical CRF9–41

Conti, L. H., Costello, D. G., Martin, L. A., White, M. F., & Abreu, M. E. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90559-2 · Cited by 49

Deoxycholic Acid Conjugates Are Muscarinic Cholinergic Receptor Antagonists

Raufman, J.-P., Chen, Y., Zimniak, P., & Cheng, K. (2002) · Pharmacology · doi:10.1159/000064347 · Cited by 47

Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene

Luo, H., Chaudhuri, A., Johnson, K. R., Neote, K., Zbrzezna, V., He, Y., & Pogo, A. O. (1997) · Genome Research · doi:10.1101/gr.7.9.932 · Cited by 42

Adrenergic regulation of lipolysis in human fat cells during exercise

WAHRENBERG, H., BOLINDER, J., & ARNER, P. (1991) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1991.tb01406.x · Cited by 41

Mutual regulation of vasopressin- and oxytocin-induced glucagon secretion in V1b vasopressin receptor knockout mice

Fujiwara, Y., Hiroyama, M., Sanbe, A., Yamauchi, J., Tsujimoto, G., & Tanoue, A. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.06864 · Cited by 36

Dopamine receptor pruning during the peripubertal period is not attenuated by NMDA receptor antagonism in rat

Teicher, M. H., Krenzel, E., Thompson, A. P., & Andersen, S. L. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01475-1 · Cited by 34

Insulin binding in the hypothalamus of lean and genetically obese Zucker rats

Wilcox, B. J., Corp, E. S., Dorsa, D. M., Figlewicz, D. P., Greenwood, M. R. C., Woods, S. C., & Baskin, D. G. (1989) · Peptides · doi:10.1016/0196-9781(89)90008-9 · Cited by 32

125I‐d(CH2)5[Tyr(Me)2,Tyr(NH2)9]AVP: Iodination and binding characteristics of a vasopressin receptor ligand

Elands, J., Barberis, C., Jard, S., Lammek, B., Manning, M., Sawyer, W. H., & de Kloet, E. R. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)81135-9 · Cited by 28

Peripheral Benzodiazepine Receptor: Characterization in Human T-Lymphoma Jurkat Cells

Costa, B., Salvetti, A., Rossi, L., Spinetti, F., Lena, A., Chelli, B., Rechichi, M., Da Pozzo, E., Gremigni, V., & Martini, C. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.015289 · Cited by 26

Neutrophil β 2 -adrenergic receptor coupling efficiency to Gs protein in subjects with post-traumatic stress disorder and normal controls

Gurguis, G. N. M., Andrews, R., Antai-Otong, D., Vo, S. P., Blakeley, J. E., Orsulak, P. J., & Rush, A. J. (1999) · Psychopharmacology · doi:10.1007/s002130050928 · Cited by 24

Binding and degradation of lipoprotein(a) and LDL by primary cultures of human hepatocytes. Comparison with cultured human monocyte-macrophages and fibroblasts.

Snyder, M. L., Hay, R. V., Whitington, P. F., Scanu, A. M., & Fless, G. M. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.770 · Cited by 21

Binding of tricyclic antidepressant drugs to trophozoites of giardia lamblia

Weinbach, E. C., Levenbook, L., & Alling, D. W. (1992) · Comparative Biochemistry and Physiology Part C: Comparative Pharmacology · doi:10.1016/0742-8413(92)90131-p · Cited by 18