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The origin of the vasopressinergic and oxytocinergic innervation of the rat brain with special reference to the lateral septum
Open accessAbstract
The origin of the vasopressin-containing fibers in the rat lateral septum was studied by means of lesioning specific areas, in which vasopressin-containing cells are found, or by surgically separating the septum from the underlying structures. Following these procedures sections of the brain were stained immunocytochemically for the presence of vasopressin. In addition, retrograde labeling tracers were injected in the lateral septum. Lesioning of the paraventricular nucleus did not result in the disappearance of vasopressin fibers from the lateral septum, nor from the various other areas studied. It did, however, cause the disappearance of fibers from the nucleus of the solitary tract and the nucleus ambiguus. By contrast, after the same lesion practically the whole oxytocinergic innervation of the brain disappeared. Injection of tracers into the lateral septum revealed retrograde labeled cells, e.g. in the bed nucleus of the stria terminalis, but not in the paraventricular and supraoptic nucleus. Horizontal cuts under the lateral septum, intersecting the diagonal band of Broca, resulted in a dramatic decrease of the vasopressin fibers in the lateral septum, suggesting that the fibers enter the septum via this structure. Moreover, since the vasopressin fiber density was found to decrease drastically in the lateral septum after lesioning the bed nucleus of the stria terminalis, the vasopressin cells found in this area are probably the source of these fibers. Other areas where fibers were seen to decrease after lesions of the bed nucleus are the diagonal band of Broca, the area of the anterior amygdala, the lateral habenular nucleus, the periventricular gray, and the locus coeruleus.
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TL;DR
Using lesions and retrograde tracing in rats, this study shows that the vasopressin (VP) fibers innervating the lateral septum arise from the bed nucleus of the stria terminalis (BNST), not from the paraventricular (PVN), supraoptic (SON) or suprachiasmatic nuclei. In contrast, the brain's oxytocinergic innervation appears to derive predominantly from the PVN.
Key findings
- Unilateral horizontal knife cuts separating the septum from underlying structures drastically reduced VP fiber density in the lateral septum only when the cut extended far enough rostrally to intersect the diagonal band of Broca; more caudal cuts produced only slight reduction. Intersected fibers appeared swollen, suggesting accumulation proximal to transection.
- Unilateral BNST lesions (diameter ~2.5 mm) clearly reduced VP fiber density ipsilaterally in the diagonal band of Broca, lateral septum, lateral habenular nucleus, area of the anterior amygdala, periventricular gray and locus coeruleus; no diminution was noted in other areas studied (Table I).
- Small PVN lesions (~1.5 mm) decreased VP fibers only in the nucleus of the solitary tract and nucleus ambiguus. Large PVN lesions (~2.5 mm) additionally eliminated VP staining in the periventricular and dorsomedial hypothalamic nuclei, and caused almost complete disappearance of the brain's oxytocinergic innervation — but did not remove VP fibers from the lateral septum.
- Retrograde tracer injections into the VP-dense part of the lateral septum labeled cells in the BNST (and lateral hypothalamic area, just lateral to PVN, and dorsal to SON) but not in the SCN, PVN or SON.
Methods
- Retrograde labeling: 37 male Wistar rats (250–300 g) received injections into the lateral septum of HRP (stereotactic or iontophoretic), WGA-HRP, True Blue or Granular Blue; sections processed with diaminobenzidine or tetramethylbenzidine methods or viewed by fluorescence microscopy.
- Lesion studies: male Wistar rats (160–190 g) received radiofrequency lesions of the PVN (5 small at 50 °C, 5 large at 60 °C) or unilateral BNST lesions (6 rats at 65 °C), or Halász-knife horizontal cuts separating the septum unilaterally from underlying structures (6 rats). After 2.5–3 weeks, 100 μm vibratome sections were stained immunocytochemically for VP or oxytocin and fiber density compared with untreated controls.
- Hippocampal and ventral tegmental labeling served as positive controls for retrograde tracing efficacy.
Limitations
- The authors state they cannot exclude that VP fibers in the lateral septum originate outside the BNST and merely pass through it; they note this requires combining immunocytochemistry with retrograde tracing.
- The origin of VP fibers in the dorsal raphe nucleus, medial amygdala, hippocampus and ventral tegmental area remained obscure, as no lesion reduced fibers in these areas.
- Bilateral BNST lesions were not performed because bilaterally lesioned rats failed to survive surgery; residual fibers after unilateral lesions could reflect contralateral crossover or additional sources (stated by the authors).
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14 Own result · 10 Own interpretation · 6 No full text of the sources · 1 Sources not found · 1 Not checked yet
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Injection of tracers into the lateral septum revealed retrograde labeled cells, e.g. in the bed nucleus of the stria terminalis, but not in the paraventricular and supraoptic nucleus.”
- Also stated in: § Retrograde tracing studies · p. 6 · plain
“Some labeled cells were also found in the ventral part of the bed nucleus of the stria terminalis (Fig. 2B).”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Retrograde tracing studies · p. 6 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The lesioned area had a diameter of about 2.5 mm (Fig. 7) and resulted in a clear decline in VP fiber density within the ipsilateral diagonal band of Broca, the lateral septum, the lateral habenular nucleus, the area of the anterior amygdala, the periventricular gray and the locus coeruleus (Figs. 8, 9, 10A and B).”
boosteddirect- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“since the vasopressin fiber density was found to decrease drastically in the lateral septum after lesioning the bed nucleus of the stria terminalis, the vasopressin cells found in this area are probably the source of these fibers.”
- Also stated in: § DISCUSSION · p. 9 · plain
“after unilateral lesioning of this structure VP fiber density was drastically reduced in the lateral septum as well as in various other areas.”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § DISCUSSION · p. 9 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Although lesioning the PVN did result in the disappearance of VP fibers in the nucleus of the solitary tract and the nucleus ambiguus, it did not impair the VP fiber density in the lateral septum.”
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
“Lesioning of the paraventricular nucleus did not result in the disappearance of vasopressin fibers from the lateral septum, nor from the various other areas studied.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Horizontal cuts under the lateral septum, intersecting the diagonal band of Broca, resulted in a dramatic decrease of the vasopressin fibers in the lateral septum, suggesting that the fibers enter the septum via this structure.”
- Also stated in: § Effect of different lesions on vasopressin fiber density in termination area · p. 7 · plain
“In those rats where the lesion extended far enough rostral to intersect the diagonal band of Broca a pronounced unilateral loss of VP fibers was seen within the lateral septum (Figs. 6A and C).”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Effect of different lesions on vasopressin fiber density in termination area · p. 7 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The same lesion resulted in an almost complete disappearance of the oxytocinergic innervation of the brain (Figs. 4A and B).”
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
“after the same lesion practically the whole oxytocinergic innervation of the brain disappeared.”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Ventral to the cut, the intersected VP fibers were seen to be swollen as if VP was accumulating proximal to the transection.”
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Since the VP fiber density remained unaffected in most other areas of the brain, the PVN and its accessory cell groups do not contribute for a major part to the VP innervation of the brain.”
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“After this lesion, VP fibers were seen to decrease only in the nucleus of the solitary tract and the nucleus ambiguus.”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Although the present study has clarified the sites of origin of VP fibers in many areas, the origin of VP fibers within the dorsal raphe nucleus, the nucleus of the medial amygdala, the hippocampus and the ventral tegmental area is still quite obscure, because in none of the lesion experiments mentioned were VP fibers seen to decrease in these areas.”
plain- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 7
- The quote only partly states this claim. 1
- Probably not a substantial claim. 2
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In none of the experiments were labeled cells found in the SCN, PVN or SON (Fig. 2A).”
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
“Injection of tracers into the lateral septum revealed retrograde labeled cells, e.g. in the bed nucleus of the stria terminalis, but not in the paraventricular and supraoptic nucleus.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“in VP fibers within the nucleus of the solitary tract and the nucleus ambiguus, and in the disappearance of the fiber staining in the periventricular (Figs. 5A and B) and the dorsomedial hypothalamic nuclei.”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At the level of the PVN cells were found just lateral to the PVN, lining the fornix. Many labeled cells were present in the lateral hypothalamic area, just dorsal to the SON. Some labeled cells were also found in the ventral part of the bed nucleus of the stria terminalis (Fig. 2B).”
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In rats with more caudally situated knife cuts, only a slight reduction was seen in the VP fiber density (Figs. 6B and D).”
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“For example, the VP cells of the bed nucleus of the stria terminalis probably receive a totally different input than the VP cells in the PVN or SCN, which obviously causes the output to be different as well.”
hedgeddirect- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The actions of VP, in turn, are probably linked in the various areas of which the VP fibers have a common origin, but could be independent when the fibers are derived from different nuclei.”
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The results of these experiments make it clear that neither the PVN nor the SON send VP fibers to the lateral septum.”
boosted- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“The largest number of extrahypothalamic VP cells was found in the bed nucleus of the stria terminalis. In addition, VP-immunopositive cells were revealed in other areas, e.g. in the rostral part of the lateral septum, the amygdala and the locus coeruleus27.”
What the sources say
- Not checked — no full text of the sourcecites Van Leeuwen and Caffe, 1983 source
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Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It receives vasopressinergic inputs directly from the MeA (Caffe et al., 1987) and the bed nucleus of the stria terminalis (BNST) (De Vries & Buijs, 1983).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as De Vries & Buijs, 1983
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“More importantly, previous data have shown that the BST and CMA are interconnected, and lesions of the BST disrupt AVP expression in the amygdala.35”
From Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression (2012) · cites this paper as [35]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The lateral septum receives projections from the BNST (De Vries and Buijs, 1983), a primary node in the neural network thought to play a role in social behavior (Newman, 1999).”
From Sexually dimorphic role for vasopressin in the development of social play (2014) · cites this paper as De Vries and Buijs, 1983
The cited source says what the claim attributes to it.
In the citing paper
“The conclusion that the BST is an important source of septal AVP-ir fibers therefore rests on solid evidence (De Vries and Buijs, 1983).”
From Sexual differentiation of central vasopressin and vasotocin systems in vertebrates: different mechanisms, similar endpoints (2006) · cites this paper as De Vries and Buijs, 1983
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“The lateral septum receives most of its AVP innervation from the bed nucleus of the stria terminalis (BNST) and the medial amygdala (MeA) (De Vries and Buijs, 1983; Caffé et al., 1987).”
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“As mentioned above, AVP also mediates olfactory social recognition and is produced and centrally released by the PVN into the hypothalamus (De Vries and Buijs, 1983).”
Sex Differences in Vasopressin and Other Neurotransmitter Systems in the Brain
De Vries, G. J., Buijs, R. M., & Van Leeuwen, F. W. (1984) · Progress in Brain Research · doi:10.1016/s0079-6123(08)64435-0 · Cited by 106
Self-citationKelly, A. M., & Goodson, J. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322554111 · Cited by 106
“In rodents, the LS receives direct innervation from VP neurons in the BSTm and OT neurons in the PVN (although light) (32), in addition to apparent paracrine modulation from VP-OT neurons in the SON and PVN (4–6).”
BackgroundVasopressin in the septal area of the golden hamster controls scent marking and grooming
Irvin, R. W., Szot, P., Dorsa, D. M., Potegal, M., & Ferris, C. F. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90213-n · Cited by 105
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Self-citationIsoflurane exposure in newborn rats induces long-term cognitive dysfunction in males but not females
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“The lateral septum contains high numbers of vasopressin receptors (De Vries and Buijs, 1983) and has reciprocal connections to higher order brain regions including the thalamus and hippocampus (Caffe et al., 1987; Bielsky and Young, 2004).”
BackgroundEdwards, S., Guerrero, M. A., Ghoneim, O. M., Roberts, E., & Koob, G. F. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00291.x · Cited by 104
“Vasopressin-synthesizing neurons are also centrally localized (Buijs 1978; Buijs et al. 1983; De Vries & Buijs 1983), originating within the paraventricular nucleus (PVN), bed nucleus of the stria terminalis (BNST), medial amygdala (MeA) and suprachiasmatic nucleus (SCN).”
BackgroundNeural basis of maternal behavior in the rat
Numan, M. J. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90006-6 · Cited by 104
Septal release of vasopressin in response to osmotic, hypovolemic and electrical stimulation in rats
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Lateral septal vasopressin in rats: role in social and object recognition?
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Organization of vasotocin‐immunoreactive cells and fibers in the canary brain
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Behavioural impact of intraseptally released vasopressin and oxytocin in rats
Englemann, M., Wotjak, C. T., Ebner, K., & Landgraf, R. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00015.x · Cited by 94
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Sexual dimorphism in the vasotocin system of the bullfrog (Rana catesbeiana)
Boyd, S. K., Tyler, C. J., & Vries, G. J. D. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903250213 · Cited by 96
Oxytocin as feeding inhibitor: Maintaining homeostasis in consummatory behavior
Olszewski, P. K., Klockars, A., Schiöth, H. B., & Levine, A. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.026 · Cited by 92
Salomé, N., Stemmelin, J., Cohen, C., & Griebel, G. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0424-1 · Cited by 89
“Thus, vasopressin could be released from local terminals or might travel over long distances ( De Vries and Buijs 1983; Landgraf et al. 1995).”
BackgroundDevelopment of the human hypothalamus
Swaab, D. F. (1995) · Neurochemical Research · doi:10.1007/bf01694533 · Cited by 91
Vasopressin administration modulates anxiety-related behavior in rats
Appenrodt, E., Schnabel, R., & Schwarzberg, H. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00119-x · Cited by 91
Neuropeptide binding reflects convergent and divergent evolution in species-typical group sizes
Goodson, J. L., Evans, A. K., & Wang, Y. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.03.005 · Cited by 93
“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript VT/VP afferents to the ventral pallidum and LS likely arise predominantly from the BSTm (De Vries and Buijs, 1983; De Vries and Panzica, 2006).”
BackgroundLitvin, Y., Murakami, G., & Pfaff, D. W. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.007 · Cited by 93
Bupesh, M., Legáz, I., Abellán, A., & Medina, L. M. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22581 · Cited by 89
Roozendaal, B., Wiersma, A. T., Driscoll, P., Koolhaas, J. M., & Bohus, B. (1992) · Brain Research · doi:10.1016/0006-8993(92)91529-n · Cited by 88
Oxytocin and vasopressin in the rodent hippocampus
Cilz, N. I., Cymerblit‐Sabba, A., & Young, W. S. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12535 · Cited by 92
Fuxe, K., Borroto-Escuela, D. O., Romero-Fernandez, W., Ciruela, F., Manger, P., Leo, G., Díaz-Cabiale, Z., & Agnati, L. F. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.062 · Cited by 81
“The major ascending oxytocinergic pathways largely arise from the paraventricular nucleus (PVN) and someminor groups in themedial preoptic area innervating the subcortical limbic structures and the ventral and dorsal striatum (De Vries and Buijs, 1983; McEwen, 2004).”
BackgroundLearning About Oxytocin: Pharmacologic and Behavioral Issues
Chini, B., Leonzino, M., Braida, D., & Sala, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.029 · Cited by 91
“amygdala (49) and contains OT and AVP receptors (50–52).”
Kirkpatrick, B. W., Carter, C. S., Newman, S. W., & Insel, T. R. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.3.501 · Cited by 86
Sex differences in the regulation of offensive aggression and dominance by arginine-vasopressin
Terranova, J. I., Ferris, C. F., & Albers, H. E. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00308 · Cited by 85
Mayer, U., Salva, O. R., & Vallortígara, G. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.031 · Cited by 81
Lasion of hypothalamic paraventricular nucleus and maternal aggressive behavior in female rats
Consiglio, A. R. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02117-5 · Cited by 85
Testosterone-sensitive vasotocin-immunoreactive cells and fibers in the canary brain
Voorhuis, T. A. M., Kiss, J. Z., de Kloet, E. R., & de Wied, D. (1988) · Brain Research · doi:10.1016/0006-8993(88)91441-2 · Cited by 85
Ebner, K., Wotjak, C. T., Holsboer, F., Landgraf, R., & Engelmann, M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00508.x · Cited by 86
“…high level of plasma testosterone during critical stages of development, AVP is synthesized, e.g. in neurons of the bed nucleus of the stria terminalis (Caffe´ & Van Leeuwen, 1983; Van Leeuwen & Caffe´, 1983) that projects to both the ventral and mediolateral septum (De Vries & Buijs, 1983).”
BackgroundGriebel, G., Stemmelin, J., Gal, C. S., & Soubrié, P. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053764797 · Cited by 86
“Vasopressin-containing neurons have been characterized in extrahypothalamic structures, including the bed nucleus of the stria terminalis and the medial amygdala [16-18].”
Backgroundvan Leeuwen, F. W., & Wolters, P. S. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90223-9 · Cited by 84
To flock or fight: Neurochemical signatures of divergent life histories in sparrows
Goodson, J. L., Wilson, L. C., & Schrock, S. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203394109 · Cited by 85
“The relevance of these binding sites to flocking is supported by the demonstrations that intraventricular and intraseptal infusions of nonapeptide receptor antagonists (V1a and oxytocin receptor antagonists) reduce preferences for larger groups in the highly gregarious zebra finch (11, 13), as does antisense knockdown…”
BackgroundZaninetti, M., & Raggenbass, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00290.x · Cited by 82
Neuroendocrinology and sexual differentiation in eusocial mammals
Holmes, M. M., Goldman, B. D., Goldman, S. L., Seney, M. L., & Forger, N. G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.010 · Cited by 80
“throughout the brain [40]; it is these centrally-projecting cells that appear to modulate social functions.”
Efferent connections of the hypothalamic “grooming area” in the rat
Roeling, T. A. P., Veening, J. G., Peters, J. P. W., Vermelis, M. E. J., & Nieuwenhuys, R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90574-y · Cited by 79
Desmedt, A., Garcia, R., & Jaffard, R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00480.1998 · Cited by 81
“…modulation of hippocampal–septal transmission might involve the bed nucleus of the stria terminalis, which receives fibers from the CEA (Weller and Smith, 1982) and in turn sends vasopressinergic fibers to several forebrain areas, including the LS (De Vries and Buijs, 1983; Woodhams et al., 1983).”
BackgroundFerris, C. F., Gold, L., Vries, G. J. D., & Potegal, M. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902930310 · Cited by 78
Landgraf, R., Neumann, I. D., Russell, J. A., & Pittman, Q. J. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34364.x · Cited by 78
“44 p1/30-min sample),8 (2) differences in the in vitro recovery of radiolabeled OT (('HIOT: 2.”
BackgroundMethodWang, Z., Toloczko, D., Young, L. J., Moody, K., Newman, J. D., & Insel, T. R. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00636-7 · Cited by 75
Ho, J. M., Murray, J. H., Demas, G. E., & Goodson, J. L. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.021 · Cited by 76
“In fact, although the BSTM appears to contribute most or all of the direct AVP innervation to the LS (De Vries and Buijs, 1983; De Vries and Panzica, 2006), neurophysiological studies demonstrate that ventral LS neurons are also modulated by AVP derived from the PVN (Disturnal et al., 1986), and…”
Vasopressin analgesia: Specificity of action and non-opioid effects
Kordower, J. H., & Bodnar, R. J. (1984) · Peptides · doi:10.1016/0196-9781(84)90017-2 · Cited by 76
Role of Vasopressin in Aggressive and Dominant/Subordinate Behaviors
Ferris, C. F. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34357.x · Cited by 76
Changes with aging in the vasopressin and oxytocin innervation of the rat brain
Fliers, E., Vries, G. J. D., & Swaab, D. F. (1985) · Brain Research · doi:10.1016/0006-8993(85)90351-8 · Cited by 75
Stoll, C., & Voorn, P. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902390206 · Cited by 74
Pierman, S., Sica, M., Allieri, F., Viglietti‐Panzica, C., Panzica, G., & Bakker, J. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.02.001 · Cited by 74
“Centrally, AVP projections to the lateral septum are primarily coming from the bed nucleus of the stria terminalis (BNST) and the medial amygdala (Me) in the rat (De Vries and Buijs, 1983).”
Social Circuits: Peptidergic Regulation of Mammalian Social Behavior
Storm, E. E., & Tecott, L. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.004 · Cited by 73
“AVP and OT are predominantly expressed in neurons of the hypothalamic paraventricular and supraoptic nuclei that project to diverse central sites and to the posterior pituitary gland (De Vries and Buijs, 1983).”
BackgroundBrain Vasotocin Pathways and the Control of Sexual Behaviors in the Bullfrog
Boyd, S. K. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00213-x · Cited by 71
“Those AVP-ir cells are the major source of sexually dimorphic fibers in the lateral habenular nucleus of the rat [25].”
Neuropeptide diversity and the regulation of social behavior in New World primates
French, J. A., Taylor, J. H., Mustoe, A. C., & Cavanaugh, J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.004 · Cited by 66
Brain Sexual Dimorphism and Sex Differences in Parental and Other Social Behaviorsa
Vries, G. J. D., & Villalba, C. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51926.x · Cited by 68
Raggenbass, M., Tribollet, E., & Dreifuss, J. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7778 · Cited by 68
Vasopressin Localization and Putative Functions in the Brain
Buijs, R. M. (1987) · Springer eBooks · doi:10.1007/978-1-4615-8129-1_2 · Cited by 70
Self-citationPattern of afferents to the lateral septum in the guinea pig
Staiger, J. F., & N�rnberger, F. (1989) · Cell and Tissue Research · doi:10.1007/bf00221457 · Cited by 67
Plumari, L., Viglietti‐Panzica, C., Allieri, F., Honda, S., Harada, N., Absil, P., Balthazart, J., & Panzica, G. C. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00866.x · Cited by 66
“For example, the bed nucleus of the stria terminalis (BNST) and the medial amygdala (2) contain more AVPimmunoreactive (AVP-ir) cells in males than in females and projections from these nuclei to the lateral septum are denser in males than in females ( 3 , 4). The AVP cells and fibres located in these brain regions ar…”
BackgroundRigney, N., Whylings, J., Mieda, M., de Vries, G. J., & Petrulis, A. (2019) · eNeuro · doi:10.1523/eneuro.0415-18.2019 · Cited by 63
“In rats, where AVP release in the septum, one of the most prominent projection areas of BNST and MeA AVP cells (De Vries and Buijs, 1983; De Vries and Panzica, 2006), correlates positively with intermale aggression in a resident-intruder test, a behavioral response could be blocked by…”
BackgroundNuman, M. J., FLEMING, A., & Lévy, F. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50040-3 · Cited by 63
Hertz, L., & Chen, Y. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.018 · Cited by 64
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Self-citationEngelmann, M., Ludwig, M., & Landgraf, R. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90907-l · Cited by 64
An ultrastructural study of GABA-immunoreactive neurons and terminals in the septum of the rat
Onteniente, B., Geffard, M., Campistron, G., & Calas, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-01-00048.1987 · Cited by 63
“…interactions are frequent in the CNS (Ribak et al., 1979; Bolam et al., 1983; Oertel et al., 1984; Mugnaini, 1985) and were observed in the lateral and medial septum, which correlated with electrophysiological data demonstrating an inhibition of inhibitory septal interneurons (De France, 1976).”
BackgroundCaldwell, H. K. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-1704-0_12 · Cited by 58
Goodson, J. L., Rinaldi, J., & Kelly, A. M. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.10.007 · Cited by 62
Sparapani, S., Millet-Boureima, C., Oliver, J., Mu, K., Hadavi, P., Kalostian, T., Ali, N., Avelar, C. M., Bardies, M., Barrow, B., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9010089 · Cited by 64
Albers, H. E., Rowland, C. M., & Ferris, C. F. (1991) · Brain Research · doi:10.1016/0006-8993(91)90696-s · Cited by 59
Metadata
- Authors
- de Vries, G. J., & Buijs, R. M.
- ORCID
- Buijs, R.M.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1983-08
- Volume
- 273
- Issue
- 2
- Pages
- 307-317
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2061489766
- Cited by
- 524
- References
- 28
- Citations by year
- 2026: 9 · 2025: 8 · 2023: 9 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 8 · 2014: 16 · 2013: 21 · 2012: 15
- FWCI
- 35.17
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- vasopressin, oxytocin, lateral septum, paraventricular nucleus, bed nucleus of the stria terminalis, diagonal band of Broca, nucleus tractus solitarius, nucleus ambiguus, retrograde tracing, lesioning, rat brain
- MeSH terms
- Animals, Brain Mapping, Diencephalon, Male, Neural Pathways, Synaptic Transmission, Oxytocin, Rats, Inbred Strains, Septum Pellucidum, Telencephalon, Vasopressins, Rats
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