The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index; none of the 11 sources its claims cite is checked for support yet.
The origin of the vasopressinergic and oxytocinergic innervation of the rat brain with special reference to the lateral septum
Open accessAbstract
The origin of the vasopressin-containing fibers in the rat lateral septum was studied by means of lesioning specific areas, in which vasopressin-containing cells are found, or by surgically separating the septum from the underlying structures. Following these procedures sections of the brain were stained immunocytochemically for the presence of vasopressin. In addition, retrograde labeling tracers were injected in the lateral septum. Lesioning of the paraventricular nucleus did not result in the disappearance of vasopressin fibers from the lateral septum, nor from the various other areas studied. It did, however, cause the disappearance of fibers from the nucleus of the solitary tract and the nucleus ambiguus. By contrast, after the same lesion practically the whole oxytocinergic innervation of the brain disappeared. Injection of tracers into the lateral septum revealed retrograde labeled cells, e.g. in the bed nucleus of the stria terminalis, but not in the paraventricular and supraoptic nucleus. Horizontal cuts under the lateral septum, intersecting the diagonal band of Broca, resulted in a dramatic decrease of the vasopressin fibers in the lateral septum, suggesting that the fibers enter the septum via this structure. Moreover, since the vasopressin fiber density was found to decrease drastically in the lateral septum after lesioning the bed nucleus of the stria terminalis, the vasopressin cells found in this area are probably the source of these fibers. Other areas where fibers were seen to decrease after lesions of the bed nucleus are the diagonal band of Broca, the area of the anterior amygdala, the lateral habenular nucleus, the periventricular gray, and the locus coeruleus.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
Using lesions and retrograde tracing in rats, this study shows that the vasopressin (VP) fibers innervating the lateral septum arise from the bed nucleus of the stria terminalis (BNST), not from the paraventricular (PVN), supraoptic (SON) or suprachiasmatic nuclei. In contrast, the brain's oxytocinergic innervation appears to derive predominantly from the PVN.
Key findings
- Unilateral horizontal knife cuts separating the septum from underlying structures drastically reduced VP fiber density in the lateral septum only when the cut extended far enough rostrally to intersect the diagonal band of Broca; more caudal cuts produced only slight reduction. Intersected fibers appeared swollen, suggesting accumulation proximal to transection.
- Unilateral BNST lesions (diameter ~2.5 mm) clearly reduced VP fiber density ipsilaterally in the diagonal band of Broca, lateral septum, lateral habenular nucleus, area of the anterior amygdala, periventricular gray and locus coeruleus; no diminution was noted in other areas studied (Table I).
- Small PVN lesions (~1.5 mm) decreased VP fibers only in the nucleus of the solitary tract and nucleus ambiguus. Large PVN lesions (~2.5 mm) additionally eliminated VP staining in the periventricular and dorsomedial hypothalamic nuclei, and caused almost complete disappearance of the brain's oxytocinergic innervation — but did not remove VP fibers from the lateral septum.
- Retrograde tracer injections into the VP-dense part of the lateral septum labeled cells in the BNST (and lateral hypothalamic area, just lateral to PVN, and dorsal to SON) but not in the SCN, PVN or SON.
Methods
- Retrograde labeling: 37 male Wistar rats (250–300 g) received injections into the lateral septum of HRP (stereotactic or iontophoretic), WGA-HRP, True Blue or Granular Blue; sections processed with diaminobenzidine or tetramethylbenzidine methods or viewed by fluorescence microscopy.
- Lesion studies: male Wistar rats (160–190 g) received radiofrequency lesions of the PVN (5 small at 50 °C, 5 large at 60 °C) or unilateral BNST lesions (6 rats at 65 °C), or Halász-knife horizontal cuts separating the septum unilaterally from underlying structures (6 rats). After 2.5–3 weeks, 100 μm vibratome sections were stained immunocytochemically for VP or oxytocin and fiber density compared with untreated controls.
- Hippocampal and ventral tegmental labeling served as positive controls for retrograde tracing efficacy.
Limitations
- The authors state they cannot exclude that VP fibers in the lateral septum originate outside the BNST and merely pass through it; they note this requires combining immunocytochemistry with retrograde tracing.
- The origin of VP fibers in the dorsal raphe nucleus, medial amygdala, hippocampus and ventral tegmental area remained obscure, as no lesion reduced fibers in these areas.
- Bilateral BNST lesions were not performed because bilaterally lesioned rats failed to survive surgery; residual fibers after unilateral lesions could reflect contralateral crossover or additional sources (stated by the authors).
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
14 Own result · 10 Own interpretation · 6 No full text of the sources · 1 Sources not found · 1 Not checked yet
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Injection of tracers into the lateral septum revealed retrograde labeled cells, e.g. in the bed nucleus of the stria terminalis, but not in the paraventricular and supraoptic nucleus.”
- Also stated in: § Retrograde tracing studies · p. 6 · plain
“Some labeled cells were also found in the ventral part of the bed nucleus of the stria terminalis (Fig. 2B).”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Retrograde tracing studies · p. 6 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The lesioned area had a diameter of about 2.5 mm (Fig. 7) and resulted in a clear decline in VP fiber density within the ipsilateral diagonal band of Broca, the lateral septum, the lateral habenular nucleus, the area of the anterior amygdala, the periventricular gray and the locus coeruleus (Figs. 8, 9, 10A and B).”
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“since the vasopressin fiber density was found to decrease drastically in the lateral septum after lesioning the bed nucleus of the stria terminalis, the vasopressin cells found in this area are probably the source of these fibers.”
- Also stated in: § DISCUSSION · p. 9 · plain
“after unilateral lesioning of this structure VP fiber density was drastically reduced in the lateral septum as well as in various other areas.”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § DISCUSSION · p. 9 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Although lesioning the PVN did result in the disappearance of VP fibers in the nucleus of the solitary tract and the nucleus ambiguus, it did not impair the VP fiber density in the lateral septum.”
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
“Lesioning of the paraventricular nucleus did not result in the disappearance of vasopressin fibers from the lateral septum, nor from the various other areas studied.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Horizontal cuts under the lateral septum, intersecting the diagonal band of Broca, resulted in a dramatic decrease of the vasopressin fibers in the lateral septum, suggesting that the fibers enter the septum via this structure.”
- Also stated in: § Effect of different lesions on vasopressin fiber density in termination area · p. 7 · plain
“In those rats where the lesion extended far enough rostral to intersect the diagonal band of Broca a pronounced unilateral loss of VP fibers was seen within the lateral septum (Figs. 6A and C).”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Effect of different lesions on vasopressin fiber density in termination area · p. 7 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The same lesion resulted in an almost complete disappearance of the oxytocinergic innervation of the brain (Figs. 4A and B).”
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
“after the same lesion practically the whole oxytocinergic innervation of the brain disappeared.”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Ventral to the cut, the intersected VP fibers were seen to be swollen as if VP was accumulating proximal to the transection.”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Since the VP fiber density remained unaffected in most other areas of the brain, the PVN and its accessory cell groups do not contribute for a major part to the VP innervation of the brain.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“After this lesion, VP fibers were seen to decrease only in the nucleus of the solitary tract and the nucleus ambiguus.”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Although the present study has clarified the sites of origin of VP fibers in many areas, the origin of VP fibers within the dorsal raphe nucleus, the nucleus of the medial amygdala, the hippocampus and the ventral tegmental area is still quite obscure, because in none of the lesion experiments mentioned were VP fibers seen to decrease in these areas.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- It may state two separate claims as one. 7
- The quote only partly states this claim. 1
- Probably not a substantial claim. 2
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In none of the experiments were labeled cells found in the SCN, PVN or SON (Fig. 2A).”
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
“Injection of tracers into the lateral septum revealed retrograde labeled cells, e.g. in the bed nucleus of the stria terminalis, but not in the paraventricular and supraoptic nucleus.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § G. J. DE VRIES and R. M. BUIJS · p. 2 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“in VP fibers within the nucleus of the solitary tract and the nucleus ambiguus, and in the disappearance of the fiber staining in the periventricular (Figs. 5A and B) and the dorsomedial hypothalamic nuclei.”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At the level of the PVN cells were found just lateral to the PVN, lining the fornix. Many labeled cells were present in the lateral hypothalamic area, just dorsal to the SON. Some labeled cells were also found in the ventral part of the bed nucleus of the stria terminalis (Fig. 2B).”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In rats with more caudally situated knife cuts, only a slight reduction was seen in the VP fiber density (Figs. 6B and D).”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The quote only partly states this claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For example, the VP cells of the bed nucleus of the stria terminalis probably receive a totally different input than the VP cells in the PVN or SCN, which obviously causes the output to be different as well.”
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The actions of VP, in turn, are probably linked in the various areas of which the VP fibers have a common origin, but could be independent when the fibers are derived from different nuclei.”
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The results of these experiments make it clear that neither the PVN nor the SON send VP fibers to the lateral septum.”
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“The largest number of extrahypothalamic VP cells was found in the bed nucleus of the stria terminalis. In addition, VP-immunopositive cells were revealed in other areas, e.g. in the rostral part of the lateral septum, the amygdala and the locus coeruleus27.”
What the sources say
- Not checked — no full text of the sourcecites Van Leeuwen and Caffe, 1983 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It receives vasopressinergic inputs directly from the MeA (Caffe et al., 1987) and the bed nucleus of the stria terminalis (BNST) (De Vries & Buijs, 1983).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as De Vries & Buijs, 1983
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“More importantly, previous data have shown that the BST and CMA are interconnected, and lesions of the BST disrupt AVP expression in the amygdala.35”
From Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression (2012) · cites this paper as [35]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The lateral septum receives projections from the BNST (De Vries and Buijs, 1983), a primary node in the neural network thought to play a role in social behavior (Newman, 1999).”
From Sexually dimorphic role for vasopressin in the development of social play (2014) · cites this paper as De Vries and Buijs, 1983
The cited source says what the claim attributes to it.
In the citing paper
“The conclusion that the BST is an important source of septal AVP-ir fibers therefore rests on solid evidence (De Vries and Buijs, 1983).”
From Sexual differentiation of central vasopressin and vasotocin systems in vertebrates: different mechanisms, similar endpoints (2006) · cites this paper as De Vries and Buijs, 1983
Citations
Cites
A stereotaxic atlas of the rat brain
Pellegrino, L. J., & Cushman, A. J. (1967) · Plenum Press eBooks · Cited by 4,688
Mesulam, M. M. (1978) · Journal of Histochemistry & Cytochemistry · doi:10.1177/26.2.24068 · Cited by 4,303
The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem
König, J. F. R., & Klippel, R. (1986) · Medical Entomology and Zoology · Cited by 4,134
Swanson, L. W., & Cowan, W. M. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901720104 · Cited by 1,592
Swanson, L. W., & Kuypers, H. G. J. M. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901940306 · Cited by 1,413
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029
Self-citationIntra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M. (1978) · Cell and Tissue Research · doi:10.1007/bf00212323 · Cited by 830
Self-citationConrad, L. C. A., & Pfaff, D. W. (1976) · The Journal of Comparative Neurology · doi:10.1002/cne.901690206 · Cited by 633
Conrad, L. C. A., & Pfaff, D. W. (1976) · The Journal of Comparative Neurology · doi:10.1002/cne.901690205 · Cited by 484
Research works printed but not linked: 2
- De Vries, G. J., Best, W. and Sluiter, A. A., The influence of gonadal steroids on a sex difference in the vasopressinergic innervation of the brain, Develop. Brain Res., in press.
- Schober, 1978, Darstellung der neurosekretorischen hypothalamo-rhombenzephalen Verbindung bei der Ratte durch retrograden axonalen Transport von Meerrettich-Peroxidase, Acta biol. med. Germ., 37, 165
Cited by
Sorted by citations
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804
Connections of the rat lateral septal complex 1Published on the World Wide Web on 2 June 1997. 1
Risold, P. Y., & Swanson, L. W. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00009-x · Cited by 671
Neuropeptidergic regulation of affiliative behavior and social bonding in animals
Lim, M. M., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.028 · Cited by 624
“Lesions of the PVN result in a near complete loss of the brain oxytocinergic system (De Vries and Buijs, 1983), and a delay in the onset of maternal behavior in naïve rats (Insel and Harbaugh, 1989).”
BackgroundOxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder
Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.123 · Cited by 549
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
Regulation of affect by the lateral septum: implications for neuropsychiatry
Sheehan, T. P., Chambers, R. A., & Russell, D. S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.009 · Cited by 514
“Vasopressin reaches the LS from two regions in rats: the medial amygdala and the bed nucleus of the stria terminalis [57,107].”
BackgroundThe vasopressinergic innervation of the brain in normal and castrated rats
DeVries, G. J., Buijs, R. M., van Leeuwen, F. W., Caffé, A. R., & Swaab, D. F. (1985) · Journal of Comparative Neurology · doi:10.1002/cne.902330206 · Cited by 522
Self-citationVasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504
“Anxiety—High densities of vasopressinergic fibers (De Vries and Buijs, 1983) and Avpr1a (Ostrowski et al., 1992) are found within the septum.”
BackgroundOxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468
Griebel, G., Simiand, J., Serradeil-Le Gal, C., Wagnon, J., Pascal, M., Scatton, B., Maffrand, J.-P., & Soubrié, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092012099 · Cited by 471
Oxytocin, vasopressin, and social recognition in mammals
Bielsky, I. F., & Young, L. J. (2004) · Peptides · doi:10.1016/j.peptides.2004.05.019 · Cited by 460
Engelmann, M., Landgraf, R., & Wotjak, C. T. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.09.001 · Cited by 450
Tribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91437-0 · Cited by 442
The neurobiology of pair bonding: Insights from a socially monogamous rodent
Young, K. A., Gobrogge, K. L., Liu, Y., & Wang, Z. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.006 · Cited by 389
“As BNST-AVP neurons project to the LS [60], these data suggest that mating facilitates AVP synthesis”
Swaab, D. F., Purba, J. S., & Hofman, M. A. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.2.7852523 · Cited by 421
Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster).
Wang, Z., Ferris, C. F., & De Vries, G. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.400 · Cited by 381
Numan, M., & Stolzenberg, D. S. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.10.002 · Cited by 361
De Vries, G. J., & Panzica, G. C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.050 · Cited by 346
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337
“Vasopressin has a neurotropic action by being centrally localized and originating in the PVN, BNST, medial amygdala, and suprachiasmatic nucleus and projecting extensively throughout the basal forebrain (Veinante and Freund-Mercier, 1997; De Vries and Buijs, 1983).”
BackgroundHolstege, G., Meiners, L. C., & Tan, K. (1985) · Experimental Brain Research · doi:10.1007/bf00235319 · Cited by 339
Central vasopressin and oxytocin release: regulation of complex social behaviours
VEENEMA, A., & NEUMANN, I. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00422-6 · Cited by 338
“…aggressive and territorial behaviours comprises AVP neurons originating in the medial amygdala and the BNST and projecting to the lateral septum (De Vries and Buijs, 1983; Koolhaas et al., 1998), and of AVP projections to hypothalamic regions, especially the anterior hypothalamus (Ferris et al.,…”
BackgroundInfluentialVasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole
Lim, M. M., & Young, L. J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.008 · Cited by 322
Chapter 14 Descending motor pathways and the spinal motor system: Limbic and non-limbic components
Holstege, G. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63057-5 · Cited by 323
Characterization of the oxytocin system regulating affiliative behavior in female prairie voles
Ross, H. E., Cole, C. D., Smith, Y., Neumann, I. D., Landgraf, R., Murphy, A. Z., & Young, L. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.055 · Cited by 309
Pitkow, L. J., Sharer, C. A., Ren, X., Insel, T. R., Terwilliger, E. F., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07392.2001 · Cited by 295
“In rats, the septal AVP innervation arises from the bed nucleus of the stria terminalis and the medial amygdala ( DeVries and Buijs, 1983 ).”
BackgroundThe Mouse Defense Test Battery: pharmacological and behavioral assays for anxiety and panic
Blanchard, D. C., Griebel, G., & Blanchard, R. J. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01276-7 · Cited by 295
“…ACTH secretion by potentiating the stimulatory effects of CRF. Extra hypothalamic arginine vasopressin-containing neurons have also been characterized in the medial amygdala , which innervate limbic structures such as the lateral septum and the ventral hippocampus (De Vries and Buijs, 1983).”
BackgroundDong, H., & Swanson, L. W. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20002 · Cited by 296
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 296
“Vasopressin expression levels in brain areas outside the hypothalamus are sexually dimorphic: males have higher numbers of vasopressin expressing cells in the BST and more fibres in the LS and lateral habenula (De Vries & Buijs 1983; De Vries et al. 1983; De Vries 1990).”
BackgroundCaffé, A. R., van Leeuwen, F. W., & Luiten, P. G. M. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902610206 · Cited by 286
Bester‐Meredith, J. K., Young, L. J., & Marler, C. A. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1522 · Cited by 285
Sex difference in the bed nucleus of the stria terminalis of the human brain
Allen, L. S., & Gorski, R. A. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903020402 · Cited by 281
Dabrowska, J., Hazra, R., Ahern, T. H., Guo, J.-D., McDonald, A. J., Mascagni, F., Muller, J. F., Young, L. J., & Rainnie, D. G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.003 · Cited by 274
“Both OT and AVP levels are increased in the extended amygdala in response to stress, (Landgraf and Neumann, 2004; Ebner et al., 2005), as a result of release from local fibers (De Vries and Buijs, 1983; Sofroniew, 1983).”
Central regulation of sodium appetite
Geerling, J. C., & Loewy, A. D. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2007.039891 · Cited by 281
“Since these PVH neurones represent the only known source of oxytocin in the brain (De Vries & Buijs, 1983), they are presumably responsible for inhibition of sodium appetite by central oxytocinergic release (Stricker & Verbalis, 1987, 1996).”
BackgroundEngelmann, M., Wotjak, C. T., Neumann, I. D., Ludwig, M., & Landgraf, R. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00059-3 · Cited by 269
Gulya, K., Dave, J. R., & Hoffman, P. L. (1991) · Brain Research · doi:10.1016/0006-8993(91)90125-f · Cited by 265
Risold, P. Y., & Swanson, L. W. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00008-8 · Cited by 263
van Leeuwen, F. W., Caffe, A. R., & Vries, G. J. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)90348-8 · Cited by 248
Mesotocin and nonapeptide receptors promote estrildid flocking behavior
Goodson, J. L., Schrock, S. E., Klatt, J. D., Kabelik, D., & Kingsbury, M. A. (2009) · Science · doi:10.1126/science.1174929 · Cited by 241
Morphological and electrophysiological classification of hypothalamic supraoptic neurons
Armstrong, W. E. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)80005-s · Cited by 246
Targeted activation of the hippocampal CA2 area strongly enhances social memory
Smith, A. S., Williams Avram, S. K., Cymerblit-Sabba, A., Song, J., & Young, W. S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.189 · Cited by 236
Aggression and anxiety: social context and neurobiological links
Neumann, I. D. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00012 · Cited by 252
“In rats, testosterone-dependent AVP pathways, which originate in the BST/medial amygdala and project to the lateral septum (de Vries and Buijs, 1983), are diminished after castration (de Vries et al., 1984) as are levels of aggression (Koolhaas et al., 1990).”
BackgroundSimerly, R. B., Gorski, R. A., & Swanson, L. W. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902460305 · Cited by 236
Nonapeptides and the evolutionary patterning of sociality
GOODSON, J. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00401-9 · Cited by 228
“The LS provides a concrete example: although the BSTm provides the only direct AVP innervation of the LS (De Vries and Buijs, 1983; De Vries and Panzica, 2006), neurophysiological studies indicate that AVP projections from the PVN also influence LS activity (Disturnal et al., 1986, 1987).”
BackgroundGonadal hormone actions on the morphology of the vasopressinergic innervation of the adult rat brain
De Vries, G. J., Buijs, R. M., & Sluiter, A. A. (1984) · Brain Research · doi:10.1016/0006-8993(84)91157-0 · Cited by 224
Self-citationOxytocin, vasopressin, and autism: Is there a connection?
Insel, T. R., O’Brien, D. J., & Leckman, J. F. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00142-5 · Cited by 226
Sex Differences in Neurotransmitter Systems
Vries, G. J. D. (1990) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1990.tb00385.x · Cited by 226
Young, W. S., Li, J., Wersinger, S. R., & Palkovits, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.040 · Cited by 222
“Alternatively, the Avpr1b may be transported to the axon terminals in the lateral septum where vasopressin innervation (De Vries and Buijs, 1983; Caffe et al., 1987) could affect neurotransmission and behavior.”
BackgroundAnatomy, Development, and Function of Sexually Dimorphic Neural Circuits in the Mammalian Brain
Vries, G. J. D., & Simerly, R. B. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50066-4 · Cited by 221
Neuroendocrinology of social information processing in rats and mice
Choleris, E., Clipperton-Allen, A. E., Phan, A., & Kavaliers, M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.003 · Cited by 205
Goodson, J. L., & Kabelik, D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.007 · Cited by 209
“For instance, while direct VT/VP projections to the LS appear to arise almost exclusively from the BSTm [21,26], physiological data demonstrate that the PVN cell group also exerts significant effects on the LS [30,31].”
BackgroundVasopressin-immunoreactive cell bodies in the bed nucleus of the stria terminalis of the rat
van Leeuwen, F., & Caffé, R. (1983) · Cell and Tissue Research · doi:10.1007/bf00211473 · Cited by 206
Efferent projections of the suprachiasmatic nucleus in the golden hamster (Mesocricetus auratus)
Kalsbeek, A., Teclemariam‐Mesbah, R., & Péavet, P. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903320304 · Cited by 205
Sexual dimorphism in the mammalian limbic system
Madeira, M. D., & Lieberman, A. R. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00052-j · Cited by 207
Albers, H. E. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.07.001 · Cited by 200
“These nuclei, however, are also the source of AVP-containing fibers that project to other brain regions (Buijs, 1978; Hoorneman and Buijs, 1982; Sawchenko and Swanson, 1982; De Vries and Buijs, 1983; Alonso et al., 1986).”
BackgroundEbner, K., Bosch, O. J., Krömer, S. A., Singewald, N., & Neumann, I. D. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300607 · Cited by 205
“These fibers have been found to originate predominantly from the PVN, since OXT fiber density decreases dramatically in all OXT projection sites after lesioning this hypothalamic area (De Vries and Buijs, 1983; Van Leeuwen and Caffe, 1983).”
BackgroundCaffe´, A. R., & van Leeuwen, F. W. (1983) · Cell and Tissue Research · doi:10.1007/bf00222229 · Cited by 199
Fliers, E., Swaab, D. F., W. Pool, C., & Verwer, R. W. H. (1985) · Brain Research · doi:10.1016/0006-8993(85)91351-4 · Cited by 190
Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?
Griebel, G., & Holsboer, F. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3702 · Cited by 194
Vasopressin and oxytocin—their role in neurotransmission
Buijs, R. M. (1983) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(83)90056-6 · Cited by 191
Self-citationOxytocin-induced penile erection and yawning: site of action in the brain
Melis, M. R., Argiolas, A., & Gessa, G. L. (1986) · Brain Research · doi:10.1016/0006-8993(86)91485-x · Cited by 190
Brain oxytocin in social fear conditioning and its extinction: involvement of the lateral septum
Zoicas, I., Slattery, D. A., & Neumann, I. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.156 · Cited by 189
Chapter 1.1 Anatomy and function of extrahypothalamic vasopressin systems in the brain
Vries, G. J. D., & MILLER, M. A. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61558-7 · Cited by 189
Fever: Causes and consequences
Moltz, H. (1993) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80009-0 · Cited by 180
Veenema, A. H., Beiderbeck, D. I., Lukas, M., & Neumann, I. D. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.006 · Cited by 180
“The BST contains AVP-expressing neurons that send fibers to the LS (De Vries and Buijs, 1983; De Vries et al., 1984; van Leeuwen et al., 1985; Caffe et al., 1987).”
BackgroundBamshad, M., Novak, M. A., & De Vries, G. J. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00480.x · Cited by 175
The neurobiology of social recognition, approach, and avoidance
Young, L. J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01268-9 · Cited by 177
Argiolas, A., Melis, M. R., Mauri, A., & Gessa, G. L. (1987) · Brain Research · doi:10.1016/0006-8993(87)91305-9 · Cited by 172
Vasopressin and oxytocin: distribution and putative functions in the brain
Buijs, R. M., De Vries, G. J., Van Leeuwen, F. W., & Swaab, D. F. (1983) · Progress in Brain Research · doi:10.1016/s0079-6123(08)64379-4 · Cited by 167
Self-citationSex differences in vasopressin and oxytocin innervation of the brain
DEVRIES, G. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00402-0 · Cited by 169
“Together these data identified the BNST as the most important source of the innervation of the lateral septum (De Vries and Buijs, 1983).”
BackgroundLim, M. M., Murphy, A. Z., & Young, L. J. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.10973 · Cited by 163
Sex-specific modulation of juvenile social play by vasopressin
Veenema, A. H., Bredewold, R., & De Vries, G. J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.002 · Cited by 166
“To test whether AVP projections of the BNST or MeA modulate social play, we targeted the LS because this area receives projections from AVP-expressing neurons in the BNST and MeA that are denser in males than in females (De Vries & Buijs, 1983; Van Leeuwen et al., 1985; Caffe et al., 1987).”
BackgroundLandgraf, R., Frank, E., Aldag, J. M., Neumann, I. D., Sharer, C. A., Ren, X., Terwilliger, E. F., Niwa, M., Wigger, A., & Young, L. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02750.x · Cited by 169
“Regardless of the species, the septal brain area plays a key role in behavioural regulation as it contains a high density of V1aR and a dense network of AVP-immunoreactive fibers (De Vries & Buijs, 1983).”
BackgroundAnatomy and neurochemistry of the pair bond
Young, L. J., Murphy Young, A. Z., & Hammock, E. A. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20771 · Cited by 163
Goodson, J. L., & Kingsbury, M. A. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.05.006 · Cited by 160
“In mammals, most of the direct VP–OT innervation of the brain appears to come from the PVN, particularly in the case of OT (much of the VP arises from extrahypothalamic sites), although the supraoptic nucleus likely makes a contribution, as well (De Vries and Buijs, 1983; Rood et al., 2013 ).”
Veenema, A. H. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.002 · Cited by 172
“VP-expressing neurons in the BNST and MeA show projections to several forebrain regions, including the lateral septum (Caffé et al., 1987; De Vries and Buijs, 1983).”
BackgroundThe vasopressin system — From antidiuresis to psychopathology
Frank, E., & Landgraf, R. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.063 · Cited by 162
“The effects of vasopressin on social learning and memory were foremost attributed to the lateral septum, which receives vasopressinergic projections from both the bed nucleus of the stria terminalis and the medial amygdala (De Vries and Buijs, 1983).”
BackgroundInnovative Approaches for the Treatment of Depression: Targeting the HPA Axis
THOMSON, F. J., & Craighead, M. W. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9518-3 · Cited by 158
“Vasopressin-expressing neurones have been identified in the hypothalamus and in limbic regions such as the medial amygdala and the bed nucleus of the stria terminalis [98, 99], both of which project to the lateral septum.”
BackgroundDe Vries, G. J., Duetz, W., Buijs, R. M., van Heerikhuize, J., & Vreeburg, J. T. M. (1986) · Brain Research · doi:10.1016/0006-8993(86)91519-2 · Cited by 153
Self-citationSmith, C. J. W., Poehlmann, M. L., Li, S., Ratnaseelan, A. M., Bredewold, R., & Veenema, A. H. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1260-7 · Cited by 143
“AVP is also synthesized in the bed nucleus of the stria terminalis (BNST) and medial amygdala (Sofroniew and Weindl 1978; Sofroniew 1980; Caffé et al. 1987; De Vries et al. 1981; De Vries and Buijs 1983; Rood and De Vries 2011).”
MethodPhillips, P. A., Abrahams, J. M., Kelly, J., Paxinos, G., Grzonka, Z., Mendelsohn, F. A. O., & Johnston, C. I. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90180-7 · Cited by 150
Everts, H. G. J., & Koolhaas, J. M. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00004-7 · Cited by 147
“medial amygdala and the bed nucleus of the stria terminalis (BNST) [5,9,10,47].”
Aste, N., Balthazart, J., Absil, P., Grossmann, R., M�lhbauer, E., Viglietti‐Panzica, C., & Panzica, G. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980629)396:2 · Cited by 149
Kelly, A. M., & Goodson, J. L. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.005 · Cited by 150
“…et al. also demonstrated that castration results in a virtual disappearance of both VP-immunoreactive (-ir) neurons in the BSTm and VP-ir fibers in the LS (De Vries et al., 1985), and that the VP-ir innervation of the LS was virtually eliminated by lesions of the BSTm (De Vries and Buijs, 1983).”
BackgroundThe neurophysin-containing innervation of the forebrain of the mouse
Castel, M., & Morris, J. F. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90078-4 · Cited by 143
Bredewold, R., & Veenema, A. H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.011 · Cited by 144
“The LS receives vasopressinergic innervations from the bed nucleus of the stria terminalis (BNST) and medial amygdala (MeA) [13,14].”
BackgroundEvolving nonapeptide mechanisms of gregariousness and social diversity in birds
Goodson, J. L., Kelly, A. M., & Kingsbury, M. A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.005 · Cited by 139
“All doi:10.1016/j.yhbeh.2012.01.005 a b s t r a c t a r t i c l e i n f o Available online 13 January 2012”
InfluentialBeiderbeck, D. I., Neumann, I. D., & Veenema, A. H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05974.x · Cited by 142
“In particular, extrahypothalamic AVP neurons originating in the medial amygdala and the BNST and projecting to the lateral septum (De Vries & Buijs, 1983; Caffe et al., 1987) seem to be involved in the regulation of aggressive behaviours in rodents (Irvin et al., 1990; Koolhaas et al., 1990, 1991;…”
BackgroundWang, Z., Smith, W., Major, D. E., & Vries, G. J. D. (1994) · Brain Research · doi:10.1016/0006-8993(94)91784-1 · Cited by 141
Vries, G. J. D., Best, W., & Sluiter, A. A. (1983) · Developmental Brain Research · doi:10.1016/0165-3806(83)90019-6 · Cited by 139
Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
Rizzi-Wise, C. A., & Wang, D. V. (2021) · eNeuro · doi:10.1523/eneuro.0315-21.2021 · Cited by 161
“The neural pathways that support these social behaviors are unclear; however, the LS likely receives oxytocin and vasopressin from the PVN and bed nucleus of the stria terminalis (BNST), respectively, in executing these social functions (De Vries and Buijs, 1983).”
BackgroundThe Central Vasopressinergic System: Examining the Opportunities for Psychiatric Drug Development
Ring, R. H. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382241 · Cited by 142
“The importance of the PVN to homeostatic regulation of autonomic functions suggests that these projections are responsible for vasopressinergic control of autonomic activity and nociception at the spinal level.”
BackgroundOxytocin in the central nervous system and sexual behaviour in male rats
Hughes, A. M., Everitt, B. J., Lightman, S. L., & Todd, K. (1987) · Brain Research · doi:10.1016/0006-8993(87)91333-3 · Cited by 140
Vasopressin innervation of the mouse ( Mus musculus ) brain and spinal cord
Rood, B. D., & De Vries, G. J. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22635 · Cited by 134
MILLER, M. A., URBAN, J. H., & DORSA, D. M. (1989) · Endocrinology · doi:10.1210/endo-125-5-2335 · Cited by 134
The role of central oxytocin in obsessive compulsive disorder and related normal behavior
Leckman, J. F., Goodman, W. K., North, W. G., Chappell, P. B., Price, L. H., Pauls, D. L., Anderson, G. M., Riddle, M. A., McDougle, C. J., Barr, L. C., et al. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90021-3 · Cited by 133
Valence-sensitive neurons exhibit divergent functional profiles in gregarious and asocial species
Goodson, J. L., & Wang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606278103 · Cited by 138
Wang, Z., Young, L. J., Vries, G. J. D., & Insel, T. R. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61589-7 · Cited by 132
Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129
Metadata
- Authors
- de Vries, G. J., & Buijs, R. M.
- ORCID
- Buijs, R.M.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1983-08
- Volume
- 273
- Issue
- 2
- Pages
- 307-317
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2061489766
- Cited by
- 524
- References
- 28
- Citations by year
- 2026: 9 · 2025: 8 · 2023: 9 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 8 · 2014: 16 · 2013: 21 · 2012: 15
- FWCI
- 35.17
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- vasopressin, oxytocin, lateral septum, paraventricular nucleus, bed nucleus of the stria terminalis, diagonal band of Broca, nucleus tractus solitarius, nucleus ambiguus, retrograde tracing, lesioning, rat brain
- MeSH terms
- Animals, Brain Mapping, Diencephalon, Male, Neural Pathways, Synaptic Transmission, Oxytocin, Rats, Inbred Strains, Septum Pellucidum, Telencephalon, Vasopressins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-12, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-12 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
