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Aging in the nematode Caenorhabditis elegans: Major biological and environmental factors influencing life span
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Cited by
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
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Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214
Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209
Rates of Behavior and Aging Specified by Mitochondrial Function During Development
Dillin, A., Hsu, A.-L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Science · doi:10.1126/science.1077780 · Cited by 1,121
Garigan, D., Hsu, A.-L., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Genetics · doi:10.1093/genetics/161.3.1101 · Cited by 803
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Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.047 · Cited by 801
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
Hansen, M., Chandra, A., Mitic, L. L., Onken, B., Driscoll, M., & Kenyon, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040024 · Cited by 766
Stem cells, ageing and the quest for immortality
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Onken, B., & Driscoll, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008758 · Cited by 671
Jia, K., Chen, D., & Riddle, D. L. (2004) · Development · doi:10.1242/dev.01255 · Cited by 615
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Maures, T. J., Greer, E. L., Hauswirth, A. G., & Brunet, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00738.x · Cited by 256
Garrity, P. A., Goodman, M. B., Samuel, A. D., & Sengupta, P. (2010) · Genes & Development · doi:10.1101/gad.1953710 · Cited by 197
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de Magalhães, J. P., Wuttke, D., Wood, S. H., Plank, M., & Vora, C. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.004499 · Cited by 136
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“The discovery of the role of IIS in the modulation of longevity was the result of applying the most successful strategy to extend lifespan thus far, dietary restriction (Klass, 1977, 1983; Kenyon et al., 1993), and trying to understand its mechanisms.”
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Goodman, M. B., & Sengupta, P. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2089-5 · Cited by 69
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Pandya, J. D., Royland, J. E., MacPhail, R. C., Sullivan, P. G., & Kodavanti, P. R. S. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.027 · Cited by 50
Iser, W. B., Gami, M. S., & Wolkow, C. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.04.467 · Cited by 48
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PACRG, a protein linked to ciliary motility, mediates cellular signaling
Loucks, C. M., Bialas, N. J., Dekkers, M. P. J., Walker, D. S., Grundy, L. J., Li, C., Inglis, P. N., Kida, K., Schafer, W. R., Blacque, O. E., et al. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-07-0490 · Cited by 23
Ferguson, G. W., Jones, J. R., Gehrmann, W. H., Hammack, S. H., Talent, L. G., Hudson, R. D., Dierenfeld, E. S., Fitzpatrick, M. P., Frye, F. L., Holick, M. F., et al. (1996) · Zoo Biology · doi:10.1002/(sici)1098-2361(1996)15:3
Metadata
- Authors
- Klass, M. R.
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 1977-01
- Volume
- 6
- Issue
- 6
- Pages
- 413-429
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2042986568
- Cited by
- 790
- References
- 0
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.