Hydrogels in controlled release formulations: Network design and mathematical modeling

The mathematics of diffusion

Crank, J. (1956) · CERN Document Server (European Organization for Nuclear Research) · Cited by 18,978

Principles of Polymer Chemistry.

Huggins, M. L. (1954) · Journal of the American Chemical Society · doi:10.1021/ja01639a090 · Cited by 16,550

Principles of polymer chemistry

(1995) · Choice Reviews Online · doi:10.5860/choice.33-2140 · Cited by 15,218

The mathematics of diffusion

Park, G. S. (1975) · Polymer · doi:10.1016/0032-3861(75)90130-5 · Cited by 14,967

Poly(N-isopropylacrylamide): experiment, theory and application

Schild, H. G. (1992) · Progress in Polymer Science · doi:10.1016/0079-6700(92)90023-r · Cited by 5,147

Hydrogels in pharmaceutical formulations

Peppas, N. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00090-4 · Cited by 4,011

Molecular Transport in Liquids and Glasses

Cohen, M. H., & Turnbull, D. (1959) · The Journal of Chemical Physics · doi:10.1063/1.1730566 · Cited by 3,959

Environment-sensitive hydrogels for drug delivery

Qiu, Y., & Park, K. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00203-4 · Cited by 3,911

Biodegradable polymeric nanoparticles as drug delivery devices

Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549

Hydrophilic gels for biological use

WICHTERLE, O., & LÍM, D. (1960) · Nature · doi:10.1038/185117a0 · Cited by 2,996

Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)

Siepmann, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00112-0 · Cited by 2,613

Alginate hydrogels as synthetic extracellular matrix materials

Rowley, J. A., Madlambayan, G., & Mooney, D. J. (1999) · Biomaterials · doi:10.1016/s0142-9612(98)00107-0 · Cited by 2,342

Functional hydrogel structures for autonomous flow control inside microfluidic channels

Beebe, D. J., Moore, J. S., Bauer, J. M., Yu, Q., Liu, R. H., Devadoss, C., & Jo, B.-H. (2000) · Nature · doi:10.1038/35007047 · Cited by 1,971

On the importance and mechanisms of burst release in matrix-controlled drug delivery systems

Huang, X., & Brazel, C. S. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00248-6 · Cited by 1,813

A simple equation for the description of solute release. III. Coupling of diffusion and relaxation

Peppas, N. A., & Sahlin, J. J. (1989) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(89)90306-2 · Cited by 1,771

Polymeric system for dual growth factor delivery

Richardson, T. P., Peters, M. C., Ennett, A. B., & Mooney, D. J. (2001) · Nature Biotechnology · doi:10.1038/nbt1101-1029 · Cited by 1,752

Photopolymerizable hydrogels for tissue engineering applications

Nguyen, K. T., & West, J. L. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00175-8 · Cited by 1,669

Hydrogels in Medicine and Pharmacy

Peppas, N. A. (1987) · Cited by 1,648

Protein release from alginate matrices

Gombotz, W. R., & Wee, S. F. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.007 · Cited by 1,609

PEGylated nanoparticles for biological and pharmaceutical applications

Otsuka, H., Nagasaki, Y., & Kataoka, K. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00226-0 · Cited by 1,588

Protein release from alginate matrices

Gombotz, W. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00124-5 · Cited by 1,550

Synthetic Matrix Metalloproteinase-Sensitive Hydrogels for the Conduction of Tissue Regeneration: Engineering Cell-Invasion Characteristics

Lutolf, M. P., Lauer-Fields, J. L., Schmoekel, H. G., Metters, A. T., Weber, F. E., Fields, G. B., & Hubbell, J. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737381100 · Cited by 1,508

Thermosensitive sol-gel reversible hydrogels

Jeong, B., Kim, S. W., & Bae, Y. H. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00242-3 · Cited by 1,478

Scaffold design and fabrication technologies for engineering tissues — state of the art and future perspectives

Hutmacher, D. W. (2001) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856201744489 · Cited by 1,409

In situ-forming hydrogels--review of temperature-sensitive systems

Ruel-Gariépy, E., & Leroux, J.-C. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.03.019 · Cited by 1,297

Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH

Chen, G., & Hoffman, A. S. (1995) · Nature · doi:10.1038/373049a0 · Cited by 1,219

Colloidal Gold: A Novel Nanoparticle Vector for Tumor Directed Drug Delivery

Paciotti, G. F., Myer, L., Weinreich, D., Goia, D., Pavel, N., McLaughlin, R. E., & Tamarkin, L. (2004) · Drug Delivery · doi:10.1080/10717540490433895 · Cited by 1,185

Protein drug stability: a formulation challenge

Frokjaer, S., & Otzen, D. E. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1695 · Cited by 1,096

Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology

Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., & Zhang, J. (2000) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.2.1.9 · Cited by 1,016

Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering

Burdick, J. A., & Anseth, K. S. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00176-x · Cited by 1,008

Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers

Sawhney, A. S., Pathak, C. P., & Hubbell, J. A. (1993) · Macromolecules · doi:10.1021/ma00056a005 · Cited by 974

Solute Diffusion within Hydrogels. Mechanisms and Models

Amsden, B. (1998) · Macromolecules · doi:10.1021/ma980765f · Cited by 942

Physical models of diffusion for polymer solutions, gels and solids

Masaro, L., & Zhu, X. X. (1999) · Progress in Polymer Science · doi:10.1016/s0079-6700(99)00016-7 · Cited by 913

Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing

Hern, D. L., & Hubbell, J. A. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199802)39:2<266::aid-jbm14>3.0.co;2-b · Cited by 904

Effective drug delivery by PEGylated drug conjugates

Greenwald, R. B., Choe, Y. H., McGuire, J., & Conover, C. D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00180-1 · Cited by 869

Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery

Bromberg, L. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00121-x · Cited by 838

Biodegradable microspheres for protein delivery

Sinha, V. R., & Trehan, A. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00194-9 · Cited by 814

Mathematical modeling of bioerodible, polymeric drug delivery systems

Siepmann, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00116-8 · Cited by 772

Responsive polymeric delivery systems

Kost, J., & Langer, R. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00136-8 · Cited by 747

Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering

Mann, B. K., Gobin, A. S., Tsai, A. T., Schmedlen, R. H., & West, J. L. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00051-5 · Cited by 704

Correlation between mesh size and equilibrium degree of swelling of polymeric networks

Canal, T., & Peppas, N. A. (1989) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820231007 · Cited by 672

Preparation, structure and diffusional behavior of hydrogels in controlled release

Peppas, N. A., & Khare, A. R. (1993) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(93)90025-y · Cited by 665

Polymer–drug conjugates: Progress in polymeric prodrugs

Khandare, J., & Minko, T. (2006) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2005.09.004 · Cited by 639

Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels

Cruise, G. M., Scharp, D. S., & Hubbell, J. A. (1998) · Biomaterials · doi:10.1016/s0142-9612(98)00025-8 · Cited by 612

Technology of mammalian cell encapsulation

Uludag, H., De Vos, P., & Tresco, P. A. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00053-3 · Cited by 601

Poly(ethylene glycol)-containing hydrogels in drug delivery

Peppas, N. A., Keys, K. B., Torres-Lugo, M., & Lowman, A. M. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00027-9 · Cited by 598

The diffusion of electrolytes in a cation-exchange resin membrane I. Theoretical

Mackie, J. S., & Meares, P. (1955) · Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences · doi:10.1098/rspa.1955.0234 · Cited by 588

Control of encapsulation efficiency and initial burst in polymeric microparticle systems

Yeo, Y., & Park, K. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02980037 · Cited by 567

Development of fibrin derivatives for controlled release of heparin-binding growth factors

Sakiyama-Elbert, S. E., & Hubbell, J. A. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00221-7 · Cited by 565

Human Bone Morphogenetic Protein 2 Contains a Heparin‐Binding Site which Modifies Its Biological Activity

Ruppert, R., Hoffmann, E., & Sebald, W. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0295n.x · Cited by 558

Cell‐demanded release of VEGF from synthetic, biointeractive cell‐ingrowth matrices for vascularized tissue growth

Zisch, A. H., Lutolf, M. P., Ehrbar, M., Raeber, G. P., Rizzi, S. C., Davies, N., Schmökel, H., Bezuidenhout, D., Djonov, V., Zilla, P., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-1041fje · Cited by 534

Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery

Sheridan, M. H., Shea, L. D., Peters, M. C., & Mooney, D. J. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00138-8 · Cited by 528

Cell‐Responsive Synthetic Hydrogels

Lutolf, M. P., Raeber, G. P., Zisch, A. H., Tirelli, N., & Hubbell, J. A. (2003) · Advanced Materials · doi:10.1002/adma.200304621 · Cited by 526

Permeability of solutes through hydrated polymer membranes. Part I. Diffusion of sodium chloride

Yasuda, H., Lamaze, C. E., & Ikenberry, L. D. (1968) · Die Makromolekulare Chemie · doi:10.1002/macp.1968.021180102 · Cited by 526

Equilibrium swelling behavior of pH-sensitive hydrogels

Brannon-Peppas, L., & Peppas, N. A. (1991) · Chemical Engineering Science · doi:10.1016/0009-2509(91)80177-z · Cited by 512

Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks

Elisseeff, J., McIntosh, W., Anseth, K., Riley, S., Ragan, P., & Langer, R. (2000) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(200008)51:2<164::aid-jbm4>3.0.co;2-w · Cited by 510

Effect of the morphology of hydrophilic polymeric matrices on the diffusion and release of water soluble drugs

Korsmeyer, R. W., & Peppas, N. A. (1981) · Journal of Membrane Science · doi:10.1016/s0376-7388(00)80265-3 · Cited by 479

In situ forming degradable networks and their application in tissue engineering and drug delivery

Anseth, K. S., Metters, A. T., Bryant, S. J., Martens, P. J., Elisseeff, J. H., & Bowman, C. N. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00500-4 · Cited by 479

Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens

JIANG, W., GUPTA, R., DESHPANDE, M., & SCHWENDEMAN, S. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.09.003 · Cited by 478

Equilibrium swelling and kinetics of pH-responsive hydrogels: models, experiments, and simulations

De, S. K., Aluru, N. R., Johnson, B., Crone, W. C., Beebe, D. J., & Moore, J. (2002) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2002.803281 · Cited by 459

Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix

Sakiyama-Elbert, S. E., & Hubbell, J. A. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00296-0 · Cited by 423

Poly(N-isopropylacrylamide-co-propylacrylic acid) Copolymers That Respond Sharply to Temperature and pH

Yin, X., Hoffman, A. S., & Stayton, P. S. (2006) · Biomacromolecules · doi:10.1021/bm0507812 · Cited by 416

Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells

Simmons, C. A., Alsberg, E., Hsiong, S., Kim, W. J., & Mooney, D. J. (2004) · Bone · doi:10.1016/j.bone.2004.02.027 · Cited by 413

Oral delivery of insulin using pH‐responsive complexation gels

Lowman, A. M., Morishita, M., Kajita, M., Nagai, T., & Peppas, N. A. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js980337n · Cited by 406

Stimulus-Responsive “Smart” Hydrogels as Novel Drug Delivery Systems

Soppimath, K. S., Aminabhavi, T. M., Dave, A. M., Kumbar, S. G., & Rudzinski, W. E. (2002) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120006428 · Cited by 389

Ionic polymer–metal composites: III. Modeling and simulation as biomimetic sensors, actuators, transducers, and artificial muscles

Shahinpoor, M., & Kim, K. J. (2004) · Smart Materials and Structures · doi:10.1088/0964-1726/13/6/009 · Cited by 379

Hydrogels for Pharmaceutical and Biomedical Applications

Kashyap, N., Kumar, N., & Kumar, M. N. V. R. (2005) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v22.i2.10 · Cited by 376

Fundamental studies of a novel, biodegradable PEG-b-PLA hydrogel

Metters, A. (2000) · Polymer · doi:10.1016/s0032-3861(99)00629-1 · Cited by 372

Mechanisms of solute and drug transport in relaxing, swellable, hydrophilic glassy polymers

Brazel, C. S., & Peppas, N. A. (1999) · Polymer · doi:10.1016/s0032-3861(98)00546-1 · Cited by 372

HPMC-Matrices for Controlled Drug Delivery: A New Model Combining Diffusion, Swelling, and Dissolution Mechanisms and Predicting the Release Kinetics

Siepmann, J., Kranz, H., Bodmeier, R., & Peppas, N. A. (1999) · Pharmaceutical Research · doi:10.1023/a:1018914301328 · Cited by 365

Modeling of drug release from Swellable polymers

Brazel, C. S., & Peppas, N. A. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00058-2 · Cited by 352

Really smart bioconjugates of smart polymers and receptor proteins

Hoffman, A. S., Stayton, P. S., Bulmus, V., Chen, G., Chen, J., Cheung, C., Chilkoti, A., Ding, Z., Dong, L., Fong, R., et al. (2000) · Journal of Biomedical Materials Research · doi:10.1002/1097-4636(20001215)52:4<577::aid-jbm1>3.0.co;2-5 · Cited by 350

Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering

Holland, T. A., Tabata, Y., & Mikos, A. G. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.07.004 · Cited by 341

Network Formation and Degradation Behavior of Hydrogels Formed by Michael-Type Addition Reactions

Metters, A., & Hubbell, J. (2005) · Biomacromolecules · doi:10.1021/bm049607o · Cited by 338

Mutual influence of pH and temperature on the swelling of ionizable and thermosensitive hydrogels

Feil, H., Bae, Y. H., Feijen, J., & Kim, S. W. (1992) · Macromolecules · doi:10.1021/ma00046a063 · Cited by 321

Synthesis and Characterization of Thermo- and Chemomechanically Responsive Poly(N-isopropylacrylamide-co-methacrylic acid) Hydrogels

Brazel, C. S., & Peppas, N. A. (1995) · Macromolecules · doi:10.1021/ma00128a007 · Cited by 317

Molecular aspects of muco- and bioadhesion:

Huang, Y., Leobandung, W., Foss, A., & Peppas, N. A. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00233-3 · Cited by 316

Molecular Design and in Vitro Studies of Novel pH-Sensitive Hydrogels for the Oral Delivery of Calcitonin

Torres-Lugo, M., & Peppas, N. A. (1999) · Macromolecules · doi:10.1021/ma990541c · Cited by 299

Injection molding of chondrocyte/alginate constructs in the shape of facial implants

Chang, S. C. N., Rowley, J. A., Tobias, G., Genes, N. G., Roy, A. K., Mooney, D. J., Vacanti, C. A., & Bonassar, L. J. (2001) · Journal of Biomedical Materials Research · doi:10.1002/1097-4636(20010615)55:4<503::aid-jbm1043>3.0.co;2-s · Cited by 298

Controlled‐release of IGF‐I and TGF‐β1 in a photopolymerizing hydrogel for cartilage tissue engineering

Elisseeff, J., McIntosh, W., Fu, K., Blunk, T., & Langer, R. (2001) · Journal of Orthopaedic Research · doi:10.1016/s0736-0266(01)00054-7 · Cited by 296

MMP‐2 sensitive, VEGF‐bearing bioactive hydrogels for promotion of vascular healing

Seliktar, D., Zisch, A. H., Lutolf, M. P., Wrana, J. L., & Hubbell, J. A. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.20091 · Cited by 295

Swelling-controlled release in hydrogel matrices for oral route

Colombo, P. (1993) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(93)90026-z · Cited by 294

Drug Delivery: Engineering Principles for Drug Therapy

Saltzman, W. M. (2001) · Cited by 287

A Novel Approach to the Oral Delivery of Micro- or Nanoparticles

Bodmeier, R., Chen, H., & Paeratakul, O. (1989) · Pharmaceutical Research · doi:10.1023/a:1015987516796 · Cited by 276

Dynamic swelling behavior of pH‐sensitive anionic hydrogels used for protein delivery

Kim, B., La Flamme, K., & Peppas, N. A. (2003) · Journal of Applied Polymer Science · doi:10.1002/app.12337 · Cited by 270

Solute diffusion in swollen membranes. IX. Scaling laws for solute diffusion in gels

Lustig, S. R., & Peppas, N. A. (1988) · Journal of Applied Polymer Science · doi:10.1002/app.1988.070360401 · Cited by 264

Protein delivery from poly (lactic-co-glycolic acid) biodegradable microspheres: Release kinetics and stability issues

Crotts, G., & Park, T. G. (1998) · Journal of Microencapsulation · doi:10.3109/02652049809008253 · Cited by 263

Importance of in vitro experimental conditions on protein release kinetics, stability and polymer degradation in protein encapsulated poly (d,l-lactic acid-co-glycolic acid) microspheres

Park, T. G., Lu, W., & Crotts, G. (1995) · Journal of Controlled Release · doi:10.1016/0168-3659(94)00084-8 · Cited by 255

Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury

Taylor, S. J., McDonald, J. W., & Sakiyama-Elbert, S. E. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.05.003 · Cited by 249

Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries.

Edelman, E. R., Nugent, M. A., Smith, L. T., & Karnovsky, M. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115607 · Cited by 245

Photopolymerized hydrogel materials for drug delivery applications

West, J. L., & Hubbell, J. A. (1995) · Reactive Polymers · doi:10.1016/0923-1137(94)00096-n · Cited by 244

Delivery of osteoinductive growth factors from degradable PEG hydrogels influences osteoblast differentiation and mineralization

Burdick, J. A., Mason, M. N., Hinman, A. D., Thorne, K., & Anseth, K. S. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00181-5 · Cited by 240

Controlled Release Polymeric Formulations

(1976) · ACS Symposium Series · doi:10.1021/bk-1976-0033 · Cited by 238

Investigation of the Swelling Response and Loading of Ionic Microgels with Drugs and Proteins: The Dependence on Cross-Link Density

Eichenbaum, G. M., Kiser, P. F., Dobrynin, A. V., Simon, S. A., & Needham, D. (1999) · Macromolecules · doi:10.1021/ma981945s · Cited by 229

Kinetics of electrically and chemically induced swelling in polyelectrolyte gels

Grimshaw, P. E., Nussbaum, J. H., Grodzinsky, A. J., & Yarmush, M. L. (1990) · The Journal of Chemical Physics · doi:10.1063/1.458729 · Cited by 225

Hydrophilic Matrices for Controlled Drug Delivery: An Improved Mathematical Model to Predict the Resulting Drug Release Kinetics (the “sequential Layer” Model)

Siepmann, J., & Peppas, N. A. (2000) · Pharmaceutical Research · doi:10.1023/a:1026455822595 · Cited by 222

Controlled release of biologically active compounds from bioerodible polymers

Heller, J. (1980) · Biomaterials · doi:10.1016/0142-9612(80)90060-5 · Cited by 220

Pulsatile drug delivery systems using hydrogels

Yoshida, R., Sakai, K., Okano, T., & Sakurai, Y. (1993) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(93)90028-3 · Cited by 216

Transport of Nanoparticles Across the Rat Nasal Mucosa

Brooking, J., Davis, S. S., & Illum, L. (2001) · Journal of Drug Targeting · doi:10.3109/10611860108997935 · Cited by 206

Characterization of hydrogels formed from acrylate modified poly(vinyl alcohol) macromers

Martens, P., & Anseth, K. S. (2000) · Polymer · doi:10.1016/s0032-3861(00)00123-3 · Cited by 205

Predicting Controlled-Release Behavior of Degradable PLA-b-PEG-b-PLA Hydrogels

Mason, M. N., Metters, A. T., Bowman, C. N., & Anseth, K. S. (2001) · Macromolecules · doi:10.1021/ma010025y · Cited by 202

Calcium-alginate beads for the oral delivery of transforming growth factor-β1 (TGF-β1): stabilization of TGF-β1 by the addition of polyacrylic acid within acid-treated beads

Mumper, R. J., Huffman, A. S., Puolakkainen, P. A., Bouchard, L. S., & Gombotz, W. R. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90030-2 · Cited by 199

Rational Design of Transglutaminase Substrate Peptides for Rapid Enzymatic Formation of Hydrogels

Hu, B.-H., & Messersmith, P. B. (2003) · Journal of the American Chemical Society · doi:10.1021/ja038593b · Cited by 198

Poly(ethylene glycol) hydrogels formed by conjugate addition with controllable swelling, degradation, and release of pharmaceutically active proteins

van de Wetering, P., Metters, A. T., Schoenmakers, R. G., & Hubbell, J. A. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.10.029 · Cited by 196

Photopolymerization of multilaminated poly(HEMA) hydrogels for controlled release

Lu, S. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00125-4 · Cited by 196

Controlled release of bioactive TGF-β1 from microspheres embedded within biodegradable hydrogels

DeFail, A. J., Chu, C. R., Izzo, N., & Marra, K. G. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2005.08.013 · Cited by 188

A New Model Describing the Swelling and Drug Release Kinetics from Hydroxypropyl Methylcellulose Tablets

Siepmann, J., Podual, K., Sriwongjanya, M., Peppas, N. A., & Bodmeier, R. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js9802291 · Cited by 188

A Statistical Kinetic Model for the Bulk Degradation of PLA-b-PEG-b-PLA Hydrogel Networks

Metters, A. T., Bowman, C. N., & Anseth, K. S. (2000) · The Journal of Physical Chemistry B · doi:10.1021/jp000523t · Cited by 188

Controlled release of biologically active compounds from bioerodible polymers

HELLER, J. (2006) · The Biomaterials · doi:10.1016/b978-008045154-1/50001-0 · Cited by 188

Evaluating proteins release from, and their interactions with, thermosensitive poly (N-isopropylacrylamide) hydrogels

Wu, J.-Y., Liu, S.-Q., Heng, P. W.-S., & Yang, Y.-Y. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.10.008 · Cited by 185

Long-term and zero-order release of basic fibroblast growth factor from heparin-conjugated poly(l-lactide-co-glycolide) nanospheres and fibrin gel

Jeon, O., Kang, S.-W., Lim, H.-W., Hyung Chung, J., & Kim, B.-S. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2005.08.030 · Cited by 181

Development of growth factor fusion proteins for cell‐triggered drug delivery

Sakiyama-Elbert, S. E., Panitch, A., & Hubbell, J. A. (2001) · The FASEB Journal · doi:10.1096/fj.00-0564fje · Cited by 181

Modeling of polymer erosion

Gopferich, A., & Langer, R. (1993) · Macromolecules · doi:10.1021/ma00068a006 · Cited by 178

A New Mathematical Model Quantifying Drug Release from Bioerodible Microparticles Using Monte Carlo Simulations

Siepmann, J., Faisant, N., & Benoit, J.-P. (2002) · Pharmaceutical Research · doi:10.1023/a:1021457911533 · Cited by 173

Novel Method Using a Temperature-Sensitive Polymer (Methylcellulose) to Thermally Gel Aqueous Alginate as a pH-Sensitive Hydrogel

Liang, H.-F., Hong, M.-H., Ho, R.-M., Chung, C.-K., Lin, Y.-H., Chen, C.-H., & Sung, H.-W. (2004) · Biomacromolecules · doi:10.1021/bm049813w · Cited by 173

Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity

Ehrbar, M., Metters, A., Zammaretti, P., Hubbell, J. A., & Zisch, A. H. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.07.018 · Cited by 171

Release Behavior of High Molecular Weight Solutes from Poly(ethylene glycol)-Based Degradable Networks

Lu, S., & Anseth, K. S. (2000) · Macromolecules · doi:10.1021/ma9915024 · Cited by 168

Modeling of Drug Release from Erodible Tablets

Katzhendler, I., Hoffman, A., Goldberger, A., & Friedman, M. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js9600538 · Cited by 162

Synthetic hydrogels VI. Hydrogel composites as wound dressings and implant materials

Corkhill, P. H., Hamilton, C. J., & Tighe, B. J. (1989) · Biomaterials · doi:10.1016/0142-9612(89)90002-1 · Cited by 160

Calculation of the required size and shape of hydroxypropyl methylcellulose matrices to achieve desired drug release profiles

Siepmann, J. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00390-2 · Cited by 153

Dimensionless analysis of swelling of hydrophilic glassy polymers with subsequent drug release from relaxing structures

Brazel, C. S. (1999) · Biomaterials · doi:10.1016/s0142-9612(98)00215-4 · Cited by 152

Novel pH-sensitive hydrogels with adjustable swelling kinetics

Akala, E. O., Kopečková, P., & Kopec̆ek, J. (1998) · Biomaterials · doi:10.1016/s0142-9612(98)00023-4 · Cited by 149

Dual growth factor-induced angiogenesis in vivo using hyaluronan hydrogel implants

Peattie, R. A., Rieke, E. R., Hewett, E. M., Fisher, R. J., Shu, X. Z., & Prestwich, G. D. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.09.035 · Cited by 143

Understanding and Predicting Drug Delivery from Hydrophilic Matrix Tablets Using the “Sequential Layer” Model

Siepmann, J., Streubel, A., & Peppas, N. A. (2002) · Pharmaceutical Research · doi:10.1023/a:1014447102710 · Cited by 139

DNA delivery from photocrosslinked PEG hydrogels: encapsulation efficiency, release profiles, and DNA quality

Quick, D. J., & Anseth, K. S. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.01.021 · Cited by 134

Modeling of Drug Release from Polymeric Delivery Systems?A Review;

Lopina, S. T., & Kanjickal, D. (2004) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v21.i5.10 · Cited by 133

Preparation and Characterization of pH-Responsive Poly(methacrylic acid-g-ethylene glycol) Nanospheres

Robinson, D. N., & Peppas, N. A. (2002) · Macromolecules · doi:10.1021/ma011525u · Cited by 133

Diffusion of small-molecule penetrants in polyethylene: free volume and morphology

Hedenqvist, M. S., Angelstok, A., Edsberg, L., Larsson, P. T., & Gedde, U. W. (1996) · Polymer · doi:10.1016/0032-3861(96)89384-0 · Cited by 127

Controlled Release from Crosslinked Degradable Networks;

Davis, K. A., & Anseth, K. S. (2002) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v19.i45.30 · Cited by 126

Mathematical modeling and in vitro study of controlled drug release via a highly swellable and dissoluble polymer matrix: polyethylene oxide with high molecular weights

Wu, N., Wang, L., Tan, D., Moochhala, S., & Yang, Y. Y. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.11.002 · Cited by 124

Drug–polymer interactions and their effect on thermoresponsive poly(N-isopropylacrylamide) drug delivery systems

Coughlan, D., & CORRIGAN, O. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.02.005 · Cited by 122

Novel Degradable Poly(Ethylene Glycol) Hydrogels for Controlled Release of Protein

Zhao, X., & Harris, J. M. (1998) · Journal of Pharmaceutical Sciences · doi:10.1021/js980065o · Cited by 122

Nasal Delivery of Vaccines

Almeida, A. J., & Alpar, H. O. (1996) · Journal of drug targeting · doi:10.3109/10611869609015965 · Cited by 117

Amphiphilic Hydrogel Nanoparticles. Preparation, Characterization, and Preliminary Assessment as New Colloidal Drug Carriers

Missirlis, D., Tirelli, N., & Hubbell, J. A. (2005) · Langmuir · doi:10.1021/la047367s · Cited by 115

A Statistical Kinetic Model for the Bulk Degradation of PLA-b-PEG-b-PLA Hydrogel Networks: Incorporating Network Non-Idealities

Metters, A. T., Anseth, K. S., & Bowman, C. N. (2001) · The Journal of Physical Chemistry B · doi:10.1021/jp004083h · Cited by 115

pH/temperature-sensitive polymers for macromolecular drug loading and release

Yong-Hee, K., Bae, Y. H., & Kim, S. W. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90161-9 · Cited by 112

Controlled Release Polymeric Formulations

Baker, R. W. (1977) · Journal of Membrane Science · doi:10.1016/s0376-7388(00)83244-5 · Cited by 110

Exogenously Triggered, Enzymatic Degradation of Photopolymerized Hydrogels with Polycaprolactone Subunits: Experimental Observation and Modeling of Mass Loss Behavior

Rice, M. A., Sanchez‐Adams, J., & Anseth, K. S. (2006) · Biomacromolecules · doi:10.1021/bm060086+ · Cited by 110

Enzymatic and chemoenzymatic approaches to synthesis of sugar-based polymer and hydrogels

Chen, X., Martin, B. D., Neubauer, T., Linhardt, R. J., Dordick, J. S., & Rethwisch, D. G. (1995) · Carbohydrate Polymers · doi:10.1016/0144-8617(95)00082-8 · Cited by 108

Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase

Vakkalanka, S. K., Brazel, C. S., & Peppas, N. A. (1997) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856296x00192 · Cited by 107

Bimodal drug release achieved with multi-layer matrix tablets: transport mechanisms and device design

Streubel, A., Siepmann, J., Peppas, N. A., et al. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00334-5 · Cited by 106

Effect of non-uniform initial drug concentration distribution on the kinetics of drug release from glassy hydrogel matrices

Lee, P. I. (1984) · Polymer · doi:10.1016/0032-3861(84)90082-x · Cited by 105

Therapeutic uses of microencapsulated genetically engineered cells

Chang, T. M. S., & Prakash, S. (1998) · Molecular Medicine Today · doi:10.1016/s1357-4310(98)01246-5 · Cited by 104

Solute diffusion in swollen membranes

Peppas, M. L. B. A. N. A. (1987) · Journal of Membrane Science · doi:10.1016/s0376-7388(00)85001-2 · Cited by 102

Buccal delivery systems using hydrogels

Nagai, T., & Machida, Y. (1993) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(93)90032-y · Cited by 100

Synthesis and characterization of pH-sensitive glycopolymers for oral drug delivery systems

Kim, B., & Peppas, N. A. (2002) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856202320893000 · Cited by 99

Enhanced hydrogel adhesion by polymer interdiffusion: Use of linear poly(ethylene glycol) as an adhesion promoter

Sahlin, J. J., & Peppas, N. A. (1997) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856297x00362 · Cited by 98

Modeling monomer release from bioerodible polymers

Göpferich, A. M., & Langer, R. (1995) · Journal of Controlled Release · doi:10.1016/0168-3659(94)00064-2 · Cited by 97

Release behavior of bioactive agents from pH-sensitive hydrogels

Khare, A. R., & Peppas, N. A. (1993) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856293x00564 · Cited by 95

Delivering DNA from photocrosslinked, surface eroding polyanhydrides

Quick, D. J., Macdonald, K. K., & Anseth, K. S. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.03.001 · Cited by 91

Reduction in the Initial-Burst Release by Surface Crosslinking of PLGA Microparticles Containing Hydrophilic or Hydrophobic Drugs

Thote, A. J., Chappell, J. T., Kumar, R., & Gupta, R. B. (2005) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-43985 · Cited by 89

Synthesis and characterization of degradable hydrogels formed from acrylate modified poly(vinyl alcohol) macromers

Martens, P. J., Holland, T. V., & Anseth, K. S. (2002) · Polymer · doi:10.1016/s0032-3861(02)00561-x · Cited by 88

Poly(ethylene glycol)-containing Hydrogels for Oral Protein Delivery Applications

Kim, B., & Peppas, N. A. (2003) · Biomedical Microdevices · doi:10.1023/a:1027313931273 · Cited by 86

Equilibrium swelling behavior of dilute ionic hydrogels in electrolytic solutions

Brannon‐Peppas, L., & Peppas, N. A. (1991) · Journal of Controlled Release · doi:10.1016/0168-3659(91)90009-3 · Cited by 86

Simultaneous application of basic fibroblast growth factor and hepatocyte growth factor to enhance the blood vessels formation

Marui, A., Kanematsu, A., Yamahara, K., Doi, K., Kushibiki, T., Yamamoto, M., Itoh, H., Ikeda, T., Tabata, Y., & Komeda, M. (2005) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2004.10.029 · Cited by 84

Preparation and Characterization of Temperature-Sensitive Poly(N-isopropylacrylamide)-b-poly( d , l -lactide) Microspheres for Protein Delivery

Liu, S., Yang, Y. Y., Liu, X., & Tong, Y. W. (2003) · Biomacromolecules · doi:10.1021/bm034189t · Cited by 84

Release Characteristics of Novel pH-Sensitive p(HEMA-DMAEMA) Hydrogels Containing 3-(Trimethoxy-silyl) Propyl Methacrylate

Brahim, S. I., Narinesingh, D., & Guiseppi‐Elie, A. (2003) · Biomacromolecules · doi:10.1021/bm034048r · Cited by 80

Synthesis, Characterization, and Modeling of Cationic Amphiphilic Model Hydrogels: Effects of Polymer Composition and Architecture

Triftaridou, A. I., Hadjiyannakou, S. C., Vamvakaki, M., & Patrickios, C. S. (2002) · Macromolecules · doi:10.1021/ma0114077 · Cited by 78

Gene Delivery in Tissue Engineering: A Photopolymer Platform to Coencapsulate Cells and Plasmid DNA

Quick, D. J., & Anseth, K. S. (2003) · Pharmaceutical Research · doi:10.1023/b:pham.0000003368.66471.6a · Cited by 74

Controlled release of tethered molecules via engineered hydrogel degradation: Model development and validation

DuBose, J., Cutshall, C., & Metters, A. T. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30307 · Cited by 71

Solute transport analysis in pH-responsive, complexing hydrogels of poly(methacrylic acid-g-ethylene glycol)

Lowman, A. M., & Peppas, N. A. (1999) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856299x00586 · Cited by 63

Poly(d,l-Lactide-Co-Glycolide) Encapsulated Poly(Vinyl Alcohol) Hydrogel as a Drug Delivery System

Mandal, T. K., Bostanian, L. A., Graves, R. A., & Chapman, S. R. (2002) · Pharmaceutical Research · doi:10.1023/a:1020765615379 · Cited by 61

Modeling of theophylline release from different geometrical erodible tablets

Karasulu, H. Y. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00082-x · Cited by 60

Modeling of polymer erosion in three dimensions: Rotationally symmetric devices

Göpferich, A. M., & Langer, R. (1995) · AIChE Journal · doi:10.1002/aic.690411012 · Cited by 58

Enhanced Protein Delivery from Photopolymerized Hydrogels Using a Pseudospecific Metal Chelating Ligand

Lin, C., & Metters, A. T. (2006) · Pharmaceutical Research · doi:10.1007/s11095-005-9395-x · Cited by 53

Modeling of drug release from partially coated matrices made of a high viscosity HPMC

Grassi, M., Zema, L., Sangalli, M. E., Maroni, A., Giordano, F., & Gazzaniga, A. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.02.016 · Cited by 49

Hydrogels for buccal drug delivery: Properties relevant for muco‐adhesion

de Vries, M. E., Boddé, H. E., Busscher, H. J., & Junginger, H. E. (1988) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820221106 · Cited by 49

Minimization of initial burst in poly(vinyl alcohol) hydrogels by surface extraction and surface-preferential crosslinking

Huang, X. B., Chestang, B. L., & Brazel, C. S. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00433-7 · Cited by 47

Photopolymerized, Multilaminated Matrix Devices with Optimized Nonuniform Initial Concentration Profiles To Control Drug Release

Lu, S., Ramirez, W. F., & Anseth, K. S. (2000) · Journal of Pharmaceutical Sciences · doi:10.1002/(sici)1520-6017(200001)89:1<45::aid-jps5>3.0.co;2-8 · Cited by 45

Modelling of water transport and solute release in physiologically sensitive gels

Hariharan, D., & Peppas, N. A. (1993) · Journal of Controlled Release · doi:10.1016/0168-3659(93)90038-7 · Cited by 43

Modeling the release of proteins from degrading crosslinked dextran microspheres using kinetic Monte Carlo simulations

Vlugt-Wensink, K. D. F., Vlugt, T. J. H., Jiskoot, W., Crommelin, D. J. A., Verrijk, R., & Hennink, W. E. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.11.021 · Cited by 37

Designing hydrogels for controlled drug delivery

Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 4,832

Controlled drug delivery vehicles for cancer treatment and their performance

Senapati, S., Mahanta, A. K., Kumar, S., & Maiti, P. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-017-0004-3 · Cited by 2,167

Designing Cell-Compatible Hydrogels for Biomedical Applications

Seliktar, D. (2012) · Science · doi:10.1126/science.1214804 · Cited by 1,923

Bioactive modification of poly (ethylene glycol) hydrogels for tissue engineering

Zhu, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.044 · Cited by 1,457

Responsive polymers in controlled drug delivery

Bajpai, A. K., Shukla, S. K., Bhanu, S., & Kankane, S. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2008.07.005 · Cited by 1,391