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Obesity and vulnerability of the CNS
Open accessAbstract
The incidence of obesity is increasing worldwide, and is especially pronounced in developed western countries. While the consequences of obesity on metabolic and cardiovascular physiology are well established, epidemiological and experimental data are beginning to establish that the central nervous system (CNS) may also be detrimentally affected by obesity and obesity-induced metabolic dysfunction. In particular, data show that obesity in human populations is associated with cognitive decline and enhanced vulnerability to brain injury, while experimental studies in animal models confirm a profile of heightened vulnerability and decreased cognitive function. This review will describe findings from human and animal studies to summarize current understanding of how obesity affects the brain. Furthermore, studies aimed at identifying key elements of body-brain dialog will be discussed to assess how various metabolic and adipose-related signals could adversely affect the CNS. Overall, data suggest that obesity-induced alterations in metabolism may significantly synergize with age to impair brain function and accelerate age-related diseases of the nervous system. Thus, enhanced understanding of the effects of obesity and obesity-related metabolic dysfunction on the brain are especially critical as increasing numbers of obese individuals approach advanced age.
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“It is becoming clear that the obesity-induced toxic internal environment does not spare the brain ([24](#B24), [46](#B46), [48](#B48), [52](#B52), [59](#B59), [95](#B95), [121](#B121), [127](#B127), [177](#B177), [182](#B182), [198](#B198)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [24]
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Reward, dopamine and the control of food intake: implications for obesity
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BackgroundCognitive impairment following high fat diet consumption is associated with brain inflammation
Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce‐Keller, A. J. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.010 · Cited by 623
“Overall, these data are consistent with a growing body of literature describing the sensitivity of the brain to obesity and obesityinduced metabolic dysfunction (reviewed in Bruce-Keller et al., 2009).”
Self-citationObesity-Induced Neuroinflammation: Beyond the Hypothalamus
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Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity
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“of mental illness is obesity, which dramatically increases risk of depression, dementia, and stroke, and is associated with increased brain pathology and decreased brain function [reviewed in (2)].”
Self-citation
Metadata
- Authors
- Bruce-Keller, A. J., Keller, J. N., & Morrison, C. D.
- Affiliations
- Pennington Biomedical Research Center (US)
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 1792
- Issue
- 5
- Pages
- 395-400
- ISSN
- 0925-4439 (ISSN-L)
- PMC
- PMC2699212
- OpenAlex
- W2154638777
- Cited by
- 200
- References
- 124
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 13 · 2022: 5 · 2021: 18 · 2020: 8 · 2019: 14 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 7 · 2014: 13 · 2013: 14 · 2012: 16
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Civil War Book Review (submittedVersion)
- HAL (submittedVersion, other-oa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- National Institute on Aging (P01AG005119)
- National Institute of Neurological Disorders and Stroke (R01NS046267)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- obesity, central nervous system, cognitive decline, metabolic dysfunction, aging, neurodegenerative diseases, animal models of obesity
- MeSH terms
- Aging, Animals, Brain, Energy Metabolism, Humans, Obesity, Signal Transduction
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