Cited by 268Fatty Acid Research and HealthGut microbiota and healthBirth, Development, and Health

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Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood

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Robertson, Ruairi C., Seira Oriach, Clara, Murphy, Kiera, Moloney, Gerard M., Cryan, John F., Dinan, Timothy G., Paul Ross, R., Stanton, Catherine·2017·Brain Behavior and Immunity

DOI 10.1016/j.bbi.2016.07.145

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Abstract

Background Neurodevelopment is strongly influenced by maternal and early-postnatal diet. Omega-3 polyunsaturated fatty acids (n-3 PUFA) are vital structural and functional components of the developing brain. The gut microbiota is also influenced by n-3 PUFA status, however, little is known about the role of maternal and early-life n-3 PUFA intake on offspring gut microbiota development and subsequent interactions with central nervous system functioning and behavioural outcomes.Methods Pregnant female C57BL/6 mice and their male offspring were fed a control (CON), omega-3 deficient (O3-) or omega-3 supplemented (O3+) diet. Cognitive, depressive and social behaviours were assessed through a battery of behaviour tests in the male offspring at both adolescence (week 4-5) and adulthood (week 11-13). Hypothalamic-pituitary-adrenal axis (HPA) activation was assessed by analysis of stress-induced corticosterone production. Fecal microbiota composition was analysed by 16S sequencing at both adolescent and adulthood. In addition, stimulated spleen cytokine levels were assessed.Results n-3 PUFA interventions induced subtle changes in offspring early-life and adolescent behaviours, which were further evident in adulthood, such that O3- animals displayed impaired communication, social and depression-related behaviours and O3+ animals displayed enhanced cognition. O3- mice displayed an elevated Firmicutes:Bacteroidetes ratio and blunted systemic LPS responsiveness. Contrastingly, O3+ mice displayed greater fecal Bifidobacterium and Lactobacillus abundance and dampened HPA-axis activity.Conclusions Neurobehavioural development related to cognitive, anxiety and social behaviours, is highly dependent upon in utero and lifelong n-3 PUFA availability. In addition, neurobehavioural changes induced by altering n-3 PUFA status are closely associated with comprehensive alterations in gut microbiota composition, HPA-axis activity and inflammation.

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See all 268

Authors: Robertson, R. C., Seira Oriach, C., Murphy, K., Moloney, G. M., Cryan, J. F., Dinan, T. G., Paul Ross, R., & Stanton, C.
Affiliations: Teagasc - The Irish Agriculture and Food Development Authority (IE)
University College Cork (IE)
Corresponding author: Stanton, Catherine
ORCID: Robertson, Ruairi C.
Murphy, Kiera
Moloney, Gerard M.
Cryan, John F.
Dinan, Timothy G.
Stanton, Catherine
Venue: Brain Behavior and Immunity
Publisher: Elsevier BV
Published: 2017-01
Volume: 59
Pages: 21-37
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2016.07.145
OpenAlex: W2462715376
Cited by: 268
References: 128
Citations by year: 2026: 12 · 2025: 25 · 2024: 28 · 2023: 32 · 2022: 35 · 2021: 34 · 2020: 28 · 2019: 32 · 2018: 18 · 2017: 20
FWCI: 25.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 341 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Brain Behavior and Immunity (acceptedVersion)
PubMed (publishedVersion)
Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
Funders: Science Foundation Ireland (SFI/12/RC/2273)
APC Microbiome Institute
Health Research Board of Ireland (HRA_POR/2011/23, HRA_POR/2012/32)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: omega-3 polyunsaturated fatty acids, maternal diet, gut microbiota, brain development, adolescent behavior, social behavior, depression-like behavior, cognitive function, hypothalamic-pituitary-adrenal axis, corticosterone, lipopolysaccharide response, inflammation, Bifidobacterium, Lactobacillus, Firmicutes/Bacteroidetes ratio
MeSH terms: Gastrointestinal Microbiome, Aging, Animals, Behavior, Animal, Cognition, Corticosterone, Depression, Fatty Acids, Fear, Female, Hypothalamo-Hypophyseal System, Male, Mice, Inbred C57BL, Pituitary-Adrenal System, Pregnancy, Social Behavior, Stress, Psychological, Swimming, Vocalization, Animal, Fatty Acids, Omega-3, Cytokines, Recognition, Psychology, Mice

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Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood

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