Anxiolytic-like effect of oxytocin in the simulated public speaking test

de Oliveira, Danielle CG; Zuardi, Antonio W; Graeff, Frederico G; Queiroz, Regina HC; Crippa, José AS

doi:10.1177/0269881111400642

Cited by 154Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Anxiolytic-like effect of oxytocin in the simulated public speaking test

de Oliveira, Danielle CG, Zuardi, Antonio W, Graeff, Frederico G, Queiroz, Regina HC, Crippa, José AS·2012·Journal of Psychopharmacology

DOI 10.1177/0269881111400642

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Abstract

Oxytocin (OT) is known to be involved in anxiety, as well as cardiovascular and hormonal regulation. The objective of this study was to assess the acute effect of intranasally administered OT on subjective states, as well as cardiovascular and endocrine parameters, in healthy volunteers ( n = 14) performing a simulated public speaking test. OT or placebo was administered intranasally 50 min before the test. Assessments were made across time during the experimental session: (1) baseline (−30 min); (2) pre-test (−15 min); (3) anticipation of the speech (50 min); (4) during the speech (1:03 h), post-test time 1 (1:26 h), and post-test time 2 (1:46 h). Subjective states were evaluated by self-assessment scales. Cortisol serum and plasma adrenocorticotropic hormone (ACTH) were measured. Additionally, heart rate, blood pressure, skin conductance, and the number of spontaneous fluctuations in skin conductance were measured. Compared with placebo, OT reduced the Visual Analogue Mood Scale (VAMS) anxiety index during the pre-test phase only, while increasing sedation at the pre-test, anticipation, and speech phases. OT also lowered the skin conductance level at the pre-test, anticipation, speech, and post-test 2 phases. Other parameters evaluated were not significantly affected by OT. The present results show that OT reduces anticipatory anxiety, but does not affect public speaking fear, suggesting that this hormone has anxiolytic properties.

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A review of human studies suggests that oxytocin may exert both anxiogenic and anxiolytic effects, depending on individual and context variables, which are not always reflected in changes in cortisol levels.
“a review of human studies examining the effect of oxytocin on cortisol suggests that oxytocin may exert both anxiogenic and anxiolytic effects, depending on a variety of individual and context variables 77, 78, which are not always reflected in changes in cortisol levels 79, 80.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [80]
OT administration resulted in decreased subjective anxiety during a public speaking stressor in healthy individuals.
“Behaviorally, OT administration resulted in decreased subjective anxiety during a public speaking stressor in healthy individuals (de Oliveira et al, 2012) and increased (recall of) extinction learning in both rodents (Zoicas et al, 2014) and healthy males (Acheson et al, 2013).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as de Oliveira et al, 2012

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Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.1 · Cited by 132 · see citing works
Oxytocin and psychotherapy: a pilot study of its physiological, behavioral and subjective effects in males with depression
MacDonald, K., MacDonald, T. M., Brüne, M., Lamb, K., Wilson, M. P., Golshan, S., & Feifel, D. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.05.014 · Cited by 140 · see citing works
Oxytocin and Pain Perception: From Animal Models to Human Research
Boll, S., de Minas, A. C. A., Raftogianni, A., Herpertz, S. C., & Grinevich, V. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.041 · Cited by 137 · see citing works
Early life stress modulates amygdala‐prefrontal functional connectivity: Implications for oxytocin effects
Fan, Y., Herrera-Meléndez, A. L., Pestke, K., Feeser, M., Aust, S., Otte, C., Pruessner, J. C., Böker, H., Bajbouj, M., & Grimm, S. (2014) · Human Brain Mapping · doi:10.1002/hbm.22553 · Cited by 134 · see citing works
The calming effect of a new wearable device during the anticipation of public speech
Azevedo, R., Bennett, N., Bilicki, A., Hooper, J., Markopoulou, F., & Tsakiris, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02274-2 · Cited by 121 · see citing works
Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study
McRae-Clark, A. L., Baker, N. L., Maria, M. M.-S., & Brady, K. T. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3062-4 · Cited by 124 · see citing works
Oxytocin facilitates the sensation of social stress
Eckstein, M., Scheele, D., Weber, K., Stoffel‐Wagner, B., Maier, W., & Hurlemann, R. (2014) · Human Brain Mapping · doi:10.1002/hbm.22508 · Cited by 119 · see citing works
Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: salience processing and fear inhibition processes
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.018 · Cited by 123 · see citing works
Commentary on “Autism, oxytocin and interoception”: Alexithymia, not Autism Spectrum Disorders, is the consequence of interoceptive failure
Brewer, R., Happé, F., Cook, R., & Bird, G. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.006 · Cited by 117 · see citing works
Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students
Linnen, A.-M., Ellenbogen, M. A., Cardoso, C., & Joober, R. (2012) · Stress · doi:10.3109/10253890.2011.631154 · Cited by 104 · see citing works
Boosting recovery rather than buffering reactivity: Higher stress-induced oxytocin secretion is associated with increased cortisol reactivity and faster vagal recovery after acute psychosocial stress
Engert, V., Koester, A. M., Riepenhausen, A., & Singer, T. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.029 · Cited by 103 · see citing works
Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment
Quintana, D. S., Westlye, L. T., Rustan, Ø. G., Tesli, N., Poppy, C. L., Smevik, H., Tesli, M., Røine, M., Mahmoud, R. A., Smerud, K. T., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.93 · Cited by 103 · see citing works
Oxytocin for the treatment of drug and alcohol use disorders
Lee, M. R., & Weerts, E. M. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000258 · Cited by 105 · see citing works
Intranasal oxytocin effects on social cognition: A critique
Evans, S. L., Dal Monte, O., Noble, P., & Averbeck, B. B. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.008 · Cited by 97 · see citing works
Oxytocin Gene Polymorphisms Influence Human Dopaminergic Function in a Sex-Dependent Manner
Love, T. M., Enoch, M.-A., Hodgkinson, C. A., Peciña, M., Mickey, B., Koeppe, R. A., Stohler, C. S., Goldman, D., & Zubieta, J.-K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.033 · Cited by 97 · see citing works
Oxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99 · see citing works
Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients
Koch, S. B., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.299 · Cited by 98 · see citing works
Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men
Lieberz, J., Scheele, D., Spengler, F. B., Matheisen, T., Schneider, L., Stoffel‐Wagner, B., Kinfe, T. M., & Hurlemann, R. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0582-6 · Cited by 93 · see citing works
The Role of the Oxytocin System in Anxiety Disorders
Yoon, S., & Kim, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9705-0_7 · Cited by 95 · see citing works
Oxytocin and the modulation of pain experience: Implications for chronic pain management
Tracy, L. M., Georgiou‐Karistianis, N., Gibson, S. J., & Giummarra, M. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.013 · Cited by 89 · see citing works
The many faces of oxytocin: Implications for psychiatry
Zik, J. B., & Roberts, D. L. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.11.048 · Cited by 85 · see citing works
Postprandial Oxytocin Secretion Is Associated With Severity of Anxiety and Depressive Symptoms in Anorexia Nervosa
Lawson, E. A., Holsen, L. M., Santin, M., DeSanti, R., Meenaghan, E. M., Eddy, K. T., Herzog, D. B., Goldstein, J. M., & Klibanski, A. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m08154 · Cited by 73 · see citing works
Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males
Alvares, G. A., Chen, N. T. M., Balleine, B. W., Hickie, I. B., & Guastella, A. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.018 · Cited by 71 · see citing works
Oxytocin administration alters HPA reactivity in the context of parent–infant interaction
Weisman, O., Zagoory-Sharon, O., & Feldman, R. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.06.006 · Cited by 70 · see citing works
The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials
Paloyelis, Y., Krahé, C., Maltezos, S., Williams, S. C., Howard, M. A., & Fotopoulou, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12347 · Cited by 61 · see citing works
Oxytocin facilitates adaptive fear and attenuates anxiety responses in animal models and human studies—potential interaction with the corticotropin-releasing factor (CRF) system in the bed nucleus of the stria terminalis (BNST)
Janeček, M., & Dabrowska, J. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2889-8 · Cited by 61 · see citing works
Oxytocin and anxiety disorders
Gottschalk, M. G., & Domschke, K. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_25 · Cited by 61 · see citing works
Neuroendocrine Aspects of Tourette Syndrome
Martino, D., Macerollo, A., & Leckman, J. F. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-411546-0.00009-3 · Cited by 55 · see citing works
Oxytocin and vasopressin receptor polymorphisms interact with circulating neuropeptides to predict human emotional reactions to stress.
Moons, W. G., Way, B. M., & Taylor, S. E. (2014) · Emotion · doi:10.1037/a0035503 · Cited by 55 · see citing works
Anxiolytic Effects of Chronic Intranasal Oxytocin on Neural Responses to Threat Are Dose-Frequency Dependent
Kou, J., Zhang, Y., Zhou, F., Gao, Z., Yao, S., Zhao, W., Li, H., Lei, Y., Gao, S., Kendrick, K. M., et al. (2022) · Psychotherapy and Psychosomatics · doi:10.1159/000521348 · Cited by 54 · see citing works
Low Fasting Oxytocin Levels Are Associated With Psychopathology in Anorexia Nervosa in Partial Recovery
Afinogenova, Y., Schmelkin, C., Plessow, F., Thomas, J. J., Pulumo, R., Micali, N., Miller, K. K., Eddy, K. T., & Lawson, E. A. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15m10217 · Cited by 51 · see citing works
INTRANASAL OXYTOCIN ADMINISTRATION PRIOR TO EXPOSURE THERAPY FOR ARACHNOPHOBIA IMPEDES TREATMENT RESPONSE: Research Article: Intranasal Oxytocin Administration
Acheson, D. T., Feifel, D., Kamenski, M., Mckinney, R., & Risbrough, V. B. (2015) · Depression and Anxiety · doi:10.1002/da.22362 · Cited by 44 · see citing works
Dysphoric Milk Ejection Reflex: The Psychoneurobiology of the Breastfeeding Experience
Deif, R., Burch, E. M., Azar, J., Yonis, N., Gabal, M. A., Kramani, N. E., & Dakhlallah, D. A. (2021) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.669826 · Cited by 44 · see citing works
Men perform comparably to women in a perspective taking task after administration of intranasal oxytocin but not after placebo
Theodoridou, A., Rowe, A. C., & Mohr, C. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00197 · Cited by 40 · see citing works
“OT might act anxiolytically (Carter et al., 2001; Heinrichs et al., 2001, 2003; Cardoso et al., 2012; de Oliveira et al., 2012; for reviews see Meyer-Lindenberg et al., 2011; Striepens et al., 2011; MacDonald and Feifel, 2012) decreasing discomfort and concern for one’s own self.”
Background
Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects
Naja, W., & Aoun, M. P. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0819-1 · Cited by 40 · see citing works
Oxytocin interference in the effects induced by inhalation of 7.5% CO2 in healthy volunteers
de Oliveira, D. C. G., Chagas, M. H. N., Garcia, L. V., Crippa, J. A. S., & Zuardi, A. W. (2012) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.2237 · Cited by 39 · see citing works
Self-citation
Breastfeeding experience differentially impacts recognition of happiness and anger in mothers
Krol, K. M., Kamboj, S. K., Curran, H. V., & Grossmann, T. (2014) · Scientific Reports · doi:10.1038/srep07006 · Cited by 36 · see citing works
Effect of oxytocin pretreatment on cannabis outcomes in a brief motivational intervention
Sherman, B. J., Baker, N. L., & McRae‐Clark, A. L. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.01.027 · Cited by 37 · see citing works
Oxytocin does not improve performance of patients with schizophrenia and healthy volunteers in a facial emotion matching task
Horta de Macedo, L. R., Zuardi, A. W., Machado-de-Sousa, J. P., Chagas, M. H. N., & Hallak, J. E. C. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.07.082 · Cited by 35 · see citing works
Self-citation
Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study
Zunhammer, M., Geis, S., Busch, V., Eichhammer, P., & Greenlee, M. W. (2016) · Scientific Reports · doi:10.1038/srep31606 · Cited by 35 · see citing works
Postnatal development of neurotransmitter systems and their relevance to extinction of conditioned fear
Kim, J. H., Perry, C. J., Ganella, D. E., & Madsen, H. B. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.10.018 · Cited by 35 · see citing works
Oxytocin response to youth-mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior
Lebowitz, E. R., Silverman, W. K., Martino, A., Zagoory‐Sharon, O., Feldman, R., & Leckman, J. F. (2017) · Depression and Anxiety · doi:10.1002/da.22585 · Cited by 35 · see citing works
Oxytocin receptor gene variation rs53576 and alcohol abuse in a longitudinal population representative study
Vaht, M., Kurrikoff, T., Laas, K., Veidebaum, T., & Harro, J. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.018 · Cited by 37 · see citing works
Effect of intranasal oxytocin on alcohol withdrawal syndrome: a randomized placebo-controlled double-blind clinical trial
Melby, K., Gråwe, R. W., Aamo, T. O., Salvesen, Ø., & Spigset, O. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.01.003 · Cited by 33 · see citing works
Oxytocin and interpersonal relationships
Patin, A., Scheele, D., & Hurlemann, R. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_22 · Cited by 32 · see citing works
Oxytocin effects on the cognition of women with postpartum depression: A randomized, placebo-controlled clinical trial
Donadon, M. F., Martín‐Santos, R., & Osório, F. D. L. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110098 · Cited by 32 · see citing works
Intranasal oxytocin dampens cue-elicited cigarette craving in daily smokers: a pilot study
Miller, M. A., Bershad, A. K., King, A. C., Lee, R., & de Wit, H. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000260 · Cited by 30 · see citing works
Oxytozin: Evidenz für ein therapeutisches Potenzial des sozialen Neuromodulators
Eckstein, M., & Hurlemann, R. (2013) · Der Nervenarzt · doi:10.1007/s00115-013-3832-6 · Cited by 28 · see citing works
Effects of chronic intranasal oxytocin on behavior and cerebral glucose uptake in juvenile titi monkeys
Razo, R. A., Berger, T., Conley, A. J., Freeman, S. M., Goetze, L. R., Jacob, S., Lawrence, R. H., Mendoza, S. P., Rothwell, E. S., Savidge, L. E., et al. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104494 · Cited by 28 · see citing works
The Multidimensional Therapeutic Potential of Targeting the Brain Oxytocin System for the Treatment of Substance Use Disorders
Bowen, M. T., & Neumann, I. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_17 · Cited by 28 · see citing works
An acute dose of intranasal oxytocin rapidly increases maternal communication and maintains maternal care in primiparous postpartum California mice
Guoynes, C. D., & Marler, C. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244033 · Cited by 28 · see citing works
The influence of gender and oxytocin on stress reactivity, cigarette craving, and smoking in a randomized, placebo-controlled laboratory relapse paradigm
McClure, E. A., Baker, N. L., Gray, K. M., Hood, C. O., Tomko, R. L., Carpenter, M. J., Ramakrishnan, V., Buchanan, C. J., & Saladin, M. E. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05392-z · Cited by 26 · see citing works
Effects of Intranasal Oxytocin on Stress-Induced Cigarette Craving in Daily Smokers
Hedger, K. V., Bershad, A. K., Lee, R., & de Wit, H. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty159 · Cited by 24 · see citing works
Experimental public speaking: Contributions to the understanding of the serotonergic modulation of fear
Garcia-Leal, C., Graeff, F. G., & Del‐Ben, C. M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.011 · Cited by 23 · see citing works
Self-citation
The Role of Endogenous Oxytocin in Anxiolysis: Structural and Functional Correlates
Lancaster, K., Goldbeck, L., Pournajafi‐Nazarloo, H., Connelly, J. J., Carter, C. S., & Morris, J. P. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.10.003 · Cited by 23 · see citing works
DNA methylation ofOXTRis associated with parasympathetic nervous system activity and amygdala morphology
Lancaster, K., Goldbeck, L., Puglia, M. H., Morris, J. P., & Connelly, J. J. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy086 · Cited by 23 · see citing works
L’ocytocine et la dépression du post-partum
Cardaillac, C., Rua, C., Simon, E. G., & El‐Hage, W. (2016) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/j.jgyn.2016.05.002 · Cited by 22 · see citing works
Dyadic Coping and Its Underlying Neuroendocrine Mechanisms – Implications for Stress Regulation
Zietlow, A., Eckstein, M., Hernández, C., Nonnenmacher, N., Reck, C., Schaer, M., Bodenmann, G., Heinrichs, M., & Ditzen, B. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02600 · Cited by 22 · see citing works
Perinatal high‐fat diet exposure alters oxytocin and corticotropin releasing factor inputs onto vagal neurocircuits controlling gastric motility
Carson, K. E., Alvarez, J., Mackley, J., Travagli, R. A., & Browning, K. N. (2023) · The Journal of Physiology · doi:10.1113/jp284726 · Cited by 23 · see citing works
The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage
Chen, Y., Li, Q., Zhang, Q., Kou, J., Zhang, Y., Cui, H., Wernicke, J., Montag, C., Becker, B., Kendrick, K. M., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.589878 · Cited by 23 · see citing works
Breastfeeding dynamically changes endogenous oxytocin levels and emotion recognition in mothers
Matsunaga, M., Kikusui, T., Mogi, K., Nagasawa, M., Ooyama, R., & Myowa, M. (2020) · Biology Letters · doi:10.1098/rsbl.2020.0139 · Cited by 26 · see citing works
Intranasal oxytocin enhances approach-related EEG frontal alpha asymmetry during engagement of direct eye contact
Soriano, J. R., Daniëls, N., Prinsen, J., & Alaerts, K. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa093 · Cited by 20 · see citing works
Intranasal oxytocin administration impacts the acquisition and consolidation of trauma-associated memories: a double-blind randomized placebo-controlled experimental study in healthy women
Schultebraucks, K., Maslahati, T., Wingenfeld, K., Hellmann‐Regen, J., Kraft, J., Kownatzki, M., Behnia, B., Ripke, S., Otte, C., & Roepke, S. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01247-4 · Cited by 20 · see citing works
Sex differences in stress reactivity after intranasal oxytocin in recreational cannabis users
Reed, S. C., Haney, M., Manubay, J. M., Campagna, B. R., Reed, B., Foltin, R. W., & Evans, S. M. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.11.008 · Cited by 20 · see citing works
Effects of oxytocin on background anxiety in rats with high or low baseline startle
Ayers, L. W., Agostini, A., Schulkin, J. A., & Rosen, J. B. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4267-0 · Cited by 19 · see citing works
The effect of oxytocin, gender, and ovarian hormones on stress reactivity in individuals with cocaine use disorder
Sherman, B. J., Baker, N. L., Brady, K. T., Joseph, J. E., Nunn, L. M., & McRae‐Clark, A. L. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05516-w · Cited by 19 · see citing works
Oxytocin administration enhances pleasantness and neural responses to gentle stroking but not moderate pressure social touch by increasing peripheral concentrations
Chen, Y., Zou, H., Hou, X., Lan, C., Wang, J., Qing, Y., Chen, W., Yao, S., & Kendrick, K. M. (2023) · eLife · doi:10.7554/elife.85847 · Cited by 18 · see citing works
Under pressure: the interaction between high-stakes contexts and individual differences in decision-making in humans and non-human species
Sosnowski, M. J., & Brosnan, S. F. (2023) · Animal Cognition · doi:10.1007/s10071-023-01768-z · Cited by 16 · see citing works
MATERNAL MENTAL HEALTH MODERATES THE RELATIONSHIP BETWEEN OXYTOCIN AND INTERACTIVE BEHAVIOR
Samuel, S., Hayton, B. C., Gold, I., Feeley, N., Carter, C. S., & Zelkowitz, P. (2015) · Infant Mental Health Journal · doi:10.1002/imhj.21521 · Cited by 16 · see citing works
Working Smarter Not Harder: Oxytocin Increases Domestic Dogs’ (Canis familiaris) Accuracy, but Not Attempts, on an Object Choice Task
Oliva, J. L., Mengoli, M., Mendonça, T., Cozzi, A., Pageat, P., Chabaud, C., Teruel, E., Lafont‐Lecuelle, C., & Bienboire‐Frosini, C. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02141 · Cited by 15 · see citing works
Oxytocin: An Old Hormone, a Novel Psychotropic Drug and its Possible Use in Treating Psychiatric Disorders
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16 · see citing works
Intranasal oxytocin selectively modulates the behavior of rhesus monkeys in an expression matching task
Taubert, J., Flessert, M., Liu, N., & Ungerleider, L. G. (2019) · Scientific Reports · doi:10.1038/s41598-019-51422-3 · Cited by 16 · see citing works
Intranasal oxytocin affects the stress response to social isolation in sheep
Damián, J. P., de Soto, L., Espindola, D., Gil, J., & van Lier, E. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113282 · Cited by 16 · see citing works
Oxytocin blocks pet dog (Canis familiaris) object choice task performance being predicted by owner-perceived intelligence and owner attachment.
Oliva, J. L., Rault, J., Appleton, B., & Lill, A. (2016) · Pet Behaviour Science · doi:10.21071/pbs.v0i1.3991 · Cited by 15 · see citing works
Oxytocin Attenuates the Stress-Induced Reinstatement of Alcohol-Seeking in Male Rats: Role of the Central Amygdala
Ballas, H. S., Wilfur, S. M., Freker, N. A., & Leong, K.-C. (2021) · Biomedicines · doi:10.3390/biomedicines9121919 · Cited by 15 · see citing works
The role of oxytocin on peaceful associations and sociality in mammals
Romero, T., Onishi, K., & Hasegawa, T. (2016) · Behaviour · doi:10.1163/1568539x-00003358 · Cited by 13 · see citing works
Acute effects of oxytocin in music performance anxiety: a crossover, randomized, placebo-controlled trial
Sabino, A. D. V., Chagas, M. H. N., & Osório, F. L. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05493-0 · Cited by 13 · see citing works
The impact of oxytocin administration on brain activity: a systematic review and meta-analysis protocol
Quintana, D. S., Outhred, T., Westlye, L. T., Malhi, G. S., & Andreassen, O. A. (2016) · Systematic Reviews · doi:10.1186/s13643-016-0386-2 · Cited by 13 · see citing works
Genetic Variation in the Maternal Oxytocin System Affects Cortisol Responsiveness to Breastfeeding in Infants and Mothers
Krol, K. M., Monakhov, M. V., Lai, P. S., Ebstein, R. P., Heinrichs, M., & Großmann, T. (2018) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-018-0090-7 · Cited by 15 · see citing works
Schizophrenia and alcohol dependence: Diverse clinical effects of oxytocin and their evolutionary origins
Pedersen, C. A. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.050 · Cited by 12 · see citing works
Oxytocin enhances the recovery of eye-contact induced autonomic arousal: A treatment mechanism study with placebo-controlled design
Daniëls, N., Prinsen, J., Soriano, J. R., & Alaerts, K. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.08.004 · Cited by 12 · see citing works
Intranasal oxytocin as a treatment for anxiety and autism: From subclinical to clinical applications
Yin, H., Jiang, M., Han, T., & Xu, X. (2024) · Peptides · doi:10.1016/j.peptides.2024.171211 · Cited by 11 · see citing works
Serotonin mediates the panicolytic-like effect of oxytocin in the dorsal periaqueductal gray
Sergio, T. D. O., Frias, A. T., Vilela‐Costa, H. H., de Oliveira, D. C., Zuardi, A. W., & Zangrossi, H. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120907960 · Cited by 11 · see citing works
Self-citation
The 5-HT1D/1B receptor agonist sumatriptan enhances fear of simulated speaking and reduces plasma levels of prolactin
de Rezende, M. G., Garcia-Leal, C., Graeff, F. G., & Del‐Ben, C. M. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881112472560 · Cited by 10 · see citing works
Self-citation
Effects of intranasal oxytocin on the self-perception and anxiety of singers during a simulated public singing performance: A randomized, placebo-controlled trial
Osório, F. D. L., Rojas, G. V. E., & AGUIAR-RICZ, L. N. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.943578 · Cited by 9 · see citing works
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Effect of oxytocin on experimentally induced anxiety in healthy volunteers
Chaves, D. I. (2007) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Oxytocin interference in the effects induced by inhalation of 7.5% CO2 in healthy volunteers
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Self-citation
Effects of intranasal oxytocin on the self-perception and anxiety of singers during a simulated public singing performance: A randomized, placebo-controlled trial
Osório, F. D. L., Rojas, G. V. E., & AGUIAR-RICZ, L. N. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.943578 · Cited by 9 · see citing works
Efeito da ocitocina sobre a ansiedade experimental induzida em voluntários saudáveis
Chaves, D. I. (2007) · doi:10.11606/d.60.2007.tde-21052007-100039 · Cited by 1 · see citing works
Simulated public speaking as a model of clinical anxiety
McNair, D. M., Frankenthaler, L. M., Czerlinsky, T., White, T. W., Sasson, S., & Fisher, S. (1982) · Psychopharmacology · doi:10.1007/bf00436092 · Cited by 140 · see citing works

Authors: de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., & Crippa, J. A.
Affiliations: Department of Neurosciences and Behavior, Division of Psychiatry, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Universidade de São Paulo (BR)
National Science and Technology Institute (INCT) for Translational Medicine, CNPq, Ribeirão Preto, São Paulo, Brazil
ORCID: Graeff, Frederico G
Venue: Journal of Psychopharmacology
Publisher: SAGE Publications
Published: 2011-05-09
Volume: 26
Issue: 4
Pages: 497-504
ISSN: 0269-8811 (ISSN-L)
1461-7285
DOI: 10.1177/0269881111400642
OpenAlex: W2023279242
Cited by: 154
References: 66
Citations by year: 2026: 5 · 2025: 11 · 2024: 3 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 14 · 2019: 8 · 2018: 15 · 2017: 12 · 2016: 17 · 2015: 10 · 2014: 17 · 2013: 12 · 2012: 7
FWCI: 16.93
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (publishedVersion)
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, anxiolytic effects, anticipatory anxiety, public speaking anxiety, speech performance, intranasal administration, cortisol, ACTH, heart rate, blood pressure, skin conductance, sedation
MeSH terms: Administration, Intranasal, Adrenocorticotropic Hormone, Adult, Fear, Humans, Hydrocortisone, Oxytocin, Speech, Anti-Anxiety Agents

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Anxiolytic-like effect of oxytocin in the simulated public speaking test

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