Cited by 661Electrochemical sensors and biosensorsAnalytical Chemistry and SensorsElectrochemical Analysis and Applications

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Biosensors for real-time in vivo measurements

Wilson, George S., Gifford, Raeann·2005·Biosensors and Bioelectronics

DOI 10.1016/j.bios.2004.12.003

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Abstract

The current status of sensors capable of continuous measurement of analytes in biological media is reviewed. This review containing 173 references deals with devices whose use in single cells, tissue slices, animal models and humans has been demonstrated. In addition to sensors specific for glucose, lactate, glutamate, pyruvate, choline and acetylcholine, insights obtained from monitoring nitric oxide, Na(+), K(+), Ca(2+), and dopamine are presented. Performance criteria for sensor performance are described as is the subject of biosensor calibration. Biocompatibility issues are dealt with in some detail as is the status of continuous blood glucose monitoring in humans.

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Authors: Wilson, G. S., & Gifford, R.
Affiliations: University of Kansas (US)
Corresponding author: Wilson, George S.
ORCID: Wilson, George S.
Venue: Biosensors and Bioelectronics
Publisher: Elsevier BV
Published: 2005-06
Volume: 20
Issue: 12
Pages: 2388-2403
ISSN: 0956-5663 (ISSN-L)
DOI: 10.1016/j.bios.2004.12.003
OpenAlex: W2090868198
Cited by: 660
References: 174
Citations by year: 2026: 17 · 2025: 21 · 2024: 14 · 2023: 16 · 2022: 17 · 2021: 13 · 2020: 23 · 2019: 27 · 2018: 36 · 2017: 25 · 2016: 37 · 2015: 39 · 2014: 40 · 2013: 50 · 2012: 52
FWCI: 2.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biosensors and Bioelectronics (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Sensors
Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
Keywords: biosensors, in vivo monitoring, glucose sensor, lactate sensor, glutamate sensor, nitric oxide sensor, ion sensors, dopamine sensor, sensor calibration, biocompatibility, continuous glucose monitoring
MeSH terms: Blood Glucose, Equipment Design, Transducers, Blood Glucose Self-Monitoring, Biosensing Techniques, Monitoring, Ambulatory, Cell Culture Techniques, Prostheses and Implants

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Biosensors for real-time in vivo measurements

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