Cited by 129Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsNanoparticle-Based Drug Delivery

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The barrier and interface mechanisms of the brain barrier, and brain drug delivery

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Zhang, Shanshan, Gan, Lin, Cao, Fengye, Wang, Hao, Gong, Peng, Ma, Congcong, Ren, Li, Lin, Yubo, Lin, Xianming·2022·Brain Research Bulletin

DOI 10.1016/j.brainresbull.2022.09.017

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Abstract

Three different barriers are formed between the cerebrovascular and the brain parenchyma: the blood-brain barrier (BBB), the blood-cerebrospinal fluid barrier (BCSFB), and the cerebrospinal fluid-brain barrier (CBB). The BBB is the main regulator of blood and central nervous system (CNS) material exchange. The semipermeable nature of the BBB limits the passage of larger molecules and hydrophilic small molecules, Food and Drug Administration (FDA)-approved drugs for the CNS have been generally limited to lipid-soluble small molecules. Although the complexity of the BBB affects CNS drug delivery, understanding the composition and function of the BBB can provide a platform for the development of new methods for CNS drug delivery. This review summarizes the classification of the brain barrier, the composition and role of the basic structures of the BBB, and the transport, barrier, and destruction mechanisms of the BBB; discusses the advantages and disadvantages of different drug delivery methods and prospects for future drug delivery strategies.

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See all 129

Authors: Zhang, S., Gan, L., Cao, F., Wang, H., Gong, P., Ma, C., Ren, L., Lin, Y., & Lin, X.
Affiliations: Zhejiang Chinese Medical University (CN)
Corresponding author: Lin, Xianming
ORCID: Zhang, Shanshan
Cao, Fengye
Gong, Peng
Ma, Congcong
Lin, Yubo
Lin, Xianming
Venue: Brain Research Bulletin
Publisher: Elsevier BV
Published: 2022-11
Volume: 190
Pages: 69-83
ISSN: 0361-9230 (ISSN-L)
DOI: 10.1016/j.brainresbull.2022.09.017
OpenAlex: W4297090285
Cited by: 129
References: 211
Citations by year: 2026: 37 · 2025: 42 · 2024: 33 · 2023: 17
FWCI: 2.37
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Brain Research Bulletin (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (82174502)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: blood-brain barrier, blood-CSF barrier, brain drug delivery
MeSH terms: Biological Transport, Blood-Brain Barrier, Brain, Central Nervous System, Drug Delivery Systems

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The barrier and interface mechanisms of the brain barrier, and brain drug delivery

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