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Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein
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Wnt signaling pathways are important for multiple biological processes during development and disease. Wnt proteins are secreted factors that activate target-gene expression in both a short- and long-range manner. Currently, little is known about how Wnts are released from cells and which factors facilitate their secretion. Here, we identify a conserved multipass transmembrane protein, Evenness interrupted (Evi/Wls), through an RNAi survey for transmembrane proteins involved in Drosophila Wingless (Wg) signaling. During development, evi mutants have patterning defects that phenocopy wg loss-of-function alleles and fail to express Wg target genes. evi's function is evolutionarily conserved as depletion of its human homolog disrupts Wnt signaling in human cells. Epistasis experiments and clonal analysis place evi in the Wg-producing cell. Our results show that Wg is retained by evi mutant cells and suggest that evi is the founding member of a gene family specifically required for Wg/Wnt secretion.
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“The porcupine protein has been shown to play an important role in the palmitolation of the Wnt proteins, and their secretion is regulated by the wntless or evenness interrupted proteins and the retromer complex.11–14”
From Wnt signal transduction pathways (2008) · cites this paper as [12]
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Cites
Tree View: An application to display phylogenetic trees on personal computers
Page, R. (1996) · Computer applications in the biosciences · doi:10.1093/bioinformatics/12.4.357 · Cited by 10,223
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
Brand, A. H., & Perrimon, N. (1993) · Development · doi:10.1242/dev.118.2.401 · Cited by 9,510
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Mutations affecting segment number and polarity in Drosophila
Nüsslein‐Volhard, C., & Wieschaus, E. F. (1980) · Nature · doi:10.1038/287795a0 · Cited by 4,370
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
A new member of the frizzled family from Drosophila functions as a Wingless receptor
Bhanot, P., van den Brink, M. R. M., Samos, C. H., Hsieh, J.-C., Wang, Y., Macke, J. P., Andrew, D. J., Nathans, J., & Nusse, R. (1996) · Nature · doi:10.1038/382225a0 · Cited by 1,504
Wetering, M. L. V. D., Cavallo, R. A., Dooijes, D., van Beest, M., van Es, J. V., Loureiro, J., Ypma, A., Hursh, D., Jones, T. L., Bejsovec, A., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81925-x · Cited by 1,347
SMART 5: domains in the context of genomes and networks
Letunić, I. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj079 · Cited by 983
arrow encodes an LDL-receptor-related protein essential for Wingless signalling
Wehrli, M., Dougan, S. T., Caldwell, K. A., O’Keefe, L. V., Schwartz, S. L., Vaizel-Ohayon, D., Schejter, E. D., Tomlinson, A., & DiNardo, S. (2000) · Nature · doi:10.1038/35035110 · Cited by 871
The BDGP Gene Disruption Project
Bellen, H. J., Levis, R. W., Liao, G., He, Y., Carlson, J. W., Tsang, G., Evans-Holm, M. E., Hiesinger, P. R., Schulze, K. L., Rubin, G. M., et al. (2004) · Genetics · doi:10.1534/genetics.104.026427 · Cited by 864
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Zhan, T., Rindtorff, N., & Boutros, M. (2017) · Oncogene · doi:10.1038/onc.2016.304 · Cited by 2,626
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Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors
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Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila
Port, F., Chen, H.-M., Lee, T., & Bullock, S. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405500111 · Cited by 1,046
Active Wnt proteins are secreted on exosomes
Gross, J. C., Chaudhary, V., Bartscherer, K., & Boutros, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2574 · Cited by 1,025
Self-citationWnt signaling in development and tissue homeostasis
Steinhart, Z., & Angers, S. (2018) · Development · doi:10.1242/dev.146589 · Cited by 821
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Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T., & Takada, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.003 · Cited by 809
Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764
Bovolenta, P., Esteve, P., Ruiz, J. M., Cisneros, E., & López-Rı́os, J. (2008) · Journal of Cell Science · doi:10.1242/jcs.026096 · Cited by 655
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Nusse, R. (2008) · Cell Research · doi:10.1038/cr.2008.47 · Cited by 597
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Korkut, C., Ataman, B., Ramachandran, P., Ashley, J., Barria, R., Gherbesi, N., & Budnik, V. (2009) · Cell · doi:10.1016/j.cell.2009.07.051 · Cited by 443
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Monroe, D. G., McGee‐Lawrence, M. E., Oursler, M. J., & Westendorf, J. J. (2011) · Gene · doi:10.1016/j.gene.2011.10.044 · Cited by 400
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Maeda, K., Kobayashi, Y., Koide, M., Uehara, S., Okamoto, M., Ishihara, A., Kayama, T., Saito, M., & Marumo, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225525 · Cited by 360
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Willert, K., & Nusse, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007864 · Cited by 370
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Foulquier, S., Daskalopoulos, E. P., Lluri, G., Hermans, K. C. M., Deb, A., & Blankesteijn, W. M. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.013896 · Cited by 350
Harterink, M., Port, F., Lorenowicz, M. J., McGough, I. J., Silhankova, M., Betist, M. C., van Weering, J. R. T., van Heesbeen, R. G. H. P., Middelkoop, T. C., Basler, K., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2281 · Cited by 327
RNAi screening comes of age: improved techniques and complementary approaches
Mohr, S. E., Smith, J. A., Shamu, C. E., Neumüller, R. A., & Perrimon, N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3860 · Cited by 344
Belenkaya, T. Y., Wu, Y., Tang, X., Zhou, B., Cheng, L., Sharma, Y. V., Yan, D., Selva, E. M., & Lin, X. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.12.003 · Cited by 327
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Boutros, M., Brás, L. P., & Huber, W. K. (2006) · Genome biology · doi:10.1186/gb-2006-7-7-r66 · Cited by 306
Self-citationWassmer, T., Attar, N., Harterink, M., van Weering, J. R. T., Traer, C. J., Oakley, J. D., Goud, B., Stephens, D. J., Verkade, P., Korswagen, H. C., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.04.016 · Cited by 293
Prevalence of off-target effects in Drosophila RNA interference screens
Ma, Y., Creanga, A., Lum, L., & Beachy, P. A. (2006) · Nature · doi:10.1038/nature05179 · Cited by 287
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Davidson, G. R., Shen, J., Huang, Y., Su, Y., Karaulanov, E., Bartscherer, K., Hassler, C., Stannek, P., Boutros, M., & Niehrs, C. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.11.006 · Cited by 284
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Lee, Y., Lee, J., Ahn, S. H., Lee, J., & Nam, D. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.140 · Cited by 278
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Port, F., Kuster, M., Herr, P., Furger, E., Bänziger, C., Hausmann, G., & Basler, K. (2008) · Nature Cell Biology · doi:10.1038/ncb1687 · Cited by 278
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Chen, D., Jarrell, A., Guo, C., Lang, R., & Atit, R. (2012) · Development · doi:10.1242/dev.076463 · Cited by 260
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Whangbo, J., & Hunter, C. P. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.03.007 · Cited by 268
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Yang, P., Lorenowicz, M. J., Macůrková, M., Coudreuse, D. Y. M., Betist, M. C., & Korswagen, H. C. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.12.004 · Cited by 259
Franch‐Marro, X., Wendler, F., Guidato, S., Griffith, J. M., Baena-López, L. A., Itasaki, N., Maurice, M. M., & Vincent, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1678 · Cited by 260
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
Voloshanenko, O., Erdmann, G., Dubash, T. D., Augustin, I., Metzig, M. O., Moffa, G., Hundsrucker, C., Kerr, G., Sandmann, T., Anchang, B., et al. (2013) · Nature Communications · doi:10.1038/ncomms3610 · Cited by 257
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Nusse, R., Fuerer, C., Ching, W., Harnish, K., Logan, C. Y., Zeng, A. M., ten Berge, D., & Kalani, Y. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.035 · Cited by 260
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Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation
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Porcupine-mediated lipidation is required for Wnt recognition by Wls.
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Scholz, B., Korn, C., Wojtarowicz, J., Mogler, C., Augustin, I., Boutros, M., Niehrs, C., & Augustin, H. G. (2016) · Developmental Cell · doi:10.1016/j.devcel.2015.12.015 · Cited by 193
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Zhong, Z. A., Diegel, C. R., Schumacher, C. A., Baker, J. J., Carpenter, A. C., Rao, S., Yao, W., Guan, M., Helms, J. A., Lane, N. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120407109 · Cited by 180
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Beckett, K., Monier, S., Palmer, L., Alexandre, C., Green, H., Bonneil, É., Raposo, G., Thibault, P., Borgne, R. L., & Vincent, J. (2012) · Traffic · doi:10.1111/tra.12016 · Cited by 177
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Cordero, J. B., Stefanatos, R. K. A., Scopelliti, A., Vidal, M., & Sansom, O. J. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.248 · Cited by 170
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Port, F., Strein, C., Stricker, M., Rauscher, B., Heigwer, F., Zhou, J., Beyersdörffer, C., Frei, J., Hess, A., Kern, K., et al. (2020) · eLife · doi:10.7554/elife.53865 · Cited by 154
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Franco, C. A., Jones, M. L., Bernabéu, M. O., Vion, A.-C., Barbacena, P., Fan, J., Mathivet, T., Fonseca, C. G., Ragab, A., Yamaguchi, T. P., et al. (2016) · eLife · doi:10.7554/elife.07727 · Cited by 154
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Metadata
- Authors
- Bartscherer, K., Pelte, N., Ingelfinger, D., & Boutros, M.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Boutros, Michael
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 125
- Issue
- 3
- Pages
- 523-533
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2067937471
- Cited by
- 580
- References
- 53
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 21 · 2023: 20 · 2022: 24 · 2021: 31 · 2020: 33 · 2019: 34 · 2018: 35 · 2017: 33 · 2016: 35 · 2015: 29 · 2014: 45 · 2013: 29 · 2012: 37
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt secretion, Wnt signaling, Drosophila, transmembrane proteins, gene family evolution, epistasis, clonal analysis, RNAi screen, developmental patterning
- MeSH terms
- Animals, Cell Line, Cells, Cultured, Clone Cells, Drosophila melanogaster, Humans, Membrane Proteins, Mutation, Phenotype, Signal Transduction, Conserved Sequence, Gene Expression Regulation, Developmental, Cell Lineage, Evolution, Molecular, Body Patterning, Drosophila Proteins, RNA Interference, Intracellular Signaling Peptides and Proteins, Wnt Proteins
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