The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Acne and sebaceous gland function
Abstract
The embryologic development of the human sebaceous gland is closely related to the differentiation of the hair follicle and the epidermis. The number of sebaceous glands remains approximately the same throughout life, whereas their size tends to increase with age. The development and function of the sebaceous gland in the fetal and neonatal periods appear to be regulated by maternal androgens and by endogenous steroid synthesis, as well as by other morphogens. The most apparent function of the glands is to excrete sebum. A strong increase in sebum excretion occurs a few hours after birth; this peaks during the first week and slowly subsides thereafter. A new rise takes place at about age 9 years with adrenarche and continues up to age 17 years, when the adult level is reached. The sebaceous gland is an important formation site of active androgens. Androgens are well known for their effects on sebum excretion, whereas terminal sebocyte differentiation is assisted by peroxisome proliferator-activated receptor ligands. Estrogens, glucocorticoids, and prolactin also influence sebaceous gland function. In addition, stress-sensing cutaneous signals lead to the production and release of corticotrophin-releasing hormone from dermal nerves and sebocytes with subsequent dose-dependent regulation of sebaceous nonpolar lipids. Among other lipid fractions, sebaceous glands have been shown to synthesize considerable amounts of free fatty acids without exogenous influence. Sebaceous lipids are responsible for the three-dimensional skin surface lipid organization. Contributing to the integrity of the skin barrier. They also exhibit strong innate antimicrobial activity, transport antioxidants to the skin surface, and express proinflammatory and anti-inflammatory properties. Acne in childhood has been suggested to be strongly associated with the development of severe acne during adolescence. Increased sebum excretion is a major factor in the pathophysiology of acne vulgaris. Other sebaceous gland functions are also associated with the development of acne, including sebaceous proinflammatory lipids; different cytokines produced locally; periglandular peptides and neuropeptides, such as corticotrophin-releasing hormone, which is produced by sebocytes; and substance P, which is expressed in the nerve endings at the vicinity of healthy-looking glands of acne patients. Current data indicate that acne vulgaris may be a primary inflammatory disease. Future drugs developed to treat acne not only should reduce sebum production and Propionibacterium acnes populations, but also should be targeted to reduce proinflammatory lipids in sebum, down-regulate proinflammatory signals in the pilosebaceous unit, and inhibit leukotriene B(4)-induced accumulation of inflammatory cells. They should also influence peroxisome proliferator-activated receptor regulation. Isotretinoin is still the most active available drug for the treatment of severe acne.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, sebaceous lipids make an important contribution in maintaining the integrity of the skin barrier along with lipids of epidermal origin2,52 thus contributing to the body's first line of defence.53”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [52]
Citations
Cites
Slominski, A., Wortsman, J., Luger, T., Paus, R., & Solomon, S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.979 · Cited by 776
Inflammatory Events Are Involved in Acne Lesion Initiation
Jeremy, A. H. T., Holland, D. B., Roberts, S. G., Thomson, K. F., & Cunliffe, W. J. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12321.x · Cited by 541
Structural and functional changes of normal aging skin
Fenske, N. A., & Lober, C. W. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70208-9 · Cited by 535
Differential activation of adipogenesis by multiple PPAR isoforms.Preprint
Brun, R. P., Tontonoz, P., FORMAN, B. M., Ellis, R., Chen, J., Evans, R. M., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.8.974 · Cited by 480
Role of Hormones in Pilosebaceous Unit Development
Deplewski, D., & Rosenfield, R. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.4.0404 · Cited by 443
Control and function of sebaceous glands
Thody, A. J., & Shuster, S. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.2.383 · Cited by 401
Toyoda, M., & Morohashi, M. (2001) · Medical Molecular Morphology · doi:10.1007/s007950100002 · Cited by 383
Vowels, B. R., Yang, S., & Leyden, J. J. (1995) · Infection and Immunity · doi:10.1128/iai.63.8.3158-3165.1995 · Cited by 331
Current Use and Future Potential Role of Retinoids in Dermatology
Orfanos, C. E., Zouboulis, C. C., Almond‐Roesler, B., & Geilen, C. C. (1997) · Drugs · doi:10.2165/00003495-199753030-00003 · Cited by 330
Self-citationChoudhry, R., Hodgins, M. B., van der Kwast, T., Brinkmann, A. O., & Boersma, W. J. A. (1992) · Journal of Endocrinology · doi:10.1677/joe.0.1330467 · Cited by 318
Research works printed but not linked: 5
- Benfenati, 1939, Sulla distribuzione delle ghiandole sebacee nella cute del corpo umino, Arch Ital Dermatol, 15, 33
- Wheatley, 1956, Sebum, Am Perfumer, 68, 37
- Pochi, 1977, Sebum, acne and androgens in children, Clin Res, 25, 531A
- Billich, 2000, Immunohistochemical localization of steroid sulfatase in acne lesions, Horm Res, 53, 99
- Cunliffe, 1987, Androgen control of the pilosebaceous duct, Br J Dermatol, 116, 449
Cited by
Sorted by citations
Schweiger, D., Baufeld, C., Drescher, P., Oltrogge, B., Höpfner, S., Mess, A., Lüttke, J., Rippke, F., Filbry, A. W., & Max, H. (2013) · Skin Pharmacology and Physiology · doi:10.1159/000348473 · Cited by 1,349
Knop, E., Knop, N., Millar, T., Obata, H., & Sullivan, D. A. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6997c · Cited by 1,093
“The addition of IL-1- to isolated pilosebaceous units in vitro results in hypercornification,(451) as discussed by Zouboulis.(151) Similar events are described in the obstructive disease (acne) of the hair-associated sebaceous glands of the skin, as discussed by Kurokawa et al.”
BackgroundNeuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. S. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 693
New developments in our understanding of acne pathogenesis and treatment
Kurokawa, I., Danby, F. W., Ju, Q., Wang, X., Xiang, L. F., Xia, L., Chen, W., Nagy, I., Picardo, M., Suh, D. H., et al. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00890.x · Cited by 584
Self-citationObesity and the skin: Skin physiology and skin manifestations of obesity
Yosipovitch, G., DeVore, A., & Dawn, A. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.12.004 · Cited by 524
Slominski, A. T., Zmijewski, M. A., Skobowiat, C., Zbytek, B., Slominski, R. M., & Steketee, J. D. (2012) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-19683-6 · Cited by 505
Exploring the potential of using algae in cosmetics
Wang, H., Chen, C.-C., Huynh, P., & Chang, J. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.12.001 · Cited by 509
Rojas, J., Chávez-Castillo, M., Olivar, L. C., Rojas, M., Morillo, J., Mejias, J. A., Calvo, M. C. C., & Bermúdez, V. (2014) · International Journal of Reproductive Medicine · doi:10.1155/2014/719050 · Cited by 504
Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461
Acne Scars: Pathogenesis, Classification and Treatment
Fabbrocini, G., Annunziata, M. C., D′Arco, V., Vita, V. D., Lodi, G., Mauriello, M. C., Pastore, F., & Monfrecola, G. (2010) · Dermatology Research and Practice · doi:10.1155/2010/893080 · Cited by 442
“Neutral and polar lipids produced by sebaceous glands serve a variety of roles in signal transduction and are involved in biological pathways [7].”
BackgroundTuchayi, S. M., Makrantonaki, E., Ganceviciene, R., Dessinioti, C., Feldman, S. R., & Zouboulis, C. C. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.29 · Cited by 432
Self-citationKey role of CRF in the skin stress response system
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400
Nagy, I., Pivarcsi, A., Kis, K., Koreck, A., Bodai, L., McDowell, A., Seltmann, H., Patrick, S., Zouboulis, C. C., & Kemény, L. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.04.001 · Cited by 375
“Sebocytes are proposed to participate in several pathophysiologic processes, especially in the pathogenesis of acne [1,4,6].”
BackgroundSelf-citationAging Skin: Histology, Physiology, and Pathology
Khavkin, J., & Ellis, D. A. F. (2011) · Facial Plastic Surgery Clinics of North America · doi:10.1016/j.fsc.2011.04.003 · Cited by 358
“Increased sebum production is a major factor in the pathophysiology of acne vulgaris.(7) Sebum secretion declines with age by about 23% per decade in men and 32% per decade in women.”
BackgroundBiochemistry of human skin—our brain on the outside
Tobin, D. J. (2005) · Chemical Society Reviews · doi:10.1039/b505793k · Cited by 354
Pappas, A. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.2.7811 · Cited by 326
Pereira, L. (2018) · Cosmetics · doi:10.3390/cosmetics5040068 · Cited by 327
An update on the role of the sebaceous gland in the pathogenesis of acne
Makrantonaki, E., Gancevičienė, R., & Zouboulis, C. C. (2011) · Dermato-Endocrinology · doi:10.4161/derm.3.1.13900 · Cited by 312
“Increased sebum excretion, alteration of lipid composition and the oxidant/antioxidant ratio characteristic of the skin surface lipids are major concurrent events associated with the development of acne.(5) If sebum interferes with the process of follicular keratinisation in the pilosebaceous unit, pore blockage may o…”
BackgroundInfluentialSelf-citationMicrobiome in healthy skin, update for dermatologists
Dréno, B., Araviiskaia, E., Berardesca, E., Gontijo, G., Sanchez Viera, M., Xiang, L. F., Martin, R., & Bieber, T. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13965 · Cited by 292
Boer, M., Duchnik, E., Maleszka, R., & Marchlewicz, M. (2016) · Advances in Dermatology and Allergology · doi:10.5114/pdia.2015.48037 · Cited by 286
“al structure of epidermal lipids, which helps maintain its integrity [20, 23, 27].”
BackgroundThe balance of metagenomic elements shapes the skin microbiome in acne and health
Barnard, E., Shi, B., Kang, D., Craft, N. A., & Li, H. (2016) · Scientific Reports · doi:10.1038/srep39491 · Cited by 271
Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions
Zouboulis, C. C., Jourdan, E., & Picardo, M. (2014) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12298 · Cited by 286
Self-citationFischer, C. L., Drake, D. R., Dawson, D. V., Blanchette, D. R., Brogden, K. A., & Wertz, P. W. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05151-11 · Cited by 244
“These sebaceous secretions contribute to (i) the transport of fatsoluble antioxidants to the skin and mucosal surfaces, (ii) the proand anti-inflammatory properties of the skin and mucosal surfaces, and (iii) the innate antimicrobial activity of the skin and mucosal surfaces (20, 26, 27).”
BackgroundINDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES
Baru, P. C. R. (2014) · ADVANCED SCIENCES INDEX · Cited by 236
Fournière, M., Latire, T., Souak, D., Feuilloley, M. G. J., & Bedoux, G. (2020) · Microorganisms · doi:10.3390/microorganisms8111752 · Cited by 227
Peroxisome Proliferator-Activated Receptors Increase Human Sebum Production
Trivedi, N. R., Cong, Z., Nelson, A. M., Albert, A. J., Rosamilia, L. L., Sivarajah, S., Gilliland, K. L., Liu, W., Mauger, D. T., Gabbay, R. A., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700336 · Cited by 184
Human skin stem cells and the ageing process
Zouboulis, C. C., Adjaye, J., Akamatsu, H., Moe-Behrens, G., & Niemann, C. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.09.001 · Cited by 176
“Sebaceous gland development and cell differentiation 19 The development of the sebaceous glands is closely related to the differentiation of the other two epidermal lineages, hair follicles and epidermis (Zouboulis, 2004).”
BackgroundSelf-citationSkin changes in the obese patient
Hirt, P. A., Castillo, D. E., Yosipovitch, G., & Keri, J. E. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.12.070 · Cited by 182
Ottaviani, M., Alestas, T., Flori, E., Mastrofrancesco, A., Zouboulis, C. C., & Picardo, M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700434 · Cited by 180
“Although excess of sebum excretion is involved in the pathophysiology of acne (Zouboulis, 2004), it is still unclear whether it is associated with the severity of the disease (Pochi ORIGINAL ARTICLE”
BackgroundSelf-citationAutophagy induction by trehalose: Molecular mechanisms and therapeutic impacts
Moghaddam, K. H., Caraglia, M., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26583 · Cited by 173
“Recent reports have revealed an increasing number of females with hitch, in whom various degrees of hyperandrogenemia and an enhanced action of androgens in the sebaceous glands are found (Howard, 2014; Silverberg & Weinberg, 2001; Thiboutot, Gilliland, Light, & Lookingbill, 1999; Zouboulis, 2004).”
BackgroundStudy of Psychological Stress, Sebum Production and Acne Vulgaris in Adolescents
Yosipovitch, G., Tang, M. L. K., Dawn, A., Chen, M. I.-C., Goh, C., Huak, Y., & Seng, L. (2007) · Acta Dermato Venereologica · doi:10.2340/00015555-0231 · Cited by 164
Thormar, H., & Hilmarsson, H. (2007) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2007.06.220 · Cited by 161
Recent Advances in Acne Pathogenesis: Implications for Therapy
Das, S., & Reynolds, R. V. (2014) · American Journal of Clinical Dermatology · doi:10.1007/s40257-014-0099-z · Cited by 157
Sebaceous-immunobiology is orchestrated by sebum lipids
Lovászi, M., Szegedi, A., Zouboulis, C. C., & Törőcsik, D. (2017) · Dermato-Endocrinology · doi:10.1080/19381980.2017.1375636 · Cited by 151
Self-citationBowe, W. P., Joshi, S. S., & Shalita, A. R. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.07.043 · Cited by 150
Propionibacterium acnes Activates the NLRP3 Inflammasome in Human Sebocytes
Li, Z. J., Choi, D. K., Sohn, K., Seo, M. S., Lee, H. E., Lee, Y., Seo, Y., Lee, Y., Shi, G., Zouboulis, C. C., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.221 · Cited by 152
“INTRODUCTION Clinically relevant inflammation in acne may be initiated by disruption of the follicular epithelium followed by the spread of bacteria, including Propionibacterium acnes, to the dermis, leading to the development of papules, pustules, and nodulocystic lesions (Zouboulis, 2005; Kurokawa et al., 2009).”
BackgroundSelf-citationFoitzik, K., Krause, K., Conrad, F., Nakamura, M., Funk, W., & Paus, R. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050468 · Cited by 148
“Therefore, it will be interesting to investigate whether PRL is able to modulate androgen receptor expression and/or androgen metabolism in the human pilosebaceous unit.(65,66) In summary, our study shows that human anagen scalp HFs are very sensitive for inhibitory PRL-R-mediated signals.”
BackgroundAbuse of anabolic‐androgenic steroids and bodybuilding acne: an underestimated health problem
Melnik, B. C., Jansen, T., & Grabbe, S. (2007) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2007.06176.x · Cited by 148
Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris
Gancevičienė, R., Gražienë, V., Fimmel, S., & Zouboulis, C. C. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08959.x · Cited by 146
Self-citationSebum analysis of individuals with and without acne.
Pappas, A., Johnsen, S. A., Liu, J.-C., & Eisinger, M. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.3.8473 · Cited by 144
Matsue, M., Mori, Y., Nagase, S., Sugiyama, Y., Hirano, R., Ogai, K., Ogura, K., Kurihara, S., & Okamoto, S. (2019) · Cell Transplantation · doi:10.1177/0963689719881366 · Cited by 151
Dissolution of materials in artificial skin surface film liquids
Stefaniak, A. B., & Harvey, C. J. (2006) · Toxicology in Vitro · doi:10.1016/j.tiv.2006.05.011 · Cited by 133
Organization of the skin immune system and compartmentalized immune responses in infectious diseases
Quaresma, J. A. S. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00034-18 · Cited by 149
“Sebaceous glands, as with hair follicles, originate from the same epithelial sheath and secrete cholesterol and triglycerides (252, 253, 266, 267).”
BackgroundZouboulis, C. C., Coenye, T., He, L., Kabashima, K., Kobayashi, T., Niemann, C., Nomura, T., Oláh, A., Picardo, M., Quist, S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1029818 · Cited by 143
“Despite the knowledge that sebaceous lipids form 90% of the skin surface lipids in adolescent and adult individuals (1), it was only recently shown that the sebaceous gland density in fl uences the stratum corneum lipidome (300).”
BackgroundSelf-citationAcne‐associated syndromes: models for better understanding of acne pathogenesis
Chen, W., Obermayer-Pietsch, B. M., Hong, J., Melnik, B., Yamasaki, O., Dessinioti, C., Ju, Q., Liakou, A. I., Al-Khuzaei, S., Katsambas, A., et al. (2010) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03937.x · Cited by 126
Self-citationRole of hormones in acne vulgaris
Arora, M. K., Yadav, A., & Saini, V. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.06.984 · Cited by 121
“The embryologic development of the human sebaceous gland is closely related to the differentiation of the hair follicle and the epidermis [11].”
BackgroundSkin barrier and microbiome in acne
Rocha, M., & Bagatin, E. (2017) · Archives of Dermatological Research · doi:10.1007/s00403-017-1795-3 · Cited by 120
“Pro-inflammatory sebum lipid fractions (monounsaturated fatty acid-MUFA and lipo-peroxides) are additional factors in the pathogenesis of acne [62].”
BackgroundCelso, C. L., Berta, M., Braun, K. M., Frye, M., Lyle, S. R., Zouboulis, C. C., & Watt, F. M. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0651 · Cited by 120
Self-citationProlactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone
Foitzik, K., Langan, E. A., & Paus, R. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.348 · Cited by 116
Culture, Immortalization, and Characterization of Human Meibomian Gland Epithelial Cells
Liu, S., Hatton, M. P., Khandelwal, P., & Sullivan, D. A. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-5108 · Cited by 114
The role of isotretinoin in acne therapy: why not as first-line therapy? facts and controversies
Rigopoulos, D., Larios, G., & Katsambas, A. (2009) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2009.03.005 · Cited by 105
Burris, J., Rietkerk, W., & Woolf, K. (2014) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2013.11.010 · Cited by 109
Zouboulis, C. C., Schagen, S., & Alestas, T. (2008) · Archives of Dermatological Research · doi:10.1007/s00403-008-0879-5 · Cited by 105
“... of acne, the most common disease of the sebaceous follicle, has currently been attributed to multiple factors such as increased sebum production, alteration of the quality of sebum lipids, regulation of cutaneous steroidogenesis, androgen activity, interaction with neuropeptides, exhibition of pro- and anti inXamm…”
Self-citationAcne as a chronic systemic disease
Zouboulis, C. C. (2013) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2013.11.005 · Cited by 104
“56 Three diagnostic criteria for this syndrome have been proposed: (1) chronic recurrent multifocal osteomyelitis with or without skin manifestations; (2) acute or chronic sterile arthritis associated with either pustular psoriasis or palmoplantar pustulosis or severe acne; and (3) sterile osteitis in the presence of…”
BackgroundSelf-citationHarrison, W. J., Bull, J. J., Seltmann, H., Zouboulis, C. C., & Philpott, M. P. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700743 · Cited by 101
“Lipid synthesis and accumulation is a major part of sebocyte differentiation (Downie and Kealey, 1998; Zouboulis, 2004).”
BackgroundSelf-citationToll-Like Receptors: Role in Dermatological Disease
Hari, A., Flach, T. L., Shi, Y., & Mydlarski, P. R. (2010) · Mediators of Inflammation · doi:10.1155/2010/437246 · Cited by 104
“…the piloseba-ceous follicle and is attributed to increased sebum excretion, sebum lipid alteration, androgen and neuropeptide activities, follicular hyperkeratinization, dsyregulation of cutaneous steroidogenesis, and growth of anaerobic, gram positive Propionibacterium acne ( P. acnes) [131, 132].”
BackgroundUpdate on etiopathogenesis and treatment of Acne
Bhat, Y. J., Latief, I., & Hassan, I. (2017) · Indian Journal of Dermatology Venereology and Leprology · doi:10.4103/0378-6323.199581 · Cited by 100
Cutaneous Stem Cells and Wound Healing
Roh, C., & Lyle, S. R. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000203572.51876.ba · Cited by 101
“The sebaceous gland is composed of a thin rim of progenitor basaloid cells and sebocytes which accumulate lipid and undergo holocrine secretion to produce the sebum (5).”
BackgroundChernyshov, P. V., Zouboulis, C. C., Tomas-Aragones, L., Jemec, G. B. E., Manolache, L., Tzellos, T., Sampogna, F., Evers, A. W. M., Dessinioti, C., Marrón, S. E., et al. (2017) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14585 · Cited by 98
Self-citationCarrier-Based Drug Delivery System for Treatment of Acne
Vyas, A., Sonker, A. K., & Gidwani, B. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/276260 · Cited by 97
Lolis, M. S., Bowe, W. P., & Shalita, A. R. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2009.08.008 · Cited by 95
New Uses of AbobotulinumtoxinA in Aesthetics
Schlessinger, J., Gilbert, E., Cohen, J. L., & Kaufman, J. (2017) · Aesthetic Surgery Journal · doi:10.1093/asj/sjx005 · Cited by 95
Environmental Air Pollutants Affecting Skin Functions with Systemic Implications
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310502 · Cited by 94
“Moreover, hyperseborrhea and dysseborrhea, which are important etiopathogenetic factors in acne [231], were measured on the forehead of citizens in two highly polluted cities, namely Shanghai and Mexico City [79,232].”
BackgroundAge and ethnic variations in sebaceous lipids
Pappas, A., Fantasia, J., & Chen, T. (2013) · Dermato-Endocrinology · doi:10.4161/derm.25366 · Cited by 93
Sebocytes contribute to skin inflammation by promoting the differentiation of T helper 17 cells
Mattii, M., Lovászi, M., Garzorz, N., Atenhan, A., Quaranta, M., Lauffer, F., Konstantinow, A., Küpper, M., Zouboulis, C. C., Kemény, L. V., et al. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15879 · Cited by 98
Self-citationIinuma, K., Sato, T., Akimoto, N., Noguchi, N., Sasatsu, M., Nishijima, S., Kurokawa, I., & Itô, A. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.46 · Cited by 92
“acnes-augmented TG production in the differentiated hamster sebocytes Arachidonic acid metabolites have been reported to be associated with acne development and deterioration in vivo (Zouboulis, 2004; Alestas et al., 2006).”
BackgroundCytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways
Slominski, A. T., Zmijewski, M. A., Semak, I. V., Zbytek, B., Pisarchik, A. V., Li, W., Zjawiony, J. K., & Tuckey, R. C. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/18715206113139990308 · Cited by 91
Zouboulis, C. C., & Bettoli, V. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13639 · Cited by 90
Self-citationAntibiotic resistant Cutibacterium acnes among acne patients in Jordan: a cross sectional study
Alkhawaja, E., Hammadi, S., Malek, M. A., Mahasneh, N., Alkhawaja, B. A., & Abdelmalek, S. M. A. (2020) · BMC Dermatology · doi:10.1186/s12895-020-00108-9 · Cited by 90
Sakuma, T. H., & Maïbach, H. I. (2012) · Skin Pharmacology and Physiology · doi:10.1159/000338978 · Cited by 89
Zhang, Z., Dales, N. A., & Winther, M. D. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm401516c · Cited by 87
Taye, M., Lee, W., Caetano-Anollés, K., Dessie, T., Hanotte, O., Mwai, O. A., Kemp, S. J., Cho, S., Oh, S. J., Lee, H., et al. (2017) · Animal Science Journal · doi:10.1111/asj.12851 · Cited by 85
Harada, N., Okajima, K., Arai, M., Kurihara, H., & Nakagata, N. (2007) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2007.04.009 · Cited by 90
“Since sebaceous lipids are responsible for three-dimensional skin surface lipid organization, thereby contributing to the integrity of the skin barrier [28], stimulation of sensory neurons by capsaicin and isoflavone might contribute to maintenance of skin integrity though enhancement of IGF-I expression in the sebace…”
BackgroundCorrelation of facial sebum to serum insulin-like growth factor-1 in patients with acne
Vora, S., Ovhal, A., Jerajani, H., Nair, N., & Chakrabortty, A. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08764.x · Cited by 114
Wang, Y., Dai, A., Huang, S., Kuo, S., Shu, M., Tapia, C., Yu, J., Two, A. M., Zhang, H., Gallo, R. L., et al. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0031 · Cited by 90
“P. acnes also is a regular resident within the hair follicle (Zouboulis, 2004).”
BackgroundMakrantonaki, E., & Zouboulis, C. C. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.07.002 · Cited by 87
“Furthermore, the sebaceous gland transports antioxidants in and on the skin and exhibits a natural light protective activity (Zouboulis, 2004).”
BackgroundSelf-citationTopical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris
Khodaeiani, E., Fouladi, R. F., Amirnia, M., Saeidi, M., & Karimi, E. R. (2013) · International Journal of Dermatology · doi:10.1111/ijd.12002 · Cited by 83
Acne: The role of medical nutrition therapy
Burris, J., Rietkerk, W., & Woolf, K. (2013) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.11.016 · Cited by 82
Transient Receptor Potential Vanilloid-1 Signaling as a Regulator of Human Sebocyte Biology
Tóth, B. I., Géczy, T., Griger, Z., Dózsa, A., Seltmann, H., Kovács, L., Nagy, L., Zouboulis, C. C., Paus, R., & Bíró, T. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.258 · Cited by 90
“…cellular modifications induced by AA strikingly resemble those seen in acne vulgaris, a common, multi-factorial pilosebaceous inflammatory skin disease in which lipid synthesis of sebocytes are pathologically increased (reviewed in Zouboulis et al., 1998; Zouboulis, 2004; Zouboulis et al., 2005).”
BackgroundInfluentialSelf-citationKim, H., Moon, S. Y., Sohn, M. Y., & Lee, W. J. (2017) · Annals of Dermatology · doi:10.5021/ad.2017.29.1.20 · Cited by 80
Skin steroidogenesis in health and disease
Nikolakis, G., Stratakis, C. A., Kanaki, T., Slominski, A., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9390-z · Cited by 76
Self-citationSchwingen, J., Kaplan, M., & Kurschus, F. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030699 · Cited by 78
Mias, C., Mengeaud, V., Bessou‐Touya, S., & Duplan, H. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18794 · Cited by 88
LXRα Enhances Lipid Synthesis in SZ95 Sebocytes
Hong, I., Lee, M.-H., Na, T.-Y., Zouboulis, C. C., & Lee, M.-O. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701134 · Cited by 77
Self-citationHigh-temperature gas chromatography-mass spectrometry for skin surface lipids profiling
Michael‐Jubeli, R., Bleton, J., & Baillet‐Guffroy, A. (2010) · Journal of Lipid Research · doi:10.1194/jlr.d008094 · Cited by 78
Endocrinology and immunology of acne: Two sides of the same coin
Zouboulis, C. C. (2020) · Experimental Dermatology · doi:10.1111/exd.14172 · Cited by 78
Self-citationThe role of neuropeptides in the multifactorial pathogenesis of acne vulgaris
Gancevičienė, R., Böhm, M., Fimmel, S., & Zouboulis, C. C. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.3.8496 · Cited by 74
Self-citationFacial sebum affects the development of acne, especially the distribution of inflammatory acne
Choi, C. W., Choi, J. W., Park, K. ‐., & Youn, S. W. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04384.x · Cited by 73
Models for acne: A comprehensive study
Kanwar, I. L., Haider, T., Kumari, A., Dubey, S., Jain, P., & Soni, V. (2018) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2018.01079 · Cited by 72
“Sebocytes’ makeup” - Novel mechanisms and concepts in the physiology of the human sebaceous glands
Tóth, B. I., Oláh, A., Szöllősi, A. G., Czifra, G., & Bíró, T. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0941-6 · Cited by 76
“Of further importance, novel etiological models emphasize that acne may develop without the colonization of pathogenic microorganisms, provided that some other factors (e.g., enhanced effect of androgenic hormones, activation of peroxisome proliferator-activated receptors (PPAR), SPmediated stress response, other horm…”
BackgroundCancer-associated genodermatoses: Skin neoplasms as clues to hereditary tumor syndromes
Ponti, G., Pellacani, G., Seidenari, S., Pollio, A., Muscatello, U., & Tomasi, A. (2012) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2012.07.001 · Cited by 71
Interkingdom Transfer of the Acne-Causing Agent, Propionibacterium acnes, from Human to Grapevine
Campisano, A., Ometto, L., Compant, S., Pancher, M., Antonielli, L., Yousaf, S., Varotto, C., Anfora, G., Pertot, I., Sessitsch, A., et al. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu075 · Cited by 72
A practical guide for the study of human and murine sebaceous glands in situ
Hinde, E., Haslam, I. S., Schneider, M. R., Langan, E. A., Kloepper, J. E., Schramm, C., Zouboulis, C. C., & Paus, R. (2013) · Experimental Dermatology · doi:10.1111/exd.12207 · Cited by 72
Self-citationShields, M. V., Abdullah, L., & Namdari, S. (2016) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2016.01.009 · Cited by 70
Brogden, N. K., Mehalick, L. A., Fischer, C. L., Wertz, P. W., & Brogden, K. A. (2012) · Skin Pharmacology and Physiology · doi:10.1159/000337927 · Cited by 71
Human synthetic sebum formulation and stability under conditions of use and storage
Wertz, P. W. (2009) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2008.00468.x · Cited by 69
Zhang, H., Liao, W., Woon, C. H. A. O., Chen, Q., Hanxiang, Z. E. N. G., Wu, C.-P., Shaoxi, W., & Hon In, H. O. (2008) · The Journal of Dermatology · doi:10.1111/j.1346-8138.2008.00523.x · Cited by 69
Zouboulis, C. C. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.2.7804 · Cited by 77
Self-citationReactions and Products of Squalene and Ozone: A Review
Coffaro, B., & Weisel, C. P. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.1c07611 · Cited by 70
Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors
Uto, Y. (2015) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2015.08.018 · Cited by 70
Metadata
- Authors
- Zouboulis, C. C.
- Affiliations
- Stiftung Charité (DE)
- Corresponding author
- Zouboulis, Christos C.
- Venue
- Clinics in Dermatology
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 22
- Issue
- 5
- Pages
- 360-366
- ISSN
- 0738-081X (ISSN-L)
- OpenAlex
- W2031661874
- Cited by
- 561
- References
- 85
- Citations by year
- 2026: 15 · 2025: 27 · 2024: 21 · 2023: 28 · 2022: 24 · 2021: 30 · 2020: 29 · 2019: 35 · 2018: 22 · 2017: 36 · 2016: 31 · 2015: 19 · 2014: 55 · 2013: 25 · 2012: 19
- FWCI
- 14.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- sebaceous glands, sebum production, androgens, peroxisome proliferator-activated receptors, sebaceous lipids, corticotropin-releasing factor, substance P, Propionibacterium acnes, skin barrier, epidermal differentiation, adrenarche
- MeSH terms
- Acne Vulgaris, Adolescent, Adult, Age Factors, Child, Dermatologic Agents, Humans, Neuropeptides, Sebaceous Glands, Sebum, Cytokines, Inflammation Mediators
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
