A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
Newgard, Christopher B., An, Jie, Bain, James R., Muehlbauer, Michael J., Stevens, Robert D., Lien, Lillian F., Haqq, Andrea M., Shah, Svati H., Arlotto, Michelle, Slentz, Cris A., Rochon, James, Gallup, Dianne, Ilkayeva, Olga, Wenner, Brett R., Yancy, William S., Eisenson, Howard, Musante, Gerald, Surwit, Richard S., Millington, David S., Butler, Mark D., Svetkey, Laura P.·2009·Cell Metabolism
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- Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylationKim, Jeong-Ho, Yoon, Mee-Sup, Chen, Jie · 2009 · Journal of Biological Chemistry
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- Branched-Chain Amino Acids Are Linked with Alzheimer’s Disease-Related Pathology and Cognitive DeficitsSiddik, Md Abu Bakkar, Mullins, Caitlyn A., Kramer, Alyssa, Shah, Harsh, Gannaban, Ritchel B., Zabet-Moghaddam, Masoud, Huebinger, Ryan M., Hegde, Vijay K., MohanKumar, Sheba M. J., MohanKumar, Puliyur S. et al. · 2022 · Cells
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- The Relationship between Physical Activity, Physical Exercise, and Human Gut Microbiota in Healthy and Unhealthy Subjects: A Systematic ReviewCataldi, Stefania, Bonavolontà, Valerio, Poli, Luca, Clemente, Filipe Manuel, De Candia, Michele, Carvutto, Roberto, Silva, Ana Filipa, Badicu, Georgian, Greco, Gianpiero, Fischetti, Francesco · 2022 · Biology
- Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individualsKim, Minkyung, Kim, Minjoo, Kang, Miso, Yoo, Hye Jin, Kim, Min Sun, Ahn, Young-Tae, Sim, Jae-Hun, Jee, Sun Ha, Lee, Jong Ho · 2017 · Food & Function
- Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivityHuffman, Kim M., Slentz, Cris A., Bateman, Lori A., Thompson, Dana, Muehlbauer, Michael J., Bain, James R., Stevens, Robert D., Wenner, Brett R., Kraus, Virginia Byers, Newgard, Christopher B. et al. · 2011 · Diabetes Care
- Optimizing Adult Protein Intake During Catabolic Health ConditionsPhillips, Stuart M, Paddon-Jones, Douglas, Layman, Donald K · 2020 · Advances in Nutrition
- Control of protein and energy intake - brain mechanismsDavidenko, O, Darcel, N, Fromentin, G, Tomé, D · 2013 · European Journal of Clinical Nutrition
- High Insulin Combined With Essential Amino Acids Stimulates Skeletal Muscle Mitochondrial Protein Synthesis While Decreasing Insulin Sensitivity in Healthy HumansRobinson, Matthew M., Soop, Mattias, Sohn, Tae Seo, Morse, Dawn M., Schimke, Jill M., Klaus, Katherine A., Nair, K. Sreekumaran · 2014 · The Journal of Clinical Endocrinology & Metabolism
- A single night of sleep curtailment increases plasma acylcarnitines: Novel insights in the relationship between sleep and insulin resistancevan den Berg, Rosa, Mook-Kanamori, Dennis O., Donga, Esther, van Dijk, Marieke, van Dijk, J. Gert, Lammers, Gert-Jan, van Kralingen, Klaas W., Prehn, Cornelia, Adamski, Jerzy, Romijn, Johannes A. et al. · 2016 · Archives of Biochemistry and Biophysics
- Nutritional Modulation of Insulin ResistanceWeickert, Martin O. · 2012 · Scientifica
- Branched-Chain Amino Acids (Leucine, Isoleucine, and Valine) and Skeletal MuscleGorissen, Stefan H.M., Phillips, Stuart M. · 2019 · Nutrition and Skeletal Muscle
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- The interplay between nonalcoholic fatty liver disease and atherosclerotic cardiovascular diseaseFinney, Alexandra C., Das, Sandeep, Kumar, Dhananjay, McKinney, M. Peyton, Cai, Bishuang, Yurdagul, Arif, Rom, Oren · 2023 · Frontiers in Cardiovascular Medicine
- Associations between plasma branched-chain amino acids, β-aminoisobutyric acid and body compositionRietman, Annemarie, Stanley, Takara L., Clish, Clary, Mootha, Vamsi, Mensink, Marco, Grinspoon, Steven K., Makimura, Hideo · 2016 · Journal of Nutritional Science
- Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulationStephens, Francis B., Mendis, Buddhike, Shannon, Chris E., Cooper, Scott, Ortori, Catharine A., Barrett, David A., Mansell, Peter, Tsintzas, Kostas · 2014 · Clinical Science
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- Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypesNogiec, Christopher, Burkart, Alison, Dreyfuss, Jonathan M., Lerin, Carles, Kasif, Simon, Patti, Mary-Elizabeth · 2015 · Molecular Metabolism
- Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in AdulthoodParker, Daniel, Sloane, Richard, Pieper, Carl F, Hall, Katherine S, Kraus, Virginia B, Kraus, William E, Huebner, Janet L, Ilkayeva, Olga R, Bain, James R, Newby, L Kristin et al. · 2019 · The Journals of Gerontology: Series A
- Asparagine signals mitochondrial respiration and can be targeted to impair tumour growthKrall, Abigail S., Mullen, Peter J., Surjono, Felicia, Momcilovic, Milica, Schmid, Ernst W., Halbrook, Christopher J., Thambundit, Apisadaporn, Mittelman, Steven D., Lyssiotis, Costas A., Shackelford, David B. et al. · 2020
- Efficacy and safety of Obex® in overweight and obese subjects: a randomised, double-blind, placebo-controlled clinical trialCabrera-Rode, Eduardo, Cubas-Dueñas, Ileana, Acosta, Janet Rodríguez, Hernández, Jeddú Cruz, González, Ana Ibis Conesa, Calero, Teresa M. González, Domínguez, Yuri Arnold, Rodríguez, José Hernández, Rodríguez, Antonio D. Reyes, Álvarez Álvarez, Aimee et al. · 2023 · BMC Complementary Medicine and Therapies