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Cytosolic Sensing of Viruses

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Goubau, Delphine, Deddouche, Safia, Reis e Sousa, Caetano·2013·Immunity
DOI 10.1016/j.immuni.2013.05.007
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Abstract

Cells are equipped with mechanisms that allow them to rapidly detect and respond to viruses. These defense mechanisms rely partly on receptors that monitor the cytosol for the presence of atypical nucleic acids associated with virus infection. RIG-I-like receptors detect RNA molecules that are absent from the uninfected host. DNA receptors alert the cell to the abnormal presence of that nucleic acid in the cytosol. Signaling by RNA and DNA receptors results in the induction of restriction factors that prevent virus replication and establish cell-intrinsic antiviral immunity. In light of these formidable obstacles, viruses have evolved mechanisms of evasion, masking nucleic acid structures recognized by the host, sequestering themselves away from the cytosol or targeting host sensors, and signaling adaptors for deactivation or degradation. Here, we detail recent advances in the molecular understanding of cytosolic nucleic acid detection and its evasion by viruses.

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Cited by

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Metadata

Authors
Goubau, D., Deddouche, S., & Reis e Sousa, C.
Venue
Immunity
Publisher
Elsevier BV
Published
2013-05
Volume
38
Issue
5
Pages
855-869
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2013.05.007
OpenAlex
W2063310200
Cited by
843
References
14
FWCI
37.13
Type
journal article
Language
en
Open access
bronze
Licence

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CoChat. (2026). Citation check: Cytosolic Sensing of Viruses. https://app.cochat.ai/papers/10.1016/j.immuni.2013.05.007
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Goubau, D., Deddouche, S., & Reis e Sousa, C. (2013). Cytosolic Sensing of Viruses. Immunity. https://doi.org/10.1016/j.immuni.2013.05.007

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