Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413

Hay fever, hygiene, and household size.

Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

The International IBD Genetics Consortium (IIBDGC), Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., et al. (2012) · Nature · doi:10.1038/nature11582 · Cited by 4,722

Richness of human gut microbiome correlates with metabolic markers

Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413

Lysine acetylation targets protein complexes and co-regulates major cellular functions

Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., & Mann, M. (2009) · Science · doi:10.1126/science.1175371 · Cited by 4,040

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752

The impact of the gut microbiota on human health: an integrative view

Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241

Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides

Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872

Gut Microbiota Metabolism of Dietary Fiber Influences Allergic Airway Disease and Hematopoiesis

Trompette, A., Gollwitzer, E. S., Yadava, K., Sichelstiel, A. K., Sprenger, N., Ngom-Bru, C., Blanchard, C., Junt, T., Nicod, L. P., Harris, N. L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3444 · Cited by 2,862

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22

Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614

Human nutrition, the gut microbiome and the immune system

Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518

The Placenta Harbors a Unique Microbiome

Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428

The role of short chain fatty acids in health and disease

Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425

Bifidobacteria can protect from enteropathogenic infection through production of acetate

Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., et al. (2011) · Nature · doi:10.1038/nature09646 · Cited by 2,387

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368

Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach

Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.

Chang, P. V., Hao, L., Offermanns, S., & Medzhitov, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322269111 · Cited by 2,175

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167

Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases

Simopoulos, A. P. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719248 · Cited by 2,060

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024

Regulation of inflammation by short chain fatty acids

Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724

The asthma epidemic

Eder, W., Ege, M. J., & von Mutius, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054308 · Cited by 1,621

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., & Tsujimoto, G. (2004) · Nature Medicine · doi:10.1038/nm1168 · Cited by 1,580

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

Kimura, I., Ozawa, K., Inoue, D., Imamura, T., Kimura, K., Maeda, T., Terasawa, K., Kashihara, D., Hirano, K., Tani, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms2852 · Cited by 1,512

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., et al. (2012) · Nature · doi:10.1038/nature11228 · Cited by 1,271

Diet, gut microbiota and immune responses

Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261

Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

Chen, L., Fischle, W., Verdin, E. M., & Greene, W. C. (2001) · Science · doi:10.1126/science.1062374 · Cited by 1,231

Family size, infection and atopy: the first decade of the 'hygiene hypothesis'

Strachan, D. (2000) · Thorax · doi:10.1136/thorax.55.suppl_1.s2 · Cited by 1,183

HÆMOSTATIC FUNCTION AND PLATELET POLYUNSATURATED FATTY ACIDS IN ESKIMOS

Dyerberg, J., & Bang, H. O. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91490-9 · Cited by 1,001

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

Zaki, M. H., Boyd, K. L., Vogel, P., Kastan, M. B., Lamkanfi, M., & Kanneganti, T.-D. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.003 · Cited by 989

Deacetylase inhibition promotes the generation and function of regulatory T cells

Tao, R. N., de Zoeten, E. F., Özkaynak, E., Chen, C., Wang, L., Porrett, P. M., Li, B., Turka, L. A., Olson, E. N., Greene, M. I., et al. (2007) · Nature Medicine · doi:10.1038/nm1652 · Cited by 927

Bacteroides thetaiotaomicron and Faecalibacterium prausnitziiinfluence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

Wrzosek, L., Miquel, S., Noordine, M.-L., Bouet, S., Curt, M. J.-C., Robert, V., Philippe, C., Bridonneau, C., Cherbuy, C., Masselot, C. R., et al. (2013) · BMC Biology · doi:10.1186/1741-7007-11-61 · Cited by 863

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

Geuking, M. B., Cahenzli, J., Lawson, M. A. E., Ng, D. C. K., Slack, E., Hapfelmeier, S., McCoy, K. D., & Macpherson, A. J. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.021 · Cited by 840

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

Li, Y., Innocentin, S., Withers, D. R., Roberts, N. A., Gallagher, A., Grigorieva, E. F., Wilhelm, C., & Veldhoen, M. (2011) · Cell · doi:10.1016/j.cell.2011.09.025 · Cited by 837

IgA Response to Symbiotic Bacteria as a Mediator of Gut Homeostasis

Peterson, D. A., McNulty, N. P., Guruge, J. L., & Gordon, J. I. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.09.013 · Cited by 828

Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles

Kiss, E. A., Vonarbourg, C., Kopfmann, S., Hobeika, E., Finke, D., Esser, C., & Diefenbach, A. (2011) · Science · doi:10.1126/science.1214914 · Cited by 801

GPR109A Is a G-protein–Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4466 · Cited by 789

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation

Yan, Y., Jiang, W., Spinetti, T., Tardivel, A., Castillo, R., Bourquin, C., Guarda, G., Tian, Z., Tschopp, J., & Zhou, R. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.015 · Cited by 784

Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation

Harig, J. M., Soergel, K. H., KOMOROWSKI, R. A., & Wood, C. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200105 · Cited by 751

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M. A., Motoike, T., Kedzierski, R. M., & Yanagisawa, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2637002100 · Cited by 745

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

Wlodarska, M., Thaiss, C. A., Nowarski, R., Henao-Mejia, J., Zhang, J.-P., Brown, E. M., Frankel, G., Levy, M., Katz, M. N., Philbrick, W. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.026 · Cited by 708

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

Ichimura, A., Hirasawa, A., Poulain‐Godefroy, O., Bonnefond, A., Hara, T., Yengo, L., Kimura, I., Leloire, A., Liu, N., Iida, K., et al. (2012) · Nature · doi:10.1038/nature10798 · Cited by 662

Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans

Ou, J., Carbonero, F., Zoetendal, E. G., DeLany, J. P., Wang, M., Newton, K., Gaskins, H. R., & O’Keefe, S. J. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.056689 · Cited by 646

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

Shan, M., Gentile, M., Yeiser, J. R., Walland, A. C., Bornstein, V. U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., et al. (2013) · Science · doi:10.1126/science.1237910 · Cited by 642

Twin Study Indicates Loss of Interaction Between Microbiota and Mucosa of Patients With Ulcerative Colitis

Lepage, P., Häsler, R., Spehlmann, M. E., Rehman, A., Žvirblienė, A., Begun, A., Ott, S. J., Kupčinskas, L., Dore, J. M., Raedler, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.011 · Cited by 592

Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E 1 and E 2 production by intestinal myofibroblasts

Willemsen, L. E. M., Koetsier, M. A., van Deventer, S. J. H., & van Tol, E. A. F. (2003) · Gut · doi:10.1136/gut.52.10.1442 · Cited by 518

Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases

Dupaul-Chicoine, J., Yeretssian, G., Doiron, K., Bergstrom, K. S. B., McIntire, C. R., LeBlanc, P. M., Meunier, C., Turbide, C., Gros, P., Beauchemin, N., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.012 · Cited by 517

Does the microbiota regulate immune responses outside the gut?

Noverr, M. C., & Huffnagle, G. B. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.10.008 · Cited by 499

The “Perfect Storm” for Type 1 Diabetes

Vaarala, O., Atkinson, M. A., & Neu, J. (2008) · Diabetes · doi:10.2337/db08-0331 · Cited by 497

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

Herbst, T., Sichelstiel, A., Schär, C., Yadava, K., Bürki, K., Cahenzli, J., McCoy, K., Marsland, B. J., & Harris, N. L. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1574oc · Cited by 440

Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding

Vogt, M. C., Paeger, L., Heß, S., Steculorum, S. M., Awazawa, M., Hampel, B., Neupert, S., Nicholls, H. T., Mauer, J., Hausen, A. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.008 · Cited by 374

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

Normand, S., Delanoye, A., Bressenot, A., Huot, L., Grandjean, T., Peyrin‐Biroulet, L., Lemoine, Y., Hot, D., & Chamaillard, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100981108 · Cited by 374

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

Sapieha, P., Sirinyan, M., Hamel, D., Zaniolo, K., Joyal, J.-S., Cho, J.-H., Honoré, J.-C., Kermorvant-Duchemin, E., Varma, D. R., Tremblay, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1873 · Cited by 359

An Official American Thoracic Society Workshop Report: Obesity and Asthma

Dixon, A. E., Holguín, F., Sood, A., Salome, C. M., Pratley, R. E., Beuther, D. A., Celedon, J. C., & Shore, S. A. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200903-013st · Cited by 352

Dietary Fiber Intake and Mortality in the NIH-AARP Diet and Health Study

Park, Y., Subar, A. F., Hollenbeck, A. R., & Schatzkin, A. G. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.18 · Cited by 344

Inflammatory Bowel Disease as a Model for Translating the Microbiome

Huttenhower, C., Kostic, A. D., & Xavier, R. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.013 · Cited by 332

Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney

Toma, I., Kang, J. J., Sipos, A., Vargas, S., Bansal, E., Hanner, F., Meer, E., & Peti-Peterdi, J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33293 · Cited by 322

Finding the Missing Links among Metabolites, Microbes, and the Host

Dorrestein, P. C., Mazmanian, S. K., & Knight, R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.015 · Cited by 317

Identification of β-Arrestin2 as a G Protein-Coupled Receptor-Stimulated Regulator of NF-κB Pathways

Gao, H., Sun, Y., Wu, Y., Luan, B., Wang, Y., Qu, B., & Pei, G. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00216-3 · Cited by 313

The increase in the prevalence of asthma and allergy: food for thought

Devereux, G. S. (2006) · Nature reviews. Immunology · doi:10.1038/nri1958 · Cited by 309

Trends in Dietary Fiber Intake in the United States, 1999-2008

King, D. E., Mainous, A. G., & Lambourne, C. A. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.01.019 · Cited by 295

A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma

Wood, L. G., Garg, M. L., & Gibson, P. G. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.036 · Cited by 283

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

Lukasova, M., Malaval, C., Gille, A., Kero, J. T., & Offermanns, S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci41651 · Cited by 269

Molecules in focus: Indoleamine 2,3-dioxygenase

King, N. J. C., & Thomas, S. R. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.01.004 · Cited by 265

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

Alenghat, T., Osborne, L. C., Saenz, S. A., Kobuley, D. E., Ziegler, C. G. K., Mullican, S. E., Choi, I., Grunberg, S., Sinha, R., Wynosky-Dolfi, M. A., et al. (2013) · Nature · doi:10.1038/nature12687 · Cited by 255

Manipulating antioxidant intake in asthma: a randomized controlled trial

Wood, L. G., Garg, M. L., Smart, J. M., Scott, H. A., Barker, D., & Gibson, P. G. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.032623 · Cited by 247

Medium-chain Fatty Acid-sensing Receptor, GPR84, Is a Proinflammatory Receptor

Suzuki, M., Takaishi, S., Nagasaki, M., Onozawa, Y., Iino, I., Maeda, H., Komai, T., & Oda, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.420042 · Cited by 234

Effect of diet on asthma and allergic sensitisation in the International Study on Allergies and Asthma in Childhood (ISAAC) Phase Two

Nagel, G., Weinmayr, G., Kleiner, A., García‐Marcos, L., Strachan, D. P., & the ISAAC Phase Two Study Group (2010) · Thorax · doi:10.1136/thx.2009.128256 · Cited by 234

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

Macia, L., Thorburn, A. N., Binge, L. C., Mariño, E., Rogers, K. E., Maslowski, K. M., Vieira, A. T., Kranich, J., & Mackay, C. R. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01080.x · Cited by 227

Anti-Inflammatory Effects of Nicotinic Acid in Human Monocytes Are Mediated by GPR109A Dependent Mechanisms

Digby, J. E., Martínez, F. O., Jefferson, A., Ruparelia, N., Chai, J. T., Wamil, M., Greaves, D. R., & Choudhury, R. P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.241836 · Cited by 222

Treatment of distal ulcerative colitis with short-chain fatty acid enemas a placebo-controlled trial

Scheppach, W. M., & German-Austrian Scfa Study Group (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02071409 · Cited by 204

Asthma and obesity

Boulet, L. ‐. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.04040.x · Cited by 199

Treatment of ulcerative colitis by feeding with germinated barley foodstuff: first report of a multicenter open control trial

Kanauchi, O., Suga, T., Tochihara, M., Hibi∥, T., Naganuma, M., Homma, T., Asakura, H., Nakano, H., Takahama, K., Fujiyama, Y., et al. (2002) · Journal of Gastroenterology · doi:10.1007/bf03326417 · Cited by 194

Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells

Wang, L., de Zoeten, E. F., Greene, M. I., & Hancock, W. W. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd3031 · Cited by 186

Dietary influences on intestinal immunity

Veldhoen, M., & Brucklacher-Waldert, V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3299 · Cited by 167

Obesity and the lung: 4 {middle dot} Obesity and asthma

Sin, D. D., & Sutherland, E. R. (2008) · Thorax · doi:10.1136/thx.2007.086819 · Cited by 147

Investigation of the association between dietary intake, disease severity and airway inflammation in asthma

Berthon, B. S., MacDonald‐Wicks, L. K., Gibson, P. G., & Wood, L. G. (2012) · Respirology · doi:10.1111/resp.12015 · Cited by 146

Fecal Short-Chain Fatty Acids in Children with Inflammatory Bowel Disease

Treem, W. R., Ahsan, N., Shoup, M., & Hyams, J. S. (1994) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199402000-00007 · Cited by 139

Innate immune responses to mycobacteria and the downregulation of atopic responses

Rook, G. A. W., Martinelli, R., & Brunet, L. R. (2003) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200310000-00003 · Cited by 136

Mediterranean Diet as a Protective Factor for Wheezing in Preschool Children

Castro-Rodríguez, J. A., García‐Marcos, L., Rojas, J. D. A., Valverde‐Molina, J., & Sánchez‐Solís, M. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.01.003 · Cited by 127

Mining the human gut microbiota for effector strains that shape the immune system

Ahern, P. P., Faith, J. J., & Gordon, J. I. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.012 · Cited by 123

Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin

Digby, J. E., McNeill, E., Dyar, O. J., Lam, V. K. L., Greaves, D. R., & Choudhury, R. P. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.08.045 · Cited by 122

The role of HCA2 (GPR109A) in regulating macrophage function

Zandi‐Nejad, K., Takakura, A., Jurewicz, M. M., Chandraker, A. K., Offermanns, S., Mount, D. B., & Abdi, R. (2013) · The FASEB Journal · doi:10.1096/fj.12-223933 · Cited by 120

GPR109A as an Anti-Inflammatory Receptor in Retinal Pigment Epithelial Cells and Its Relevance to Diabetic Retinopathy

Gambhir, D., Ananth, S., Veeranan‐Karmegam, R., Elangovan, S., Hester, S., Jennings, E., Offermanns, S., Nussbaum, J. J., Smith, S. B., Thangaraju, M., et al. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8447 · Cited by 113

Obesity and childhood asthma – mechanisms and manifestations

Jensen, M. E., Wood, L. G., & Gibson, P. G. (2012) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e3283508df5 · Cited by 75

A GPR40 Agonist GW9508 Suppresses CCL5, CCL17, and CXCL10 Induction in Keratinocytes and Attenuates Cutaneous Immune Inflammation

Fujita, T., Matsuoka, T., Honda, T., Kabashima, K., Hirata, T., & Narumiya, S. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.123 · Cited by 75

Dietary fiber fraction of germinated barley foodstuff attenuated mucosal damage and diarrhea, and accelerated the repair of the colonic mucosa in an experimental colitis

Kanauchi, O., Iwanaga, T., Andoh, A., Araki, Y., Nakamura, T., Mitsuyama, K., Suzuki, A., Hibi, T., & Bamba, T. (2001) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2001.02427.x · Cited by 69

Metabolites from intestinal microbes shape Treg

Geuking, M. B., McCoy, K. D., & Macpherson, A. J. (2013) · Cell Research · doi:10.1038/cr.2013.125 · Cited by 52

Dietary Cycloinulooligosaccharides Enhance Intestinal Immunoglobulin A Production in Mice

Ishikawa, T., & Nanjo, F. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.80733 · Cited by 38

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Parada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820

Gut microbiota, metabolites and host immunity

Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409

Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications

Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S. J., Berenjian, A., & Ghasemi, Y. (2019) · Foods · doi:10.3390/foods8030092 · Cited by 1,848

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome

De Filippis, F., Pellegrini, N., Vannini, L., Jeffery, I. B., La Storia, A., Laghi, L., Serrazanetti, D. I., Di Cagno, R., Ferrocino, I., Lazzi, C., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309957 · Cited by 1,638

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., Wong, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7734 · Cited by 1,439

Diet, the Gut Microbiome, and Autoimmune Diseases

Mackay, C. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812102-3.00019-1 · Cited by 4

Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

Richards, J. L., Yap, Y. A., McLeod, K. H., Mackay, C. R., & Mariño, E. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.29 · Cited by 250

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

Macia, L., Thorburn, A. N., Binge, L. C., Mariño, E., Rogers, K. E., Maslowski, K. M., Vieira, A. T., Kranich, J., & Mackay, C. R. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01080.x · Cited by 227

The nutrition‐gut microbiome‐physiology axis and allergic diseases

McKenzie, C. I., Tan, J., Macia, L., & Mackay, C. R. (2017) · Immunological Reviews · doi:10.1111/imr.12556 · Cited by 281

Metabolite-Sensing G Protein-Coupled Receptors Connect the Diet-Microbiota-Metabolites Axis to Inflammatory Bowel Disease

Melhem, H., Kaya, B., Ayata, C. K., Hruz, P. L., & Niess, J. H. (2019) · Cells · doi:10.3390/cells8050450 · Cited by 96