The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index; none of the 58 sources its claims cite is checked for support yet.
Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease in U.S. Adults
Open accessAbstract
Background Plant-based diets are recommended for coronary heart disease (CHD) prevention. However, not all plant foods are necessarily beneficial for health. Objectives To examine associations between plant-based diet indices and CHD incidence. Methods We included 73,710 women in Nurses’ Health Study (NHS) (1984–2012), 92,329 women in NHS2 (1991–2013), and 43,259 men in Health Professionals Follow-up Study (1986–2012), free of chronic diseases at baseline. We created an overall plant-based diet index (PDI) from repeated semi quantitative food-frequency questionnaire data, by assigning positive scores to plant foods and reverse scores to animal foods. We also created a healthful PDI (hPDI) where healthy plant foods (whole grains, fruits/vegetables, nuts/legumes, oils, tea/coffee) received positive scores, while less-healthy plant foods (juices/sweetened beverages, refined grains, potatoes/fries, sweets) and animal foods received reverse scores. To create an unhealthful PDI (uPDI), we gave positive scores to less-healthy plant foods and reverse scores to animal and healthy plant foods. Results Over 4,833,042 person-years of follow-up, we documented 8,631 incident CHD cases. In pooled multivariable analysis, higher adherence to PDI was independently inversely associated with CHD (HR comparing extreme deciles: 0.92, 95% CI: 0.83–1.01; p trend=0.003). This inverse association was stronger for hDPI (HR: 0.75, 95% CI: 0.68–0.83; p trend<0.001). Conversely, uPDI was positively associated with CHD (HR: 1.32, 95% CI: 1.20–1.46; p trend<0.001). Conclusions Higher intake of a plant-based diet index rich in healthier plant foods is associated with substantially lower CHD risk, while a plant-based diet index that emphasizes less-healthy plant foods is associated with higher CHD risk.
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TL;DR
In three large US prospective cohorts, greater adherence to an overall plant-based diet index was modestly associated with lower coronary heart disease (CHD) risk, but the association depended on plant food quality. A healthful plant-based diet index was associated with substantially lower CHD risk, whereas an unhealthful plant-based diet index was associated with higher CHD risk.
Key findings
- Over 4,833,042 person-years of follow-up, 8,631 incident CHD cases occurred.
- Higher overall plant-based diet index (PDI) adherence was modestly inversely associated with CHD: HR comparing extreme deciles 0.92 (95% CI 0.83–1.01); p trend=0.003.
- Higher healthful plant-based diet index (hPDI) adherence was more strongly inversely associated with CHD: HR comparing extreme deciles 0.75 (95% CI 0.68–0.83); p trend<0.001.
- Higher unhealthful plant-based diet index (uPDI) adherence was positively associated with CHD: HR comparing extreme deciles 1.32 (95% CI 1.20–1.46); p trend<0.001.
Methods
- Prospective cohort analysis including 73,710 women in Nurses’ Health Study, 92,320 women in NHS2, and 43,259 men in Health Professionals Follow-up Study, free of chronic diseases at baseline.
- Diet was assessed with repeated semi-quantitative food-frequency questionnaires; three indices were created by assigning positive or reverse scores to 18 food groups: PDI, hPDI, and uPDI.
- Cox proportional-hazards regression estimated hazard ratios for CHD by deciles of each index, with cumulative averaging of diet over follow-up; cohort-specific results were pooled using a fixed effects model.
Limitations
- The paper states that measurement error in diet assessment is likely, although cumulative averaging reduces random errors; residual and unmeasured confounding are possible in this observational study, and modest effect sizes such as those for PDI should be interpreted with caution.
- Evident from the text: the study is observational, so causality cannot be established; diet and covariates were largely self-reported.
- Evident from the text: participants were US health professionals, which may limit generalizability to other populations.
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Claims the paper makes
26 Own result · 18 Not checked yet · 7 Own method · 5 Own interpretation
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The results were largely unchanged upon red meat adjustment: [pooled HR for extreme deciles of (PDI, 0.93; 95% CI, 0.84–1.03; p trend=0.01) (hPDI, 0.76; 95% CI, 0.68, 0.84; p trend<0.001) (uPDI, 1.32; 95% CI, 1.19, 1.46; p trend<0.001)]”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
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In the paper
“This inverse association was stronger for hDPI (HR: 0.75, 95% CI: 0.68–0.83; p trend<0.001).”
- Also stated in: § Results · plain
“we found a stronger inverse association between hPDI and CHD incidence (HR comparing extreme deciles: 0.75, 95% CI: 0.68–0.83; HR per 10-unit increase: 0.88, 95% CI: 0.85–0.91; p trend<0.001)”
- Also stated in: § Discussion · boosted
“This inverse association was considerably stronger for adherence to a healthier version (hPDI) [0.75 (0.68–0.83)]”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Abstract > Results
boostedcorrelationaln = 8,631 ·- Asserted: passes — The authors put it forward as true.
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- Also stated in: § Results · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Associations of both indices were significantly stronger among more active relative to less active participants (p interaction=0.002 for both);”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
plaincorrelational- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The association of uPDI with CHD was non-linear (p for test of curvature=0.01; p for non-linear association<0.001) (Central Illustration panel A and Online Figure 1).”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
plaincorrelationaln = 8,631 ·- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Given the previously observed inverse association between fish intake and CHD,(23) we modified hPDI to score fish intake positively, and found similar results (pooled HR for extreme deciles, 0.74; 95% CI, 0.67–0.81; p trend<0.001).”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
plaincorrelational- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The results were slightly attenuated when we modified hPDI to score healthy animal foods positively (dairy except ice cream, egg, and fish) (HR comparing extreme deciles: 0.78, 95% CI: 0.71–0.86; HR per 10-unit increase: 0.91, 95% CI: 0.89–0.94; p trend<0.001).”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“the association of uPDI with CHD was slightly stronger among ever smokers compared with never smokers (p interaction=0.04).”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
plaincorrelational- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“HR per 10-unit increase: 0.93, 95% CI: 0.90–0.97”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
plaincorrelationaln = 8,631 ·- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“HR per 10-unit increase: 0.88, 95% CI: 0.85–0.91”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
plaincorrelationaln = 8,631 ·- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The associations of hPDI and uPDI with risk of CHD were consistently observed across strata defined by age, BMI, family history of CHD, and sex (Figure 1).”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 14
- The quote only partly states this claim. 1
- Probably not a substantial claim. 14
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“When, in place of the indices, we entered variables for the three food categories together into the fully adjusted model, we found an inverse association for healthy plant foods, and positive associations for animal foods and less healthy plant foods (Central Illustration panel B and Online Table 2).”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We found no evidence of deviation from linearity for PDI and hPDI (p for test of curvature>0.20 for both; p for linearity=0.001 for PDI, and <0.001 for hPDI).”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
plainn = 8,631- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
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In the paper
“and changed in expected directions with SSB adjustment [pooled HR for extreme deciles of (PDI, 0.90; 95% CI, 0.81–0.99; p trend=0.001) (hPDI, 0.79; 95% CI, 0.71, 0.88; p trend<0.001) (uPDI, 1.22; 95% CI, 1.10, 1.36; p trend=0.005)]”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Adjustment for additional potential intermediates in the causal pathway, (updated history of hypertension, hypercholesterolemia, and diabetes instead of baseline history) slightly attenuated associations of hPDI and uPDI with CHD [pooled HR for extreme deciles of (PDI, 0.92; 95% CI, 0.83–1.02; p trend=0.003) (hPDI, 0.80; 95% CI, 0.73–0.89; p trend<0.001) (uPDI, 1.24; 95% CI, 1.12, 1.37; p trend=0.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results > Sensitivity analyses
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one. The quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“When we created the plant-based diet indices with quintiles of energy-adjusted food groups (instead of with quintiles of unadjusted food groups as we had originally done), the association of PDI with CHD became slightly stronger, but that of uPDI with CHD was slightly attenuated (Online Table 4).”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results > Sensitivity analyses
plaincorrelational- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“When we examined associations of the three food categories with CHD risk, less healthy plant foods and animal foods were both associated with increased risk, with a potentially stronger association for less healthy plant foods.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Discussion
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“all of which could aid in weight loss/maintenance, enhance glycemic control and insulin regulation, improve lipid profile, reduce blood pressure, improve vascular health, decrease inflammation, and foster more favorable diet- gut microbiome interactions (e.g. through lowered levels of trimethylamine N-oxide), thereby lowering CHD risk.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Discussion
What the sources say
- Not checked yetcites [2] McEvoy, 2012, Vegetarian diets, low-meat diets and health: a review, Public Health Nutr source
- Not checked yetcites [24] Jenkins, 2003, Type 2 diabetes and the vegetarian diet, Am J Clin Nutr source
- Not checked yetcites [25] Hu, 2003, Plant-based foods and prevention of cardiovascular disease: an overview, Am J Clin Nutr source
- Not checked yetcites [26] Jenkins, 2003, Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein, JAMA source
- Not checked yetcites [27] Levine, 2014, Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population, Cell Metab source
- Not checked yetcites [28] Salonen, 1992, High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men, Circulation source
- Not checked yetcites [29] Hunnicutt, 2014, Dietary iron intake and body iron stores are associated with risk of coronary heart disease in a meta-analysis of prospective cohort studies, J Nutr
- Not checked yetcites [30] Tang, 2013, Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk, N Engl J Med source
- Not checked yetcites [31] Baer, 2011, Risk factors for mortality in the Nurses’ Health Study: a competing risks analysis, Am J Epidemiol source
- Not checked yetcites [32] Song, 2016, Association of animal and plant protein intake with all-cause and cause-specific mortality, JAMA Intern Med source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This highlights the wide variation in nutritional quality of plant foods, making it crucial to consider the quality of plant foods consumed in plant-rich diets.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Discussion
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“Dietary recommendations based on the hPDI would also be environmentally sustainable, as plant-based food systems use fewer resources than food systems that are heavily reliant on animal foods.(34)”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Discussion
What the sources say
- Not checked yetcites [34] Pimentel, 2003, Sustainability of meat-based and plant-based diets and the environment, Am J Clin Nutr source
hedgeddirect- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The results of this study are in line with the recently released 2015 Dietary Guidelines for Americans,(33) which recommends higher consumption of high quality plant foods.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Discussion
What the sources say
- Not checked yetcites [33] U.S. Department of Health and Human Services and U.S. Department of Agriculture. 2015–2020 Dietary Guidelines for Americans 2015. Available at: http://health.gov/dietaryguidelines/2015/guidelines/. Accessed June 10, 2017.
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Specifically, greater adherence to hPDI would lead to diets high in dietary fiber, antioxidants, unsaturated fat, and micronutrient content, and low in saturated fat and heme iron content (Online Table 1), all of which could aid in weight loss/maintenance, enhance glycemic control and insulin regulation, improve lipid profile, reduce blood pressure, improve vascular health, decrease inflammation,”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Discussion
hedgeddirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Greater adherence to uPDI, on the other hand, leads to diets with higher glycemic load and index, and added sugar, and lower levels of dietary fiber, unsaturated fats, micronutrients, and antioxidants, which could result in higher CHD risk through the above-mentioned pathways.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Discussion
hedgeddirect- Asserted: passes — The authors put it forward as true.
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What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The proportional hazards assumption was tested by including interaction terms between the indices, and age and calendar year.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Methods > Statistical analysis
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Plant-based diets have been associated with a lower risk of various diseases,(1–3) including coronary heart disease (CHD),(4–9) the leading global cause of death.(10)”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Introduction
What the sources say
- Not checked yetcites [1] Fraser, 2009, Vegetarian diets: what do we know of their effects on common chronic diseases?, Am J Clin Nutr source
- Not checked yetcites [2] McEvoy, 2012, Vegetarian diets, low-meat diets and health: a review, Public Health Nutr source
- Not checked yetcites [3] Martinez-Gonzalez, 2014, A provegetarian food pattern and reduction in total mortality in the Prevencion con Dieta Mediterranea (PREDIMED) study, Am J Clin Nutr source
- Not checked yetcites [4] Huang, 2012, Cardiovascular disease mortality and cancer incidence in vegetarians: a meta-analysis and systematic review, Ann Nutr Metab source
- Not checked yetcites [5] Key, 1999, Mortality in vegetarians and nonvegetarians: detailed findings from a collaborative analysis of 5 prospective studies, Am J Clin Nutr source
- Not checked yetcites [6] Kwok, 2014, Vegetarian diet, Seventh Day Adventists and risk of cardiovascular mortality: a systematic review and meta-analysis, Int J Cardiol source
- Not checked yetcites [7] Orlich, 2013, Vegetarian dietary patterns and mortality in Adventist Health Study 2, JAMA Internal Med source
- Not checked yetcites [8] Crowe, 2013, Am J Clin Nutr source
- Not checked yetcites [9] Fraser, 1995, Effect of risk factor values on lifetime risk of and age at first coronary event: the Adventist Health Study, Am J Epidemiol source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Participants self-reporting newly diagnosed CHD on the biennial questionnaires were asked permission to access their medical records to confirm diagnosis, which was done through blinded review by study physicians.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Methods > Outcome ascertainment
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Indices were cumulatively averaged over follow-up to better capture long-term diet; for instance, for the 2001–2003 risk set, plant-based diet index scores in 1991, 1995, and 1999 were averaged to predict CHD risk”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Methods > Statistical analysis
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Given the previously observed inverse association between fish intake and CHD,(23) we modified hPDI to score fish intake positively, and found similar results”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
What the sources say
- Not checked yetcites [23] Zheng, 2012, Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies, Public Health Nutr source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Because diagnosis of conditions such as type 2 diabetes, stroke, and cancer could change an individual’s diet and potentially be associated with the underlying risk of CHD, we stopped updating diet upon diagnosis of these conditions.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Methods > Statistical analysis
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“However, measurement error in diet assessment is likely, although evaluating cumulatively averaged intake reduces random errors(17) while allowing for the examination of long-term dietary intake.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Discussion > Potential study limitations
What the sources say
- Not checked yetcites [17] Willett, 2013
hedgeddirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“With the exception of a recent investigation,(3) prior studies(4–9) have defined plant-based diets as ‘vegetarian’ diets, which constitute a family of dietary patterns that exclude some or all animal foods.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Introduction
What the sources say
- Not checked yetcites [4] Huang, 2012, Cardiovascular disease mortality and cancer incidence in vegetarians: a meta-analysis and systematic review, Ann Nutr Metab source
- Not checked yetcites [5] Key, 1999, Mortality in vegetarians and nonvegetarians: detailed findings from a collaborative analysis of 5 prospective studies, Am J Clin Nutr source
- Not checked yetcites [6] Kwok, 2014, Vegetarian diet, Seventh Day Adventists and risk of cardiovascular mortality: a systematic review and meta-analysis, Int J Cardiol source
- Not checked yetcites [7] Orlich, 2013, Vegetarian dietary patterns and mortality in Adventist Health Study 2, JAMA Internal Med source
- Not checked yetcites [8] Crowe, 2013, Am J Clin Nutr source
- Not checked yetcites [9] Fraser, 1995, Effect of risk factor values on lifetime risk of and age at first coronary event: the Adventist Health Study, Am J Epidemiol source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“We adjusted for time-varying covariates including smoking status, alcohol intake, physical activity, CHD family history, multivitamin use, aspirin use, energy intake, margarine intake, body mass index (BMI), postmenopausal status and hormone use (women), and oral contraceptive use (NHS2).”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Methods > Statistical analysis
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“The results of this study are in line with the recently released 2015 Dietary Guidelines for Americans,(33) which recommends higher consumption of high quality plant foods.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Discussion
What the sources say
- Not checked yetcites [33] U.S. Department of Health and Human Services and U.S. Department of Agriculture. 2015–2020 Dietary Guidelines for Americans 2015. Available at: http://health.gov/dietaryguidelines/2015/guidelines/. Accessed June 10, 2017.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“In three US cohorts, we previously documented that the PDI was inversely associated with type 2 diabetes risk with a stronger inverse association for hPDI, and a positive association for uPDI(14).”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Introduction
What the sources say
- Not checked yetcites [14] Satija, 2016, Plant-based dietary patterns and incidence of type 2 diabetes in US men and women: results from Three Prospective Cohort Studies, PLoS Med source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The analysis was carried out separately for each cohort, and combined using a fixed effects model; heterogeneity was examined using the Cochrane Q statistic(21) and the I2 statistic.(22)”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Methods > Statistical analysis
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“We additionally adjusted for baseline self-reported hypertension, hypercholesterolemia, and diabetes.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Methods > Statistical analysis
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
The paper relies on this without support.
Recommendations based on incremental dietary changes are easier to adopt.
“As recommendations based on incremental dietary changes are easier to adopt, it is important to understand how gradual reductions in animal food intake with concomitant increases in consumption of plant foods affect cardiovascular health.”
The paper relies on this without support.
CHD has a long etiologic period.
“However, these studies have examined plant-based diets at a single time point, making it difficult to fully capture the association of a time-varying exposure such as diet on the development of CHD which has a long etiologic period.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In addition, a poorly formulated vegan diet can include low-quality plant foods, such as refined carbohydrates and added sugars.22”
From Cardiometabolic Effects of Omnivorous vs Vegan Diets in Identical Twins: A Randomized Clinical Trial (2023) · cites this paper as [22]
The cited source says what the claim attributes to it.
In the citing paper
“Although our findings suggest that vegan diets offer a protective cardiometabolic advantage compared with a healthy, omnivorous diet, excluding all meats and/or dairy products may not be necessary because research22,50 suggests that cardiovascular benefits can be achieved with modest reductions in animal foods and increases in healthy plant-based foods compared with typical diets.”
From Cardiometabolic Effects of Omnivorous vs Vegan Diets in Identical Twins: A Randomized Clinical Trial (2023) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Abstract > Methods
“92,329 women in NHS2 (1991–2013)”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Methods > Study population
“92,320 women in NHS2”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Results
“Animal food intake ranged from 5–6 servings/day in the highest decile to 3–4 servings/day in the lowest decile of the indices.”
§ Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults > Discussion
“those in the lowest decile of PDI consumed 5–6 servings of animal foods per day, while those in the highest decile consumed 3 servings of animal foods per day.”
Citations
Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
The combination of estimates from different experiments
Cochran, W. G. (1954) · Biometrics · doi:10.2307/3001666 · Cited by 5,380
Reproducibility and validity of a semiquantitative food frequency questionnaire
WILLETT, W. C., SAMPSON, L., STAMPFER, M. J., ROSNER, B., BAIN, C., WITSCHI, J., HENNEKENS, C. H., & SPEIZER, F. E. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114086 · Cited by 4,274
Self-citationIntestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,400
Rimm, E. B., Giovannucci, E. L., Stampfer, M. J., Colditz, G. A., Litin, L. B., & Willett, W. C. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116211 · Cited by 2,104
Self-citationWillett, W. C. (2012) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199754038.001.0001 · Cited by 1,754
Self-citationSalonen, J. T., Nyyssönen, K., Korpela, H., Tuomilehto, J., Seppänen, R., & Salonen, R. (1992) · Circulation · doi:10.1161/01.cir.86.3.803 · Cited by 1,284
Satija, A., Bhupathiraju, S. N., Rimm, E. B., Spiegelman, D., Chiuve, S. E., Borgi, L., Willett, W. C., Manson, J. E., Sun, Q., & Hu, F. B. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1002039 · Cited by 1,069
Self-citationSustainability of meat-based and plant-based diets and the environment
Pimentel, D., & Pimentel, M. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.660s · Cited by 1,021
Added sugar intake and cardiovascular diseases mortality among US adults
Yang, Q., Zhang, Z., Gregg, E. W., Flanders, W. D., Merritt, R., & Hu, F. B. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.13563 · Cited by 947
Self-citation
Cited by
Sorted by citations
Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems
Willett, W., Rockström, J., Loken, B., Springmann, M., Lang, T., Vermeulen, S., Garnett, T., Tilman, D., DeClerck, F., Wood, A., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(18)31788-4 · Cited by 10,880
Self-citationArnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., Himmelfarb, C. D., Khera, A., Lloyd-Jones, D., McEvoy, J. W., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000678 · Cited by 4,536
(2019) · doi:10.1161/cir.0000000000000677 · Cited by 4,501
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease
Arnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., Himmelfarb, C. D., Khera, A., Lloyd-Jones, D., McEvoy, J. W., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.010 · Cited by 1,896
Virani, S. S., Newby, L. K., Arnold, S. V., Bittner, V., Brewer, L. C., Demeter, S. H., Dixon, D. L., Fearon, W. F., Hess, B., Johnson, H. M., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001168 · Cited by 1,598
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary
Arnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., Himmelfarb, C. D., Khera, A., Lloyd-Jones, D., McEvoy, J. W., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.009 · Cited by 1,193
Lichtenstein, A. H., Appel, L. J., Vadiveloo, M., Hu, F. B., Kris-Etherton, P. M., Rebholz, C. M., Sacks, F. M., Thorndike, A. N., Van Horn, L., Wylie-Rosett, J., et al. (2021) · Circulation · doi:10.1161/cir.0000000000001031 · Cited by 1,065
Self-citationAsnicar, F., Berry, S. E., Valdes, A. M., Nguyen, L. H., Piccinno, G., Drew, D. A., Leeming, E., Gibson, R., Le Roy, C., Khatib, H. A., et al. (2021) · Nature Medicine · doi:10.1038/s41591-020-01183-8 · Cited by 995
Food based dietary patterns and chronic disease prevention
Schulze, M. B., Martínez‐González, M. Á., Fung, T. T., Lichtenstein, A. H., & Forouhi, N. G. (2018) · BMJ · doi:10.1136/bmj.k2396 · Cited by 620
Virani, S. S., Newby, L. K., Arnold, S. V., Bittner, V., Brewer, L. C., Demeter, S. H., Dixon, D. L., Fearon, W. F., Hess, B., Johnson, H. M., et al. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.04.003 · Cited by 596
Plant-based diets and cardiovascular health
Satija, A., & Hu, F. B. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.02.004 · Cited by 550
Self-citationDietary Strategies for Metabolic Syndrome: A Comprehensive Review
Castro‐Barquero, S., Ruiz-León, A. M., Sierra-Pérez, M., Estruch, R., & Casas, R. M. (2020) · Nutrients · doi:10.3390/nu12102983 · Cited by 530
Lee, K. A., Thomas, A. M., Bolte, L. A., Björk, J. R., de Ruijter, L. K., Armanini, F., Asnicar, F., Blanco-Miguez, A., Board, R., Calbet-Llopart, N., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01695-5 · Cited by 464
Association Between Healthy Eating Patterns and Risk of Cardiovascular Disease
Shan, Z., Li, Y., Baden, M. Y., Bhupathiraju, S. N., Wang, D. D., Sun, Q., Rexrode, K. M., Rimm, E. B., Qi, L., Willett, W. C., et al. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.2176 · Cited by 448
Self-citationKim, H., Caulfield, L. E., Garcia‐Larsen, V., Steffen, L. M., Coresh, J., & Rebholz, C. M. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012865 · Cited by 437
Qian, F., Liu, G., Hu, F. B., Bhupathiraju, S. N., & Sun, Q. (2019) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.2195 · Cited by 366
Self-citationA review of statistical methods for dietary pattern analysis
Zhao, J., Li, Z., Gao, Q., Zhao, H., Chen, S., Huang, L., Wang, W., & Wang, T. (2021) · Nutrition Journal · doi:10.1186/s12937-021-00692-7 · Cited by 343
Lifestyle Strategies for Risk Factor Reduction, Prevention, and Treatment of Cardiovascular Disease
Rippe, J. M. (2018) · American Journal of Lifestyle Medicine · doi:10.1177/1559827618812395 · Cited by 362
Guasch-Ferré, M., Satija, A., Blondin, S. A., Janiszewski, M., Emlen, E., O’Connor, L. E., Campbell, W. W., Hu, F. B., Willett, W. C., & Stampfer, M. J. (2019) · Circulation · doi:10.1161/circulationaha.118.035225 · Cited by 304
Self-citationTen things to know about ten cardiovascular disease risk factors
Bays, H. E., Taub, P. R., Epstein, E., Michos, E. D., Ferraro, R. A., Bailey, A. L., Kelli, H. M., Ferdinand, K. C., Echols, M. R., Weintraub, H., et al. (2021) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2021.100149 · Cited by 274
Plant-Based Diets for Personal, Population, and Planetary Health
Hemler, E. C., & Hu, F. B. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy117 · Cited by 292
Self-citationTrautwein, E. A., & McKay, S. (2020) · Nutrients · doi:10.3390/nu12092671 · Cited by 257
Reducing meat consumption in the USA: a nationally representative survey of attitudes and behaviours
Neff, R., Edwards, D. M., Palmer, A., Ramsing, R., Righter, A., & Wolfson, J. A. (2018) · Public Health Nutrition · doi:10.1017/s1368980017004190 · Cited by 281
Tso, R., & Forde, C. G. (2021) · Nutrients · doi:10.3390/nu13082527 · Cited by 251
Optimal dietary patterns for healthy aging
Tessier, A., Wang, F., Korat, A. V. A., Eliassen, A. H., Chavarro, J. E., Grodstein, F., Li, J., Liang, L., Willett, W. C., Sun, Q., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03570-5 · Cited by 261
Self-citationGroßmann, L., & McClements, D. J. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.10.004 · Cited by 238
Ultra-Processed Foods and Incident Cardiovascular Disease in the Framingham Offspring Study
Juul, F., Vaidean, G., Lin, Y., Deierlein, A. L., & Parekh, N. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.047 · Cited by 227
Changes in Plant-Based Diet Quality and Total and Cause-Specific Mortality
Baden, M. Y., Liu, G., Satija, A., Li, Y., Sun, Q., Fung, T. T., Rimm, E. B., Willett, W. C., Hu, F. B., & Bhupathiraju, S. N. (2019) · Circulation · doi:10.1161/circulationaha.119.041014 · Cited by 241
Self-citationChen, Z., Zuurmond, M. G., van der Schaft, N., Nano, J., Wijnhoven, H. A. H., Ikram, M. A., Franco, O. H., & Voortman, T. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0414-8 · Cited by 238
Wang, Y., Liu, B., Han, H., Hu, Y., Zhu, L., Rimm, E. B., Hu, F. B., & Sun, Q. (2023) · Nutrition Journal · doi:10.1186/s12937-023-00877-2 · Cited by 220
Self-citationDiet strategies for promoting healthy aging and longevity: An epidemiological perspective
Hu, F. B. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13728 · Cited by 241
Self-citationBlue poo: impact of gut transit time on the gut microbiome using a novel marker
Asnicar, F., Leeming, E. R., Dimidi, E., Mazidi, M., Franks, P. W., Khatib, H. A., Valdes, A. M., Davies, R., Bakker, E., Francis, L., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323877 · Cited by 208
Plant-based and vegetarian diets: an overview and definition of these dietary patterns
Hargreaves, S. M., Rosenfeld, D. L., Moreira, A. V. B., & Zandonadi, R. P. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03086-z · Cited by 225
Diet quality and risk and severity of COVID-19: a prospective cohort study
Merino, J., Joshi, A. D., Nguyen, L. H., Leeming, E. R., Mazidi, M., Drew, D. A., Gibson, R., Graham, M. S., Lo, C., Pujol, J. C., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-325353 · Cited by 217
Self-citationPlant-Based Diets and Incident CKD and Kidney Function
Kim, H., Caulfield, L. E., García-Larsen, V., Steffen, L. M., Grams, M. E., Coresh, J., & Rebholz, C. M. (2019) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.12391018 · Cited by 211
Plant-Based Diets for Cardiovascular Disease Prevention: All Plant Foods Are Not Created Equal
Hemler, E. C., & Hu, F. B. (2019) · Current Atherosclerosis Reports · doi:10.1007/s11883-019-0779-5 · Cited by 220
Self-citationThompson, A. S., Tresserra-Rimbau, A., Karavasiloglou, N., Jennings, A., Cantwell, M., Hill, C., Perez-Cornago, A., Bondonno, N. P., Murphy, N., Rohrmann, S., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.4714 · Cited by 203
Gehring, J., Touvier, M., Baudry, J., Julia, C., Buscail, C., Srour, B., Herçberg, S., Péneau, S., Kesse‐Guyot, E., & Allès, B. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa196 · Cited by 227
Vegetarian and vegan diets: benefits and drawbacks
Wang, T., Masedunskas, A., Willett, W. C., & Fontana, L. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad436 · Cited by 222
Self-citationHealthy Plant-Based Diets Are Associated with Lower Risk of All-Cause Mortality in US Adults
Kim, H., Caulfield, L. E., & Rebholz, C. M. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy019 · Cited by 196
A Heart-Healthy Diet for Cardiovascular Disease Prevention: Where Are We Now?
Diab, A., Dastmalchi, L. N., Gulati, M., & Michos, E. D. (2023) · Vascular Health and Risk Management · doi:10.2147/vhrm.s379874 · Cited by 221
Nutritional Status and the Influence of the Vegan Diet on the Gut Microbiota and Human Health
Sakkas, H., Bozidis, P., Touzios, C., Kolios, D., Αθανασίου, Γ., Athanasopoulou, E., Gerou, I., & Gartzonika, C. (2020) · Medicina · doi:10.3390/medicina56020088 · Cited by 175
Dinu, M., Pagliai, G., Angelino, D., Rosi, A., Dall'Asta, M., Bresciani, L., Ferraris, C., Guglielmetti, M., Godos, J., Del Bo', C., et al. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa006 · Cited by 164
van Vliet, S., Bain, J. R., Muehlbauer, M. J., Provenza, F. D., Kronberg, S. L., Pieper, C. F., Huffman, K. M., & Kraus, W. (2021) · Scientific Reports · doi:10.1038/s41598-021-93100-3 · Cited by 185
Long-Term Changes in Gut Microbial Metabolite Trimethylamine N-Oxide and Coronary Heart Disease Risk
Heianza, Y., Ma, W., DiDonato, J. A., Sun, Q., Rimm, E. B., Hu, F. B., Rexrode, K. M., Manson, J. E., & Qi, L. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.11.060 · Cited by 161
Self-citationFermentation for Designing Innovative Plant-Based Meat and Dairy Alternatives
Boukid, F., Hassoun, A., Zouari, A., Tulbek, M. C., Mefleh, M., Aït‐Kaddour, A., & Castellari, M. (2023) · Foods · doi:10.3390/foods12051005 · Cited by 157
Diet Quality Assessment and the Relationship between Diet Quality and Cardiovascular Disease Risk
Petersen, K. S., & Kris‐Etherton, P. M. (2021) · Nutrients · doi:10.3390/nu13124305 · Cited by 175
Eisen, M. B., & Brown, P. O. (2022) · PLOS Climate · doi:10.1371/journal.pclm.0000010 · Cited by 165
Leroy, F., Abraini, F., Beal, T., Domínguez-Salas, P., Gregorini, P., Manzano, P., Rowntree, J. E., & van Vliet, S. (2022) · animal · doi:10.1016/j.animal.2022.100457 · Cited by 147
Metabolically healthy obesity: what–s in a name?
Magkos, F. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz133 · Cited by 148
Fackelmann, G., Manghi, P., Carlino, N., Heidrich, V., Piccinno, G., Ricci, L., Piperni, E., Arrè, A., Bakker, E., Creedon, A. C., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-024-01870-z · Cited by 142
The role of the Mediterranean diet on weight loss and obesity-related diseases
Estruch, R., & Ros, E. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09579-0 · Cited by 153
Islam, S. U., Ahmed, M. B., Ahsan, H., & Lee, Y. S. (2021) · Antioxidants · doi:10.3390/antiox10050784 · Cited by 144
Ten things to know about ten cardiovascular disease risk factors – 2022
Bays, H. E., Agarwala, A., German, C. A., Satish, P., Iluyomade, A., Dudum, R., Thakkar, A., Rifai, M. A., Mehta, A., Thobani, A., et al. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100342 · Cited by 148
Changes in intake of plant-based diets and weight change: Results from 3 prospective cohort studies
Satija, A., Malik, V., Rimm, E. B., Sacks, F., Willett, W., & Hu, F. B. (2019) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz049 · Cited by 131
Self-citationDesmond, M. A., Sobiecki, J. G., Jaworski, M., Płudowski, P., Antoniewicz, J., Shirley, M. K., Eaton, S. D., Książyk, J., Cortina‐Borja, M., Stavola, B. L. D., et al. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa445 · Cited by 134
Characterization of the Degree of Food Processing in Relation With Its Health Potential and Effects
Fardet, A. (2018) · Advances in Food and Nutrition Research · doi:10.1016/bs.afnr.2018.02.002 · Cited by 93
A Fad too Far? Dietary Strategies for the Prevention and Treatment of NAFLD
Moore, M. P., Cunningham, R. P., Dashek, R. J., Mucinski, J. M., & Rector, R. S. (2020) · Obesity · doi:10.1002/oby.22964 · Cited by 131
INTERDISCIPLINARY CLINICAL PRACTICE GUIDELINES "MANAGEMENT OF OBESITY AND ITS COMORBIDITIES"
Dedov, I. I., Shestakova, M. V., Mel'nichenko, G. A., Mazurina, N. V., Andreeva, E. N., Bondarenko, I. Z., Руслановна, Г. З., Dzgoeva, F. K., Елисеев, М. С., Ershova, E. V., et al. (2021) · Obesity and metabolism · doi:10.14341/omet12714 · Cited by 163
Gan, Z. H., Cheong, H. C., Tu, Y., & Kuo, P. (2021) · Nutrients · doi:10.3390/nu13113952 · Cited by 126
Viroli, G., Kalmpourtzidou, Α., & Cena, H. (2023) · Nutrients · doi:10.3390/nu15224723 · Cited by 135
Development of a Danish Adapted Healthy Plant-Based Diet Based on the EAT-Lancet Reference Diet
Lassen, A. D., Christensen, L. M., & Trolle, E. (2020) · Nutrients · doi:10.3390/nu12030738 · Cited by 130
Kim, H., Lee, K., Rebholz, C. M., & Kim, J. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003371 · Cited by 125
A Clinician's Guide to Healthy Eating for Cardiovascular Disease Prevention
Pallazola, V. A., Davis, D. M., Whelton, S. P., Cardoso, R. N., Latina, J. M., Michos, E. D., Sarkar, S., Blumenthal, R. S., Arnett, D. K., Stone, N. J., et al. (2019) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2019.05.001 · Cited by 134
Quek, J., Lim, G., Lim, W. H., Ng, C. H., So, W. Z., Toh, J. Z. K., Pan, X. H., Chin, Y. H., Muthiah, M. D., Chan, S. P., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.756810 · Cited by 128
Chen, H., Shen, J., Xuan, J., Zhu, A., Ji, J. S., Liu, X., Cao, Y., Zong, G., Zeng, Y., Wang, X., et al. (2021) · Nature Aging · doi:10.1038/s43587-022-00180-5 · Cited by 119
Magkos, F., Tetens, I., Bügel, S. G., Felby, C., Schacht, S. R., Hill, J. O., Ravussin, E., & Astrup, A. (2020) · Advances in Nutrition · doi:10.1093/advances/nmz090 · Cited by 119
Association of plant-based diet index with prostate cancer risk
Loeb, S., Fu, B. C., Bauer, S. R., Pernar, C. H., Chan, J. M., Blarigan, E. L. V., Giovannucci, E. L., Kenfield, S. A., & Mucci, L. A. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab365 · Cited by 122
Ultra-processed foods: A new holistic paradigm?
Fardet, A., & Rock, E. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.09.016 · Cited by 130
Cardiometabolic Effects of Omnivorous vs Vegan Diets in Identical Twins: A Randomized Clinical Trial
Landry, M. J., Ward, C. P., Cunanan, K. M., Durand, L. R., Perelman, D., Robinson, J. L., Hennings, T., Koh, L., Dant, C., Zeitlin, A., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.44457 · Cited by 109
Impact of Plant-Based Meat Alternatives on the Gut Microbiota of Consumers: A Real-World Study
Toribio-Mateas, M. A., Bester, A., & Klimenko, N. S. (2021) · Foods · doi:10.3390/foods10092040 · Cited by 118
Emerging factors affecting peri‐implant bone metabolism
Ínsua, Á., Galindo‐Moreno, P., Miron, R. J., Wang, H., & Monje, A. (2023) · Periodontology 2000 · doi:10.1111/prd.12532 · Cited by 119
Heianza, Y., Zhou, T., Sun, D., Hu, F. B., & Qi, L. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.06.018 · Cited by 108
Self-citationEmerging trends in the agri-food sector: Digitalisation and shift to plant-based diets
Hassoun, A., Boukid, F., Pasqualone, A., Bryant, C. J., Garcia‐Garcia, G., Parra-López, C., Jagtap, S., Trollman, H., Cropotova, J., & Barba, F. J. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.11.010 · Cited by 107
Bolte, L. A., Lee, K. A., Björk, J. R., Leeming, E. R., Campmans-Kuijpers, M. J. E., de Haan, J. J., Vila, A. V., Maltez-Thomas, A., Segata, N., Board, R., et al. (2023) · JAMA Oncology · doi:10.1001/jamaoncol.2022.7753 · Cited by 106
Chinese Guideline on the Primary Prevention of Cardiovascular Diseases
Chinese Society of Cardiology of Chinese Medical Association, C. D. P. A. R. C. O. C. A. O. R. M. (2021) · Cardiology Discovery · doi:10.1097/cd9.0000000000000025 · Cited by 109
The Role of Healthy Diets in Environmentally Sustainable Food Systems
Clark, M., Macdiarmid, J. I., Jones, A. D., Ranganathan, J., Herrero, M., & Fanzo, J. (2020) · Food and Nutrition Bulletin · doi:10.1177/0379572120953734 · Cited by 123
Colizzi, C., Harbers, M. C., Vellinga, R. E., Verschuren, W. M. M., Boer, J. M. A., Biesbroek, S., Temme, E. H. M., & van der Schouw, Y. T. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.026318 · Cited by 106
Plant-Based Diets in the Reduction of Body Fat: Physiological Effects and Biochemical Insights
Najjar, R. S., & Feresin, R. G. (2019) · Nutrients · doi:10.3390/nu11112712 · Cited by 115
Healthy dietary patterns and the risk of individual chronic diseases in community-dwelling adults
Shang, X., Liu, J., Zhu, Z., Zhang, X., Huang, Y., Liu, S., Wang, W., Zhang, X., Tang, S., Hu, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42523-9 · Cited by 111
Piperni, E., Nguyen, L. H., Manghi, P., Kim, H., Pasolli, E., Andreu‐Sánchez, S., Arrè, A., Bermingham, K. M., Blanco‐Míguez, A., Manara, S., et al. (2024) · Cell · doi:10.1016/j.cell.2024.06.018 · Cited by 108
The Influence of Metabolic Factors and Diet on Fertility
Łakoma, K., Kukharuk, O., & Śliż, D. (2023) · Nutrients · doi:10.3390/nu15051180 · Cited by 113
Plasma metabolite profiles related to plant-based diets and the risk of type 2 diabetes
Wang, F., Baden, M. Y., Guasch‐Ferré, M., Wittenbecher, C., Li, J., Li, Y., Wan, Y., Bhupathiraju, S. N., Tobias, D. K., Clish, C. B., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05692-8 · Cited by 100
Self-citationQuality of Plant-Based Diet and Risk of Total, Ischemic, and Hemorrhagic Stroke
Baden, M. Y., Shan, Z., Wang, F., Li, Y., Manson, J. E., Rimm, E. B., Willett, W. C., Hu, F. B., & Rexrode, K. M. (2021) · Neurology · doi:10.1212/wnl.0000000000011713 · Cited by 101
Self-citationGastaldello, A., Giampieri, F., Giuseppe, R. D., Grosso, G., Baroni, L., & Battino, M. A. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.07.005 · Cited by 103
Lonnie, M., & Johnstone, A. M. (2020) · Nutrition Bulletin · doi:10.1111/nbu.12453 · Cited by 105
Jafari, S., Hezaveh, E., Jalilpiran, Y., Jayedi, A., Wong, A., Safaiyan, A., & Barzegar, A. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1918628 · Cited by 99
Wang, Y. B., Shivappa, N., Hébert, J. R., Page, A. J., Gill, T. K., & Melaku, Y. A. (2021) · Nutrients · doi:10.3390/nu13051536 · Cited by 95
Belardo, D., Michos, E. D., Blankstein, R., Blumenthal, R. S., Ferdinand, K. C., Hall, K., Klatt, K., Natajaran, P., Ostfeld, R. J., Reddy, K., et al. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100323 · Cited by 90
Plant-Based Nutrition: An Essential Component of Cardiovascular Disease Prevention and Management
Patel, H. N., Chandra, S., Alexander, S., Soble, J. S., & Williams, K. A., Sr. (2017) · Current Cardiology Reports · doi:10.1007/s11886-017-0909-z · Cited by 95
Health and environmental impacts of plant-rich dietary patterns: a US prospective cohort study
Musicus, A. A., Wang, D. D., Janiszewski, M., Eshel, G., Blondin, S. A., Willett, W. C., & Stampfer, M. J. (2022) · The Lancet Planetary Health · doi:10.1016/s2542-5196(22)00243-1 · Cited by 121
Self-citationZhang, S., Dukuzimana, J., Stubbendorff, A., Ericson, U., Borné, Y., & Sonestedt, E. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.02.018 · Cited by 95
Higher adherence to plant-based diets are associated with lower likelihood of fatty liver
Mazidi, M., & Kengne, A. P. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.010 · Cited by 87
Baden, M. Y., Satija, A., Hu, F. B., & Huang, T. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy301 · Cited by 84
Self-citationAssociation of dietary insulinemic potential and colorectal cancer risk in men and women
Tabung, F. K., Wang, W., Fung, T. T., Smith‐Warner, S. A., Keum, N., Wu, K., Fuchs, C. S., Hu, F. B., & Giovannucci, E. L. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy093 · Cited by 83
Self-citationPerspective: Whole and Refined Grains and Health—Evidence Supporting “Make Half Your Grains Whole”
Jones, J. M., Guzmán, C., & Braun, H. J. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz114 · Cited by 90
Sawicki, C. M., Ramesh, G., Bui, L., Nair, N. K., Hu, F. B., Rimm, E. B., Stampfer, M. J., Willett, W. C., & Bhupathiraju, S. N. (2024) · The Lancet Planetary Health · doi:10.1016/s2542-5196(24)00170-0 · Cited by 90
Self-citationGlenn, A. J., Viguiliouk, E., Seider, M., Boucher, B. A., Khan, T. A., Mejía, S. B., Jenkins, D. J. A., Kahleová, H., Rahelić, D., Salas‐Salvadó, J., et al. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00080 · Cited by 89
Salomé, M., Huneau, J., Baron, C. L., Kesse‐Guyot, E., Fouillet, H., & Mariotti, F. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab146 · Cited by 89
Dietary patterns, dietary nutrients and cardiovascular disease
Nestel, P. J., & Mori, T. A. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2301017 · Cited by 95
Metadata
- Authors
- Satija, A., Bhupathiraju, S. N., Spiegelman, D., Chiuve, S. E., Manson, J. E., Willett, W., Rexrode, K. M., Rimm, E. B., & Hu, F. B.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Satija, Ambika
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 70
- Issue
- 4
- Pages
- 411-422
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC5555375
- OpenAlex
- W2735659721
- Semantic Scholar
- 8da1730e179d8b18025a96b300c15dfac3a7f532
- Cited by
- 991
- References
- 36
- Citations by year
- 2026: 107 · 2025: 146 · 2024: 157 · 2023: 133 · 2022: 119 · 2021: 118 · 2020: 110 · 2019: 57 · 2018: 38 · 2017: 6
- FWCI
- 54.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Agriculture
- National Institutes of Health (UM1-CA-176726, UM1-CA167552, CA176726, CA-167552, CA186107)
- National Heart, Lung, and Blood Institute (R01HL060712, R01HL035464, R01HL034594)
- National Cancer Institute (UM1CA176726, UM1CA186107, UM1CA167552)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Physical Sciences › Environmental Science › Ecology › Agriculture Sustainability and Environmental Impact
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- plant-based diet, coronary artery disease, whole grains, fruits and vegetables, legumes and nuts, refined grains, sweetened beverages, animal food, Nurses' Health Study, Health Professionals Follow-up Study, dietary adherence, cardiovascular disease prevention, dietary quality assessment, food frequency questionnaire
- MeSH terms
- Adult, Aged, Coronary Disease, Female, Follow-Up Studies, Forecasting, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, United States, Diet, Vegetarian, Incidence
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