The DOI matches its Crossref record; 495 of the 496 references it cites were found in a registry or an index.
2019 Alzheimer’s disease facts and figures.
Abstract
This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society. The Special Report examines the use of brief cognitive assessments by primary care physicians as a tool for improving early detection of dementia. An estimated 5.8 million Americans have Alzheimer's dementia. By mid‐century, the number of people living with Alzheimer's dementia in the United States may grow to 13.8 million, fueled in large part by the aging baby boom generation. In 2017, official death certificates recorded 121,404 deaths from AD, making AD the sixth leading cause of death in the United States and the fifth leading cause of death among Americans age ≥65 years. Between 2000 and 2017, deaths resulting from stroke, heart disease, and prostate cancer decreased, whereas reported deaths from AD increased 145%. In 2018, more than 16 million family members and other unpaid caregivers provided an estimated 18.5 billion hours of care to people with Alzheimer's or other dementias. This care is valued at nearly $234 billion, but its costs extend to family caregivers' increased risk for emotional distress and negative mental and physical health outcomes. Average per‐person Medicare payments for services to beneficiaries age ≥65 years with Alzheimer's or other dementias are more than three times as great as payments for beneficiaries without these conditions. Total payments in 2019 for health care, long‐term care and hospice services for people age ≥65 years with dementia are estimated to be $290 billion. Early detection of Alzheimer's offers numerous medical, emotional and financial benefits—benefits that accrue to affected individuals and their families as well as to society at large. Alzheimer's Association surveys regarding brief cognitive assessments for detection of dementia found that while a large majority of seniors and primary care physicians say the assessments are important, only half of seniors have received an assessment, and only 16 percent of seniors receive regular cognitive assessments. Many educational opportunities exist to facilitate increased use of brief cognitive assessments in the primary care setting.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“precise identification of FTD and AD, which are the two most common types of dementia in the younger-elderly population (Bang et al., 2015; Association, 2019), is of vital clinical significance in the diagnosis of dementias.”
From Deep Learning-Based Classification and Voxel-Based Visualization of Frontotemporal Dementia and Alzheimer's Disease (2021) · cites this paper as Association, 2019
Citations
Cites
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
ASSESSMENT OF COMA AND IMPAIRED CONSCIOUSNESS
Teasdale, G., & Jennett, B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91639-0 · Cited by 13,215
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Dementia prevention, intervention, and care
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072
International Statistical Classification of Diseases and Related Health Problems
(2010) · Springer eBooks · doi:10.1007/978-0-387-79948-3_3055 · Cited by 4,182
What is cognitive reserve? Theory and research application of the reserve concept
STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Research works printed but not linked: 26
- Grossberg GT, 2010, The art of sharing the diagnosis and management of Alzheimer's disease with patients and caregivers: Recommendations of an expert consensus panel, Prim Care Companion J Clin Psychiatry, 12
- 2015, Cognitive Aging: Progress in Understanding and Opportunity for Action
- Sajeev G, Diabetes. The AlzRisk Database. Alzheimer Research Forum
- Steptoe A, 2005, Aging, Health, and Public Policy
- He W, 2016, International Population Reports, P95/16‐1, An Aging World: 2015
- 2006, Early‐Onset Dementia: A National Challenge, a Future Crisis
- Manly JJ, 2004, Critical perspectives on racial and ethnic differentials in health in late life, 95
- Prince MJ, 2015, World Alzheimer Report 2015: The Global Impact of Dementia: An Analysis of Prevalence
- Ortman JM, 2014, An Aging Nation: The Older Population in the United States, Current Population Reports, P25‐1140
- Heron M, 2018, Deaths: Leading causes for 2016
- Kasper JD, 2014, Disability and Care Needs of Older Americans by Dementia Status: An Analysis of the 2011 National Health and Aging Trends Study
- Maslow K, 2012, Translating Innovation to Impact: Evidence‐Based Interventions to Support People with Alzheimer's Disease and their Caregiver at Home and in the Community
- Zarit SH, 2009, Aging families and caregiving, 131
- Whitlatch CJ, 2018, Meeting the informational, educational, and psychosocial support needs of persons living with dementia and their family caregivers, Gerontologist, 58, S58
- Khatutsky G, 2011, Understanding direct care workers: A snapshot of two of America's most important jobs: Certified nursing assistants and home health aides
- Stone R, 2012, Universal Coverage of Long‐Term Care in the United States: Can We Get There from Here?, 155
- Eldercare Workforce Alliance, 2012, Geriatrics Workforce Shortage: A Looming Crisis for our Families
- National Academies of Sciences, 2016, Engineering, and Medicine. Families Caring for an Aging America
- Eiken S, 2018, Medicaid Expenditures for Long‐Term Services and Supports in FY 2016. IAP Medicaid Innovation Accelerator Program
- Bynum J, 2009, Unpublished; provided under contract with the Alzheimer's Association
- Jacobson G, 2017, Income and Assets of Medicare Beneficiaries, 2016‐2035
- National Association of Insurance Commissioners and the Center for Insurance Policy and Research, 2016, The State of Long‐Term Care Insurance: The Market, Challenges and Future Innovations
- Reaves EL, 2015, Medicaid and Long‐Term Services and Supports: A Primer
- 10.1111/j.1525-1497.2005.0126.x · DOI
- Albert SM, 2010, The MetLife Study of working caregivers and employer health care costs
- Shriver M, 2010, The Shriver Report: A Woman's Nation Takes on Alzheimer's
Cited by
Sorted by citations
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
Long, J. M., & Holtzman, D. M. (2019) · Cell · doi:10.1016/j.cell.2019.09.001 · Cited by 3,204
2021 Alzheimer's disease facts and figures
Anonymous (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12328 · Cited by 2,339
Sex and gender: modifiers of health, disease, and medicine
Mauvais-Jarvis, F., Bairey Merz, N., Barnes, P. J., Brinton, R. D., Carrero, J.-J., DeMeo, D. L., De Vries, G. J., Epperson, C. N., Govindan, R., Klein, S. L., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31561-0 · Cited by 2,001
Diagnosis and Management of Dementia: Review
Arvanitakis, Z., Shah, R. C., & Bennett, D. A. (2019) · JAMA · doi:10.1001/jama.2019.4782 · Cited by 1,561
López, J. A., González, H. M., & Léger, G. C. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00013-3 · Cited by 887
The Epidemiology of Alzheimer's Disease Modifiable Risk Factors and Prevention
Zhang, X.-X., Tian, Y., Wang, Z.-T., Ma, Y.-H., Tan, L., & Yu, J.-T. (2021) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2021.15 · Cited by 789
Alzheimer’s disease: Recent treatment strategies
Vaz, M., & Silvestre, S. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173554 · Cited by 547
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Esfehani, R. J., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 586
Kent, S. A., Spires-Jones, T. L., & Durrant, C. S. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02196-w · Cited by 446
Targa Dias Anastacio, H., Matosin, N., & Ooi, L. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02024-7 · Cited by 401
Alzheimer’s Disease and Vascular Aging
Cortes-Canteli, M., & Iadecola, C. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.10.062 · Cited by 400
Impact of dementia: Health disparities, population trends, care interventions, and economic costs
Aranda, M., Kremer, I. N., Hinton, L., Zissimopoulos, J., Whitmer, R. A., Hummel, C. H., Trejo, L., & Fabius, C. D. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17345 · Cited by 430
Dhapola, R., Hota, S. S., Sarma, P., Bhattacharyya, A., Medhi, B., & Reddy, D. H. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00889-6 · Cited by 383
“Gradually the person becomes bedridden and ultimately leads to death of the Alzheimer’s Association (2019).”
BackgroundBiological aging processes underlying cognitive decline and neurodegenerative disease
Gonzales, M. M., Garbarino, V. R., Pollet, E., Palavicini, J. P., Kellogg, D. L., Kraig, E., & Orr, M. E. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158453 · Cited by 426
Best practices for stress measurement: how to measure psychological stress in health research
Crosswell, A. D., & Lockwood, K. G. (2020) · Health Psychology Open · doi:10.1177/2055102920933072 · Cited by 372
Zhao, J., Fu, Y., Yamazaki, Y., Ren, Y., Davis, M. D., Liu, C.-C., Lu, W., Wang, X., Chen, K., Cherukuri, Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19264-0 · Cited by 374
Ling, Z., Liu, X., Cheng, Y., Yan, X., & Wu, S. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1867054 · Cited by 378
Interpretation of risk loci from genome-wide association studies of Alzheimer's disease
Andrews, S. J., Fulton-Howard, B., & Goate, A. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30435-1 · Cited by 314
Monteiro, A. R., Barbosa, D. J., Remião, F., & Silva, R. V. D. S. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115522 · Cited by 375
Cognitive symptoms of Alzheimer’s disease: clinical management and prevention
Joe, E., & Ringman, J. M. (2019) · BMJ · doi:10.1136/bmj.l6217 · Cited by 339
Neff, R. A., Wang, M., Vatansever, S., Guo, L., Ming, C., Wang, Q., Wang, E., Horgusluoglu-Moloch, E., Song, W.-M., Li, A., et al. (2021) · Science Advances · doi:10.1126/sciadv.abb5398 · Cited by 306
Machine learning identifies candidates for drug repurposing in Alzheimer’s disease
Rodriguez, S., Hug, C., Todorov, P., Moret, N., Boswell, S. A., Evans, K., Zhou, G., Johnson, N. T., Hyman, B. T., Sorger, P. K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21330-0 · Cited by 299
Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation
Jannati, A., Oberman, L. M., Rotenberg, A., & Pascual‐Leone, Á. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01453-8 · Cited by 326
Public Health Challenges and Responses to the Growing Ageing Populations
Khan, H. T. A., Addo, K. M., & Findlay, H. (2024) · Public Health Challenges · doi:10.1002/puh2.213 · Cited by 298
A Deep Siamese Convolution Neural Network for Multi-Class Classification of Alzheimer Disease
Mehmood, A., Maqsood, M., Bashir, M., & Shuyuan, Y. (2020) · Brain Sciences · doi:10.3390/brainsci10020084 · Cited by 264
Pike, K. E., Cavuoto, M. G., Li, L., Wright, B. J., & Kinsella, G. (2021) · Neuropsychology Review · doi:10.1007/s11065-021-09522-3 · Cited by 285
Jiang, H., Cao, P., Ming-yi, X., Yang, J., & Zai͏̈ane, O. R. (2020) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2020.104096 · Cited by 252
Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease
Ling, Z., Zhu, M., Yan, X., Cheng, Y., Shao, L., Liu, X., Jiang, R., & Wu, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.634069 · Cited by 252
Maestú, F., de Haan, W., Busche, M. A., & DeFelipe, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101372 · Cited by 245
Xiong, B., Wang, Y., Chen, Y., Xing, S., Liao, Q., Chen, Y., Li, Q., Li, W., & Sun, H. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00910 · Cited by 232
Wu, L., Han, Y., Zheng, Z., Peng, G., Liu, P., Yue, S., Zhu, S., Chen, J., Lv, H., Shao, L., et al. (2021) · Nutrients · doi:10.3390/nu13010228 · Cited by 227
Jurcău, M. C., Andronie-Cioara, F. L., Jurcău, A., Marcu, F., Ţiț, D. M., Pașcalău, N., & Nistor-Cseppentö, D. C. (2022) · Antioxidants · doi:10.3390/antiox11112167 · Cited by 226
Alzheimer’s Disease: Key Insights from Two Decades of Clinical Trial Failures
Kim, C. K., Lee, Y. R., Ong, L., Gold, M., Kalali, A., & Sarkar, J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215699 · Cited by 241
Azman, K. F., & Zakaria, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126827 · Cited by 244
Olfactory dysfunction in aging and neurodegenerative diseases
Dan, X., Wechter, N., Gray, S., Mohanty, J. G., Croteau, D. L., & Bohr, V. A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101416 · Cited by 238
Neurogenesis in aging and age-related neurodegenerative diseases
Čulig, L., Chu, X., & Bohr, V. A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101636 · Cited by 235
El-Hayek, Y. H., Wiley, R. E., Khoury, C. P., Daya, R. P., Ballard, C., Evans, A. R., Karran, M., Molinuevo, J. L., Norton, M., & Atri, A. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-190426 · Cited by 216
T‐MoCA: A valid phone screen for cognitive impairment in diverse community samples
Katz, M. J., Wang, C., Nester, C. O., Derby, C. A., Zimmerman, M. E., Lipton, R. B., Sliwinski, M. J., & Rabin, L. A. (2021) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1002/dad2.12144 · Cited by 214
Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism
Pilozzi, A. R., Carro, C., & Huang, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010338 · Cited by 261
Blood–Brain Barrier Breakdown in Alzheimer’s Disease: Mechanisms and Targeted Strategies
Alkhalifa, A. E., Al-Ghraiybah, N. F., Odum, J., Shunnarah, J. G., Austin, N., & Kaddoumi, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216288 · Cited by 212
Designing the next-generation clinical care pathway for Alzheimer’s disease
Hampel, H., Au, R., Mattke, S., van der Flier, W. M., Aisen, P., Apostolova, L., Chen, C., Cho, M., De Santi, S., Gao, P., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00269-x · Cited by 191
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208
Subramaniapillai, S., Almey, A., Rajah, M. N., & Einstein, G. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100879 · Cited by 215
Role of reactive oxygen species in the progression of Alzheimer’s disease
Bhatt, S., Puli, L., & Patil, C. R. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.12.004 · Cited by 217
Association of Neighborhood-Level Disadvantage With Alzheimer Disease Neuropathology
Powell, W. R., Buckingham, W. R., Larson, J. L., Vilen, L. H., Yu, M., Salamat, M. S., Bendlin, B. B., Rissman, R. A., & Kind, A. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.7559 · Cited by 211
GABAergic Inhibitory Interneuron Deficits in Alzheimer’s Disease: Implications for Treatment
Xu, Y., Zhao, M., Han, Y., & Zhang, H. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00660 · Cited by 203
Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure
Chen, X., Sun, G., Tian, E., Zhang, M., Davtyan, H., Beach, T. G., Reiman, E. M., Blurton‐Jones, M., Holtzman, D. M., & Shi, Y. (2021) · Advanced Science · doi:10.1002/advs.202101462 · Cited by 200
Early-Onset Alzheimer’s Disease: What Is Missing in Research?
Ayodele, T., Rogaeva, E. A., Kurup, J. T., Beecham, G. W., & Reitz, C. (2021) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-020-01090-y · Cited by 210
Deep learning for Alzheimer's disease diagnosis: A survey
Khojaste-Sarakhsi, M., Haghighi, S. S., Ghomi, S. M. T. F., & Marchiori, E. (2022) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2022.102332 · Cited by 194
Nelson, M. E., Jester, D. J., Petkus, A. J., & Andel, R. (2021) · Neuropsychology Review · doi:10.1007/s11065-021-09478-4 · Cited by 221
Aducanumab: evidence from clinical trial data and controversies
Tampi, R. R., Forester, B. P., & Agronin, M. (2021) · Drugs in Context · doi:10.7573/dic.2021-7-3 · Cited by 190
Deep Learning of Static and Dynamic Brain Functional Networks for Early MCI Detection
Kam, T., Zhang, H., Jiao, Z., & Shen, D. G. (2019) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2019.2928790 · Cited by 196
A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6‐month RCT
Fortier, M., Castellano, C., St‐Pierre, V., Myette‐Côté, É., Langlois, F., Roy, M., Morin, M., Bocti, C., Fülöp, T., Godin, J., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12206 · Cited by 190
The use of neuroimaging techniques in the early and differential diagnosis of dementia
Chouliaras, L., & O’Brien, J. T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02215-8 · Cited by 221
“Dementia, the umbrella term for global cognitive decline causing functional impairment, affects ~55 million people worldwide [1].”
BackgroundAlzheimer’s Disease: The Link Between Amyloid-β and Neurovascular Dysfunction
Solis, E., Hascup, K. N., & Hascup, E. R. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200473 · Cited by 192
Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders
Moradi, S. Z., Momtaz, S., Bayrami, Z., Farzaei, M. H., & Abdollahi, M. R. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00238 · Cited by 187
Knupp, A., Mishra, S., Martinez, R., Braggin, J. E., Szabo, M., Kinoshita, C., Hailey, D. W., Small, S. A., Jayadev, S., & Young, J. E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107719 · Cited by 165
PM2.5 exposure in association with AD-related neuropathology and cognitive outcomes
Thiankhaw, K., Chattipakorn, N., & Chattipakorn, S. C. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118320 · Cited by 180
Intranasal Insulin for Alzheimer’s Disease
Hallschmid, M. (2021) · CNS Drugs · doi:10.1007/s40263-020-00781-x · Cited by 188
Late-onset vs nonmendelian early-onset Alzheimer disease
Reitz, C., Rogaeva, E. A., & Beecham, G. W. (2020) · Neurology Genetics · doi:10.1212/nxg.0000000000000512 · Cited by 184
Promoting Successful Cognitive Aging: A Ten-Year Update
Krivanek, T. J., Gale, S. A., McFeeley, B. M., Nicastri, C. M., & Daffner, K. R. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201462 · Cited by 189
Xie, X., Song, Q., Dai, C., Cui, S., Tang, R., Li, S., Chang, J. K., Li, P., Wang, J., Li, J., et al. (2023) · General Psychiatry · doi:10.1136/gpsych-2023-101143 · Cited by 171
Mitochondrial Dysfunction: Pathophysiology and Mitochondria-Targeted Drug Delivery Approaches
Khan, T., Waseem, R., Zehra, Z., Aiman, A., Bhardwaj, P., Ansari, J., Hassan, M. I., & Islam, A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122657 · Cited by 178
Automatic assessment of Alzheimer’s disease diagnosis based on deep learning techniques
Puente-Castro, A., Fernández-Blanco, E., Pazos, A., & Munteanu, C. R. (2020) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2020.103764 · Cited by 174
Cardiovascular Disease and Alzheimer's Disease: The Heart–Brain Axis
Saeed, A., López, O. L., Cohen, A. D., & Reís, S. E. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.030780 · Cited by 181
“14 Although the pathophysiologic mechanisms for AD have not been fully elucidated, studies link AD with CVD manifested by hypertension 15,16 and intra-and extracranial athero sclerosis and arterio sclerosis.”
BackgroundCerebrospinal Fluid Biomarkers of Alzheimer’s Disease: Current Evidence and Future Perspectives
McGrowder, D. A., Miller, F. G., Vaz, K., Nwokocha, C. R., Wilson-Clarke, C. F., Anderson, M., Brown, J., Anderson-Jackson, L., Williams, L., Latore, L., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11020215 · Cited by 169
The Toxicity and Polymorphism of β-Amyloid Oligomers
Huang, Y., & Liu, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124477 · Cited by 176
Guo, J., Wang, Z., Liu, R., Huang, Y., Zhang, N., & Zhang, R. (2020) · Brain and Behavior · doi:10.1002/brb3.1831 · Cited by 165
Past, present and future role of retinal imaging in neurodegenerative disease
Kashani, A. H., Asanad, S., Chan, J. W., Singer, M., Zhang, J., Sharifi, M., Khansari, M. M., Abdolahi, F., Shi, Y., Biffi, A., et al. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100938 · Cited by 169
Origins, Biology, and Diseases of Tissue Macrophages
Cox, N., Pokrovskii, M. V., Vicario, R., & Geissmann, F. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-111748 · Cited by 171
Arya, A. D., Verma, S. S., Chakarabarti, P., Chakrabarti, T., Elngar, A. A., Kamali, A., & Nami, M. (2023) · Brain Informatics · doi:10.1186/s40708-023-00195-7 · Cited by 161
Drabo, E. F., Barthold, D., Joyce, G., Ferido, P., Chang Chui, H., & Zissimopoulos, J. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.07.005 · Cited by 155
Cognitive impairment in the U.S.: Lifetime risk, age at onset, and years impaired
Hale, J. M., Schneider, D. C., Mehta, N. K., & Myrskylä, M. (2020) · SSM - Population Health · doi:10.1016/j.ssmph.2020.100577 · Cited by 175
Velazquez, R., Ferreira, E., Knowles, S., Fux, C., Rodin, A., Winslow, W., & Oddo, S. (2019) · Aging Cell · doi:10.1111/acel.13037 · Cited by 156
Burtscher, J., Millet, G. P., Place, N., Kayser, B., & Zanou, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126479 · Cited by 164
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota
Qian, X.-H., Song, X.-X., Liu, X.-L., Chen, S.-D., & Tang, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101317 · Cited by 153
Tsapanou, A., Papatriantafyllou, J. D., Yiannopoulou, K. G., Sali, D., Kalligerou, F., Ntanasi, E., Zoi, P., Margioti, E. S., Kamtsadeli, V., Hatzopoulou, M., et al. (2020) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5457 · Cited by 151
Lauterborn, J. C., Scaduto, P., Cox, C. D., Schulmann, A., LYNCH, G. S., Gall, C. M., Keene, C. D., & Limón, A. (2021) · Nature Communications · doi:10.1038/s41467-021-22742-8 · Cited by 149
High prevalence of geriatric syndromes in older adults
Sanford, A. M., Morley, J. E., Berg‐Weger, M., Lundy, J., Little, M. O., Leonard, K., & Malmstrom, T. K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233857 · Cited by 149
Plazas, E., Murillo, M. C. Á., Muñoz-Cendales, D. R., & Suárez, L. E. C. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106126 · Cited by 152
Bhatti, G. K., Reddy, A. P., Reddy, P. H., & Bhatti, J. S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00369 · Cited by 145
CD4+ effector T cells accelerate Alzheimer’s disease in mice
Machhi, J., Yeapuri, P., Lu, Y., Foster, E. G., Chikhale, R. V., Herskovitz, J., Namminga, K. L., Olson, K. E., Abdelmoaty, M. M., Gao, J., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02308-7 · Cited by 148
Guan, H., Liu, Y., Yang, E., Yap, P., Shen, D. G., & Liu, M. (2021) · Medical Image Analysis · doi:10.1016/j.media.2021.102076 · Cited by 153
Cunha, S., Forbes, B., Lobo, J. M. S., & Silva, A. C. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s305851 · Cited by 157
Overview of Transgenic Mouse Models for Alzheimer's Disease
Myers, A., & McGonigle, P. (2019) · Current Protocols in Neuroscience · doi:10.1002/cpns.81 · Cited by 148
The Immunopathogenesis of Alzheimer’s Disease Is Related to the Composition of Gut Microbiota
Leblhuber, F., Ehrlich, D., Steiner, K., Geisler, S., Fuchs, D., Lanser, L., & Kurz, K. (2021) · Nutrients · doi:10.3390/nu13020361 · Cited by 149
Li, M., Wang, N., & Dupre, M. E. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.02.039 · Cited by 142
Polymeric Nanoparticles for Nasal Drug Delivery to the Brain: Relevance to Alzheimer's Disease
Rabiee, N., Ahmadi, S., Afshari, R., Khalaji, S., Rabiee, M., Bagherzadeh, M., Fatahi, Y., Dinarvand, R., Tahriri, M., Tayebi, L., et al. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000076 · Cited by 144
Deep sequence modelling for Alzheimer's disease detection using MRI
Ghahnavieh, A. E., Luo, S., & Chiong, R. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104537 · Cited by 146
Liu, C., Badana, A. N. S., Burgdorf, J., Fabius, C. D., Roth, D. L., & Haley, W. E. (2021) · The Gerontologist · doi:10.1093/geront/gnaa028 · Cited by 136
Estrogen receptors and the aging brain
Maioli, S., Leander, K., Nilsson, P., & Nalvarte, I. (2021) · Essays in Biochemistry · doi:10.1042/ebc20200162 · Cited by 114
Zhou, Y., Chen, Y., He, H., Peng, M., Zeng, M., & Sun, H. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109690 · Cited by 147
Multimodal Data Analysis of Alzheimer's Disease Based on Clustering Evolutionary Random Forest
Bi, X.-A., Hu, X., Wu, H., & Wang, Y. (2020) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2020.2973324 · Cited by 137
Opwonya, J., Doan, D. N. T., Kim, S. G., Kim, J. I., Ku, B. U., Kim, S., Park, S., & Kim, J. U. (2021) · Neuropsychology Review · doi:10.1007/s11065-021-09495-3 · Cited by 156
Koklu, A., Wustoni, S., Musteata, V. E., Ohayon, D., Moser, M., McCulloch, I. A., Nunes, S. P., & Inal, S. (2021) · ACS Nano · doi:10.1021/acsnano.0c09893 · Cited by 133
Alzheimer’s Retinopathy: Seeing Disease in the Eyes
Mirzaei, N., Shi, H., Oviatt, M., Doustar, J., Rentsendorj, A., Fuchs, D.-T. S., Sheyn, J., Black, K. L., Koronyo, Y., & Koronyo‐Hamaoui, M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00921 · Cited by 136
Fitz, N. F., Nam, K. N., Wolfe, C. M., Letronne, F., Playso, B. E., Iordanova, B. E., Kozai, T. D. Y., Biedrzycki, R. J., Kagan, V. E., Tyurina, Y. Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23762-0 · Cited by 129
APOE-amyloid interaction: Therapeutic targets
Wisniewski, T., & Drummond, E. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104784 · Cited by 131
Ma, X., Sun, Z., Han, X., Li, S., Jiang, X., Chen, D., Zhang, J., & Lu, H. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01400 · Cited by 131
Nanomaterials for the treatment and diagnosis of Alzheimer's disease: An overview
Bilal, M., Barani, M., Sabir, F., Rahdar, A., & Kyzas, G. Z. (2020) · NanoImpact · doi:10.1016/j.impact.2020.100251 · Cited by 131
Metadata
- Authors
- Alzheimer's Association
- Corresponding author
- Alzheimer's Association
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2019-03
- Volume
- 15
- Issue
- 3
- Pages
- 321-387
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W4211139529
- Cited by
- 2,461
- References
- 496
- Citations by year
- 2026: 108 · 2025: 214 · 2024: 245 · 2023: 310 · 2022: 357 · 2021: 558 · 2020: 544 · 2019: 120
- FWCI
- 316.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alzheimer s & Dementia (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Geriatrics and Gerontology › Geriatric Care and Nursing Homes
- Keywords
- Alzheimer's disease, dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review