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Cytoplasmic mRNA turnover and ageing

Borbolis, Fivos, Syntichaki, Popi·2015·Mechanisms of Ageing and Development
DOI 10.1016/j.mad.2015.09.006PMC PMC4710634
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  • mRNA is a prime contender for Tier 3 therapies because manipulation of proteins and restoring them to youthful levels holds promise for rejuvenation treatments.

    “Messenger ribonucleic acid (mRNA) is another prime contender for Tier 3 therapies, as the manipulation of proteins and the ability to restore them back to youthful levels also holds great promise for rejuvenation treatments. 59”

    From Three Tiers to biological escape velocity: The quest to outwit aging (2022) · cites this paper as [59]

    The Introduction says mRNA translation and degradation help determine protein levels, and the Concluding remarks suggest that studying mRNA turnover could lead to anti-ageing interventions. The paper does not identify mRNA as a prime contender for “Tier 3” therapies or propose restoring proteins to youthful levels as a rejuvenation treatment. (LLM, conf=0.86)

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Metadata

Authors
Borbolis, F., & Syntichaki, P.
ORCID
Syntichaki, Popi
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
2015-12
Volume
152
Pages
32-42
ISSN
0047-6374
DOI
10.1016/j.mad.2015.09.006
PMC
PMC4710634
Cited by
39
References
13
Language
en
Licence

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

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