cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

IAP proteins: blocking the road to death's door

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IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

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The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases

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Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

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Drug Insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

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Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

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Molecular mechanisms of necroptosis: an ordered cellular explosion

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Regulated necrosis: the expanding network of non-apoptotic cell death pathways

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Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

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Regulation of tumour necrosis factor signalling: live or let die

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Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

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Targeting IAP proteins for therapeutic intervention in cancer

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IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer

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Regulated necrosis: disease relevance and therapeutic opportunities

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RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

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The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

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Hepatocyte Death: A Clear and Present Danger

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Kinase inhibition in autoimmunity and inflammation

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NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

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RIPK1 inhibits ZBP1-driven necroptosis during development

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Survivin and IAP proteins in cell-death mechanisms

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Microglia: Agents of the CNS Pro-Inflammatory Response

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cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

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The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

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CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

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RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

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RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

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The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

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Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade

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XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

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NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

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In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

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IAPs limit activation of RIP kinases by TNF receptor 1 during development

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Poly-ubiquitination in TNFR1-mediated necroptosis

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Ppm1b negatively regulates necroptosis through dephosphorylating Rip3

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cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation

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A20 and cell death-driven inflammation

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A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy

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Non‐apoptotic functions of apoptosis‐regulatory proteins

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TRAF2 is a biologically important necroptosis suppressor

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In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8

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An Atypical E3 Ligase Zinc Finger Protein 91 Stabilizes and Activates NF-κB-inducing Kinase via Lys63-linked Ubiquitination

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PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF

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Small molecule modulators of protein-protein interactions: selected case studies

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Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-α but not through TRAIL and FasL.

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Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases.

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RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice

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Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant

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The API2–MALT1 fusion exploits TNFR pathway-associated RIP1 ubiquitination to promote oncogenic NF-κB signaling

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Protein-Protein Interactions as Drug Targets

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