Cited by 277Opioid Use Disorder TreatmentPain Management and Opioid UseSubstance Abuse Treatment and Outcomes

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The downward spiral of chronic pain, prescription opioid misuse, and addiction: Cognitive, affective, and neuropsychopharmacologic pathways

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Garland, Eric L., Froeliger, Brett, Zeidan, Fadel, Partin, Kaitlyn, Howard, Matthew O.·2013·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2013.08.006PMC PMC3967721

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Abstract

Prescription opioid misuse and addiction among chronic pain patients are emerging public health concerns of considerable significance. Estimates suggest that more than 10% of chronic pain patients misuse opioid analgesics, and the number of fatalities related to nonmedical or inappropriate use of prescription opioids is climbing. Because the prevalence and adverse consequences of this threat are increasing, there is a pressing need for research that identifies the biobehavioral risk chain linking chronic pain, opioid analgesia, and addictive behaviors. To that end, the current manuscript draws upon current neuropsychopharmacologic research to provide a conceptual framework of the downward spiral leading to prescription opioid misuse and addiction among chronic pain patients receiving opioid analgesic pharmacotherapy. Addictive use of opioids is described as the outcome of a cycle initiated by chronic pain and negative affect and reinforced by opioidergic-dopamingeric interactions, leading to attentional hypervigilance for pain and drug cues, dysfunctional connectivity between self-referential and cognitive control networks in the brain, and allostatic dysregulation of stress and reward circuitry. Implications for clinical practice are discussed; multimodal, mindfulness-oriented treatment is introduced as a potentially effective approach to disrupting the downward spiral and facilitating recovery from chronic pain and opioid addiction.

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A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Pain mechanisms: a new theory.
Melzack, R., & Wall, P. D. (1965) · Science · doi:10.1126/science.150.3699.971 · Cited by 11,108
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299
The Self-Medication Hypothesis of Substance Use Disorders: A Reconsideration and Recent Applications
Khantzian, E. J. (1997) · Harvard Review of Psychiatry · doi:10.3109/10673229709030550 · Cited by 3,242
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126
How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective
Hölzel, B. K., Lazar, S. W., Gard, T., Schuman-Olivier, Z., Vago, D. R., & Ott, U. (2011) · Perspectives on Psychological Science · doi:10.1177/1745691611419671 · Cited by 3,024
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Pain mechanisms: A new theory
Melzack, R., & Wall, P. D. (1996) · Pain Forum · doi:10.1016/s1082-3174(96)80062-6 · Cited by 2,786
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757
Interoception: the sense of the physiological condition of the body
(Bud) Craig, A. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00090-4 · Cited by 2,556
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
The role of the basal ganglia in habit formation
Yin, H. H., & Knowlton, B. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1919 · Cited by 2,402
Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration
Thayer, J. F., & Lane, R. D. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.004 · Cited by 2,040
Dissecting components of reward: ‘liking’, ‘wanting’, and learning
Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.014 · Cited by 1,942
The Cerebral Signature for Pain Perception and Its Modulation
Tracey, I., & Mantyh, P. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.012 · Cited by 1,843
Pain and emotion interactions in subregions of the cingulate gyrus
Vogt, B. A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1704 · Cited by 1,810
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717
Habits, Rituals, and the Evaluative Brain
Graybiel, A. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112851 · Cited by 1,697
Pain-related fear is more disabling than pain itself: evidence on the role of pain-related fear in chronic back pain disability
Crombez, G., Vlaeyen, J. W. S., Heuts, P. H. T. G., & Lysens, R. (1999) · Pain · doi:10.1016/s0304-3959(98)00229-2 · Cited by 1,675
Opioids excite dopamine neurons by hyperpolarization of local interneurons
Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637
Psychological therapies for the management of chronic pain (excluding headache) in adults
Williams, A. C. D. C., Eccleston, C., & Morley, S. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007407.pub3 · Cited by 1,634
Behavioral methods for chronic pain and illness
Fordyce, W. E. (1977) · Pain · doi:10.1016/0304-3959(77)90029-x · Cited by 1,630
Mindfulness training modifies subsystems of attention
JHA, A. P., KROMPINGER, J., & BAIME, M. J. (2007) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.7.2.109 · Cited by 1,580
A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes
Tiffany, S. T. (1990) · Psychological Review · doi:10.1037/0033-295x.97.2.147 · Cited by 1,554
A new look at habits and the habit-goal interface.
Wood, W., & Neal, D. T. (2007) · Psychological Review · doi:10.1037/0033-295x.114.4.843 · Cited by 1,470
Addiction and the brain antireward system
Koob, G. F., & Le Moal, M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093548 · Cited by 1,457
Meditation experience is associated with differences in default mode network activity and connectivity
Brewer, J. A., Worhunsky, P. D., Gray, J. R., Tang, Y.-Y., Weber, J., & Kober, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112029108 · Cited by 1,409
Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation
Reynolds, D. V. (1969) · Science · doi:10.1126/science.164.3878.444 · Cited by 1,380
Self-awareness, self-regulation, and self- transcendence (S-ART): a framework for understanding the neurobiological mechanisms of mindfulness
Vago, D. R., & Silbersweig, D. A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00296 · Cited by 1,310
Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference
Farb, N. A. S., Segal, Z. V., Mayberg, H., Bean, J., McKeon, D., Fatima, Z., & Anderson, A. K. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm030 · Cited by 1,307
Acute effects of cocaine on human brain activity and emotion
Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D., Goodman, J. M., Kantor, H. L., Gastfriend, D. R., Riorden, J. P., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80374-8 · Cited by 1,270
From the gate to the neuromatrix
Melzack, R. (1999) · Pain · doi:10.1016/s0304-3959(99)00145-1 · Cited by 1,170
Trends in use of complementary and alternative medicine by US adults: 1997-2002.
Tindle, H. A., Davis, R. B., Phillips, R. S., & Eisenberg, D. M. (2005) · PubMed · Cited by 1,099
Reward Processing by the Opioid System in the Brain
Le Merrer, J., Becker, J. A. J., Befort, K., & Kieffer, B. L. (2009) · Physiological Reviews · doi:10.1152/physrev.00005.2009 · Cited by 1,013
Addiction: A Disease of Learning and Memory
Hyman, S. E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1414 · Cited by 980
Addiction: Beyond dopamine reward circuitry
Volkow, N. D., Wang, G.-J., Fowler, J. S., Tomasi, D., & Telang, F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010654108 · Cited by 959
Descending control of nociception: Specificity, recruitment and plasticity
Heinricher, M. M., Tavares, I., Leith, J. L., & Lumb, B. M. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.009 · Cited by 953
State-dependent opioid control of pain
Fields, H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1431 · Cited by 946
Behavioral Methods for Chronic Pain and Illness
Quimby, C. W. (1976) · Anesthesiology · doi:10.1097/00000542-197610000-00030 · Cited by 866
Nonorganic Physical Signs in Low-Back Pain
Waddell, G., McCulloch, J. A., Kummel, E. G., & Venner, R. M. (1980) · Spine · doi:10.1097/00007632-198003000-00005 · Cited by 841
Guidelines on the irritable bowel syndrome: mechanisms and practical management
Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P., Jones, R., Kumar, D., Rubin, G., Trudgill, N., et al. (2007) · Gut · doi:10.1136/gut.2007.119446 · Cited by 818
Patterns of abuse among unintentional pharmaceutical overdose fatalities
Hall, A. J. (2008) · JAMA · doi:10.1001/jama.2008.802 · Cited by 815
Drug craving and addiction: integrating psychological and neuropsychopharmacological approaches
Franken, I. H. A. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00081-2 · Cited by 805
A common neurobiology for pain and pleasure
Leknes, S., & Tracey, I. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2333 · Cited by 784
Systematic Review: Opioid Treatment for Chronic Back Pain: Prevalence, Efficacy, and Association with Addiction
Martell, B. A., O’Connor, P. G., Kerns, R. D., Becker, W. C., Morales, K. H., Kosten, T. R., & Fiellin, D. A. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-2-200701160-00006 · Cited by 773
Drug Addiction as a Pathology of Staged Neuroplasticity
Kalivas, P. W., & O’Brien, C. P. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301564 · Cited by 761
Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain
Baliki, M. N., Chialvo, D. R., Geha, P. Y., Levy, R. M., Harden, R. N., Parrish, T. B., & Apkarian, A. V. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3576-06.2006 · Cited by 756
Mindfulness-Based Relapse Prevention for Substance Use Disorders: A Pilot Efficacy Trial
Bowen, S., Chawla, N., Collins, S. E., Witkiewitz, K., Hsu, S., Grow, J., Clifasefi, S., Garner, M., Douglass, A., Larimer, M. E., et al. (2009) · Substance Abuse · doi:10.1080/08897070903250084 · Cited by 715
Pain: an overview
Loeser, J. D., & Melzack, R. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01311-2 · Cited by 700
Cognitive-Behavioral Treatment With Adult Alcohol and Illicit Drug Users: A Meta-Analysis of Randomized Controlled Trials
Magill, M., & Ray, L. A. (2009) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2009.70.516 · Cited by 694
Positive emotion regulation and well-being: Comparing the impact of eight savoring and dampening strategies
Quoidbach, J., Berry, E. V., Hansenne, M., & Mikolajczak, M. (2010) · Personality and Individual Differences · doi:10.1016/j.paid.2010.03.048 · Cited by 660
Development and validation of the Current Opioid Misuse Measure
Butler, S. F., Budman, S. H., Fernandez, K. C., Houle, B., Benoit, C., Katz, N., & Jamison, R. N. (2007) · Pain · doi:10.1016/j.pain.2007.01.014 · Cited by 651
Opioids and the treatment of chronic pain: Controversies, current status, and future directions.
Rosenblum, A., Marsch, L. A., Joseph, H., & Portenoy, R. K. (2008) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0013628 · Cited by 648
Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation
Zeidan, F., Martucci, K. T., Kraft, R. A., Gordon, N. S., McHaffie, J. G., & Coghill, R. C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5791-10.2011 · Cited by 640
Self-citation
Brain mechanisms of pain affect and pain modulation
Rainville, P. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00313-6 · Cited by 634
Introduction to Research Topic – Binocular Rivalry: A Gateway to Studying Consciousness
Maier, A., Panagiotaropoulos, T. I., Tsuchiya, N., & Keliris, G. A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00263 · Cited by 632
The influence of negative emotions on pain: Behavioral effects and neural mechanisms
Wiech, K., & Tracey, I. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.059 · Cited by 614
Implicit cognition and addiction: a tool for explaining paradoxical behavior
Stacy, A. W., & Wiers, R. W. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.121208.131444 · Cited by 607
A meta-analytic investigation of the relationship between attentional bias and subjective craving in substance abuse
Field, M., Munafò, M. R., & Franken, I. H. A. (2009) · Psychological Bulletin · doi:10.1037/a0015843 · Cited by 602
Neural correlates of interindividual differences in the subjective experience of pain
Coghill, R. C., McHaffie, J. G., & Yen, Y.-F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1430684100 · Cited by 601
Opioid-induced Hyperalgesia in Humans
Chu, L. F., Angst, M. S., & Clark, J. D. (2008) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31816b2f43 · Cited by 598
What Percentage of Chronic Nonmalignant Pain Patients Exposed to Chronic Opioid Analgesic Therapy Develop Abuse/Addiction and/or Aberrant Drug-Related Behaviors? A Structured Evidence-Based Review
Fishbain, D. A., Cole, B., Lewis, J. E., Rosomoff, H. L., & Rosomoff, R. S. (2007) · Pain Medicine · doi:10.1111/j.1526-4637.2007.00370.x · Cited by 565
Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans
Tracey, I. (2010) · Nature Medicine · doi:10.1038/nm.2229 · Cited by 553
Low Back Pain: A Twentieth Century Health Care Enigma
Waddell, G. (1996) · Spine · doi:10.1097/00007632-199612150-00002 · Cited by 546
Spinal opiate analgesia: Characteristics and principles of action
Yaksh, T. L. (1981) · Pain · doi:10.1016/0304-3959(81)90633-3 · Cited by 542
Neurobiology of opiate abuse
Chiara, G. D., & North, R. A. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90062-b · Cited by 538
Mindfulness-based stress reduction for chronic pain conditions: Variation in treatment outcomes and role of home meditation practice
Rosenzweig, S., Greeson, J. M., Reibel, D. K., Green, J. S., Jasser, S. A., & Beasley, D. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2009.03.010 · Cited by 517
College on Problems of Drug Dependence taskforce on prescription opioid non-medical use and abuse: position statement
Zacny, J. P., Bigelow, G. E., Compton, P. A., Foley, K. M., Iguchi, M. Y., & Sannerud, C. A. (2003) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(03)00003-6 · Cited by 517
Predictors of opioid misuse in patients with chronic pain: a prospective cohort study
Ives, T. J., Chelminski, P. R., Hammett‐Stabler, C. A., Malone, R. M., Perhac, J. S., Potisek, N. M., Shilliday, B. B., DeWalt, D. A., & Pignone, M. P. (2006) · BMC Health Services Research · doi:10.1186/1472-6963-6-46 · Cited by 512
Cognitive-processing bias in chronic pain: a review and integration.
Pincus, T., & Morley, S. (2001) · Psychological Bulletin · doi:10.1037/0033-2909.127.5.599 · Cited by 501
Neurobiological substrates for the dark side of compulsivity in addiction
Koob, G. F. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.043 · Cited by 476
When does acute pain become chronic?
Voscopoulos, C., & Lema, M. (2010) · British Journal of Anaesthesia · doi:10.1093/bja/aeq323 · Cited by 473
The neurobiology of pain
Besson, J. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01313-6 · Cited by 454
Depression, craving, and substance use following a randomized trial of mindfulness-based relapse prevention.
Witkiewitz, K., & Bowen, S. (2010) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0019172 · Cited by 453
Matters of mind: Mindfulness/mindlessness in perspective
Langer, E. J. (1992) · Consciousness and Cognition · doi:10.1016/1053-8100(92)90066-j · Cited by 443
Association Between Mental Health Disorders, Problem Drug Use, and Regular Prescription Opioid Use
Sullivan, M. D., Edlund, M. J., Zhang, L., Unützer, J., & Wells, K. B. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.19.2087 · Cited by 436
Mindfulness training increases momentary positive emotions and reward experience in adults vulnerable to depression: A randomized controlled trial.
Geschwind, N., Peeters, F., Drukker, M., van Os, J., & Wichers, M. (2011) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0024595 · Cited by 433
Mindfulness-oriented recovery enhancement for chronic pain and prescription opioid misuse: Results from an early-stage randomized controlled trial.
Garland, E. L., Manusov, E. G., Froeliger, B., Kelly, A., Williams, J. M., & Howard, M. O. (2014) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0035798 · Cited by 431
Self-citation
Predicting Opioid Misuse by Chronic Pain Patients: A Systematic Review and Literature Synthesis
Turk, D., Swanson, K., & Gatchel, R. (2008) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e31816b1070 · Cited by 416
Pain Processing in the Human Nervous System
Garland, E. L. (2012) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2012.06.013 · Cited by 403
Self-citation
Trends in use of opioids for non-cancer pain conditions 2000–2005 in Commercial and Medicaid insurance plans: The TROUP study
Sullivan, M. D., Edlund, M. J., Fan, M.-Y., DEVRIES, A. R., Braden, J. B., & Martin, B. C. (2008) · Pain · doi:10.1016/j.pain.2008.04.027 · Cited by 377
Mindfulness-based interventions for chronic pain: a systematic review of the evidence
Chiesa, A., & Serretti, A. (2011) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2009.0546 · Cited by 374
Experimental manipulation of attentional bias increases the motivation to drink alcohol
Field, M., & Eastwood, B. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0202-5 · Cited by 347
Untitled work
(2005) · PubMed · Cited by 337
Catastrophizing is associated with pain intensity, psychological distress, and pain-related disability among individuals with chronic pain after spinal cord injury
Turner, J. A., Jensen, M. P., Warms, C. A., & Cardenas, D. D. (2002) · Pain · doi:10.1016/s0304-3959(02)00045-3 · Cited by 333
Addiction related alteration in resting-state brain connectivity
Ma, N., Liu, Y., Li, N., Wang, C.-X., Zhang, H., Jiang, X., Xu, H.-S., Fu, X., Hu, X. P., & Zhang, D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.08.037 · Cited by 329
Default mode network connectivity encodes clinical pain: An arterial spin labeling study
Loggia, M. L., Kim, J., Gollub, R. L., Vangel, M. G., Kirsch, I., Kong, J., Wasan, A. D., & Napadow, V. (2012) · Pain · doi:10.1016/j.pain.2012.07.029 · Cited by 323
Mindfulness Training Modifies Cognitive, Affective, and Physiological Mechanisms Implicated in Alcohol Dependence: Results of a Randomized Controlled Pilot Trial
Garland, E. L., Gaylord, S. A., Boettiger, C. A., & Howard, M. O. (2010) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2010.10400690 · Cited by 319
Self-citation
Prestimulus functional connectivity determines pain perception in humans
Ploner, M., Lee, M., Wiech, K., Bingel, U., & Tracey, I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906186106 · Cited by 311
Prevalence, Correlates, and Comorbidity of Nonmedical Prescription Drug Use and Drug Use Disorders in the United States
Huang, B., Dawson, D. A., Stinson, F. S., Hasin, D. S., Ruan, W. J., Saha, T. D., Smith, S. M. R., Goldstein, R. B., & Grant, B. F. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0708 · Cited by 306
Opioid pharmacology.
Trescot, A. M., Datta, S., Lee, M., & Hansen, H. N. (2008) · PubMed · Cited by 296
Risks for possible and probable opioid misuse among recipients of chronic opioid therapy in commercial and medicaid insurance plans: The TROUP Study
Sullivan, M. D., Edlund, M. J., Fan, M.-Y., DEVRIES, A. R., Braden, J. B., & Martin, B. C. (2010) · Pain · doi:10.1016/j.pain.2010.05.020 · Cited by 289
Mindfulness meditation-related pain relief: evidence for unique brain mechanisms in the regulation of pain
Zeidan, F., Grant, J. A., Brown, C. A., McHaffie, J. G., & Coghill, R. C. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.082 · Cited by 284
Self-citation
Mindfulness training reduces the severity of irritable bowel syndrome in women: Results of a randomized controlled trial
Gaylord, S. A., Palsson, O. S., Garland, E. L., Faurot, K. R., Coble, R. S., Mann, D. J., Frey, W., Leniek, K., & Whitehead, W. E. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.184 · Cited by 281
Self-citation
delta-Opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin
Arvidsson, U., Dado, R. J., Riedl, M. S., Lee, J., Law, P., Hh, L., Elde, R., & Wessendorf, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-02-01215.1995 · Cited by 280
Mindful attention reduces neural and self-reported cue-induced craving in smokers
Westbrook, C., Creswell, J. D., Tabibnia, G., Julson, E., Kober, H., & Tindle, H. A. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr076 · Cited by 278
Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors.
Shippenberg, T. S., Bals-Kubik, R., & Herz, A. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38109-7 · Cited by 275
Neuropsychological consequences of chronic opioid use: a quantitative review and meta-analysis.
Baldacchino, A., Balfour, D. J. K., Passetti, F., Humphris, G., & Matthews, K. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.006 · Cited by 263
Selective attentional bias for pain-related stimuli amongst pain fearful individuals
Keogh, E., Ellery, D., Hunt, C. J., & Hannent, I. (2001) · Pain · doi:10.1016/s0304-3959(00)00422-x · Cited by 253
Affective pictures processing, attention, and pain tolerance
de Wied, M. A., & Verbaten, M. N. (2001) · Pain · doi:10.1016/s0304-3959(00)00400-0 · Cited by 248
The effects of induced mood on laboratory pain.
Zelman, D. C., Howland, E. W., Nichols, S. N., & Cleeland, C. S. (1991) · Pain · doi:10.1016/0304-3959(91)90040-5 · Cited by 247
Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain
Shurman, J., Koob, G. F., & Gutstein, H. B. (2010) · Pain Medicine · doi:10.1111/j.1526-4637.2010.00881.x · Cited by 215
“Mind the Trap”: Mindfulness Practice Reduces Cognitive Rigidity
Greenberg, J., Reiner, K., & Meiran, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036206 · Cited by 214
Therapeutic mechanisms of a mindfulness-based treatment for IBS: effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations.
Garland, E. L., Gaylord, S. A., Palsson, O., Faurot, K., Douglas Mann, J., & Whitehead, W. E. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-011-9391-z · Cited by 210
Self-citation
Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence
Smith, R. J., & Aston-Jones, G. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0191-3 · Cited by 206
Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain
Dellemijn, P. L. I., & Vanneste, J. A. L. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09024-1 · Cited by 205
Psychophysiological stress responses, muscle tension, and neck and shoulder pain among supermarket cashiers.
Lundberg, U., Dohns, I., Bo, M.-L., Sandsjö, L., Palmerud, G., Kadefors, R., Ekström, M., & Parr, D. (1999) · Journal of Occupational Health Psychology · doi:10.1037//1076-8998.4.3.245 · Cited by 204
Estimating the clinical effectiveness of cognitive behavioural therapy in the clinic: Evaluation of a CBT informed pain management programme
Morley, S., Williams, A., & Hussain, S. (2008) · Pain · doi:10.1016/j.pain.2008.02.025 · Cited by 194
Combining fMRI with a Pharmacokinetic Model to Determine Which Brain Areas Activated by Painful Stimulation Are Specifically Modulated by Remifentanil
Wise, R. G. (2002) · NeuroImage · doi:10.1006/nimg.2002.1146 · Cited by 192
The influence of film-induced mood on pain perception
Weisenberg, M., Raz, T., & Hener, T. (1998) · Pain · doi:10.1016/s0304-3959(98)00069-4 · Cited by 190
A review of the effects of opioids on psychomotor and cognitive functioning in humans.
Zacny, J. P. (1995) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.3.4.432 · Cited by 186
Assessment of stress-related psychophysiological reactions in chronic back pain patients.
Flor, H., Turk, D. C., & Birbaumer, N. (1985) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.53.3.354 · Cited by 181
Neuropsychological functioning in methadone maintenance patients versus abstinent heroin abusers
Verdejo‐García, A., Toribio, I., Orozco, C. E. R., Puente, K. L., & Pérez-Garcı́a, M. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.11.006 · Cited by 180
Responsiveness to Drug Cues and Natural Rewards in Opiate Addiction: Associations With Later Heroin Use
Lubman, D. I., Yücel, M., Kettle, J. W. L., Scaffidi, A., MacKenzie, T., Simmons, J. G., & Allen, N. B. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.522 · Cited by 176
Cue-elicited heart rate variability and attentional bias predict alcohol relapse following treatment
Garland, E. L., Franken, I. H. A., & Howard, M. O. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2618-4 · Cited by 170
Self-citation
A possible neural basis for stress-induced hyperalgesia
Martenson, M. E., Cetas, J. S., & Heinricher, M. M. (2009) · Pain · doi:10.1016/j.pain.2009.01.011 · Cited by 164
Opioid abuse and cognitive performance
Mintzer, M. Z., Copersino, M. L., & Stitzer, M. L. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.10.008 · Cited by 154
Issues in Long-term Opioid Therapy: Unmet Needs, Risks, and Solutions
Passik, S. D. (2009) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)60748-9 · Cited by 148
Effects of laughter and relaxation on discomfort thresholds
Cogan, R., Cogan, D. C., Waltz, W., & McCue, M. (1987) · Journal of Behavioral Medicine · doi:10.1007/bf00846422 · Cited by 147
Long term effects of oral sustained release morphine on neuropsychological performance in patients with chronic non-cancer pain
Tassain, V., Attal, N., Fletcher, D., Brasseur, L., Dégieux, P., CHAUVIN, M., & Bouhassira, D. (2003) · Pain · doi:10.1016/s0304-3959(03)00047-2 · Cited by 146
A combined spectroscopic and functional MRI investigation of the dorsal anterior cingulate region in opiate addiction
Yücel, M., Lubman, D. I., Harrison, B. J., Fornito, A., Allen, N. B., Wellard, R. M., Roffel, K., Clarke, K., Wood, S. J., Forman, S. D., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001955 · Cited by 144
Mindfulness-Oriented Recovery Enhancement Reduces Pain Attentional Bias in Chronic Pain Patients
Garland, E. L., & Howard, M. O. (2013) · Psychotherapy and Psychosomatics · doi:10.1159/000348868 · Cited by 141
Self-citation
Neurocognitive correlates of the effects of yoga meditation practice on emotion and cognition: a pilot study
Froeliger, B., Garland, E. L., Modlin, L. A., & McClernon, F. J. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00048 · Cited by 136
Self-citation
Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects
Wanigasekera, V., Lee, M., Rogers, R., Kong, Y., Leknes, S., Andersson, J., & Tracey, I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120201109 · Cited by 136
Functional Magnetic Resonance Imaging Measures of the Effects of Morphine on Central Nervous System Circuitry in Opioid-Naive Healthy Volunteers
Becerra, L. R., Harter, K., González, R. G., & Borsook, D. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000221457.71536.e0 · Cited by 135
Differential Opioid Action on Sensory and Affective Cerebral Pain Processing
Oertel, B., Preibisch, C., Wallenhorst, T., Hummel, T. R., Geißlinger, G., Lanfermann, H., & Lötsch, J. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100441 · Cited by 133
Definitions related to the use of pharmaceutical opioids: Extramedical use, diversion, non‐adherence and aberrant medication‐related behaviours
Larance, B., Degenhardt, L. J., Lintzeris, N., WINSTOCK, A. R., & Mattick, R. P. (2011) · Drug and Alcohol Review · doi:10.1111/j.1465-3362.2010.00283.x · Cited by 132
Gender Differences in Risk Factors for Aberrant Prescription Opioid Use
Jamison, R. N., Butler, S. F., Budman, S. H., Edwards, R. R., & Wasan, A. D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.07.016 · Cited by 132
Possible selves in chronic pain: self-pain enmeshment, adjustment and acceptance
Morley, S., Davies, C., & Barton, S. B. (2005) · Pain · doi:10.1016/j.pain.2005.02.021 · Cited by 127
Pharmacology of opioids in the treatment of chronic pain syndromes
Vallejo, R. (2011) · Pain Physician · doi:10.36076/ppj.2011/14/e343 · Cited by 124
μ-, δ- and κ-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer’s disease patients
Mathieu-Kia, A.-M., Fan, L.-Q., Kreek, M. J., Simon, E. J., & Hiller, J. M. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03302-3 · Cited by 118
Meditation-state functional connectivity (msFC): strengthening of the dorsal attention network and beyond
Froeliger, B., Garland, E. L., Kozink, R. V., Modlin, L. A., Chen, N.-K., McClernon, F. J., Greeson, J. M., & Sobin, P. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/680407 · Cited by 116
Self-citation
Neural Correlates of Chronic Low Back Pain Measured by Arterial Spin Labeling
Wasan, A. D., Loggia, M. L., Chen, L. Q., Napadow, V., Kong, J., & Gollub, R. L. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318220e880 · Cited by 116
Kicking the habit: The neural basis of ingrained behaviors in cocaine addiction
Pierce, R. C., & Vanderschuren, L. J. M. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.007 · Cited by 115
Acute opioid effects on human brain as revealed by functional magnetic resonance imaging
Leppä, M., Korvenoja, A., Carlson, S., Timonen, P., Martinkauppi, S., Ahonen, J., Rosenberg, P. H., Aronen, H. J., & Kalso, E. A. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.019 · Cited by 110
Elevated Pain Sensitivity in Chronic Pain Patients at Risk for Opioid Misuse
Edwards, R. R., Wasan, A. D., Michna, E., Greenbaum, S., Ross, E. L., & Jamison, R. N. (2011) · Journal of Pain · doi:10.1016/j.jpain.2011.02.357 · Cited by 110
Mindfulness is Inversely Associated with Alcohol Attentional Bias Among Recovering Alcohol-Dependent Adults
Garland, E. L., Boettiger, C. A., Gaylord, S., Chanon, V. W., & Howard, M. O. (2012) · Cognitive Therapy and Research · doi:10.1007/s10608-011-9378-7 · Cited by 106
Self-citation
Addressing the intersecting problems of opioid misuse and chronic pain treatment.
Denisco, R. A., Chandler, R. K., & Compton, W. M. (2008) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0013636 · Cited by 104
Cerebral interactions of pain and reward and their relevance for chronic pain
Becker, S., Gandhi, W., & Schweinhardt, P. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.013 · Cited by 103
Abnormal pain response in pain-sensitive opiate addicts after prolonged abstinence predicts increased drug craving
Ren, Z.-Y., Shi, J., Epstein, D. H., Wang, J., & Lu, L. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1472-0 · Cited by 101
Opiate receptor localization in rat cerebral cortex
Lewis, M. E., Pert, A., Pert, C. B., & Herkenham, M. A. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902160310 · Cited by 100
Craving of Prescription Opioids in Patients With Chronic Pain: A Longitudinal Outcomes Trial
Wasan, A. D., Ross, E. L., Michna, E., Chibnik, L. B., Greenfield, S. F., Weiss, R. D., & Jamison, R. N. (2012) · Journal of Pain · doi:10.1016/j.jpain.2011.10.010 · Cited by 100
Selective attentional bias towards pain-related threat in fibromyalgia: preliminary evidence for effects of mindfulness meditation training
Vago, D. R., & Nakamura, Y. (2011) · Cognitive Therapy and Research · doi:10.1007/s10608-011-9391-x · Cited by 93
Electrophysiological evidence that drug cues have greater salience than other affective stimuli in opiate addiction
Lubman, D. I., Allen, N. B., PETERS, L. A., & Deakin, J. F. W. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107083846 · Cited by 93
Attention to pain and fear of pain in patients with chronic pain
Crombez, G., Viane, I., Eccleston, C., Devulder, J., & Goubert, L. (2013) · Journal of Behavioral Medicine · doi:10.1007/s10865-012-9433-1 · Cited by 89
Targeting cognitive-affective risk mechanisms in stress-precipitated alcohol dependence: An integrated, biopsychosocial model of automaticity, allostasis, and addiction
Garland, E. L., Boettiger, C. A., & Howard, M. O. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.02.014 · Cited by 89
Self-citation
Imaging Human Cerebral Pain Modulation by Dose-dependent Opioid Analgesia
Wagner, K. J., Sprenger, T., Kochs, E. F., Tölle, T. R., Valet, M., & Willoch, F. (2007) · Anesthesiology · doi:10.1097/00000542-200703000-00020 · Cited by 84
Nonmedical Prescription Opioid Use and Mental Health and Pain Comorbidities: A Narrative Review
Amari, E., Rehm, J. T., Goldner, E. M., & Fischer, B. (2011) · The Canadian Journal of Psychiatry · doi:10.1177/070674371105600808 · Cited by 82
Attentional biases toward sensory pain words in acute and chronic pain patients.
Haggman, S. P., Sharpe, L. A., Nicholas, M. K., & Refshauge, K. M. (2010) · The Journal of Pain · doi:10.1016/j.jpain.2010.02.017 · Cited by 82
Opioid receptor systems and the endorphins: a review of their spinal organization
Yaksh, T. L. (1987) · Journal of neurosurgery · doi:10.3171/jns.1987.67.2.0157 · Cited by 79
Negative affective pictures can elicit physical symptoms in high habitual symptom reporters
Bogaerts, K., Janssens, T., Peuter, S. D., Diest, I. V., & den Bergh, O. V. (2009) · Psychology and Health · doi:10.1080/08870440902814639 · Cited by 74
Does systemic morphine increase descending inhibitory controls of dorsal horn neurones involved in nociception?
Bars, D. L., Guilbaud, G., Chitour, D., & Besson, J. M. (1980) · Brain Research · doi:10.1016/s0006-8993(80)80050-3 · Cited by 74
Addiction to prescription opioids: Characteristics of the emerging epidemic and treatment with buprenorphine.
Mendelson, J. E., Flower, K., Pletcher, M. J., & Galloway, G. P. (2008) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0013637 · Cited by 74
Do Pain Patients at High Risk for Substance Misuse Experience More Pain?: A Longitudinal Outcomes Study
Jamison, R. N., Link, C. L., & Marceau, L. D. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00679.x · Cited by 73
Increased Affective Bias Revealed Using Experimental Graded Heat Stimuli in Young Depressed Adults: Evidence of “Emotional Allodynia”
Strigo, I. A., Simmons, A. N., Matthews, S. C., Craig, A. D. B., & Paulus, M. P. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181656a48 · Cited by 73
The cognitive effects of opioids in chronic non-cancer pain
KENDALL, S., Sjøgren, P., Pimenta, C. A. D. M., Højsted, J., & Kurita, G. P. (2010) · Pain · doi:10.1016/j.pain.2010.05.012 · Cited by 70
Subjective, psychomotor, and physiological effects of cumulative doses of opioid mu agonists in healthy volunteers.
Walker, D. J., & Zacny, J. P. (1999) · PubMed · Cited by 65
A primer of drug action : a comprehensive guide to the actions, uses, and side effects of psychoactive drugs
Julien, R. M. (2005) · Cited by 65
Attentional bias for prescription opioid cues among opioid dependent chronic pain patients
Garland, E. L., Froeliger, B., Passik, S. D., & Howard, M. O. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-012-9455-8 · Cited by 64
Self-citation
Sympathetic nervous system: contribution to chronic pain.
Jänig, W., & Häbler, H. (2000) · PubMed · Cited by 64
Sympathetic nervous system: contribution to chronic pain
Jänig, W., & Häbler, H. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)80003-5 · Cited by 64
Sex differences in cardiac and autonomic response to clinical and experimental pain in LBP patients
Tousignant‐Laflamme, Y., & Marchand, S. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2005.09.003 · Cited by 64
Drama-Induced Affect and Pain Sensitivity
Zillmann, D., de Wied, M. A., King-Jablonski, C., & Jenzowsky, S. A. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199607000-00006 · Cited by 62
Comparative Cognitive and Subjective Side Effects of Immediate-Release Oxycodone in Healthy Middle-Aged and Older Adults
Cherrier, M. M., Amory, J. K., Ersek, M. T., Risler, L. J., & Shen, D. D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.03.017 · Cited by 58
Sustained attention in patients receiving and abstinent following methadone maintenance treatment for opiate dependence: Performance and neuroimaging results
Prosser, J. M., London, E. D., & GALYNKER, I. I. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.04.022 · Cited by 56
Temporal dimensions of the self-concept: Entrapped and possible selves in chronic pain
Hellström, C. (2001) · Psychology and Health · doi:10.1080/08870440108405493 · Cited by 54
Prescription Drug Abuse: Epidemiology, Regulatory Issues, Chronic Pain Management with Narcotic Analgesics
Manubay, J. M., Muchow, C., & Sullivan, M. A. (2011) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2010.11.006 · Cited by 54
Two brief interventions for acute pain
Bruehl, S. P., Carlson, C. R., & McCubbin, J. A. (1993) · Pain · doi:10.1016/0304-3959(93)90096-8 · Cited by 52
Increased bias to report heat or pain following emotional priming of pain-related fear
Kirwilliam, S. S., & Derbyshire, S. W. G. (2008) · Pain · doi:10.1016/j.pain.2007.08.012 · Cited by 51
Chronic Pain and Addiction: Challenging Co-occurring Disorders
Pohl, M., & Smith, L. (2012) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2012.684621 · Cited by 40
Strategy-dependent Dissociation of the Neural Correlates Involved in Pain Modulation
Lawrence‐Dewar, J. M., Hoeft, F., Sheau, K. E., & Mackey, S. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31822b79ea · Cited by 38
Music and Auditory Distraction Reduce Pain: Emotional or Attentional Effects?
Silvestrini, N., Piguet, V., Cedraschi, C., & Zentner, M. R. (2011) · Music and Medicine · doi:10.1177/1943862111414433 · Cited by 36
Distinguishing Features of Cancer Patients Who Smoke: Pain, Symptom Burden, and Risk for Opioid Misuse
Novy, D. M., Lam, C. Y., Gritz, E. R., Hernández, M., Driver, L., & Koyyalagunta, D. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.07.012 · Cited by 32
Effects of Fentanyl and Low Doses of Alcohol on Neuropsychological Performance in Healthy Subjects
Schneider, U., Bevilacqua, C., Jacobs, R., Karst, M., Dietrich, D. E., Becker, H., Müller‐Vahl, K., Seeland, I., Gielsdorf, D., Schedlowski, M., et al. (1999) · Neuropsychobiology · doi:10.1159/000026558 · Cited by 26
Brain imaging in research on anesthetic mechanisms: studies with propofol
Fiset, P., Plourde, G., & Backman, S. B. (2005) · Progress in brain research · doi:10.1016/s0079-6123(05)50018-9 · Cited by 24
Pain emotion and homeostasis
Panerai, A. E. (2011) · Neurological Sciences · doi:10.1007/s10072-011-0540-5 · Cited by 24
Subjective, Psychomotor, and Physiological Effects of Cumulative Doses of Opioid μ Agonists in Healthy Volunteers
Walker, D. J., & Zacny, J. P. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38292-8 · Cited by 24
Distribution of opioid binding sites in spinal cord
Traynor, J. R., & Wood, M. S. (1987) · Neuropeptides · doi:10.1016/s0143-4179(87)90065-5 · Cited by 22
A Primer of Drug Action: A Comprehensive Guide to the Actions, Uses, and Side Effects of Psychoactive Drugs
Buisman‐Pijlman, F. T. A. (2009) · Drug and Alcohol Review · doi:10.1111/j.1465-3362.2008.00046_2.x · Cited by 21
Strategies to Stop Abuse of Prescribed Opioid Drugs
Wilson, J. F. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-12-200706190-00017 · Cited by 17
Opioid-mediated regulation of A11 diencephalospinal dopamine neurons: Pharmacological evidence of activation by morphine
Pappas, S. S., Kennedy, T., Goudreau, J. L., & Lookingland, K. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.002 · Cited by 16
Molecular Biology of Mu Opioid Receptors
Pan, Y., & Pasternak, G. W. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-993-2_6 · Cited by 16
Mu Opioid Receptor Mediated Analgesia and Reward
Fields, H. L. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-993-2_10 · Cited by 14
Imaging opioid analgesia in the human brain
Lee, M., Wanigasekera, V., & Tracey, I. (2012) · Trends in Anaesthesia and Critical Care · doi:10.1016/j.tacc.2012.07.002 · Cited by 6
Functional connections between self-referential thought and chronic pain: A dysfunctional relationship
Zeidan, F. Z., & Coghill, R. C. (2012) · Pain · doi:10.1016/j.pain.2012.09.014 · Cited by 4
Self-citation
Neural correlates of opioid induced hyperalgesia
Jastrzab, L. E., Mackey, S., Chu, L. F., Stringer, E., & Younger, J. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.01.216 · Cited by 2

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Mindfulness-oriented recovery enhancement for chronic pain and prescription opioid misuse: Results from an early-stage randomized controlled trial.
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Abi‐Dargham, A., Moeller, S. J., Ali, F., DeLorenzo, C., Domschke, K., Horga, G., Jutla, A., Kotov, R., Paulus, M. P., Rubio, J. M., et al. (2023) · World Psychiatry · doi:10.1002/wps.21078 · Cited by 421
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Zeidan, F., & Vago, D. R. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13153 · Cited by 300
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Compton, W. M., Valentino, R. J., & DuPont, R. L. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00949-3 · Cited by 302
A Systematic Review of Black People Coping With Racism: Approaches, Analysis, and Empowerment
Jacob, G., Faber, S. C., Faber, N. S., Bartlett, A., Ouimet, A. J., & Williams, M. T. (2022) · Perspectives on Psychological Science · doi:10.1177/17456916221100509 · Cited by 218

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Authors: Garland, E. L., Froeliger, B., Zeidan, F., Partin, K., & Howard, M. O.
Affiliations: University of Utah (US)
Medical University of South Carolina (US)
Wake Forest University (US)
University of North Carolina at Chapel Hill (US)
Corresponding author: Garland, Eric L.
ORCID: Garland, Eric L.
Froeliger, Brett
Zeidan, Fadel
Howard, Matthew O.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2013-12
Volume: 37
Issue: 10
Pages: 2597-2607
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2013.08.006
PMC: PMC3967721
OpenAlex: W2110728022
Cited by: 277
References: 189
Citations by year: 2026: 14 · 2025: 19 · 2024: 16 · 2023: 21 · 2022: 25 · 2021: 27 · 2020: 47 · 2019: 28 · 2018: 12 · 2017: 22 · 2016: 17 · 2015: 14 · 2014: 15
FWCI: 2.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: Fahs-Beck Fund for Research and Experimentation
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: chronic pain, prescription opioid misuse, opioid use disorder, downward spiral, opioid analgesia, negative affect, opioid-dopamine interaction, drug cue reactivity, cognitive control network, mindfulness-based interventions, multimodal therapy
MeSH terms: Analgesics, Opioid, Cognition Disorders, Humans, Opioid-Related Disorders, Mood Disorders, Chronic Pain, Prescription Drug Misuse

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The downward spiral of chronic pain, prescription opioid misuse, and addiction: Cognitive, affective, and neuropsychopharmacologic pathways

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