Cited by 241Neurogenesis and neuroplasticity mechanismsTreatment of Major DepressionStress Responses and Cortisol

The DOI matches its Crossref record; 195 of the 195 references it cites were found in a registry or an index.

The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?

Open access

Petrik, David, Lagace, Diane C., Eisch, Amelia J.·2012·Neuropharmacology

DOI 10.1016/j.neuropharm.2011.09.003PMC PMC3698048

Open this paper in CoChat — free account

Abstract

Hypotheses are scaffoldings erected in front of a building and then dismantled when the building is finished. They are indispensable for the workman; but you mustn't mistake the scaffolding for the building. Johann Wolfgang von Goethe. The neurogenesis hypothesis of affective disorders - in its simplest form - postulates that the generation of neurons in the postnatal hippocampal dentate gyrus is involved in the etiology and treatment efficacy of major depressive disorder (MDD). The hypothesis was established in the 1990s but was built on a broad foundation of earlier research on the hippocampus, serotonin and MDD. It has gone through several growth phases fueled by discoveries both correlative and causative in nature. Recently, the hypothesis has also been broadened to also include potential relevance for anxiety disorders, like post-traumatic stress disorder (PTSD). As any hypothesis should be, it has been tested and challenged, sometimes vigorously. Here we review the current standing of the neurogenesis hypothesis of affective and anxiety disorders, noting in particular how a central postulate - that decreased neurogenesis results in depression or anxiety - has, in general, been rejected. We also review the controversies on whether treatments for these disorders, like antidepressants, rely on intact neurogenesis for their efficacy, and the existence of neurogenesis-dependent and -independent effects of antidepressants. In addition, we review the implications that the hypothesis has for the response to stress, PTSD, and the neurobiology of resilience, and highlight our own work showing that adult-generated neurons are functionally important for the behavioral response to social stress. We conclude by emphasizing how advancements in transgenic mouse technology, rodent behavioral analyses, and our understanding of the neurogenesis process will allow us to refine our conclusions and perform ever more specific experiments. Such scrutiny is critical, since if we "mistake the scaffolding for the building" we could overlook opportunities for translational impact in the clinic. This article is part of a special Issue entitled 'Anxiety and Depression'.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuropharm.2011.09.003

Cites

0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
Self-citation
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
Tsigos, C., & Chrousos, G. P. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00429-4 · Cited by 2,822 · cited 1×
“In addition, the gastrointestinal, cardiovascular, endocrine, and immune systems are also notably affected (e.g. O’Mahony et al., 2011; Savignac et al., 2011; Tsigos and Chrousos, 2002).”
Background
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 1×
“The social defeat model, for example, is a model of stress-induced social avoidance that produces multiple features of stress susceptibility in approximately half of subjects (Krishnan et al., 2007).”
BackgroundSelf-citation
Learning enhances adult neurogenesis in the hippocampal formation
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999) · Nature Neuroscience · doi:10.1038/6365 · Cited by 2,157
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795
Genetics of Mouse Behavior: Interactions with Laboratory Environment
Crabbe, J. C., Wahlsten, D., & Dudek, B. C. (1999) · Science · doi:10.1126/science.284.5420.1670 · Cited by 1,666
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473
Milestones of neuronal development in the adult hippocampus
Kempermann, G., Jessberger, S., Steiner, B., & Kronenberg, G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.013 · Cited by 1,460
Psychobiology and molecular genetics of resilience
Feder, A., Nestler, E. J., & Charney, D. S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2649 · Cited by 1,272
Irradiation induces neural precursor-cell dysfunction
Monje, M. L., Mizumatsu, S., Fike, J. R., & Palmer, T. D. (2002) · Nature Medicine · doi:10.1038/nm749 · Cited by 1,271
Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267
The ascent of mouse: advances in modelling human depression and anxiety
Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
Czéh, B., Michaelis, T., Watanabe, T., Frahm, J., de Biurrun, G., van Kampen, M., Bartolomucci, A., & Fuchs, E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211427898 · Cited by 1,114
Cognitive Enhancers as Adjuncts to Psychotherapy: Use of D-Cycloserine in Phobic Individuals to Facilitate Extinctionof Fear
Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1136 · Cited by 1,063
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., & Kageyama, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2185 · Cited by 1,054
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
Saxe, M. D., Battaglia, F., Wang, J.-W., Malleret, G., David, D. J., Monckton, J. E., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., Santarelli, L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607207103 · Cited by 1,020
Are New Neurons Formed in the Brains of Adult Mammals?
Altman, J. (1962) · Science · doi:10.1126/science.135.3509.1127 · Cited by 975
Adult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971
Adult brain neurogenesis and psychiatry: a novel theory of depression
Jacobs, B. L., van Praag, H., & Gage, F. H. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000712 · Cited by 964
Learning under stress: how does it work?
Joëls, M., Pu, Z., Wiegert, O., Oitzl, M. S., & Krugers, H. J. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.02.002 · Cited by 947
The GABAergic deficit hypothesis of major depressive disorder
Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934
Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
Kee, N., Teixeira, C. M., Wang, A. H., & Frankland, P. W. (2007) · Nature Neuroscience · doi:10.1038/nn1847 · Cited by 875
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning
Shors, T. J., Townsend, D. A., Zhao, M., Kozorovitskiy, Y., & Gould, E. (2002) · Hippocampus · doi:10.1002/hipo.10103 · Cited by 853
Stress and hippocampal neurogenesis
Gould, E., & Tanapat, P. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00247-4 · Cited by 818
Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment
Malberg, J. E., & Duman, R. S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300234 · Cited by 815
Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
Warner‐Schmidt, J. L., & Duman, R. S. (2006) · Hippocampus · doi:10.1002/hipo.20156 · Cited by 787
Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests1Published on the World Wide Web on 2 December 1998.1
Crawley, J. N. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01258-x · Cited by 772
Increased neurogenesis in a model of electroconvulsive therapy
Madsen, T. M., Treschow, A., Bengzon, J., Bolwig, T. G., Lindvall, O., & Tingström, A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00228-6 · Cited by 765
Radiation-Induced Cognitive Impairments are Associated with Changes in Indicators of Hippocampal Neurogenesis
Raber, J., Rola, R., LeFevour, A., Morhardt, D. R., Curley, J., Mizumatsu, S., VandenBerg, S. R., & Fike, J. R. (2004) · Radiation Research · doi:10.1667/rr3206 · Cited by 721
Limbic-frontal circuitry in major depression: a path modeling metanalysis
Seminowicz, D. A., Mayberg, H. S., McIntosh, A. R., Goldapple, K., Kennedy, S., Segal, Z., & Rafi-Tari, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.015 · Cited by 710
How widespread is adult neurogenesis in mammals?
Gould, E. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2147 · Cited by 687
Antidepressants increase neural progenitor cells in the human hippocampus
Boldrini, M., Underwood, M. D., Hen, R., Rosoklija, G. B., Dwork, A. J., John Mann, J., & Arango, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.75 · Cited by 686
Untitled work
(2000) · PubMed · Cited by 685
Posttraumatic stress disorder: a state-of-the-science review
Nemeroff, C. B., Bremner, J. D., Foa, E. B., Mayberg, H. S., North, C. S., & Stein, M. B. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.07.005 · Cited by 675
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
Schmidt, H. D., & Duman, R. S. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee2aa8 · Cited by 662
Extreme sensitivity of adult neurogenesis to low doses of X-irradiation.
Mizumatsu, S., Monje, M., Morhardt, D. R., Rola, R., Palmer, T. D., & Fike, J. R. (2003) · PubMed · Cited by 658
Adrenal hormones suppress cell division in the adult rat dentate gyrus
Gould, E., Cameron, H. A., Daniels, D., Woolley, C. S., & McEwen, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03642.1992 · Cited by 652
Neural plasticity to stress and antidepressant treatment
Duman, R. S., Malberg, J. E., & Thome, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00177-8 · Cited by 648
Fluoxetine targets early progenitor cells in the adult brain
Encinas, J. M., Vaahtokari, A., & Enikolopov, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601992103 · Cited by 637
TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
Li, Y., Luikart, B. W., Birnbaum, S., Chen, J., Kwon, C.-H., Kernie, S. G., Bassel-Duby, R., & Parada, L. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.023 · Cited by 634
Effects of Adult Neurogenesis on Synaptic Plasticity in the Rat Dentate Gyrus
Snyder, J. S., Kee, N., & Wojtowicz, J. M. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2423 · Cited by 633
Neural stem cell proliferation is decreased in schizophrenia, but not in depression
Reif, A., Fritzen, S., Finger, M., Strobel, A., Lauer, M., Schmitt, A., & Lesch, K.-P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001791 · Cited by 630
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621
The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling
Bessa, J. M., Ferreira, D., Melo, I., Marques, F., Cerqueira, J. J., Palha, J. A., Almeida, O. F. X., & Sousa, N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.119 · Cited by 598 · cited 9×
“As shown in Table 1, there are currently 21 publications that have examined the depression- and anxiety-related behavioral consequences of decreasing neurogenesis in laboratory animals (Airan et al., 2007; Bessa et al., 2009; David et al., 2009; Fuss et al., 2010a; Holick et al., 2008; Jayatissa et al., 2009; Lagace e…”
BackgroundMethodInfluential
The Hippocampal Formation in Schizophrenia
Tamminga, C. A., Stan, A. D., & Wagner, A. D. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09081187 · Cited by 597
Association of depression with medical illness: Does cortisol play a role?
Brown, E. S., Varghese, F. P., & McEwen, B. S. (2004) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00473-6 · Cited by 578 · cited 1×
“…anxiety disorders involve dysregulation of neurotransmitters (especially monoamines and serotonin) or neuropeptides; of the endocrine system (especially corticosteroid signaling); or of inflammatory responses (especially cytokines) (e.g. Brown et al., 2004; Luscher et al., 2011; Schwarzer, 2009).”
Background
Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal
Surget, A., Saxe, M., Leman, S., Ibarguen-Vargas, Y., Chalon, S., Griebel, G., Hen, R., & Belzung, C. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.022 · Cited by 556
Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells
Wang, J.-W., David, D. J., Monckton, J. E., Battaglia, F., & Hen, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3632-07.2008 · Cited by 550
Adult hippocampal neurogenesis is involved in anxiety-related behaviors
Revest, J.-M., Dupret, D., Koehl, M., Funk-Reiter, C., Grosjean, N., Piazza, P.-V., & Abrous, D. N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.15 · Cited by 549
Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats
Brezun, J. M., & Daszuta, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00693-9 · Cited by 549
Animal Models of Depression: Molecular Perspectives
Krishnan, V., & Nestler, E. J. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2010_108 · Cited by 528
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
Jiang, W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25509 · Cited by 527
Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat
Madsen, T. M., Kristjansen, P. E. G., Bolwig, T. G., & Wörtwein, G. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00199-4 · Cited by 506
Different data from different labs: Lessons from studies of gene–environment interaction
Wahłsten, D., Metten, P., Phillips, T. J., Boehm, S. L., Burkhart‐Kasch, S., Dorow, J. D., Doerksen, S., Downing, C., Fogarty, J., Rodd‐Henricks, K., et al. (2002) · Journal of Neurobiology · doi:10.1002/neu.10173 · Cited by 500
3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity
Sheline, Y. I. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00994-x · Cited by 496
Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain
Manganas, L. N., Zhang, X., Li, Y., Hazel, R. D., Smith, S. D. B., Wagshul, M. E., Henn, F. A., Benveniste, H., Djurić, P. M., Enikolopov, G., et al. (2007) · Science · doi:10.1126/science.1147851 · Cited by 495
Structural Plasticity and Hippocampal Function
Leuner, B., & Gould, E. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100359 · Cited by 478
Monoaminergic Neurotransmission: The History of the Discovery of Antidepressants from 1950s Until Today
Lopez-Munoz, F. J., & Álamo, C. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168001 · Cited by 476
Antidepressants recruit new neurons to improve stress response regulation
Surget, A., Tanti, A., Leonardo, E. D., Laugeray, A., Rainer, Q., Touma, C., Palme, R., Griebel, G., Ibarguen-Vargas, Y., Hen, R., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.48 · Cited by 471
Why new neurons? Possible functions for adult hippocampal neurogenesis
Kempermann, G. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00635.2002 · Cited by 469
Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces
Feng, R., Rampon, C., Tang, Y., Shrom, D., Jin, J., Kyin, M., Sopher, B. L., Martin, G. M., Kim, S., Langdon, R. B., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00523-2 · Cited by 467
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
Meshi, D., Drew, M. R., Saxe, M., Ansorge, M. S., David, D. J. P., Santarelli, L., Malapani, C., Moore, H. M., & Hen, R. (2006) · Nature Neuroscience · doi:10.1038/nn1696 · Cited by 458
Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action☆
Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Fuchs, E., Oomen, C. A., & Czéh, B. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.08.003 · Cited by 449
The role of defeat and entrapment in depression, anxiety, and suicide.
Taylor, P. J., Gooding, P. A., Wood, A. M., & Tarrier, N. (2011) · Psychological Bulletin · doi:10.1037/a0022935 · Cited by 446
Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections
Stanfield, B. B., & Trice, J. (1988) · Experimental Brain Research · doi:10.1007/bf00250261 · Cited by 431
Chronic Stress-induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis
Conrad, C. D. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.6.395 · Cited by 425
Maternal separation as a model of brain-gut axis dysfunction
O’Mahony, S. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2010-9 · Cited by 415
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
Airan, R. D., Meltzer, L. A., Roy, M., Gong, Y., Chen, H., & Deisseroth, K. (2007) · Science · doi:10.1126/science.1144400 · Cited by 396
Adult hippocampal neurogenesis: Regulation, functional implications, and contribution to disease pathology
Balu, D. T., & Lucki, I. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.007 · Cited by 395
Signaling in Adult Neurogenesis
Suh, H., Deng, W., & Gage, F. H. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113256 · Cited by 388
Structural and functional plasticity of the human brain in posttraumatic stress disorder
Bremner, J. D., Elzinga, B. M., Schmahl, C. G., & Vermetten, E. H. G. J. M. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)67012-5 · Cited by 379
The neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for?
Kempermann, G. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.002 · Cited by 372
Hippocampal Cytogenesis Correlates to Escitalopram-Mediated Recovery in a Chronic Mild Stress Rat Model of Depression
Jayatissa, M. N., Bisgaard, C. F., Tingström, A., Papp, M., & Wiborg, O. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301041 · Cited by 361
Hippocampal Remodeling and Damage by Corticosteroids Implications for Mood Disorders
Brown, E. S. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00054-8 · Cited by 344
Animal models of mood disorders: recent developments
Cryan, J. F., & Slattery, D. A. (2006) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3280117733 · Cited by 331
Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor
Holick, K. A., Lee, D. C., Hen, R., & Dulawa, S. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301399 · Cited by 326
Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress
Schloesser, R. J., Lehmann, M., Martinowich, K., Manji, H. K., & Herkenham, M. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.34 · Cited by 319
Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible
Heine, V. M., Maslam, S., Zareno, J., Joëls, M., & Lucassen, P. J. (2004) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.03100.x · Cited by 317
Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance
Lagace, D. C., Donovan, M. H., DeCarolis, N. A., Farnbauch, L. A., Malhotra, S., Berton, O., Nestler, E. J., Krishnan, V., & Eisch, A. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910072107 · Cited by 314
Self-citation
Neurogenesis and affective disorders
Samuels, B. A., & Hen, R. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07614.x · Cited by 303
Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task
Kempermann, G., & Gage, F. H. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02042.x · Cited by 302
Inhibition of Dentate Granule Cell Neurogenesis with Brain Irradiation Does Not Prevent Seizure-Induced Mossy Fiber Synaptic Reorganization in the Rat
Parent, J. M., Tada, E., Fike, J. R., & Lowenstein, D. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04508.1999 · Cited by 291
Comparison of different behavioral test situations used in psychopharmacology for measurement of anxiety
Belzung, C., & Pape, G. L. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90311-5 · Cited by 291
30 years of dynorphins — New insights on their functions in neuropsychiatric diseases
Schwarzer, C. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.05.006 · Cited by 291
Alterations of neuroplasticity in depression: the hippocampus and beyond
Fuchs, E., Czéh, B., Kole, M. H. P., Michaelis, T., & Lucassen, P. J. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.09.002 · Cited by 276
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders
Yamasaki, N., Maekawa, M., Kobayashi, K., Kajii, Y., Maeda, J., Soma, M., Takao, K., Tanda, K., Ohira, K., Toyama, K., et al. (2008) · Molecular Brain · doi:10.1186/1756-6606-1-6 · Cited by 269
Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date
Döbrössy, M. D., Drapeau, E., Aurousseau, C., Moal, M. L., Piazza, P. V., & Abrous, D. N. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001419 · Cited by 266
Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation
DeCarolis, N. A., & Eisch, A. J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.12.013 · Cited by 259
Self-citation
Adrenal steroids regulate postnatal development of the rat dentate gyrus: I. Effects of glucocorticoids on cell death
Gould, E., Woolley, C. S., & McEwen, B. S. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903130308 · Cited by 254
Stress, Depression and Hippocampal Apoptosis
Lucassen, P. J., Heine, V. M., Müller, M. B., van der Beek, E. M., Wiegant, V. M., de Kloet, E. R., Joëls, M., Fuchs, E., Swaab, D. F., & Czéh, B. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706778559273 · Cited by 253
Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates
Perera, T. D., Dwork, A. J., Keegan, K. A., Thirumangalakudi, L., Lipira, C. M., Joyce, N., Lange, C., Higley, J. D., Rosoklija, G., Hen, R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017600 · Cited by 244
Voluntary exercise induces anxiety‐like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis
Fuss, J., Ben Abdallah, N. M. ‐., Vogt, M. A., Touma, C., Pacifici, P. G., Palme, R., Witzemann, V., Hellweg, R., & Gass, P. (2010) · Hippocampus · doi:10.1002/hipo.20634 · Cited by 240
Reduction of Adult Hippocampal Neurogenesis Confers Vulnerability in an Animal Model of Cocaine Addiction
Noonan, M. A., Bulin, S. E., Fuller, D. C., & Eisch, A. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4256-09.2010 · Cited by 236
Self-citation
Neurogenesis in the adult hippocampus
Christie, B. R., & Cameron, H. A. (2006) · Hippocampus · doi:10.1002/hipo.20151 · Cited by 233
Reduced cell proliferation in the dentate gyrusis not correlated with the development of learned helplessness
Vollmayr, B., Simonis, C., Weber, S., Gass, P., & Henn, F. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00527-4 · Cited by 229
Intermittent Hypoxia Promotes Hippocampal Neurogenesis and Produces Antidepressant-Like Effects in Adult Rats
Zhu, X.-H., Yan, H., Zhang, J., Qu, H.-D., Qiu, X., Chen, L., Li, S.-J., Cao, X., Bean, J. C., Chen, L. H., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6414-09.2010 · Cited by 229
Dynamics of neurogenesis in the dentate gyrus of adult rats
Kinkaid, H. Y. M., & Wojtowicz, J. M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.05.022 · Cited by 228
The contribution of failing adult hippocampal neurogenesis to psychiatric disorders
Kempermann, G., Krebs, J., & Fabel, K. (2008) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3282fad375 · Cited by 225
Animal Models of Neuropsychiatric Disorders
Fernando, A. B. P., & Robbins, T. W. (2011) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032210-104454 · Cited by 223
Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients
Lucassen, P. J., Stumpel, M. W., Wang, Q., & Aronica, E. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.01.012 · Cited by 223
Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro
Manev, H., Uz, T., Smalheiser, N. R., & Manev, R. M. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00904-3 · Cited by 220
Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey
Eckenhoff, M., & RAKIC, P. T. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02729.1988 · Cited by 216
Experience Dictates Stem Cell Fate in the Adult Hippocampus
Dranovsky, A., Picchini, A. M., Moadel, T., Sisti, A. C., Yamada, A., Kimura, S., Leonardo, E. D., & Hen, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.022 · Cited by 215
Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression
Duman, R. S. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/rsduman · Cited by 210
Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes
Kalueff, A. V., Olivier, J. D. A., Nonkes, L. J. P., & Homberg, J. R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.003 · Cited by 207
Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus
Peißner, W., Köcher, M., Treuer, H., & Gillardon, F. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00170-9 · Cited by 207
Functional organization of forebrain pathways for song production and perception
Margoliash, D. (1997) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19971105)33:5 · Cited by 206
Corticolimbic Transcriptome Changes are State-Dependent and Region-Specific in a Rodent Model of Depression and of Antidepressant Reversal
Surget, A., Wang, Y., Leman, S., Ibargüen-Vargas, Y., Edgar, N. M., Griebel, G., Belzung, C., & Sibille, E. L. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.76 · Cited by 203
A new chapter in the field of memory: adult hippocampal neurogenesis
Koehl, M., & Abrous, D. N. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07609.x · Cited by 198
Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response
Schloesser, R. J., Manji, H. K., & Martinowich, K. (2009) · Neuroreport · doi:10.1097/wnr.0b013e3283293e59 · Cited by 187
The hippocampus and depression
Sheline, Y. I., Mittler, B., & Mintun, M. A. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00655-7 · Cited by 179
Requirement of adult-born neurons for hippocampus-dependent learning
Marín‐Burgin, A., & Schinder, A. F. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.001 · Cited by 174
Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine
McEwen, B. S., & Chattarji, S. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.09.008 · Cited by 174
High-fat diet selectively protects against the effects of chronic social stress in the mouse
Finger, B. C., Dinan, T. G., & Cryan, J. F. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.072 · Cited by 169
Exercise, Learned Helplessness, and the Stress-Resistant Brain
Greenwood, B. N., & Fleshner, M. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8029-y · Cited by 168
Increasing hippocampal neurogenesis: a novel mechanism for antidepressant drugs
Malberg, J., & Schechter, L. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382223 · Cited by 167
Emotion and episodic memory in neuropsychiatric disorders
Dere, E., Pause, B. M., & Pietrowsky, R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.017 · Cited by 165
Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation
Blundell, J., Kouser, M., & Powell, C. M. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.12.004 · Cited by 162 · cited 1×
“…information, strategies could be used to selectively increase or decrease neurogenesis appropriately to help augment or diminish particular memories of stressful experiences, similar to those approaches suggested for other brain neuroadaptations (e.g. Blundell et al., 2008; Ressler et al., 2004).”
Method
Neuroplasticity: from MRI to depressive symptoms
Fossati, P., Radtchenko, A., & Boyer, P. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.09.001 · Cited by 160
A Double-Blind, Placebo-Controlled Study of Venlafaxine and Fluoxetine in Geriatric Outpatients With Major Depression
Schatzberg, A. F., & Roose, S. P. (2006) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000194645.70869.3b · Cited by 143
Ageing abolishes the effects of fluoxetine on neurogenesis
Couillard-Despres, S., Wuertinger, C., Kandasamy, M., Caioni, M., Stadler, K., Aigner, R., Bogdahn, U., & Aigner, L. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.147 · Cited by 143
Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment
van Bokhoven, P., Oomen, C. A., Hoogendijk, W. J. G., Smit, A. B., Lucassen, P. J., & Spijker, S. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07668.x · Cited by 134
Learning as a Model for Neural Plasticity in Major Depression
Nissen, C., Holz, J., Blechert, J., Feige, B., Riemann, D. W., Voderholzer, U., & Normann, C. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.026 · Cited by 128
Seven principles in the regulation of adult neurogenesis
Kempermann, G. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07599.x · Cited by 124
PTSD and stress sensitisation: A tale of brain and body Part 2: Animal models
Stam, R. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.01.001 · Cited by 117
Implications of the Functional Integration of Adult-Born Hippocampal Neurons in Anxiety-Depression Disorders
David, D. J. P., Wang, J., Samuels, B. A., Rainer, Q., Mendez‐David, I., Gardier, A. M., & Hen, R. (2010) · The Neuroscientist · doi:10.1177/1073858409360281 · Cited by 115
Open questions in current models of antidepressant action
Tanti, A., & Belzung, C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00585.x · Cited by 115
Stress in early life inhibits neurogenesis in adulthood
Karten, Y. J. G., Olariu, A., & Cameron, H. A. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.01.009 · Cited by 115
Neurogenesis and depression: what animal models tell us about the link
Vollmayr, B., Mahlstedt, M. M., & Henn, F. A. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0734-2 · Cited by 115
Stress-induced changes in hippocampal function
Joëls, M., Krugers, H. J., & Karst, H. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)67001-0 · Cited by 111
Deletion of Running-Induced Hippocampal Neurogenesis by Irradiation Prevents Development of an Anxious Phenotype in Mice
Fuss, J., Ben Abdallah, N. M. B., Hensley, F. W., Weber, K.-J., Hellweg, R., & Gass, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012769 · Cited by 110 · cited 5×
“While inclusion of running here as an “antidepressant” is controversial, since in this particular study running induced an anxious and depressive phenotype (Fuss et al., 2010b), it remains notable that irradiation did not influence the performance on tests of depression or anxiety.”
BackgroundInfluential
Stress coping stimulates hippocampal neurogenesis in adult monkeys
Lyons, D. M., Buckmaster, P. S., Lee, A. G., Wu, C., Mitra, R., Duffey, L. M., Buckmaster, C. L., Her, S., Patel, P. D., & Schatzberg, A. F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914568107 · Cited by 109
Structural plasticity and tianeptine: cellular and molecular targets
McEwen, B. S., Magarinos, A. M., & Reagan, L. P. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00650-8 · Cited by 108
Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1
Uchida, S., Hara, K., Kobayashi, A., Fujimoto, M., Otsuki, K., Yamagata, H., Hobara, T., Abe, N., Higuchi, F., Shibata, T., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016424108 · Cited by 108
Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy
Lyons, L., ELBeltagy, M., Umka, J., Markwick, R., Startin, C. M., Bennett, G., & Wigmore, P. M. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2122-2 · Cited by 108
Chapter 5 Development of Neural Circuits in the Adult Hippocampus
Li, Y., Mu, Y., & Gage, F. H. (2009) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)01205-8 · Cited by 105
Synapse formation on adult‐born hippocampal neurons
Toni, N., & Sultan, S. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07604.x · Cited by 105
Dentate gyrus neurogenesis and depression
Sahay, A., Drew, M. R., & Hen, R. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63038-6 · Cited by 104
Conditional reduction of adult neurogenesis impairs bidirectional hippocampal synaptic plasticity
Massa, F., Koehl, M., Wiesner, T., Grosjean, N., Revest, J., Piazza, P., Abrous, D. N., & Oliet, S. H. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016928108 · Cited by 102
Adult neurogenesis and its alteration under pathological conditions
Kaneko, N., & Sawamoto, K. (2008) · Neuroscience Research · doi:10.1016/j.neures.2008.12.001 · Cited by 101
Cognitive Role of Neurogenesis in Depression and Antidepressant Treatment
Perera, T. D., Park, S., & Nemirovskaya, Y. (2008) · The Neuroscientist · doi:10.1177/1073858408317242 · Cited by 100
Repeated brief social defeat episodes in mice: Effects on cell proliferation in the dentate gyrus
Yap, J. J., Takase, L. F., Kochman, L. J., Fornal, C. A., Miczek, K. A., & Jacobs, B. L. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.027 · Cited by 99
Adult neurogenesis: implications for psychiatry
Eisch, A. J. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)38085-3 · Cited by 98
Self-citation
Adult Human Neurogenesis: From Microscopy to Magnetic Resonance Imaging
Sierra, A., Encinas, J. M., & Maletić‐Savatić, M. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00047 · Cited by 95
DEVELOPMENTAL PLASTICITY IN NEURAL CIRCUITS FOR A LEARNED BEHAVIOR
Bottjer, S. W., & Arnold, A. P. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.459 · Cited by 94
Hippocampus Shape Analysis and Late-Life Depression
Zhao, Z., Taylor, W. D., Styner, M. A., Steffens, D. C., Krishnan, K. R., & MacFall, J. R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001837 · Cited by 87
Decline in adult neurogenesis during aging follows a topographic pattern in the mouse hippocampus
Jinno, S. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22527 · Cited by 83
Decreased cell proliferation in the dentate gyrus does not associate with development of anhedonic-like symptoms in rats
Jayatissa, M. N., Henningsen, K., West, M. J., & Wiborg, O. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.001 · Cited by 81
Chronic fluoxetine treatment alters behavior, but not adult hippocampal neurogenesis, in BALB/cJ mice
Huang, G.-J., Bannerman, D. M., & Flint, J. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002104 · Cited by 80
Increased granule cell neurogenesis in the adult dentate gyrus following mossy fiber stimulation sufficient to induce long-term potentiation
Derrick, B. E., York, A., & Martinez, J. L. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02464-6 · Cited by 80
Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis
Aimone, J. B., & Gage, F. H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07615.x · Cited by 79
The temporal impact of chronic intermittent psychosocial stress on high-fat diet-induced alterations in body weight
Finger, B. C., Dinan, T. G., & Cryan, J. F. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.06.015 · Cited by 76
The effects of repeated social interaction stress on behavioural and physiological parameters in a stress-sensitive mouse strain
Savignac, H. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.049 · Cited by 75
Conditional ablation and recovery of forebrain neurogenesis in the mouse
Singer, B. H., Jutkiewicz, E. M., Fuller, C. L., Lichtenwalner, R. J., Zhang, H., Velander, A. J., Li, X., Gnegy, M. E., Burant, C., & Parent, J. M. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22052 · Cited by 75
Visualization and genetic manipulation of adult neurogenesis using transgenic mice
Dhaliwal, J., & Lagace, D. C. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07600.x · Cited by 74
Self-citation
Genetic Methods to Identify and Manipulate Newly Born Neurons in the Adult Brain
Imayoshi, I., Sakamoto, M., & Kageyama, R. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00064 · Cited by 72
Research in anxiety disorders: From the bench to the bedside
Garner, M. J., Möhler, H., Stein, D. J., Mueggler, T., & Baldwin, D. S. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.01.011 · Cited by 71
Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress
Dagytė, G., Crescente, I., Postema, F., Seguin, L., Gabriel, C., Mocaër, E., den Boer, J. A., & Koolhaas, J. M. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.045 · Cited by 71
Targeting the Hippocampal Mossy Fiber Synapse for the Treatment of Psychiatric Disorders
Kobayashi, K. (2009) · Molecular Neurobiology · doi:10.1007/s12035-008-8049-5 · Cited by 70
A reduced number of hippocampal granule cells does not associate with an anhedonia-like phenotype in a rat chronic mild stress model of depression
Jayatissa, M. N., Henningsen, K., Nikolajsen, G., West, M. J., & Wiborg, O. (2010) · Stress · doi:10.3109/10253890902951786 · Cited by 69
Role of corticosteroid hormones in the dentate gyrus
Joëls, M. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63021-0 · Cited by 67
Role of the Amygdala in Antidepressant Effects on Hippocampal Cell Proliferation and Survival and on Depression-like Behavior in the Rat
Castro, J. E., Varea, E., Márquez, C., Cordero, M. I., Poirier, G. L., & Sandi, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008618 · Cited by 63
Adult neurogenesis is reduced in the dorsal hippocampus of rats displaying learned helplessness behavior
Ho, Y., & Wang, S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.062 · Cited by 59
A New Strategy for Antidepressant Prescription
Lavergne, F., & Jay, T. M. (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00192 · Cited by 50
No effect of running and laboratory housing on adult hippocampal neurogenesis in wild caught long-tailed wood mouse
Hauser, T., Klaus, F., Lipp, H., et al. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-43 · Cited by 47
Oxotremorine treatment restores hippocampal neurogenesis and ameliorates depression-like behaviour in chronically stressed rats
Veena, J., Srikumar, B. N., Mahati, K., Raju, T. R., & Rao, B. S. S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2279-3 · Cited by 46
Effect of inadequate response to treatment in patients with depression.
Knoth, R. L., Bolge, S. C., Kim, E., & Tran, Q.-V. (2010) · PubMed · Cited by 46
Strain differences in proliferation of progenitor cells in the dentate gyrus of the adult rat and the response to fluoxetine are dependent on corticosterone
AlAhmed, S. H., & Herbert, J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.072 · Cited by 44
Critical maturational period of new neurons in adult dentate gyrus for their involvement in memory formation
Aasebø, I. E. J., Blankvoort, S., & Tashiro, A. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07608.x · Cited by 43
Differences in Doublecortin Immunoreactivity and Protein Levels in the Hippocampal Dentate Gyrus Between Adult and Aged Dogs
Hwang, I. K., Yoo, K., Li, H., Choi, J. H., Kwon, Y., Ahn, Y., Lee, I. S., & Won, M. H. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9366-1 · Cited by 41
Differentiation of Hippocampal Progenitor Cells in Vitro: Temporal Expression of Intercellular Coupling and Voltage- and Ligand-Gated Responses
Rozental, R., Mehler, M. F., Morales, M., et al. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1029 · Cited by 41
Stress and Affective Disorders: Animal Models Elucidating the Molecular Basis of Neuroendocrine-Behavior Interactions
Touma, C. (2011) · Pharmacopsychiatry · doi:10.1055/s-0031-1271702 · Cited by 38
p53 is dispensable for apoptosis but controls neurogenesis of mouse dentate gyrus cells following γ-irradiation
Uberti, D. L., Piccioni, L., Cadei, M., Grigolato, P., Rotter, V., & Memo, M. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00180-2 · Cited by 33
Selective Deletion of a Cell Cycle Checkpoint Kinase (ATR) Reduces Neurogenesis and Alters Responses in Rodent Models of Behavioral Affect
Onksen, J. L., Brown, E. J., & Blendy, J. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.234 · Cited by 28
Activity-dependent refinement in the goldfish retinotectal system is mediated by the dynamic regulation of processes withdrawal: An in vivo imaging study
Johnson, F. A., Dawson, A. J., & Meyer, R. L. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990419)406:4 · Cited by 23
In vivo Characterization of Brain Morphometric and Metabolic Endophenotypes in Three Inbred Strains of Mice Using Magnetic Resonance Techniques
Penet, M., Laigle, C., Fur, Y. L., Sylviane Confort-gouny, A., Heurteaux, C., Cozzone, P. J., & Viola, A. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9077-4 · Cited by 16
Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
Frankland, P. W., Sakaguchi, M., & Arruda-Carvalho, M. (2008) · Molecular Brain · doi:10.1186/1756-6606-1-5 · Cited by 13
Adult neurogenesis and systemic adaptation: animal experiments and clinical perspectives for PTSD
Takemura, N. U., & Kato, N. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)67007-1 · Cited by 10
The Neurobiology of Antidepressants
Blows, W. T. (2000) · Journal of Neuroscience Nursing · doi:10.1097/01376517-200006000-00010 · Cited by 8
Distinct neurochemical populations in the rat central nucleus of the amygdala and bed nucleus of the stria terminalis: Evidence for their selective activation by interleukin-1?
Day, H. E. W., Curran, E. J., Watson, S. J., & Akil, H. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991011)413:1

Research works printed but not linked: 7

Cryan, 2010, GABAB receptors and depression. Current status, Adv. Pharmacol., 58, 427, 10.1016/S1054-3589(10)58016-5 · DOI
Curtis, 2011, Neurogenesis in humans, Eur. J. Neurosci., 33, 1170, 10.1111/j.1460-9568.2011.07616.x · DOI
Kempermann, 2011, vol. 2
McEwen, 2000, The neurobiology of stress: from serendipity to clinical relevance, Brain Res., 886, 172, 10.1016/S0006-8993(00)02950-4 · DOI · Paper page
Parihar, 2011, Predictable chronic mild stress improves mood, hippocampal neurogenesis and memory, Mol. Psychiatry, 16, 171, 10.1038/mp.2009.130 · DOI
Perera, 2000, Neurogenesis and depression, J. Psychiatr. Pract., 6, 322, 10.1097/00131746-200011000-00003 · DOI
Tollefson, 1995, A double-blind, placebo-controlled clinical trial of fluoxetine in geriatric patients with major depression. The Fluoxetine Collaborative Study Group, Int. Psychogeriatr., 7, 89, 10.1017/S1041610295001888 · DOI

Sorted by citations

The chronic mild stress (CMS) model of depression: History, evaluation and usage
Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.002 · Cited by 959
“…of very few brain areas in which neurogenesis continues into adult life, and this process is powerfully suppressed by prolonged exposure to corticosterone or to stressors (Wong and Herbert, 2004; Samuels and Hen, 2011; Petrik et al., 2012), including CMS (Mineur et al., 2007; Oomen et al., 2007).”
Background
Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694
The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex
Liu, W., Ge, T., Leng, Y., Pan, Z., Fan, J., Yang, W., & Cui, R. (2017) · Neural Plasticity · doi:10.1155/2017/6871089 · Cited by 640
“The neurogenic hypothesis of depression emphasizes the theory that impaired adult hippocampal neurogenesis results in depression, and newborn neurons in the adult brain are critical to mood regulation and antidepressant efficacy [27, 28].”
Background
Regulation and function of adult neurogenesis: from genes to cognition.
Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., & Gage, F. H. (2014) · Physiological Reviews · doi:10.1152/physrev.00004.2014 · Cited by 635
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519
“Hippocampal neurogenesis is powerfully suppressed by stress r by prolonged corticosterone exposure (Wong and Herbert, 2004; ineur et al., 2007; Samuels and Hen, 2011; Hanson et al., 2011; etrik et al., 2012).”
Background

See all 241

Authors: Petrik, D., Lagace, D. C., & Eisch, A. J.
Affiliations: University of Ottawa (CA)
The University of Texas Southwestern Medical Center (US)
Corresponding author: Eisch, Amelia J.
ORCID: Lagace, Diane C.
Eisch, Amelia J.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2012-01
Volume: 62
Issue: 1
Pages: 21-34
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2011.09.003
PMC: PMC3698048
OpenAlex: W1988200425
Cited by: 241
References: 204
Citations by year: 2026: 5 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 19 · 2020: 11 · 2019: 13 · 2018: 14 · 2017: 12 · 2016: 29 · 2015: 22 · 2014: 35 · 2013: 29 · 2012: 25
FWCI: 2.52
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders: National Institutes of Health (R01 DA016765, K02 DA023555)
NASA (NNX07AP84G)
NSERC (371716)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: adult neurogenesis, dentate gyrus, major depressive disorder, anxiety disorders, post-traumatic stress disorder, antidepressant mechanism, stress response, resilience, social stress, serotonin, transgenic mouse model
MeSH terms: Animals, Anxiety, Hippocampus, Humans, Models, Biological, Anti-Anxiety Agents, Mood Disorders, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks