Surface-based morphometry of the cortical architecture of autism spectrum disorders: volume, thickness, area, and gyrification
Abstract
Structural neuroimaging studies of autism spectrum disorder (ASD) have uncovered widespread neuroanatomical abnormalities, which may have a significant impact on brain function, connectivity, and on behavioral symptoms of autism. The findings of previous structural MRI studies have largely been distributed across several brain areas, with limited consistency. The current study examined neuroanatomical abnormalities by comparing surface-based measures of cortical morphology (CT: cortical thickness, CSA: cortical surface area, CV: cortical volume, and GI: gyrification index) in 55 high-functioning children and adults with ASD to 60 age-and-IQ-matched typically developing (TD) peers. A few brain areas, the fusiform gyrus (FG), middle temporal gyrus (MTG), and inferior frontal gyrus (IFG), emerged to be primarily different in their morphology between the two groups. Compared to TD participants, ASD participants had significantly smaller CV in left MTG, reduced CSA in bilateral MTG and FG, reduced GI in left supramarginal gyrus, and significantly increased CT in the pars opercularis of the IFG. As a function of age, ASD participants had significant reductions in: CT in the pars opercularis, CSA of the left rostral middle frontal gyrus, and GI for left supramarginal gyrus. Thus, alterations in cortical morphology in ASD were seen primarily in regions that are considered part of the social brain. Overall, these findings point to: neuroanatomical alterations in social brain areas, developmental differences in neuroanatomy, and the need to study neuroanatomy at multiple levels in order to better characterize the cortical architecture of ASD.
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Various neurophysiological features such as cortical volume and connectivity are also altered in ASD.
“various neurophysiological features such as cortical volume 35,47 and connectivity 27 are also altered in ASD.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [47]
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Herringshaw, A. J., Ammons, C. J., DeRamus, T. P., & Kana, R. K. (2016) · Autism Research · doi:10.1002/aur.1599 · Cited by 102 · see citing works
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Cortical thickness change in autism during early childhood: CT in Early Childhood ASD
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Lee, D. K., Li, S. W., Bounni, F., Friedman, G., Jamali, M., Strahs, L., Zeliger, O., Gabrieli, P., Stankovich, M. A., Demaree, J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00888-4 · Cited by 33 · see citing works
Gharehgazlou, A., Freitas, C., Ameis, S. H., Taylor, M. J., Lerch, J. P., Radua, J., & Anagnostou, E. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhaa381 · Cited by 22 · see citing works
D'Mello, A. M., Frosch, I. R., Meisler, S. L., Grotzinger, H., Perrachione, T. K., & Gabrieli, J. D. E. (2023) · The Journal of Neuroscience · doi:10.1523/jneurosci.0608-22.2023 · Cited by 14 · see citing works
- Authors
- Libero, L. E., DeRamus, T. P., Deshpande, H. D., & Kana, R. K.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Kana, Rajesh K.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 62
- Pages
- 1-10
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2062464666
- Cited by
- 95
- References
- 139
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 10 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 11 · 2015: 7 · 2014: 1
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- UAB Department of Psychology funds
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- autism spectrum disorder, cortical morphology, cortical thickness, cortical surface area, cortical volume, gyrification index, social brain, fusiform gyrus, middle temporal gyrus, inferior frontal gyrus, supramarginal gyrus, high-functioning autism
- MeSH terms
- Adolescent, Adult, Age Factors, Brain Mapping, Cerebral Cortex, Child, Child Development Disorders, Pervasive, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Statistics as Topic, Young Adult
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