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Cited by 156Sleep and Work-Related FatigueCircadian rhythm and melatoninDietary Effects on Health

Altered postprandial hormone and metabolic responses in a simulated shift work environment

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Ribeiro, DC, Hampton, SM, Morgan, L, Deacon, S, Arendt, J·1998·Journal of Endocrinology
DOI 10.1677/joe.0.1580305
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Abstract

The circadian rhythms of most night shift workers do not adapt fully to the imposed behavioural schedule, and this factor is considered to be responsible for many of the reported health problems. One way in which such disturbances might be mediated is through inappropriate hormonal and metabolic responses to meals, on the night shift. Twelve healthy subjects (four males and eight females) were studied on three occasions at the same clock time (1330 h), but at different body clock times, after consuming test meals, first in their normal environment, secondly after a forced 9 h phase advance (body clock time approximately 2230 h) and then again 2 days later in the normal environment. They were given a low-fat pre-meal at 0800 h, then a test meal at 1330 h with blood sampling for the following 9 h. Parameters measured included plasma glucose, non-esterified fatty acids (NEFAs), triacylglycerol (TAG), insulin, C-peptide, proinsulin and glucose-dependent insulinotropic polypeptide, and urinary 6-sulphatoxymelatonin. In contrast with a previous study with a high-fat pre-meal, postprandial glucose and insulin responses were not affected by the phase shift. However, basal plasma NEFAs were lower immediately after the phase shift (P < 0.05). Incremental (difference from basal) TAG responses were significantly higher (P < 0.05) immediately after the phase shift compared with before. Two-day post-phase shift responses showed partial reversion to baseline values. This study suggests that it takes at least 2 days to adapt to eating meals on a simulated night shift, and that the nutritional content of the pre-meals consumed can have a marked effect on postprandial responses during a simulated phase shift. Such findings may provide a partial explanation for the increased occurrence of cardiovascular disease reported in shift workers.

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  • A 9-h phase advance of the circadian timing system increased the glucose and insulin response to a test meal given at the same clock time when the test meal was preceded by a high-fat but not low-fat meal.

    “A 9-h phase advance of the circadian timing system—a simulation of shift work—increased the glucose and insulin response to a test meal given at the same clock time when the test meal was preceded by a high-fat but not low-fat meal (Hampton et al., 1996; Ribeiro et al., 1998).”

    From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Ribeiro et al., 1998

  • A 9-h phase advance had a detrimental effect on the average triglyceride response to a test meal only when the pretest meal was a low- rather than high-fat meal.

    “Moreover, a 9-h phase advance only had a detrimental effect on the average triglyceride response to a test meal when the pretest meal is a low- rather than high-fat meal (Hampton et al., 1996; Ribeiro et al., 1998).”

    From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Ribeiro et al., 1998

  • Triglyceride postprandial responses do not normalize 2 days after ceasing night work.

    “The glucose and insulin, but not triglyceride, postprandial responses normalize 2 days after ceasing night work, indicating that some—but not all—of the adverse metabolic and hormonal effects of night work quickly subside after short-term exposure (Lund et al., 2001; Ribeiro et al., 1998).”

    From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Ribeiro et al., 1998

  • Glucose and insulin postprandial responses normalize 2 days after ceasing night work.

    “The glucose and insulin, but not triglyceride, postprandial responses normalize 2 days after ceasing night work, indicating that some—but not all—of the adverse metabolic and hormonal effects of night work quickly subside after short-term exposure (Lund et al., 2001; Ribeiro et al., 1998).”

    From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Ribeiro et al., 1998

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Research works printed but not linked: 4

  1. Arendt J, Deacon SJ, Morgan LM, Hampton SM, Folkard S, Owens DS & Ribeiro DCO 1997 Disordered rhythms: strategies for treatment and their relation to pancreatic and metabolic function. In Physiology, Stress and Malnutrition: Functional Correlates, Nutritional Intervention, pp 79-93. Eds JM Kinney & HN Tucker. Philadelphia: Lippincott-Raven.
  2. Eds MF Holick & EG Jung. Berlin: De Gruyter.
  3. Iakovaki M 1997 Is there a diurnal variation in plasma non-esterified fatty acid levels? MSc Thesis. University of Surrey.
  4. Van Cauter EC, Shapiro ET, Tillil H & Polonsky KS 1992 Circadian modulation of glucose and insulin response to meals: relationship to cortisol. American Journal of Physiology 262 E467-E475.

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Authors
Ribeiro, D., Hampton, S., Morgan, L., Deacon, S., & Arendt, J.
Affiliations
University of Surrey (GB)
ORCID
Venue
Journal of Endocrinology
Publisher
Bioscientifica
Published
1998-09-01
Volume
158
Issue
3
Pages
305-310
ISSN
  • 0022-0795 (ISSN-L)
  • 1479-6805
DOI
10.1677/joe.0.1580305
OpenAlex
W2072841332
Cited by
155
References
31
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 7 · 2018: 3 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 12 · 2012: 8
FWCI
2.40
Type
journal article
Language
en
Open access
Locations
  • Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • British Heart Foundation
  • Medical Research Council
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
shift work, circadian rhythm, phase advance, night shift work, postprandial blood glucose, insulin response, free fatty acids, triglycerides, 6-sulfatoxymelatonin, proinsulin, glucose-dependent insulinotropic polypeptide, cardiovascular risk
MeSH terms
Adult, Blood Glucose, C-Peptide, Circadian Rhythm, Dietary Fats, Eating, Fatty Acids, Nonesterified, Female, Gastric Inhibitory Polypeptide, Humans, Insulin, Male, Melatonin, Proinsulin, Triglycerides, Work Schedule Tolerance, Postprandial Period

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