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Neuroinflammation in the normal aging hippocampus

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Barrientos, R.M., Kitt, M.M., Watkins, L.R., Maier, S.F.·2015·Neuroscience
DOI 10.1016/j.neuroscience.2015.03.007
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Abstract

A consequence of normal aging is a greater susceptibility to memory impairments following an immune challenge such as infection, surgery, or traumatic brain injury. The neuroinflammatory response, produced by these challenges results in increased and prolonged production of pro-inflammatory cytokines in the otherwise healthy aged brain. Here we discuss the mechanisms by which long-lasting elevations in pro-inflammatory cytokines in the hippocampus produce memory impairments. Sensitized microglia are a primary source of this exaggerated neuroinflammatory response and appear to be a hallmark of the normal aging brain. We review the current understanding of the causes and effects of normal aging-induced microglial sensitization, including dysregulations of the neuroendocrine system, potentiation of neuroinflammatory responses following an immune challenge, and the impairment of memories. We end with a discussion of therapeutic approaches to prevent these deleterious effects.

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Cited by

Metadata

Authors
Barrientos, R. M., Kitt, M. M., Watkins, L. R., & Maier, S. F.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2015-11
Volume
309
Pages
84-99
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2015.03.007
OpenAlex
W2078556521
Cited by
315
References
43
FWCI
13.40
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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