Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 315

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Neuroinflammation in the normal aging hippocampus

Open access
Barrientos, R.M., Kitt, M.M., Watkins, L.R., Maier, S.F.·2015·Neuroscience
DOI 10.1016/j.neuroscience.2015.03.007
Open this paper in CoChat — free account

Abstract

A consequence of normal aging is a greater susceptibility to memory impairments following an immune challenge such as infection, surgery, or traumatic brain injury. The neuroinflammatory response, produced by these challenges results in increased and prolonged production of pro-inflammatory cytokines in the otherwise healthy aged brain. Here we discuss the mechanisms by which long-lasting elevations in pro-inflammatory cytokines in the hippocampus produce memory impairments. Sensitized microglia are a primary source of this exaggerated neuroinflammatory response and appear to be a hallmark of the normal aging brain. We review the current understanding of the causes and effects of normal aging-induced microglial sensitization, including dysregulations of the neuroendocrine system, potentiation of neuroinflammatory responses following an immune challenge, and the impairment of memories. We end with a discussion of therapeutic approaches to prevent these deleterious effects.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neuroscience.2015.03.007

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 184

  1. Abraham, 2009, Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice, Brain Behav Immun, 23, 396, 10.1016/j.bbi.2008.12.008 · DOI
  2. Abraham, 2008, Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120, Neurobiol Aging, 29, 614, 10.1016/j.neurobiolaging.2006.11.002 · DOI
  3. Akana, 1999, Interactions among chronic cold, corticosterone and puberty on energy intake and deposition, Stress, 3, 131, 10.3109/10253899909001118 · DOI
  4. 2014, 2014 Alzheimer’s disease facts and figures, Alzheimers Dement, 10, e47, 10.1016/j.jalz.2014.02.001 · DOI · Paper page
  5. Anttila, 1992, Diseases and symptoms as predictors of hospital care in an aged population. A prospective register-based study, Scand J Soc Med, 20, 79, 10.1177/140349489202000203 · DOI
  6. Ban, 1991, Receptors for interleukin-1 (alpha and beta) in mouse brain: mapping and neuronal localization in hippocampus, Neuroscience, 43, 21, 10.1016/0306-4522(91)90412-H · DOI · Paper page
  7. Ban, 1993, Regulation of interleukin-1 receptor expression in mouse brain and pituitary by lipopolysaccharide and glucocorticoids, Neuroendocrinology, 58, 581, 10.1159/000126594 · DOI
  8. Banks, 1999, Adsorptive endocytosis of HIV-1gp120 by blood–brain barrier is enhanced by lipopolysaccharide, Exp Neurol, 156, 165, 10.1006/exnr.1998.7011 · DOI
  9. Bao, 2014, Spontaneous running wheel improves cognitive functions of mouse associated with miRNA expressional alteration in hippocampus following traumatic brain injury, J Mol Neurosci, 54, 622, 10.1007/s12031-014-0344-1 · DOI
  10. Barrientos, 2011, Voluntary exercise as an anti-neuroinflammatory therapeutic, Brain Behav Immun, 25, 1061, 10.1016/j.bbi.2011.05.004 · DOI
  11. Barrientos, 2002, Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus, Behav Brain Res, 134, 291, 10.1016/S0166-4328(02)00043-8 · DOI · Paper page
  12. Barrientos, 2002, Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration, Behav Brain Res, 134, 299, 10.1016/S0166-4328(02)00045-1 · DOI
  13. Barrientos, 2004, BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration, J Neuroimmunol, 155, 119, 10.1016/j.jneuroim.2004.06.009 · DOI · Paper page
  14. Barrientos, 2006, Peripheral infection and aging interact to impair hippocampal memory consolidation, Neurobiol Aging, 27, 723, 10.1016/j.neurobiolaging.2005.03.010 · DOI · Paper page
  15. Barrientos, 2009, Characterization of the sickness response in young and aging rats following E. coli infection, Brain Behav Immun, 23, 450, 10.1016/j.bbi.2009.01.016 · DOI
  16. Barrientos, 2010, Memory impairments in healthy aging: role of aging-induced microglial sensitization, Aging Dis, 1, 212
  17. Barrientos, 2015, The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats, Brain Behav Immun, 43, 60, 10.1016/j.bbi.2014.07.004 · DOI
  18. Bauernfeind, 2011, Inflammasomes: current understanding and open questions, Cell Mol Life Sci, 68, 765, 10.1007/s00018-010-0567-4 · DOI · Paper page
  19. Bedford, 1955, Adverse cerebral effects of anaesthesia on old people, Lancet, 269, 259, 10.1016/S0140-6736(55)92689-1 · DOI · Paper page
  20. Bellinger, 1993, Interleukin-1 Beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus, Brain Res, 628, 227, 10.1016/0006-8993(93)90959-Q · DOI · Paper page
  21. Berg, 2005, Alpha-tocopherol and selenium facilitate recovery from lipopolysaccharide-induced sickness in aged mice, J Nutr, 135, 1157, 10.1093/jn/135.5.1157 · DOI
  22. Bergles, 1998, Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus, J Neurosci, 18, 7709, 10.1523/JNEUROSCI.18-19-07709.1998 · DOI · Paper page
  23. Bilbo, 2008, Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood, Brain Behav Immun, 22, 451, 10.1016/j.bbi.2007.10.003 · DOI
  24. Bramham, 2008, The immediate early gene arc/arg3.1: regulation, mechanisms, and function, J Neurosci, 28, 11760, 10.1523/JNEUROSCI.3864-08.2008 · DOI · Paper page
  25. Brothers, 2013, Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamate transporters and spatial memory, J Neuroimmune Pharmacol, 8, 1098, 10.1007/s11481-013-9476-2 · DOI
  26. Buchanan, 2008, Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice, Psychoneuroendocrinology, 33, 755, 10.1016/j.psyneuen.2008.02.013 · DOI
  27. Cacabelos, 1994, Brain interleukin-1 beta in Alzheimer’s disease and vascular dementia, Methods Find Exp Clin Pharmacol, 16, 141
  28. Campbell, 2003, CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury, FASEB J, 17, 1168, 10.1096/fj.02-0757fje · DOI
  29. Campbell, 2005, Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the central nervous system and the liver, Am J Pathol, 166, 1487, 10.1016/S0002-9440(10)62365-6 · DOI
  30. Campbell, 2007, Overexpression of IL-1beta by adenoviral-mediated gene transfer in the rat brain causes a prolonged hepatic chemokine response, axonal injury and the suppression of spontaneous behaviour, Neurobiol Dis, 27, 151, 10.1016/j.nbd.2007.04.013 · DOI
  31. Campbell, 2007, Immunomodulatory effects of etanercept in a model of brain injury act through attenuation of the acute-phase response, J Neurochem, 103, 2245, 10.1111/j.1471-4159.2007.04928.x · DOI
  32. Cao, 2010, Postoperative cognitive deficits and neuroinflammation in the hippocampus triggered by surgical trauma are exacerbated in aged rats, Prog Neuropsychopharmacol Biol Psychiatry, 34, 1426, 10.1016/j.pnpbp.2010.07.027 · DOI
  33. Cartford, 2002, Eighteen-month-old Fischer 344 rats fed a spinach-enriched diet show improved delay classical eyeblink conditioning and reduced expression of tumor necrosis factor alpha (TNFalpha) and TNFbeta in the cerebellum, J Neurosci, 22, 5813, 10.1523/JNEUROSCI.22-14-05813.2002 · DOI
  34. Chao, 2012, Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1beta release through the inhibition of Nogo-A expression, J Neuroinflammation, 9, 121, 10.1186/1742-2094-9-121 · doi:10.1186/1742-2094-9-121
  35. Chapman, 2010, Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1, J Neurosci, 30, 7598, 10.1523/JNEUROSCI.5172-09.2010 · DOI
  36. Chapman, 2012, Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus, Neurobiol Aging, 33, 832.e1, 10.1016/j.neurobiolaging.2011.07.015 · DOI
  37. Chen, 2008, Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system, Brain Behav Immun, 22, 301, 10.1016/j.bbi.2007.08.014 · DOI · Paper page
  38. Cibelli, 2010, Role of interleukin-1beta in postoperative cognitive dysfunction, Ann Neurol, 68, 360, 10.1002/ana.22082 · DOI · Paper page
  39. Colton, 2009, Heterogeneity of microglial activation in the innate immune response in the brain, J Neuroimmune Pharmacol, 4, 399, 10.1007/s11481-009-9164-4 · DOI · Paper page
  40. Coogan, 1997, Inhibition of NMDA receptor-mediated synaptic transmission in the rat dentate gyrus in vitro by IL-1 beta, NeuroReport, 8, 2107, 10.1097/00001756-199707070-00004 · DOI
  41. Corona, 2010, Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide, J Neuroinflammation, 7, 93, 10.1186/1742-2094-7-93 · DOI
  42. Cortese, 2011, Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLC{gamma}1, and ERK in hippocampal synaptoneurosomes, J Neurosci, 31, 4274, 10.1523/JNEUROSCI.5818-10.2011 · DOI
  43. Cotman, 2002, Exercise: a behavioral intervention to enhance brain health and plasticity, Trends Neurosci, 25, 295, 10.1016/S0166-2236(02)02143-4 · DOI · Paper page
  44. Craft, 2012, Session III: mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes, J Gerontol A Biol Sci Med Sci, 67, 754, 10.1093/gerona/gls112 · DOI
  45. Cullinan, 1998, IL-1 receptor accessory protein is an essential component of the IL-1 receptor, J Immunol, 161, 5614, 10.4049/jimmunol.161.10.5614 · DOI
  46. Cunningham, 2005, Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration, J Neurosci, 25, 9275, 10.1523/JNEUROSCI.2614-05.2005 · DOI · Paper page
  47. Curran, 2003, A role for c-Jun N-terminal kinase in the inhibition of long-term potentiation by interleukin-1beta and long-term depression in the rat dentate gyrus in vitro, Neuroscience, 118, 347, 10.1016/S0306-4522(02)00941-7 · DOI
  48. Danbolt, 2001, Glutamate uptake, Prog Neurobiol, 65, 1, 10.1016/S0301-0082(00)00067-8 · DOI · Paper page
  49. de Pablos, 2006, Stress increases vulnerability to inflammation in the rat prefrontal cortex, J Neurosci, 26, 5709, 10.1523/JNEUROSCI.0802-06.2006 · DOI · Paper page
  50. DeKosky, 1994, Upregulation of nerve growth factor following cortical trauma, Exp Neurol, 130, 173, 10.1006/exnr.1994.1196 · DOI
  51. Dinarello, 1988, New concepts on the pathogenesis of fever, Rev Infect Dis, 10, 168, 10.1093/clinids/10.1.168 · DOI · Paper page
  52. Ericsson, 1994, A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons, J Neurosci, 14, 897, 10.1523/JNEUROSCI.14-02-00897.1994 · DOI · Paper page
  53. Espinosa-Oliva, 2011, Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus, Neurobiol Aging, 32, 85, 10.1016/j.neurobiolaging.2009.01.012 · DOI · Paper page
  54. Frank, 2010, IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats, Brain Behav Immun, 24, 254, 10.1016/j.bbi.2009.10.005 · DOI
  55. Frank, 2010, Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo, J Neuroimmunol, 226, 181, 10.1016/j.jneuroim.2010.05.022 · DOI
  56. Frank, 2012, IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses, J Neuroimmunol, 252, 33, 10.1016/j.jneuroim.2012.07.010 · DOI
  57. Frank, 2014, Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus, Psychoneuroendocrinology, 40, 191, 10.1016/j.psyneuen.2013.11.006 · DOI
  58. Garcia-Mesa, 2011, Physical exercise protects against Alzheimer’s disease in 3xTg-AD mice, J Alzheimers Dis, 24, 421, 10.3233/JAD-2011-101635 · DOI · Paper page
  59. Gaykema, 1998, Bacterial endotoxin induces Fos immunoreactivity in primary afferent neurons of the vagus nerve, NeuroImmunoModulation, 5, 234, 10.1159/000026343 · DOI
  60. Gibbons, 2014, Voluntary wheel running, but not a diet containing (−)-epigallocatechin-3-gallate and beta-alanine, improves learning, memory and hippocampal neurogenesis in aged mice, Behav Brain Res, 272, 131, 10.1016/j.bbr.2014.05.049 · DOI
  61. Gibertini, 1995, Spatial learning impairment in mice infected with Legionella pneumophila or administered exogenous interleukin-1-beta, Brain Behav Immun, 9, 113, 10.1006/brbi.1995.1012 · DOI · Paper page
  62. Godbout, 2004, Alpha-tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain, J Neuroimmunol, 149, 101, 10.1016/j.jneuroim.2003.12.017 · DOI
  63. Goehler, 1997, Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication, Brain Res Bull, 43, 357, 10.1016/S0361-9230(97)00020-8 · DOI · Paper page
  64. Granowitz, 1992, Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans, Cytokine, 4, 353, 10.1016/1043-4666(92)90078-6 · DOI
  65. Griffiths, 2009, The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain, J Neuropathol Exp Neurol, 68, 217, 10.1097/NEN.0b013e3181996688 · DOI
  66. Hall, 2000, Rapid and selective induction of BDNF expression in the hippocampus during contextual learning, Nat Neurosci, 3, 533, 10.1038/75698 · DOI · Paper page
  67. Hauss-Wegrzyniak, 1998, Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer’s disease, Brain Res, 780, 294, 10.1016/S0006-8993(97)01215-8 · DOI · Paper page
  68. Hauss-Wegrzyniak, 1999, Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS, Brain Res, 815, 36, 10.1016/S0006-8993(98)01081-6 · DOI
  69. Hauss-Wegrzyniak, 2002, Chronic brain inflammation results in cell loss in the entorhinal cortex and impaired LTP in perforant path-granule cell synapses, Exp Neurol, 176, 336, 10.1006/exnr.2002.7966 · DOI
  70. Hein, 2010, Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice, Brain Behav Immun, 24, 243, 10.1016/j.bbi.2009.10.002 · DOI
  71. Hoek, 2000, Down-regulation of the macrophage lineage through interaction with OX2 (CD200), Science, 290, 1768, 10.1126/science.290.5497.1768 · DOI · Paper page
  72. Holmes, 2010, 11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments, J Neurosci, 30, 6916, 10.1523/JNEUROSCI.0731-10.2010 · DOI
  73. Hovens, 2013, Surgery-induced behavioral changes in aged rats, Exp Gerontol, 48, 1204, 10.1016/j.exger.2013.07.011 · DOI
  74. Hovens, 2014, Postoperative cognitive dysfunction: involvement of neuroinflammation and neuronal functioning, Brain Behav Immun, 38, 202, 10.1016/j.bbi.2014.02.002 · DOI · Paper page
  75. Hovens, 2014, Postoperative cognitive dysfunction and microglial activation in associated brain regions in old rats, Neurobiol Learn Mem, 118C, 74
  76. Jacotte-Simancas, 2014, Effects of voluntary physical exercise, citicoline, and combined treatment on object recognition memory, neurogenesis and neuroprotection after traumatic brain injury in rats, Journal of neurotrauma
  77. Jin, 2014, Minocycline improves postoperative cognitive impairment in aged mice by inhibiting astrocytic activation, NeuroReport, 25, 1
  78. Joseph, 1999, Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation, J Neurosci, 19, 8114, 10.1523/JNEUROSCI.19-18-08114.1999 · DOI · Paper page
  79. Jurgens, 2012, Influenza infection induces neuroinflammation, alters hippocampal neuron morphology, and impairs cognition in adult mice, J Neurosci, 32, 3958, 10.1523/JNEUROSCI.6389-11.2012 · DOI · Paper page
  80. Katagiri, 2001, Requirement of appropriate glutamate concentrations in the synaptic cleft for hippocampal LTP induction, Eur J Neurosci, 14, 547, 10.1046/j.0953-816x.2001.01664.x · DOI
  81. Katsuki, 1990, Interleukin-1 B inhibits long-term potentiation in the CA3 region of mouse hippocampal slices, Eur J Pharmacol, 181, 323, 10.1016/0014-2999(90)90099-R · DOI · Paper page
  82. Katsuura, 1990, Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release, Am J Physiol, 258, E163
  83. Kelly, 2003, Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus, J Biol Chem, 278, 19453, 10.1074/jbc.M301938200 · DOI
  84. Kelly, 2012, Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine, J Neurochem, 122, 995, 10.1111/j.1471-4159.2012.07864.x · DOI
  85. Kim, 2010, Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus, Exp Gerontol, 45, 357, 10.1016/j.exger.2010.02.005 · DOI · Paper page
  86. Kinoshita, 2002, Interleukin-1beta messenger ribonucleic acid and protein levels after fluid-percussion brain injury in rats: importance of injury severity and brain temperature, Neurosurgery, 51, 195, 10.1097/00006123-200207000-00027 · DOI
  87. Knoblach, 1998, Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury, Exp Neurol, 153, 143, 10.1006/exnr.1998.6877 · DOI · Paper page
  88. Kohman, 2013, Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice, J Neuroinflammation, 10, 114, 10.1186/1742-2094-10-114 · DOI
  89. Kreutzberg, 1996, Microglia: a sensor for pathological events in the CNS, Trends Neurosci, 19, 312, 10.1016/0166-2236(96)10049-7 · DOI · Paper page
  90. Lapchak, 1993, Systemic interleukin-1 beta decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation, Neuroscience, 53, 297, 10.1016/0306-4522(93)90196-M · DOI
  91. Laye, 1996, Effects of lipopolysaccharide and glucocorticoids on expression of interleukin-1 beta converting enzyme in the pituitary and brain of mice, J Neuroimmunol, 68, 61, 10.1016/0165-5728(96)00066-5 · DOI
  92. Li, 2013, Postoperative impairment of cognitive function in old mice: a possible role for neuroinflammation mediated by HMGB1, S100B, and RAGE, J Surg Res, 185, 815, 10.1016/j.jss.2013.06.043 · DOI
  93. Li, 2014, Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction, Biochem Biophys Res Commun, 449, 74, 10.1016/j.bbrc.2014.04.153 · DOI
  94. Lievens, 2000, Characterization of striatal lesions produced by glutamate uptake alteration: cell death, reactive gliosis, and changes in GLT1 and GADD45 mRNA expression, Glia, 29, 222, 10.1002/(SICI)1098-1136(20000201)29:3<222::AID-GLIA4>3.0.CO;2-0 · doi:10.1002/(sici)1098-1136(20000201)29:3<222::aid-glia4>3.0.co;2-0
  95. Link, 1995, Somatodendritic expression of an immediate early gene is regulated by synaptic activity, Proc Natl Acad Sci U S A, 92, 5734, 10.1073/pnas.92.12.5734 · DOI · Paper page
  96. Lloyd, 2008, Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury, J Neuroinflammation, 5, 28, 10.1186/1742-2094-5-28 · DOI
  97. Long, 1998, Stereological analysis of astrocyte and microglia in aging mouse hippocampus, Neurobiol Aging, 19, 497, 10.1016/S0197-4580(98)00088-8 · DOI · Paper page
  98. Lu, 2007, Bumetanide administration attenuated traumatic brain injury through IL-1 overexpression, Neurol Res, 29, 404, 10.1179/016164107X204738 · doi:10.1179/016164107x204738
  99. Lyford, 1995, Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites, Neuron, 14, 433, 10.1016/0896-6273(95)90299-6 · DOI · Paper page
  100. Lynch, 1998, Age-related impairment in long-term potentiation in hippocampus: a role for the cytokine, interleukin-1 beta?, Prog Neurobiol, 56, 571, 10.1016/S0301-0082(98)00054-9 · DOI · Paper page
  101. Ma, 1998, Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term potentiation in rats, Neuroscience, 82, 957, 10.1016/S0306-4522(97)00325-4 · DOI
  102. MacPherson, 2005, Glucocorticoids worsen excitotoxin-induced expression of pro-inflammatory cytokines in hippocampal cultures, Exp Neurol, 194, 376, 10.1016/j.expneurol.2005.02.021 · DOI · Paper page
  103. Maroney, 1998, Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway, J Neurosci, 18, 104, 10.1523/JNEUROSCI.18-01-00104.1998 · DOI · Paper page
  104. Martin, 2002, Long-term potentiation in aged rats is restored when the age-related decrease in polyunsaturated fatty acid concentration is reversed, Prostaglandins Leukot Essent Fatty Acids, 67, 121, 10.1054/plef.2002.0408 · DOI
  105. Matus-Amat, 2004, The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations, J Neurosci, 24, 2431, 10.1523/JNEUROSCI.1598-03.2004 · DOI · Paper page
  106. McAllister, 1992, Neuropsychiatric sequelae of head injuries, Psychiatr Clin North Am, 15, 395, 10.1016/S0193-953X(18)30245-4 · DOI
  107. McGahon, 1999, Age-related changes in LTP and antioxidant defenses are reversed by an alpha-lipoic acid-enriched diet, Neurobiol Aging, 20, 655, 10.1016/S0197-4580(99)00050-0 · DOI
  108. McGahon, 1999, Age-related changes in oxidative mechanisms and LTP are reversed by dietary manipulation, Neurobiol Aging, 20, 643, 10.1016/S0197-4580(99)00027-5 · DOI
  109. Menard, 2012, Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways, PLoS One, 7, e28666, 10.1371/journal.pone.0028666 · DOI
  110. Merkley, 2014, Homeostatic regulation of adult hippocampal neurogenesis in aging rats: long-term effects of early exercise, Front Neurosci, 8, 174, 10.3389/fnins.2014.00174 · DOI
  111. Minogue, 2003, Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?, J Biol Chem, 278, 27971, 10.1074/jbc.M302530200 · DOI
  112. Mizuno, 2000, Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats, J Neurosci, 20, 7116, 10.1523/JNEUROSCI.20-18-07116.2000 · DOI · Paper page
  113. Moller, 1998, Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International study of post-operative cognitive dysfunction, Lancet, 351, 857, 10.1016/S0140-6736(97)07382-0 · DOI · Paper page
  114. Monti, 2013, History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in life, Front Aging Neurosci, 5, 41, 10.3389/fnagi.2013.00041 · DOI
  115. Moore, 2005, Evidence that vitamin D3 reverses age-related inflammatory changes in the rat hippocampus, Biochem Soc Trans, 33, 573, 10.1042/BST0330573 · DOI
  116. Moser, 2008, Place cells, grid cells, and the brain’s spatial representation system, Annu Rev Neurosci, 31, 69, 10.1146/annurev.neuro.31.061307.090723 · DOI · Paper page
  117. Munhoz, 2010, Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner, J Neurosci, 30, 13690, 10.1523/JNEUROSCI.0303-09.2010 · DOI · Paper page
  118. Murray, 1998, Dietary supplementation with vitamin E reverses the age-related deficit in long term potentiation in dentate gyrus, J Biol Chem, 273, 12161, 10.1074/jbc.273.20.12161 · DOI
  119. Murray, 1999, Interleukin-1 induces lipid peroxidation and membrane changes in rat hippocampus: an age-related study, Gerontology, 45, 136, 10.1159/000022076 · DOI
  120. Nakajima, 2002, Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro, J Neurochem, 80, 697, 10.1046/j.0022-3042.2001.00752.x · DOI
  121. Nguyen, 1998, Exposure to acute stress induces brain interleukin-1beta protein in the rat, J Neurosci, 18, 2239, 10.1523/JNEUROSCI.18-06-02239.1998 · DOI · Paper page
  122. Niemann, 2014, Not only cardiovascular, but also coordinative exercise increases hippocampal volume in older adults, Front Aging Neurosci, 6, 170, 10.3389/fnagi.2014.00170 · DOI · Paper page
  123. Pang, 2004, Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF, Ageing Res Rev, 3, 407, 10.1016/j.arr.2004.07.002 · DOI · Paper page
  124. Perkins, 1999, Association of antioxidants with memory in a multiethnic elderly sample using the Third National Health and Nutrition Examination Survey, Am J Epidemiol, 150, 37, 10.1093/oxfordjournals.aje.a009915 · DOI
  125. Perrig, 1997, The relation between antioxidants and memory performance in the old and very old, J Am Geriatr Soc, 45, 718, 10.1111/j.1532-5415.1997.tb01476.x · DOI · Paper page
  126. Perry, 1998, A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation, J Neuroimmunol, 90, 113, 10.1016/S0165-5728(98)00145-3 · DOI · Paper page
  127. Perry, 1993, Altered antigen expression of microglia in the aged rodent CNS, Glia, 7, 60, 10.1002/glia.440070111 · DOI · Paper page
  128. Pita-Almenar, 2006, Different mechanisms exist for the plasticity of glutamate reuptake during early long-term potentiation (LTP) and late LTP, J Neurosci, 26, 10461, 10.1523/JNEUROSCI.2579-06.2006 · DOI
  129. Pitossi, 1997, Induction of cytokine transcripts in the central nervous system and pituitary following peripheral administration of endotoxin to mice, J Neurosci Res, 48, 287, 10.1002/(SICI)1097-4547(19970515)48:4<287::AID-JNR1>3.0.CO;2-7 · DOI
  130. Pugh, 1999, Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation, Behav Brain Res, 106, 109, 10.1016/S0166-4328(99)00098-4 · DOI
  131. Ramaiah, 2009, Postoperative cognitive dysfunction in the elderly, Anesthesiol Clin, 27, 485, 10.1016/j.anclin.2009.07.011 · DOI
  132. Remarque, 2001, Patients with Alzheimer’s disease display a pro-inflammatory phenotype, Exp Gerontol, 36, 171, 10.1016/S0531-5565(00)00176-5 · DOI
  133. Richwine, 2008, Architectural changes to CA1 pyramidal neurons in adult and aged mice after peripheral immune stimulation, Psychoneuroendocrinology, 33, 1369, 10.1016/j.psyneuen.2008.08.003 · DOI
  134. Rogers, 1988, Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer’s disease, Neurobiol Aging, 9, 339, 10.1016/S0197-4580(88)80079-4 · DOI · Paper page
  135. Rosczyk, 2008, Neuroinflammation and cognitive function in aged mice following minor surgery, Exp Gerontol, 43, 840, 10.1016/j.exger.2008.06.004 · DOI · Paper page
  136. Rosi, 2005, Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression, J Neurosci, 25, 723, 10.1523/JNEUROSCI.4469-04.2005 · DOI
  137. Rozovsky, 1998, Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation, Neurobiol Aging, 19, 97, 10.1016/S0197-4580(97)00169-3 · DOI · Paper page
  138. Rubio, 1994, Demonstration of the presence of an interleukin-1 receptor on the surface of murine astrocytes and its regulation by cytokines and Theiler’s virus, Immunology, 82, 178
  139. Rudy, 2002, Hippocampal formation supports conditioning to memory of a context, Behav Neurosci, 116, 530, 10.1037/0735-7044.116.4.530 · DOI · Paper page
  140. Sandhir, 2008, Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury, Exp Neurol, 213, 372, 10.1016/j.expneurol.2008.06.013 · DOI
  141. Sapolsky, 1999, Glucocorticoids, stress, and their adverse neurological effects: relevance to aging, Exp Gerontol, 34, 721, 10.1016/S0531-5565(99)00047-9 · DOI · Paper page
  142. Sapolsky, 1985, Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications, Science, 229, 1397, 10.1126/science.4035356 · DOI · Paper page
  143. Scheff, 1997, Morris water maze deficits in rats following traumatic brain injury: lateral controlled cortical impact, J Neurotrauma, 14, 615, 10.1089/neu.1997.14.615 · DOI · Paper page
  144. Seckl, 1997, 11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?, Front Neuroendocrinol, 18, 49, 10.1006/frne.1996.0143 · DOI
  145. Seger, 1995, The MAPK signaling cascade, FASEB J, 9, 726, 10.1096/fasebj.9.9.7601337 · DOI · Paper page
  146. Selye, 1955, Stress and disease, Science, 122, 625, 10.1126/science.122.3171.625 · DOI · Paper page
  147. Senathi-Raja, 2010, Impact of age on long-term cognitive function after traumatic brain injury, Neuropsychology, 24, 336, 10.1037/a0018239 · DOI
  148. Shah, 2006, Molecular correlates of age-specific responses to traumatic brain injury in mice, Exp Gerontol, 41, 1201, 10.1016/j.exger.2006.07.006 · DOI
  149. Sheffield, 1998, Microglial expression of MHC class II increases in normal aging of nonhuman primates, Neurobiol Aging, 19, 47, 10.1016/S0197-4580(97)00168-1 · DOI
  150. Shukitt-Hale, 2009, Effects of blackberries on motor and cognitive function in aged rats, Nutr Neurosci, 12, 135, 10.1179/147683009X423292 · DOI
  151. Siette, 2013, Age-specific effects of voluntary exercise on memory and the older brain, Biol Psychiatry, 73, 435, 10.1016/j.biopsych.2012.05.034 · DOI · Paper page
  152. Snigdha, 2014, Exercise enhances memory consolidation in the aging brain, Front Aging Neurosci, 6, 3, 10.3389/fnagi.2014.00003 · DOI
  153. Sparkman, 2008, Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress, NeuroImmunoModulation, 15, 323, 10.1159/000156474 · DOI · Paper page
  154. Sparkman, 2005, Effects of intraperitoneal lipopolysaccharide on Morris maze performance in year-old and 2-month-old female C57BL/6J mice, Behav Brain Res, 159, 145, 10.1016/j.bbr.2004.10.011 · DOI
  155. Steward, 1998, Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites, Neuron, 21, 741, 10.1016/S0896-6273(00)80591-7 · DOI · Paper page
  156. Sun, 2014, Hyperbaric oxygen preconditioning attenuates postoperative cognitive impairment in aged rats, NeuroReport, 25, 718, 10.1097/WNR.0000000000000181 · DOI
  157. Tafti, 1996, Major histocompatibility class II molecules in the CNS: increased microglial expression at the onset of narcolepsy in canine model, J Neurosci, 16, 4588, 10.1523/JNEUROSCI.16-15-04588.1996 · DOI
  158. Tajiri, 2013, Traumatic brain injury precipitates cognitive impairment and extracellular Abeta aggregation in Alzheimer’s disease transgenic mice, PLoS One, 8, e78851, 10.1371/journal.pone.0078851 · DOI · Paper page
  159. Takahashi, 2003, Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity, Ann Neurol, 53, 588, 10.1002/ana.10519 · DOI · Paper page
  160. Takao, 1990, Interleukin-1 receptors in mouse brain: characterization and neuronal localization, Endocrinology, 127, 3070, 10.1210/endo-127-6-3070 · DOI · Paper page
  161. Tan, 2014, Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats, J Neuroinflammation, 11, 93, 10.1186/1742-2094-11-93 · DOI
  162. Terrando, 2013, Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline, FASEB J, 27, 3564, 10.1096/fj.13-230276 · DOI
  163. Tilleux, 2007, Neuroinflammation and regulation of glial glutamate uptake in neurological disorders, J Neurosci Res, 85, 2059, 10.1002/jnr.21325 · DOI · Paper page
  164. Tokutomi, 2008, Age-associated increases in poor outcomes after traumatic brain injury: a report from the Japan Neurotrauma Data Bank, J Neurotrauma, 25, 1407, 10.1089/neu.2008.0577 · DOI
  165. Tomura, 2012, Effects of therapeutic hypothermia on inflammasome signaling after traumatic brain injury, J Cereb Blood Flow Metab, 32, 1939, 10.1038/jcbfm.2012.99 · DOI
  166. Turrin, 2001, Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide, Brain Res Bull, 54, 443, 10.1016/S0361-9230(01)00445-2 · DOI
  167. Tzingounis, 2007, Glutamate transporters: confining runaway excitation by shaping synaptic transmission, Nat Rev Neurosci, 8, 935, 10.1038/nrn2274 · DOI · Paper page
  168. Van Dam, 1995, Endotoxin-induced appearance of immunoreactive interleukin-1 beta in ramified microglia in rat brain: a light and electron microscopic study, Neuroscience, 65, 815, 10.1016/0306-4522(94)00549-K · DOI
  169. Varma, 2014, Low-intensity daily walking activity is associated with hippocampal volume in older adults, Hippocampus
  170. Vereker, 2000, Lipopolysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1, J Biol Chem, 275, 26252, 10.1074/jbc.M002226200 · DOI
  171. Vereker, 2000, The inhibitory effect of interleukin-1beta on long-term potentiation is coupled with increased activity of stress-activated protein kinases, J Neurosci, 20, 6811, 10.1523/JNEUROSCI.20-18-06811.2000 · DOI · Paper page
  172. Vukovic, 2012, Microglia modulate hippocampal neural precursor activity in response to exercise and aging, J Neurosci, 32, 6435, 10.1523/JNEUROSCI.5925-11.2012 · DOI · Paper page
  173. Webb, 1984, Localisation of the MRC OX-2 glycoprotein on the surfaces of neurones, J Neurochem, 43, 1061, 10.1111/j.1471-4159.1984.tb12844.x · DOI
  174. Wenk, 2004, Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid, J Neurochem, 89, 484, 10.1111/j.1471-4159.2004.02359.x · DOI
  175. Wimo, 2013, The worldwide economic impact of dementia 2010, Alzheimers Dement, 9, e13
  176. Wine, 2009, IGF-1 and pAKT signaling promote hippocampal CA1 neuronal survival following injury to dentate granule cells, Neurotox Res, 16, 280, 10.1007/s12640-009-9060-y · DOI
  177. Wyrwoll, 2011, 11beta-Hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress, Front Neuroendocrinol, 32, 265, 10.1016/j.yfrne.2010.12.001 · DOI · Paper page
  178. Yang, 2013, Chronic ceftriaxone treatment rescues hippocampal memory deficit in AQP4 knockout mice via activation of GLT-1, Neuropharmacology, 75, 213, 10.1016/j.neuropharm.2013.08.009 · DOI
  179. Yau, 2011, 11beta-Hydroxysteroid dehydrogenase type 1 deficiency prevents memory deficits with aging by switching from glucocorticoid receptor to mineralocorticoid receptor-mediated cognitive control, J Neurosci, 31, 4188, 10.1523/JNEUROSCI.6145-10.2011 · DOI
  180. Yau, 2015, Intrahippocampal glucocorticoids generated by 11beta-HSD1 affect memory in aged mice, Neurobiol Aging, 36, 334, 10.1016/j.neurobiolaging.2014.07.007 · DOI · Paper page
  181. Ye, 1999, Increased interleukin-6 expression by microglia from brain of aged mice, J Neuroimmunol, 93, 139, 10.1016/S0165-5728(98)00217-3 · DOI · Paper page
  182. Yu, 2014, Protective effect of senegenin on splenectomy-induced postoperative cognitive dysfunction in elderly rats, Exp Ther Med, 7, 821, 10.3892/etm.2014.1501 · DOI
  183. Zhang, 2014, Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor kappaB, Neuroscience, 261, 1, 10.1016/j.neuroscience.2013.12.034 · DOI
  184. Zou, 2005, TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition, Brain Res, 1034, 11, 10.1016/j.brainres.2004.11.014 · DOI · Paper page

Cited by

See all 315

Metadata

Authors
Barrientos, R. M., Kitt, M. M., Watkins, L. R., & Maier, S. F.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2015-11
Volume
309
Pages
84-99
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2015.03.007
OpenAlex
W2078556521
Cited by
315
References
43
FWCI
13.40
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.