Cited by 24Prenatal Substance Exposure EffectsEpigenetics and DNA MethylationBirth, Development, and Health

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Epigenetic mechanisms in alcohol- and adversity-induced developmental origins of neurobehavioral functioning

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Boschen, K.E., Keller, S.M., Roth, T.L., Klintsova, A.Y.·2018·Neurotoxicology and Teratology

DOI 10.1016/j.ntt.2017.12.009PMC PMC5856624

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Abstract

The long-term effects of developmental alcohol and stress exposure are well documented in both humans and non-human animal models. Damage to the brain and attendant life-long impairments in cognition and increased risk for psychiatric disorders are debilitating consequences of developmental exposure to alcohol and/or psychological stress. Here we discuss evidence for a role of epigenetic mechanisms in mediating these consequences. While we highlight some of the common ways in which stress or alcohol impact the epigenome, we point out that little is understood of the epigenome's response to experiencing both stress and alcohol exposure, though stress is a contributing factor as to why women drink during pregnancy. Advancing our understanding of this relationship is of critical concern not just for the health and well-being of individuals directly exposed to these teratogens, but for generations to come.

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Authors: Boschen, K. E., Keller, S. M., Roth, T. L., & Klintsova, A. Y.
Affiliations: University of North Carolina at Chapel Hill (US)
University of Delaware (US)
Corresponding author: Roth, T.L.
Klintsova, A.Y.
ORCID: Boschen, K.E.
Roth, T.L.
Klintsova, A.Y.
Venue: Neurotoxicology and Teratology
Publisher: Elsevier BV
Published: 2018-03
Volume: 66
Pages: 63-79
ISSN: 0892-0362 (ISSN-L)
DOI: 10.1016/j.ntt.2017.12.009
PMC: PMC5856624
OpenAlex: W2781538616
Cited by: 24
References: 293
Citations by year: 2026: 3 · 2025: 2 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 5
FWCI: 0.67
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neurotoxicology and Teratology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (P20GM103653)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD087509)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: epigenetics, developmental alcohol exposure, prenatal alcohol exposure, psychological stress, adversity, neurobehavioral function, cognitive impairment, mental illness, epigenome, teratogens, intergenerational effects
MeSH terms: Ethanol, Animals, Mental Disorders, Brain, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Maternal Exposure, DNA Methylation, Epigenesis, Genetic

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Epigenetic mechanisms in alcohol- and adversity-induced developmental origins of neurobehavioral functioning

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