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The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?
Open accessAbstract
The discovery of the antidepressant effects of ketamine has opened a breakthrough opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants (RAADs). In addition, the rapid and robust biological and behavioral effects of ketamine offered a unique opportunity to utilize the drug as a tool to thoroughly investigate the neurobiology of stress and depression in animals, and to develop sensitive and reproducible biomarkers in humans. The ketamine literature over the past two decades has considerably enriched our understanding of the mechanisms underlying chronic stress, depression, and RAADs. However, considering the complexity of the pharmacokinetics and in vivo pharmacodynamics of ketamine, several questions remain unanswered and, at times, even answered questions continue to be considered controversial or at least not fully understood. The current perspective paper summarizes our understanding of the neurobiology of depression, and the mechanisms of action of ketamine and other RAADs. The review focuses on the role of glutamate neurotransmission - reviewing the history of the "glutamate inhibition" and "glutamate activation" hypotheses, proposing a synaptic connectivity model of chronic stress pathology, and describing the mechanism of action of ketamine. It will also summarize the clinical efficacy findings of putative RAADs, present relevant human biomarker findings, and discuss current challenges and future directions.
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“A main limitation of previous methods is the lack of distinction between presynaptic glutamate release and postsynaptic activation, the latter has been related to the RAAD effects of ketamine [14,15].”
From The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects (2018) · cites this paper as [15]
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“MDD has been shown to affect, among other areas, the PFC, the hippocampus and the anterior cingulate cortex (ACC), and there is evidence that ketamine affects these areas preferentially.204–206”
From Ketamine as an antidepressant: Overview of its mechanisms of action and potential predictive biomarkers (2020) · cites this paper as [204]
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“MDD has been shown to affect, among other areas, the PFC, the hippocampus and the anterior cingulate cortex (ACC), and there is evidence that ketamine affects these areas preferentially.204–206”
From Ketamine as an antidepressant: Overview of its mechanisms of action and potential predictive biomarkers (2020) · cites this paper as [204]
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Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,525
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856
Self-citationA randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881
Self-citationNMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
Paoletti, P., Bellone, C., & Zhou, Q. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3504 · Cited by 2,523
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Self-citationNibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
Self-citationSTRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750
Self-citationSynaptic Dysfunction in Depression: Potential Therapeutic Targets
Duman, R. S., & Aghajanian, G. K. (2012) · Science · doi:10.1126/science.1222939 · Cited by 1,651
Self-citationSynaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644
MCEWEN, B. S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.001 · Cited by 1,638
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Zanos, P., Moaddel, R., Morris, P. J., Georgiou, P., Fischell, J., Elmer, G. I., Alkondon, M., Yuan, P., Pribut, H. J., Singh, N. S., et al. (2016) · Nature · doi:10.1038/nature17998 · Cited by 1,609
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393
Self-citationHomayoun, H., & Moghaddam, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2213-07.2007 · Cited by 1,231
Murrough, J. W., Iosifescu, D. V., Chang, L. C., Al Jurdi, R. K., Green, C. E., Perez, A. M., Iqbal, S., Pillemer, S., Foulkes, A., Shah, A., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13030392 · Cited by 1,205
The cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156
Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103
Ketamine blocks bursting in the lateral habenula to rapidly relieve depression
Yang, Y., Cui, Y., Sang, K., Dong, Y., Ni, Z., Ma, S., & Hu, H. (2018) · Nature · doi:10.1038/nature25509 · Cited by 1,036
Towards a glutamate hypothesis of depression
Sanacora, G., Treccani, G., & Popoli, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.036 · Cited by 1,036
Self-citationDiazgranados, N., Ibrahim, L., Brutsche, N. E., Newberg, A., Kronstein, P., Khalife, S., Kammerer, W. A., Quezado, Z., Luckenbaugh, D. A., Salvadore, G., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.90 · Cited by 963
Kempton, M. J., Salvador, Z., Munafò, M. R., Geddes, J. R., Simmons, A., Frangou, S., & Williams, S. C. R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.60 · Cited by 886
Zarate, C. A., Brutsche, N. E., Ibrahim, L., Franco-Chaves, J., Diazgranados, N., Cravchik, A., Selter, J., Marquardt, C. A., Liberty, V., & Luckenbaugh, D. A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.010 · Cited by 811
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
Trullas, R., & Skolnick, P. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90204-j · Cited by 785
Daly, E. J., Singh, J. B., Fedgchin, M., Cooper, K., Lim, P., Shelton, R. C., Thase, M. E., Winokur, A., Van Nueten, L., Manji, H., et al. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.3739 · Cited by 718
Wilkinson, S. T., Ballard, E. D., Bloch, M. H., Mathew, S. J., Murrough, J. W., Feder, A., Sos, P., Wang, G., Zarate, C. A., & Sanacora, G. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17040472 · Cited by 696
Self-citationCanuso, C. M., Singh, J. B., Fedgchin, M., Alphs, L., Lane, R., Lim, P., Pinter, C., Hough, D., Sanacora, G., Manji, H., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17060720 · Cited by 676
Self-citationMorgan, C. J. A., Curran, H. V., & the Independent Scientific Committee on Drugs (ISCD) (2012) · Addiction · doi:10.1111/j.1360-0443.2011.03576.x · Cited by 667
Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor
Gall, C. M., & Isackson, P. J. (1989) · Science · doi:10.1126/science.2549634 · Cited by 616
Feder, A., Parides, M. K., Murrough, J. W., Perez, A. M., Morgan, J. E., Saxena, S., Kirkwood, K., aan het Rot, M., Lapidus, K. A. B., Wan, L.-B., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.62 · Cited by 613
Zafra, F., Ċastrén, E., Thoenen, H., & Lindholm, D. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10037 · Cited by 580
A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders
Sanacora, G., Frye, M. A., McDonald, W., Mathew, S. J., Turner, M. S., Schatzberg, A. F., Summergrad, P., Nemeroff, C. B., & for the American Psychiatric Association (APA) Council of Research Task Force on Novel Biomarkers and Treatments (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0080 · Cited by 576
Self-citationMoghaddam, B. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13387.x · Cited by 567
Yuen, E. Y., Wei, J., Liu, W., Zhong, P., Li, X., & Yan, Z. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.033 · Cited by 558
Patterson, S. L., Grover, L. M., Schwartzkroin, P. A., & Bothwell, M. (1992) · Neuron · doi:10.1016/0896-6273(92)90067-n · Cited by 555
Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
Krystal, J. H., Sanacora, G., Blumberg, H., Anand, A., Charney, D. S., Marek, G., Epperson, C. N., Goddard, A., & Mason, G. F. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001021 · Cited by 553
Self-citationSchobel, S. A., Chaudhury, N. H., Khan, U. A., Paniagua, B., Styner, M. A., Asllani, I., Inbar, B. P., Corcoran, C. M., Lieberman, J. A., Moore, H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.011 · Cited by 549
Glutamate as a therapeutic target in psychiatric disorders
Javitt, D. C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001551 · Cited by 533
Singh, J. B., Fedgchin, M., Daly, E. J., De Boer, P., Cooper, K., Lim, P., Pinter, C., Murrough, J. W., Sanacora, G., Shelton, R. C., et al. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16010037 · Cited by 525
Self-citationPreskorn, S., Baker, B., Kolluri, S., Menniti, F. S., Krams, M., & Landen, J. W. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31818a6cea · Cited by 524
Antidepressants and neuroplasticity
D'Sa, C. M., & Duman, R. S. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01203.x · Cited by 523
Self-citationTargeting glutamate signalling in depression: progress and prospects
Murrough, J. W., Abdallah, C. G., & Mathew, S. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.16 · Cited by 482
Self-citationAcute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory
Yuen, E. Y., Liu, W., Karatsoreos, I. N., Feng, J., McEwen, B. S., & Yan, Z. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906791106 · Cited by 481
A Randomized Controlled Trial of Intranasal Ketamine in Major Depressive Disorder
Lapidus, K. A. B., Levitch, C. F., Perez, A. M., Brallier, J. W., Parides, M. K., Soleimani, L., Feder, A., Iosifescu, D. V., Charney, D. S., & Murrough, J. W. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.03.026 · Cited by 480
Singh, J. B., Fedgchin, M., Daly, E., Xi, L., Melman, C., De Bruecker, G., Tadic, A., Sienaert, P., Wiegand, F., Manji, H., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.018 · Cited by 466
Banasr, M., Chowdhury, G. M. I., Terwilliger, R., Newton, S. S., Duman, R. S., Behar, K. L., & Sanacora, G. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.106 · Cited by 458
Self-citationGrunebaum, M. F., Galfalvy, H. C., Choo, T.-H., Keilp, J. G., Moitra, V. K., Parris, M. S., Marver, J. E., Burke, A. K., Milak, M. S., Sublette, M. E., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17060647 · Cited by 431
Anand, A., Charney, D. S., Oren, D. A., Berman, R. M., Hu, X. S., Cappiello, A., & Krystal, J. H. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.270 · Cited by 426
Self-citationVollenweider, F. X., Leenders, K. L., Øye, I., Hell, D., & Angst, J. (1997) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(96)00042-9 · Cited by 413
Liu, R.-J., Lee, F. S., Li, X.-Y., Bambico, F., Duman, R. S., & Aghajanian, G. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.030 · Cited by 403
Self-citation(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.805 · Cited by 392
Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept
Rodriguez, C. I., Kegeles, L. S., Levinson, A., Feng, T., Marcus, S. M., Vermes, D., Flood, P., & Simpson, H. B. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.150 · Cited by 386
Ketamine-Associated Ulcerative Cystitis: A New Clinical Entity
Shahani, R., Streutker, C. J., Dickson, B. C., & Stewart, R. J. (2007) · Urology · doi:10.1016/j.urology.2007.01.038 · Cited by 375
McGirr, A., Berlim, M. T., Bond, D. J., Fleck, M. P., Yatham, L. N., & Lam, R. W. (2015) · Psychological Medicine · doi:10.1017/s0033291714001603 · Cited by 373
BDNF release is required for the behavioral actions of ketamine
Lepack, A. E., Fuchikami, M., Dwyer, J. M., Banasr, M., & Duman, R. S. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu033 · Cited by 368
Self-citationVollenweider, F. X., Leenders, K. L., Scharfetter, C., Antonini, A., Maguire, P., Missimer, J., & Angst, J. (1997) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(96)00039-9 · Cited by 353
Skolnick, P., Layer, R. T., Popik, P., Nowak, G., Paul, I. A., & Trullás, R. (1996) · Pharmacopsychiatry · doi:10.1055/s-2007-979537 · Cited by 344
Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory
Yuen, E. Y., Liu, W., Karatsoreos, I. N., Ren, Y., Feng, J., McEwen, B. S., & Yan, Z. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.50 · Cited by 324
Deakin, J. F. W., Lees, J., McKie, S., Hallak, J. E. C., Williams, S. R., & Dursun, S. M. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.37 · Cited by 311
Rowland, L. M., Bustillo, J. R., Mullins, P. G., Jung, R. E., Lenroot, R., Landgraf, E., Barrow, R., Yeo, R., Lauriello, J., & Brooks, W. M. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.394 · Cited by 304
Ketamine Treatment and Global Brain Connectivity in Major Depression
Abdallah, C. G., Averill, L. A., Collins, K. A., Geha, P., Schwartz, J., Averill, C., DeWilde, K. E., Wong, E., Anticevic, A., Tang, C. Y., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.186 · Cited by 300
Self-citationStone, J. M., Dietrich, C., Edden, R., Mehta, M. A., De Simoni, S., Reed, L. J., Krystal, J. H., Nutt, D., & Barker, G. J. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.171 · Cited by 295
Self-citationThe role of serendipity in drug discovery
Ban, T. A. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.3/tban · Cited by 294
Lauterborn, J. C., LYNCH, G. S., Vanderklish, P. W., Arai, A., & Gall, C. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00008.2000 · Cited by 291
13 C MRS studies of neuroenergetics and neurotransmitter cycling in humans
Rothman, D. L., De Feyter, H. M., de Graaf, R. A., Mason, G. F., & Behar, K. L. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1772 · Cited by 290
Krystal, J. H., Abi-Saab, W., Perry, E., D’Souza, D. C., Liu, N., Gueorguieva, R., McDougall, L., Hunsberger, T., Belger, A., Levine, L., et al. (2005) · Psychopharmacology · doi:10.1007/s00213-004-1982-8 · Cited by 272
Self-citationAnticevic, A., Hu, S., Zhang, S., Savic, A., Billingslea, E., Wasylink, S., Repovs, G., Cole, M. W., Bednarski, S., Krystal, J. H., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.021 · Cited by 268
Self-citationIκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity
Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267
Voleti, B., Navarria, A., Liu, R.-J., Banasr, M., Li, N., Terwilliger, R., Sanacora, G., Eid, T., Aghajanian, G., & Duman, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.025 · Cited by 264
Self-citationGlobal Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History
Anticevic, A., Brumbaugh, M. S., Winkler, A. M., Lombardo, L. E., Barrett, J., Corlett, P. R., Kober, H., Gruber, J., Repovs, G., Cole, M. W., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.031 · Cited by 263
Self-citationZarate, C. A., Mathews, D., Ibrahim, L., Chaves, J. F., Marquardt, C., Ukoh, I., Jolkovsky, L., Brutsche, N. E., Smith, M. A., & Luckenbaugh, D. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.019 · Cited by 255
Sanacora, G., & Banasr, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.032 · Cited by 239
Self-citationWang, L., Dai, Z., Peng, H., Tan, L., Ding, Y., He, Z., Zhang, Y., Xia, M., Li, Z., Li, W., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22241 · Cited by 236
Sanacora, G., Smith, M. A., Pathak, S., Su, H.-L., Boeijinga, P. H., McCarthy, D. J., & Quirk, M. C. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.130 · Cited by 236
Self-citationVariable Global Dysconnectivity and Individual Differences in Schizophrenia
Cole, M. W., Anticevic, A., Repovš, G., & Barch, D. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.010 · Cited by 235
Wook Koo, J., Labonté, B., Engmann, O., Calipari, E. S., Juarez, B., Lorsch, Z., Walsh, J. J., Friedman, A. K., Yorgason, J. T., Han, M.-H., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.009 · Cited by 231
Jourdi, H., Hsu, Y.-T., Zhou, M., Qin, Q., Bi, X., & Baudry, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6078-08.2009 · Cited by 226
Antidepressant-like actions of an AMPA receptor potentiator (LY392098)
Li, X., Tizzano, J. P., Griffey, K., Clay, M., Lindstrom, T., & Skolnick, P. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00194-5 · Cited by 225
Driesen, N. R., McCarthy, G., Bhagwagar, Z., Bloch, M., Calhoun, V, D'Souza, D. C., Gueorguieva, R., He, G., Ramachandran, R., Suckow, R. F., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.194 · Cited by 224
Self-citationKassem, M. S., Lagopoulos, J., Stait‐Gardner, T., Price, W. S., Chohan, T. W., Arnold, J. C., Hatton, S. N., & Bennett, M. R. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8365-7 · Cited by 224
Kokkinou, M., Ashok, A., & Howes, O. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.190 · Cited by 212
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
Walsh, J. J., Friedman, A. K., Sun, H., Heller, E. A., Ku, S. M., Juarez, B., Burnham, V. L., Mazei-Robison, M. S., Ferguson, D., Golden, S. A., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3591 · Cited by 210
KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS
Abdallah, C. G., Adams, T. G., Kelmendi, B., Esterlis, I., Sanacora, G., & Krystal, J. H. (2016) · Depression and Anxiety · doi:10.1002/da.22501 · Cited by 206
Self-citationMiller, O. H., Moran, J. T., & Hall, B. J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.028 · Cited by 200
Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies
Averill, L. A., Purohit, P., Averill, C. L., Boesl, M. A., Krystal, J. H., & Abdallah, C. G. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.064 · Cited by 198
Self-citationChowdhury, G. M. I., Zhang, J., Thomas, M., Banasr, M., Ma, X., Pittman, B., Bristow, L., Schaeffer, E., Duman, R. S., Rothman, D. L., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.34 · Cited by 197
Self-citationAntidepressant Effects of the Muscarinic Cholinergic Receptor Antagonist Scopolamine: A Review
Drevets, W. C., Zarate, C. A., & Furey, M. L. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.031 · Cited by 195
PRESKORN, S., MACALUSO, M., MEHRA, D. V., ZAMMIT, G., MOSKAL, J. R., & BURCH, R. M. (2015) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000462606.17725.93 · Cited by 193
Davis, M. T., Holmes, S. E., Pietrzak, R. H., & Esterlis, I. (2017) · Chronic Stress · doi:10.1177/2470547017710916 · Cited by 191
In Vivo Hippocampal Subfield Volumes in Schizophrenia and Bipolar Disorder
Haukvik, U. K., Westlye, L. T., Mørch-Johnsen, L. E., Jørgensen, K. N., Lange, E. H., Dale, A. M., Melle, I. S., Andreassen, O. A., & Agartz, I. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.020 · Cited by 186
Anticevic, A., Corlett, P. R., Cole, M. W., Savic, A., Gancsos, M., Tang, Y., Repovs, G., Murray, J. D., Driesen, N. R., Morgan, P. T., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.022 · Cited by 181
Self-citationPotential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists
Krystal, J. H., Mathew, S. J., DʼSouza, D. C., Garakani, A., Gunduz-Bruce, H., & Charney, D. S. (2010) · CNS Drugs · doi:10.2165/11533230-000000000-00000 · Cited by 180
Self-citationLepack, A. E., Bang, E., Lee, B., Dwyer, J. M., & Duman, R. S. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.09.011 · Cited by 174
Self-citationDistribution in the Brain and Metabolism of Ketamine in the Rat after Intravenous Administration
Cohen, M. L., Chan, S.-L., Way, W. L., & Trevor, A. J. (1973) · Anesthesiology · doi:10.1097/00000542-197310000-00003 · Cited by 174
Early Life Stress, Mood, and Anxiety Disorders
Syed, S. A., & Nemeroff, C. B. (2017) · Chronic Stress · doi:10.1177/2470547017694461 · Cited by 174
Ketamine for the treatment of addiction: evidence and potential mechanisms
Ivan Ezquerra-Romano, I., Lawn, W., Krupitsky, E., & Morgan, C. J. A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.017 · Cited by 163
Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder
Bloch, M. H., Wasylink, S., Landeros-Weisenberger, A., Panza, K. E., Billingslea, E., Leckman, J. F., Krystal, J. H., Bhagwagar, Z., Sanacora, G., & Pittenger, C. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.028 · Cited by 162
Self-citationNew targets for rapid antidepressant action
Machado‐Vieira, R., Henter, I. D., & Zarate, C. A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.001 · Cited by 160
Role of calcium, glutamate and NMDA in major depression and therapeutic application
Deutschenbaur, L., Beck, J., Kiyhankhadiv, A., Mühlhauser, M., Borgwardt, S., Walter, M., Hasler, G., Sollberger, D., & Lang, U. E. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.02.015 · Cited by 158
Albott, C. S., Lim, K. O., Forbes, M. K., Erbes, C. R., Tye, S. J., Grabowski, J. G., THURAS, P. D., Batres‐y‐Carr, T., Wels, J., & Shiroma, P. R. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.17m11634 · Cited by 157
Noppers, I. M., Niesters, M., Aarts, L. P. H. J., Bauer, M. C. R., Drewes, A. M., Dahan, A., & Sarton, E. Y. (2011) · Pain · doi:10.1016/j.pain.2011.03.026 · Cited by 157
The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder
Adams, T. G., Kelmendi, B., Brake, C. A., Gruner, P., Badour, C. L., & Pittenger, C. (2018) · Chronic Stress · doi:10.1177/2470547018758043 · Cited by 154
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Murrough, J. W., Abdallah, C. G., Anticevic, A., Collins, K. A., Geha, P., Averill, L. A., Schwartz, J., DeWilde, K. E., Averill, C., Jia‐Wei Yang, G., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23235 · Cited by 153
Self-citationDriesen, N. R., McCarthy, G., Bhagwagar, Z., Bloch, M. H., Calhoun, V. D., D'Souza, D. C., Gueorguieva, R., He, G., Leung, H.-C., Ramani, R., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.170 · Cited by 148
Self-citationEsterlis, I., DellaGioia, N., Pietrzak, R. H., Matuskey, D., Nabulsi, N., Abdallah, C. G., Yang, J., Pittenger, C., Sanacora, G., Krystal, J. H., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.58 · Cited by 148
Self-citationSheth, C. S., McGlade, E., & Yurgelun-Todd, D. A. (2017) · Chronic Stress · doi:10.1177/2470547017715645 · Cited by 146
Stress during development alters dendritic morphology in the nucleus accumbens and prefrontal cortex
Muhammad, A., Carroll, C., & Kolb, B. E. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.041 · Cited by 146
Krystal, J. H., Abdallah, C. G., Averill, L. A., Kelmendi, B., Harpaz-Rotem, I., Sanacora, G., Southwick, S. M., & Duman, R. S. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0829-z · Cited by 145
Self-citationGlue, P., Medlicott, N. J., Harland, S., Neehoff, S., Anderson-Fahey, B., Le Nedelec, M., Gray, A., & McNaughton, N. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117705089 · Cited by 144
Milak, M. S., Proper, C. J., Mulhern, S. T., Parter, A. L., Kegeles, L. S., Ogden, R. T., Mao, X., Rodriguez, C. I., Oquendo, M. A., Suckow, R. F., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.83 · Cited by 144
GABA interneurons mediate the rapid antidepressant-like effects of scopolamine
Wohleb, E. S., Wu, M., Gerhard, D. M., Taylor, S. R., Picciotto, M. R., Alreja, M., & Duman, R. S. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85033 · Cited by 144
Self-citationKetamine for Social Anxiety Disorder: A Randomized, Placebo-Controlled Crossover Trial
Taylor, J. H., Landeros-Weisenberger, A., Coughlin, C., Mulqueen, J., Johnson, J. A., Gabriel, D., Reed, M. O., Jakubovski, E., & Bloch, M. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.194 · Cited by 142
The Neurobiological Mechanisms of Generalized Anxiety Disorder and Chronic Stress
Patriquin, M. A., & Mathew, S. J. (2017) · Chronic Stress · doi:10.1177/2470547017703993 · Cited by 140
Pham, T. H., Defaix, C., Xu, X., Deng, S.-X., Fabresse, N., Alvarez, J.-C., Landry, D. W., Brachman, R. A., Denny, C. A., & Gardier, A. M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.020 · Cited by 131
Karasawa, J.-I., Shimazaki, T., Kawashima, N., & Chaki, S. (2005) · Brain Research · doi:10.1016/j.brainres.2005.02.032 · Cited by 131
CYLOSERINE AS AN ANTIDEPRESSANT AGENT
CRANE, G. E. (1959) · American Journal of Psychiatry · doi:10.1176/ajp.115.11.1025 · Cited by 127
Chowdhury, G. M. I., Behar, K. L., Cho, W., Thomas, M. A., Rothman, D. L., & Sanacora, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.006 · Cited by 125
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Abdallah, C. G., Jackowski, A., Salas, R., Gupta, S., Sato, J. R., Mao, X., Coplan, J. D., Shungu, D. C., & Mathew, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.49 · Cited by 123
Self-citationBobo, W. V., Voort, J. L. V., Croarkin, P. E., Leung, J. G., Tye, S. J., & Frye, M. A. (2016) · Depression and Anxiety · doi:10.1002/da.22505 · Cited by 123
Ketamine as a promising prototype for a new generation of rapid‐acting antidepressants
Abdallah, C. G., Averill, L. A., & Krystal, J. H. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12718 · Cited by 121
Self-citationSanacora, G., Johnson, M. R., Khan, A., Atkinson, S. D., Riesenberg, R. R., Schronen, J. P., Burke, M. A., Zajecka, J. M., Barra, L., Su, H.-L., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.224 · Cited by 120
Self-citationYao, N., Skiteva, O., Zhang, X., Svenningsson, P., & Chergui, K. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.239 · Cited by 118
Kwon, J. S. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.7.962 · Cited by 116
Paul, R. K., Singh, N. S., Khadeer, M., Moaddel, R., Sanghvi, M., Green, C. E., O’Loughlin, K., Torjman, M. C., Bernier, M., & Wainer, I. W. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000285 · Cited by 115
Can, A., Zanos, P., Moaddel, R., Kang, H. J., Dossou, K. S. S., Wainer, I. W., Cheer, J. F., Frost, D. O., Huang, X.-P., & Gould, T. D. (2016) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.235838 · Cited by 115
Stress-Induced Changes in Nucleus Accumbens Glutamate Synaptic Plasticity
Campioni, M. R., Xu, M., & McGehee, D. S. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91111.2008 · Cited by 115
Abdallah, C. G., Averill, C. L., Salas, R., Averill, L. A., Baldwin, P. R., Krystal, J. H., Mathew, S. J., & Mathalon, D. H. (2017) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.04.006 · Cited by 111
Self-citationGhosal, S., Bang, E., Yue, W., Hare, B. D., Lepack, A. E., Girgenti, M. J., & Duman, R. S. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.017 · Cited by 111
Self-citationLiu, R.-J., Duman, C., Kato, T., Hare, B., Lopresto, D., Bang, E., Burgdorf, J., Moskal, J., Taylor, J., Aghajanian, G., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.202 · Cited by 105
Self-citationDeLorenzo, C., DellaGioia, N., Bloch, M. H., Sanacora, G., Nabulsi, N., Abdallah, C. G., Yang, J., Wen, R., Mann, J. J., Krystal, J. H., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.024 · Cited by 105
Self-citationJavitt, D. C., Carter, C. S., Krystal, J. H., Kantrowitz, J. T., Girgis, R. R., Kegeles, L. S., Ragland, J. D., Maddock, R. J., Lesh, T. A., Tanase, C., et al. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.3572 · Cited by 100
Self-citationUncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects
Li, S.-X., Han, Y., Xu, L., Yuan, K., Zhang, R.-X., Sun, C.-Y., Xu, D.-F., Yuan, M., Deng, J.-H., Meng, S.-Q., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.85 · Cited by 100
Neuroclinical Framework for the Role of Stress in Addiction
Kwako, L. E., & Koob, G. F. (2017) · Chronic Stress · doi:10.1177/2470547017698140 · Cited by 99
Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD
Wrocklage, K. M., Averill, L. A., Scott, J. C., Averill, C. L., Schweinsburg, B. C., Trejo, M., Roy, A. M., Weisser, V. D., Kelly, C., Martini, B. L., et al. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.02.010 · Cited by 97
Self-citationPost-Traumatic Stress Disorder: The Relationship Between the Fear Response and Chronic Stress
Maeng, L. Y., & Milad, M. R. (2017) · Chronic Stress · doi:10.1177/2470547017713297 · Cited by 92
Matosin, N., Cruceanu, C., & Binder, E. B. (2017) · Chronic Stress · doi:10.1177/2470547017710764 · Cited by 91
The Loss of Serendipity in Psychopharmacology
Klein, D. F. (2008) · JAMA · doi:10.1001/jama.299.9.1063 · Cited by 82
Effects of Inhibitor of κB Kinase Activity in the Nucleus Accumbens on Emotional Behavior
Christoffel, D. J., Golden, S. A., Heshmati, M., Graham, A., Birnbaum, S., Neve, R. L., Hodes, G. E., & Russo, S. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.121 · Cited by 78
Scheinost, D., Holmes, S. E., DellaGioia, N., Schleifer, C., Matuskey, D., Abdallah, C. G., Hampson, M., Krystal, J. H., Anticevic, A., & Esterlis, I. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.229 · Cited by 73
Self-citationAbdallah, C. G., Dutta, A., Averill, C. L., McKie, S., Akiki, T. J., Averill, L. A., & William Deakin, J. F. (2018) · Chronic Stress · doi:10.1177/2470547018796102 · Cited by 70
Self-citationAbdallah, C. G., Wrocklage, K. M., Averill, C. L., Akiki, T. J., Schweinsburg, B. C., Roy, A. M., Martini, B. A., Southwick, S. M., Krystal, J. H., & Scott, J. C. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.12 · Cited by 69
Self-citationAbdallah, C. G., Coplan, J. D., Jackowski, A. P., Sato, J. R., Mao, X., Shungu, D. C., & Mathew, S. J. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.009 · Cited by 69
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Hare, B. D., Ghosal, S., & Duman, R. S. (2017) · Chronic Stress · doi:10.1177/2470547017697317 · Cited by 67
Self-citationAbdallah, C. G., Jackowski, A., Sato, J. R., Mao, X., Kang, G., Cheema, R., Coplan, J. D., Mathew, S. J., & Shungu, D. C. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.025 · Cited by 67
Self-citationSolmi, M., Veronese, N., Zaninotto, L., van der Loos, M. L. M., Gao, K., Schaffer, A., Reis, C., Normann, C., Anghelescu, I., & Correll, C. U. (2016) · CNS Spectrums · doi:10.1017/s1092852916000523 · Cited by 67
Réus, G. Z., Abelaira, H. M., dos Santos, M. A. B., Carlessi, A. S., Tomaz, D. B., Neotti, M. V., Liranço, J. L. G., Gubert, C., Barth, M., Kapczinski, F. P., et al. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.041 · Cited by 67
Warren, B. L., Sial, O. K., Parise, L. F., Greenwood, M. A., Brewer, J. S., Rozofsky, J. P., Parise, E. M., & Bolaños‐Guzmán, C. A. (2014) · Developmental Neuroscience · doi:10.1159/000362875 · Cited by 64
Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine
Li, N., He, X., Zhang, Y., Qi, X., Li, H., Zhu, X., & He, S. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001082 · Cited by 59
The Association of PTSD Symptom Severity With Localized Hippocampus and Amygdala Abnormalities
Akiki, T. J., Averill, C. L., Wrocklage, K. M., Schweinsburg, B., Scott, J. C., Martini, B., Averill, L. A., Southwick, S. M., Krystal, J. H., & Abdallah, C. G. (2017) · Chronic Stress · doi:10.1177/2470547017724069 · Cited by 58
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Chowdhury, G. M. I., Banasr, M., de Graaf, R. A., Rothman, D. L., Behar, K. L., & Sanacora, G. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.78 · Cited by 48
Self-citationMathew, S. J., Gueorguieva, R. V., Brandt, C., D, M. F. M., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.106 · Cited by 46
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Daskalakis, N. P., & Binder, E. B. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu189 · Cited by 45
Moaddel, R., Sanghvi, M., Dossou, K. S. S., Ramamoorthy, A., Green, C., Bupp, J. E., Swezey, R. R., O’Loughlin, K. G., & Wainer, I. W. (2015) · Pharmacology Research & Perspectives · doi:10.1002/prp2.157 · Cited by 41
The positive effect on ketamine as a priming adjuvant in antidepressant treatment
Melo, A., Kokras, N., Dalla, C., Ferreira, C., Ventura‐Silva, A. P., Sousa, N., & Pêgo, J. M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.66 · Cited by 40
The Neurobiology of Panic: A Chronic Stress Disorder
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Abdallah, C. G., Southwick, S. M., & Krystal, J. H. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.04.046 · Cited by 35
Self-citationTHE DESTRUCTION OF THE LOWER URINARY TRACT BY KETAMINE ABUSE: A NEW SYNDROME?
Cottrell, A. M., Warren, K., Ayres, R., Weinstock, P., Kumar, V., & Gillatt, D. A. (2008) · British Journal of Urology · doi:10.1111/j.1464-410x.2008.08146_2.x · Cited by 33
Amygdala-Hippocampal Volume and the Phenotypic Heterogeneity of Posttraumatic Stress Disorder
Pietrzak, R. H., Averill, L. A., Abdallah, C. G., Neumeister, A., Krystal, J. H., Levy, I., & Harpaz‐Rotem, I. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2470 · Cited by 32
Self-citationAverill, L. A., Abdallah, C. G., Pietrzak, R. H., Averill, C. L., Southwick, S. M., Krystal, J. H., & Harpaz‐Rotem, I. (2017) · Chronic Stress · doi:10.1177/2470547017724714 · Cited by 31
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Self-citationAleksandrova, L. R., Wang, Y. T., & Phillips, A. G. (2017) · Chronic Stress · doi:10.1177/2470547017743511 · Cited by 23
Prescot, A. P., Sheth, C. S., Legarreta, M. D., Renshaw, P. F., McGlade, E., & Yurgelun-Todd, D. A. (2018) · Chronic Stress · doi:10.1177/2470547018768771 · Cited by 10
Tang, H., Kukral, D. W., Li, Y.-W., Fronheiser, M. P., Malone, H. J., Pena, A., Pieschl, R. L., Sidik, K., Tobon, G., Chow, P. L., et al. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117746901 · Cited by 10
Coplan, J. D., Lu, D., Sehamy, A. M. E., Tang, C. Y., Jackowski, A. P., Abdallah, C. G., Nemeroff, C. B., Owens, M. J., Mathew, S. J., & Gorman, J. M. (2018) · Chronic Stress · doi:10.1177/2470547018768450 · Cited by 7
Self-citationLow-Dose d-Cycloserine for Depression?
Kim, S. W., Kushner, M. G., Yoon, G., Anker, J. J., & Grant, J. E. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15lr10272 · Cited by 2
Research works printed but not linked: 1
- Schwarcz, 2017, Endogenous kynurenic acid mediates ketamine- and (2R,6R)-hydroxynorketamine-induced increases in extracellular glutamate and antidepressant actions, Neuropsychopharmacology, 43, S111
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Metadata
- Authors
- Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H.
- Affiliations
- Yale University (US)
- Corresponding author
- Abdallah, Chadi G.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 190
- Pages
- 148-158
- ISSN
- 0163-7258 (ISSN-L)
- PMC
- PMC6165688
- OpenAlex
- W2803958441
- Cited by
- 219
- References
- 173
- Citations by year
- 2026: 9 · 2025: 29 · 2024: 22 · 2023: 29 · 2022: 25 · 2021: 24 · 2020: 35 · 2019: 31 · 2018: 15
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k23mh101498-05)
- National Institute of Mental Health (K23MH-101498(, R01MH093897)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- depression, ketamine, rapid-acting antidepressants, glutamatergic neurotransmission, chronic stress, mechanism of action, biomarkers, antidepressant efficacy
- MeSH terms
- Drug Development, Animals, Antidepressive Agents, Depression, Disease Models, Animal, Humans, Ketamine, Synaptic Transmission, Biomarkers, Glutamic Acid
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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