Septal oxytocin administration impairs peer affiliation via V1a receptors in female meadow voles
Open accessAbstract
The peptide hormone oxytocin (OT) plays an important role in social behaviors, including social bond formation. In different contexts, however, OT is also associated with aggression, social selectivity, and reduced affiliation. Female meadow voles form social preferences for familiar same-sex peers under short, winter-like day lengths in the laboratory, and provide a means of studying affiliation outside the context of reproductive pair bonds. Multiple lines of evidence suggest that the actions of OT in the lateral septum (LS) may decrease affiliative behavior, including greater density of OT receptors in the LS of meadow voles that huddle less. We infused OT into the LS of female meadow voles immediately prior to cohabitation with a social partner to determine its effects on partner preference formation. OT prevented the formation of preferences for the partner female. Co-administration of OT with a specific OT receptor antagonist did not reverse the effect, but co-administration of OT with a specific vasopressin 1a receptor (V1aR) antagonist did, indicating that OT in the LS likely acted through V1aRs to decrease partner preference. Receptor autoradiography revealed dense V1aR binding in the LS of female meadow voles. These results suggest that the LS is a brain region that may be responsible for inhibitory effects of OT administration on affiliation, which will be important to consider in therapeutic administrations of OT.
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In female meadow voles housed in winter-like conditions, injection of OT into the lateral septum prevents the formation of partner preferences, an effect blocked by co-administration of OT with a V1aR but not an OTR antagonist.
“When housed in winter-like conditions female voles form partner preferences for other females. Injection of OT into the lateral septum prevents the formation of these partner preferences, an effect that is blocked by co-administration of OT with a V1aR but not an OTR antagonist.”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [54]
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- Authors
- Anacker, A. M. J., Christensen, J. D., LaFlamme, E. M., Grunberg, D. M., & Beery, A. K.
- Affiliations
- Smith College (US)
- Corresponding author
- Beery, Annaliese K.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 68
- Pages
- 156-162
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC4851907
- OpenAlex
- W2285705771
- Cited by
- 44
- References
- 67
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 1
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 283 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Psychoneuroendocrinology (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Smith ScholarWorks (Smith College) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation (#1257162)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, vasopressin V1a receptor, lateral septum, social affiliation, mate preferences, Microtus pennsylvanicus, female social behavior, social selectivity, receptor antagonists, huddling behavior
- MeSH terms
- Animals, Autoradiography, Brain, Arvicolinae, Female, Oxytocin, Pair Bond, Peer Group, Septal Nuclei, Sexual Behavior, Animal, Social Behavior, Receptors, Vasopressin, Receptors, Oxytocin
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