Impact of circadian misalignment on energy metabolism during simulated nightshift work
Open accessAbstract
Significance: Demands of modern society force many work operations into the night, when the intrinsic circadian timing system promotes sleep. Overnight shiftwork is associated with increased risk for adverse metabolic health and sleep disruption. Uncovering potential physiological mechanisms that contribute to metabolic dysregulation when work and eating occur at inappropriate circadian times is vital to the development of effective treatment strategies. In this study, healthy volunteers underwent a commonly used simulated shiftwork protocol to quantify changes in metabolic, sleep, and circadian physiology when working and eating during the night as compared with a traditional day work schedule. We demonstrate that nightshift work reduces total daily energy expenditure, representing a contributing mechanism for unwanted weight gain and obesity.
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In simulated night shiftwork in normal weight women, reductions in total daily energy expenditure and the thermic effect of dinner contribute to weight gain, obesity, and impaired health as a result of shiftwork.
“In a study of simulated night shiftwork in normal weight women, reductions in both total daily energy expenditure and the thermic effect of dinner were highlighted as contributing mechanisms for weight gain, obesity and impaired health as a result of shiftwork [27].”
From The Health Impact of Nighttime Eating: Old and New Perspectives (2015) · cites this paper as [27]
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- Authors
- McHill, A. W., Melanson, E. L., Higgins, J., Connick, E., Moehlman, T. M., Stothard, E. R., & Wright, K. P.
- Affiliations
- University of Colorado Boulder (US)
- Endocrinology, Metabolism, and Diabetes,
- University of Colorado Anschutz (US)
- Infectious Diseases and
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-11-17
- Volume
- 111
- Issue
- 48
- Pages
- 17302-17307
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4260578
- OpenAlex
- W2069822948
- Cited by
- 349
- References
- 46
- Citations by year
- 2026: 24 · 2025: 26 · 2024: 27 · 2023: 39 · 2022: 38 · 2021: 25 · 2020: 34 · 2019: 32 · 2018: 24 · 2017: 34 · 2016: 23 · 2015: 23
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (UL1TR001082)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK092624, P30DK048520)
- National Center for Research Resources (UL1RR025780)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- circadian misalignment, night shift work, shift work, energy expenditure, thermic effect of feeding, fat utilization, carbohydrate utilization, protein utilization, leptin, peptide YY, sleep disruption, obesity risk
- MeSH terms
- Adult, Analysis of Variance, Circadian Rhythm, Eating, Electromyography, Energy Metabolism, Female, Humans, Male, Melatonin, Obesity, Risk Factors, Sleep, Sleep Deprivation, Sleep Stages, Time Factors, Wakefulness, Work Schedule Tolerance, Weight Gain, Peptide YY, Leptin, Ghrelin
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