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Cited by 279Stress Responses and CortisolHypothalamic control of reproductive hormonesNeuroendocrine regulation and behavior

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Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes

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Holder, Mary K., Blaustein, Jeffrey D.·2014·Frontiers in Neuroendocrinology
DOI 10.1016/j.yfrne.2013.10.004PMC PMC3946873
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Abstract

Puberty and adolescence are major life transitions during which an individual's physiology and behavior changes from that of a juvenile to that of an adult. Here we review studies documenting the effects of stressors during pubertal and adolescent development on the adult brain and behavior. The experience of complex or compound stressors during puberty/adolescence generally increases stress reactivity, increases anxiety and depression, and decreases cognitive performance in adulthood. These behavioral changes correlate with decreased hippocampal volumes and alterations in neural plasticity. Moreover, stressful experiences during puberty disrupt behavioral responses to gonadal hormones both in sexual performance and on cognition and emotionality. These behavioral changes correlate with altered estrogen receptor densities in some estrogen-concentrating brain areas, suggesting a remodeling of the brain's response to hormones. A hypothesis is presented that activation of the immune system results in chronic neuroinflammation that may mediate the alterations of hormone-modulated behaviors in adulthood.

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Metadata

Authors
Holder, M. K., & Blaustein, J. D.
Affiliations
University of Massachusetts Amherst (US)
Corresponding author
Blaustein, Jeffrey D.
ORCID
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2014-01
Volume
35
Issue
1
Pages
89-110
ISSN
0091-3022 (ISSN-L)
DOI
10.1016/j.yfrne.2013.10.004
PMC
PMC3946873
OpenAlex
W2030185037
Cited by
279
References
344
Citations by year
2026: 28 · 2025: 35 · 2024: 20 · 2023: 29 · 2022: 22 · 2021: 29 · 2020: 24 · 2019: 18 · 2018: 23 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 7
FWCI
0.98
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (MH093854, R21MH093854)
  • National Institute of Neurological Disorders and Stroke (R01NS019327, NS-19327)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
puberty, adolescence, developmental stress, stress reactivity, anxiety, depression, cognitive performance, hippocampal volume, neuroplasticity, gonadal hormones, sexual behavior, estrogen receptor, neuroinflammation, immune activation, neurobehavioral development
MeSH terms
Adolescent, Adolescent Behavior, Animals, Cognition, Humans, Puberty, Sexual Maturation, Stress, Psychological, Gonadal Hormones

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