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Opioid site in nucleus accumbens shell mediates eating and hedonic ‘liking’ for food: map based on microinjection Fos plumes
Abstract
Microinjection of opioid agonists, such as morphine, into the nucleus accumbens shell produces increases in eating behavior (i.e. 'wanting' for food). This study (1) reports direct evidence that activation of accumbens opioid receptors in rats also augments food 'liking', or the hedonic impact of taste, and (2) identified a neural site that definitely contains receptors capable of increasing food intake. Morphine microinjections (0.5 microgram) into accumbens shell, which caused rats to increase eating, were found also to cause selective increases in positive hedonic patterns of behavioral affective reaction elicited by oral sucrose, using the 'taste reactivity' test of hedonic palatability. This positive shift indicated that morphine microinjections enhanced the hedonic impact of food palatability. The accumbens site mediating morphine-induced increases in food 'wanting' and 'liking' was identified using a novel method based on local expression of Fos induced directly by drug microinjections. The plume-shaped region of drug-induced increase in Fos immunoreactivity immediately surrounding a morphine microinjection site (Fos plume) was objectively mapped. A point-sampling procedure was used to measure the shape and size of 'positive' plumes of Fos expression triggered by microinjections of morphine at locations that caused increases in eating behavior. This revealed a functionally 'positive' neural region, containing receptors directly activated by behaviorally-effective drug microinjections. A subtraction mapping procedure was then used to eliminate all surrounding regions containing any 'negative' Fos plumes that failed to increase food intake. The subtraction produced a conservative map of the positive site, by eliminating regions that gave mixed effects, and leaving only a positive region that must contain receptors capable of mediating increases in food intake. The resulting mapped 'opioid eating site' was contained primarily within the medial caudal subregion of the nucleus accumbens shell, and did not substantially penetrate either into the accumbens core or into other subregions of the shell. Several other structures outside the nucleus accumbens (such as rostral ventral pallidum), immediately medial and adjacent to the shell, also appeared to be included in the functional site. Opioid receptors within this site thus are capable of mediating morphine-induced increases in eating, in part by enhancing the hedonic reward properties of food.
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“Pharmacological control of the output from the NAc shell can also have profound effects on food consumption [312,313], as does surgical or chemical lesion of the nigrostriatal or mesolimbic DA pathways.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [312]
In the citing paper
“Nonetheless, the three receptor types have different behavioral domains, with MOR and DOR mediating generally positive motivation and affect, while KOR mediates generally negative motivation and aversion (Pfeiffer et al 1986; Shippenberg et al 1987; Pecina and Berridge 2000; McLaughlin et al 2003; for reviews see Van Ree et al 2000; Le Merrer et al 2009).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Pecina and Berridge 2000
In the citing paper
“Furthermore, microinjections of opiate into the nucleus accumbens increased food intake and the reward value of food (5).”
From Effects of dietary glycemic index on brain regions related to reward and craving in men (2013) · cites this paper as [5]
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Metadata
- Authors
- Peciña, S., & Berridge, K. C.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Berridge, Kent C
- ORCID
- Berridge, Kent C
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 863
- Issue
- 1-2
- Pages
- 71-86
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2053400076
- Cited by
- 405
- References
- 94
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 55 · 2019: 16 · 2018: 17 · 2017: 13 · 2016: 10 · 2015: 18 · 2014: 19 · 2013: 17 · 2012: 20
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- nucleus accumbens shell, opioid receptors, morphine, dietary intake, food liking, desire to eat, taste reactivity, functional mapping, reward, dietary habits
- MeSH terms
- Animals, Brain Mapping, Drug Interactions, Eating, Male, Microinjections, Morphine, Narcotics, Nucleus Accumbens, Receptors, Opioid, Reward, Sucrose, Taste, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Rats
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