Cited by 85Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchVisual perception and processing mechanisms

Attention – oscillations and neuropharmacology

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Deco, Gustavo, Thiele, Alexander·2009·European Journal of Neuroscience

Abstract

Attention is a rich psychological and neurobiological construct that influences almost all aspects of cognitive behaviour. It enables enhanced processing of behaviourally relevant stimuli at the expense of irrelevant stimuli. At the cellular level, rhythmic synchronization at local and long‐range spatial scales complements the attention‐induced firing rate changes of neurons. The former is hypothesized to enable efficient communication between neuronal ensembles tuned to spatial and featural aspects of the attended stimulus. Recent modelling studies suggest that the rhythmic synchronization in the gamma range may be mediated by a fine balance between N‐methyl‐d‐aspartate and α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate postsynaptic currents, whereas other studies have highlighted the possible contribution of the neuromodulator acetylcholine. This review summarizes some recent modelling and experimental studies investigating mechanisms of attention in sensory areas and discusses possibilities of how glutamatergic and cholinergic systems could contribute to increased processing abilities at the cellular and network level during states of top‐down attention.

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Crossref · 10.1111/j.1460-9568.2009.06833.x

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  • In the primary visual cortex, blockade of muscarinic but not nicotinic AChRs impairs the attentional modulation of V1 neurons.

    “Herrero et al. demonstrated that in the primary visual cortex, blockade of muscarinic but not nicotinic AChRs impaired the attentional modulation of V1 neurons (Herrero et al, 2008; see also Deco and Thiele, 2009).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Deco and Thiele, 2009

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Authors
Deco, G., & Thiele, A.
Affiliations
  • Universitat Pompeu Fabra (ES)
  • Newcastle University (GB)
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2009-08
Volume
30
Issue
3
Pages
347-354
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2063514442
Cited by
85
References
122
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 7 · 2013: 13 · 2012: 10
FWCI
0.73
Type
journal article
Language
en
Open access
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Funders
  • Wellcome Trust (070380)
  • Medical Research Council (G0700976)
  • Biotechnology and Biological Sciences Research Council (BB/F021399/1, BBS/B/09325)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
attention, neural oscillations, gamma oscillations, rhythm synchronization, NMDA receptor, AMPA receptors, acetylcholine, glutamatergic system, cholinergic system, top-down attention, neuronal ensembles, sensory processing, neuropharmacology
MeSH terms
Animals, Attention, Brain, Humans, Macaca mulatta, Neurons, Neuropharmacology

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