Attention – oscillations and neuropharmacology
Open accessAbstract
Attention is a rich psychological and neurobiological construct that influences almost all aspects of cognitive behaviour. It enables enhanced processing of behaviourally relevant stimuli at the expense of irrelevant stimuli. At the cellular level, rhythmic synchronization at local and long‐range spatial scales complements the attention‐induced firing rate changes of neurons. The former is hypothesized to enable efficient communication between neuronal ensembles tuned to spatial and featural aspects of the attended stimulus. Recent modelling studies suggest that the rhythmic synchronization in the gamma range may be mediated by a fine balance between N‐methyl‐d‐aspartate and α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate postsynaptic currents, whereas other studies have highlighted the possible contribution of the neuromodulator acetylcholine. This review summarizes some recent modelling and experimental studies investigating mechanisms of attention in sensory areas and discusses possibilities of how glutamatergic and cholinergic systems could contribute to increased processing abilities at the cellular and network level during states of top‐down attention.
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In the primary visual cortex, blockade of muscarinic but not nicotinic AChRs impairs the attentional modulation of V1 neurons.
“Herrero et al. demonstrated that in the primary visual cortex, blockade of muscarinic but not nicotinic AChRs impaired the attentional modulation of V1 neurons (Herrero et al, 2008; see also Deco and Thiele, 2009).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Deco and Thiele, 2009
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Zinke, W., Roberts, M. J., Guo, K., McDonald, J. S., Robertson, R., & Thiele, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04882.x · Cited by 96 · see citing works
Self-citationFast network oscillations induced by potassium transients in the rat hippocampus in vitro
LeBeau, F. E. N., Towers, S. K., Traub, R. D., Whittington, M. A., & Buhl, E. H. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.015933 · Cited by 93 · see citing works
Nicotine receptors are located on lateral geniculate nucleus terminals in cat visual cortex
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Additive Effects of Attention and Stimulus Contrast in Primary Visual Cortex
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Self-citationSpatial attention excludes external noise at the target location
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The Neuronal Basis of Attention: Rate versus Synchronization Modulation
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Attentional effects on contrast detection in the presence of surround masks
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Selective representation of task‐relevant objects and locations in the monkey prefrontal cortex
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Self-citation
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Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
Modes and models of forebrain cholinergic neuromodulation of cognition
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Intrinsic Coupling Modes: Multiscale Interactions in Ongoing Brain Activity
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Mechanisms of top-down attention
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Astrocytes Mediate In Vivo Cholinergic-Induced Synaptic Plasticity
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Thiele, A., & Bellgrove, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.008 · Cited by 350 · see citing works
Self-citationFree Energy, Precision and Learning: The Role of Cholinergic Neuromodulation
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Parikh, V., Ji, J., Decker, M. W., & Sarter, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5712-09.2010 · Cited by 133 · see citing works
Leveraging the cortical cholinergic system to enhance attention
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- Authors
- Deco, G., & Thiele, A.
- Affiliations
- Universitat Pompeu Fabra (ES)
- Newcastle University (GB)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2009-08
- Volume
- 30
- Issue
- 3
- Pages
- 347-354
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC2777251
- OpenAlex
- W2063514442
- Cited by
- 85
- References
- 122
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 7 · 2013: 13 · 2012: 10
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Wellcome Trust (070380)
- Medical Research Council (G0700976)
- Biotechnology and Biological Sciences Research Council (BB/F021399/1, BBS/B/09325)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- attention, neural oscillations, gamma oscillations, rhythm synchronization, NMDA receptor, AMPA receptors, acetylcholine, glutamatergic system, cholinergic system, top-down attention, neuronal ensembles, sensory processing, neuropharmacology
- MeSH terms
- Animals, Attention, Brain, Humans, Macaca mulatta, Neurons, Neuropharmacology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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