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Autism spectrum disorder
Open accessAbstract
Autism spectrum disorder is a term used to describe a constellation of early-appearing social communication deficits and repetitive sensory-motor behaviours associated with a strong genetic component as well as other causes. The outlook for many individuals with autism spectrum disorder today is brighter than it was 50 years ago; more people with the condition are able to speak, read, and live in the community rather than in institutions, and some will be largely free from symptoms of the disorder by adulthood. Nevertheless, most individuals will not work full-time or live independently. Genetics and neuroscience have identified intriguing patterns of risk, but without much practical benefit yet. Considerable work is still needed to understand how and when behavioural and medical treatments can be effective, and for which children, including those with substantial comorbidities. It is also important to implement what we already know and develop services for adults with autism spectrum disorder. Clinicians can make a difference by providing timely and individualised help to families navigating referrals and access to community support systems, by providing accurate information despite often unfiltered media input, and by anticipating transitions such as family changes and school entry and leaving.
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“Adaptive behaviour is a challenge for many individuals with ASD, who have scores below what would be expected based on IQ 286 .”
From Autism spectrum disorder (2020) · cites this paper as [286]
Experimental — accuracy not yet measuredIn the citing paper
“Findings from previous studies and reviews have suggested that children and adults with ASD/ADHD are associated with coexisting mental and neurologic conditions (such as oppositional and conduct disorders, tic disorders, epilepsy, depression, anxiety, and substance use disorders).3,4,5,57”
From Mortality in Persons With Autism Spectrum Disorder or Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-analysis (2022) · cites this paper as [4]
In the citing paper
“As children and young persons with ASD/ADHD age, they often experience emotional and social difficulties.3,4,5”
From Mortality in Persons With Autism Spectrum Disorder or Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-analysis (2022) · cites this paper as [4]
In the citing paper
“The pathogenesis involves the interactions between genetic, immune system, environment and in utero factors [207].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [207]
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Metadata
- Authors
- Lord, C., Elsabbagh, M., Baird, G., & Veenstra-Vanderweele, J.
- Affiliations
- NewYork–Presbyterian Hospital (US)
- McGill University (CA)
- Kings Health Partners (GB)
- Corresponding author
- Lord, Catherine
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 392
- Issue
- 10146
- Pages
- 508-520
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC7398158
- OpenAlex
- W2886989735
- Cited by
- 2,819
- References
- 137
- Citations by year
- 2026: 559 · 2025: 492 · 2024: 420 · 2023: 403 · 2022: 333 · 2021: 285 · 2020: 192 · 2019: 83 · 2018: 24
- FWCI
- 19.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Weill Cornell Medical College
- Health Canada
- Fonds de Recherche du Québec - Santé
- National Institute of Mental Health (R01MH104423)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD081199)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
- Keywords
- autism spectrum disorder, social communication deficits, genetic risk factors, comorbidities, coming of age, community support services, family support, media misinformation
- MeSH terms
- Autism Spectrum Disorder, Adolescent, Adult, Child, Humans, Risk Factors
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