Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?

The L-Arginine-Nitric Oxide Pathway

Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678

Metal-catalyzed oxidation of proteins. Physiological consequences

Stadtman, E. R., & Oliver, C. N. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52199-2 · Cited by 862

Chronic Granulomatous Disease

Holland, S. M. (2010) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-009-8136-z · Cited by 328

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275

Health effects of quercetin: From antioxidant to nutraceutical

Boots, A. W., Haenen, G. R. M. M., & Bast, A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.008 · Cited by 2,121

Diabetes mellitus and oxidative stress—A concise review

Asmat, U., Abad, K., & Ismail, K. (2016) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2015.03.013 · Cited by 1,570

Role of oxidative stress in cardiovascular diseases

Dhalla, N. S., Temsah, R. M., & Netticadan, T. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018060-00002 · Cited by 1,467

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., Sisodia, S. S., Rothstein, J. D., Borchelt, D. R., Price, D. L., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80272-x · Cited by 1,341

Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer: The Women’s Health Study: A Randomized Controlled Trial

Lee, I.-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.1.56 · Cited by 1,137

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176.pub2 · Cited by 924

Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis.

Pérez-Carreras, M., Del Hoyo, P., Martín, M. A., Rubio, J. C., Martín, A., Castellano, G., Colina, F., Arenas, J., & Solis-Herruzo, J. A. (2003) · Hepatology · doi:10.1002/hep.1840380426 · Cited by 734

The Potential Benefits of Red Beetroot Supplementation in Health and Disease

Clifford, T., Howatson, G., West, D., & Stevenson, E. (2015) · Nutrients · doi:10.3390/nu7042801 · Cited by 635

Absorption, metabolism and health effects of dietary flavonoids in man

Hollman, P., & Katan, M. (1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)88045-6 · Cited by 609

Antioxidant Therapy in Acute Central Nervous System Injury: Current State

Gilgun-Sherki, Y., Rosenbaum, Z., Melamed, E., & Offen, D. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.271 · Cited by 568

Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas

Reiter, R. J., Rosales-Corral, S., Tan, D. X., Jou, M. J., Galano, A., & Xu, B. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2609-7 · Cited by 558

Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant ?-lipoic acid: A 3-week multicentre randomized controlled trial (ALADIN Study)

Ziegler, D., Hanefeld, M., Ruhnau, K. J., Mei\ner, H. P., Lobisch, M., Sch�tte, K., Gries, F. A., & The ALADIN Study Group (1995) · Diabetologia · doi:10.1007/bf00400603 · Cited by 525

Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial

Bedaiwy, M. A. (2002) · Human Reproduction · doi:10.1093/humrep/17.2.426 · Cited by 485

Oxidative and nitrosative events in asthma

Andreadis, A. A., Hazen, S. L., Comhair, S. A. A., & Erzurum, S. C. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00278-8 · Cited by 327

Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis

Salonen, J. T., Nyyssönen, K., Salonen, R., Lakka, H. ‐., Kaikkonen, J., Porkkala‐Sarataho, E., Voutilainen, S., Lakka, T. A., Rissanen, T., Leskinen, L., et al. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00752.x · Cited by 327

Domestic Violence and Chronic Malnutrition among Women and Children in India

Ackerson, L. K., & Subramanian, S. V. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn049 · Cited by 299

Oxidative stress of the newborn in the pre‐ and postnatal period and the clinical utility of melatonin

Gitto, E., Pellegrino, S., Gitto, P., Barberi, I., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00649.x · Cited by 291

Oxidative stress may be a piece in the endometriosis puzzle.

Szczepańska, M., Koźlik, J., Skrzypczak, J., & Mikołajczyk, M. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00266-8 · Cited by 269

Role of oxidative stress in endometriosis

Gupta, S., Agarwal, A., Krajcir, N., & Alvarez, J. G. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)62026-3 · Cited by 240

Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease

Foy, C. J. (1999) · QJM · doi:10.1093/qjmed/92.1.39 · Cited by 235

Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases

Raposo, M., De Morais, A., & De Morais, R. (2015) · Marine Drugs · doi:10.3390/md13085128 · Cited by 228

Anti-Alzheimer’s Studies on β-Sitosterol Isolated from Polygonum hydropiper L.

Ayaz, M., Junaid, M., Ullah, F., Subhan, F., Sadiq, A., Ali, G., Ovais, M., Shahid, M., Ahmad, A., Wadood, A., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00697 · Cited by 220

Antioxidant Activity and Hepatoprotective Effects of Whey Protein and Spirulina in Rats

Gad, A. S., Khadrawy, Y. A., El-Nekeety, A. A., Mohamed, S. R., Hassan, N. S., & Abdel-Wahhab, M. A. (2011) · Nutrition · doi:10.1016/j.nut.2010.04.002 · Cited by 218

Oxidative Stress in Hypertension

de Champlain, J., Wu, R., Girouard, H., Karas, M., EL Midaoui, A., Laplante, M., & Wu, L. (2004) · Clinical and Experimental Hypertension · doi:10.1081/ceh-200031904 · Cited by 208

Antioxidant Vitamins and Trace Elements in Critical Illness

Koekkoek, W. A. C. (., & van Zanten, A. R. H. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616653832 · Cited by 203

In Vitro Methods of Assay of Antioxidants: An Overview

Singh, S., & Singh, R. P. (2008) · Food Reviews International · doi:10.1080/87559120802304269 · Cited by 182

Immune dysregulation in the aging human lung

Meyer, K. C., Ershler, W., Rosenthal, N. S., Lu, X. G., & Peterson, K. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630547 · Cited by 173

Seminal malondialdehyde concentration but not glutathione peroxidase activity is negatively correlated with seminal concentration and motility

Hsieh, Y.-Y., Chang, C.-C., & Lin, C.-S. (2006) · International Journal of Biological Sciences · doi:10.7150/ijbs.2.23 · Cited by 167

Alcohol Intake and Renal Cell Cancer in a Pooled Analysis of 12 Prospective Studies

Lee, J. E., Hunter, D. J., Spiegelman, D., Adami, H.-O., Albanes, D., Bernstein, L., van den Brandt, P. A., Buring, J. E., Cho, E., Folsom, A. R., et al. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djk181 · Cited by 126

Oxidative Stress in Critical Care

OLDHAM, K. M., & BOWEN, P. E. (1998) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(98)00230-2 · Cited by 125

Oxidative Stress, Glucose Metabolism, and the Prevention of Type 2 Diabetes: Pathophysiological Insights

Shah, S., Iqbal, M., Karam, J., Salifu, M., & McFarlane, S. I. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1629 · Cited by 115

Possible role for apple juice phenolic compounds in the acute modification of glucose tolerance and gastrointestinal hormone secretion in humans

Johnston, K. L., Clifford, M. N., & Morgan, L. M. (2002) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.1264 · Cited by 109

Plasmalogen phospholipids protect internodal myelin from oxidative damage

Luoma, A. M., Kuo, F., Cakici, O., Crowther, M. N., Denninger, A. R., Avila, R. L., Brites, P., & Kirschner, D. A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.012 · Cited by 97

A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates

Brand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95

Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older women

Wang, L., Gaziano, J. M., Norkus, E. P., Buring, J. E., & Sesso, H. D. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.3.747 · Cited by 93

Protective effect of sea cucumber (Acaudina molpadioides) fucoidan against ethanol-induced gastric damage

Wang, Y., Su, W., Zhang, C., Xue, C., Chang, Y., Wu, X., Tang, Q., & Wang, J. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.02.028 · Cited by 92

Garlic increases antioxidant levels in diabetic and hypertensive rats determined by a modified peroxidase method

Drobiova, H., Thomson, M., Al-Qattan, K., Peltonen-Shalaby, R., Al-Amin, Z., & Ali, M. (2011) · Evidence-Based Complementary and Alternative Medicine · doi:10.1093/ecam/nep011 · Cited by 91

Enhanced markers of oxidative stress, altered antioxidants and NADPH-oxidase activation in brains from fragile X mental retardation 1-deficient mice, a pathological model for fragile X syndrome

El Bekay, R., Romero‐Zerbo, Y., Decara, J., Sanchez‐Salido, L., Del Arco‐Herrera, I., Rodríguez‐de Fonseca, F., & De Diego‐Otero, Y. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05939.x · Cited by 85

Influence of second-hand smoke and prenatal tobacco smoke exposure on biomarkers, genetics and physiological processes in children-an overview in research insights of the last few years

Braun, M., Klingelhöfer, D., Oremek, G. M., Quarcoo, D., & Groneberg, D. A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17093212 · Cited by 64

OXIDATIVE STRESS AND THE PATHOGENESIS OF HEART FAILURE

Ball, A. M. M., & Sole, M. J. (1998) · Cardiology Clinics · doi:10.1016/s0733-8651(05)70043-6 · Cited by 53

Reactive oxygen species are required for zoledronic acid-induced apoptosis in osteoclast precursors and mature osteoclast-like cells

Tai, T.-W., Chen, C.-Y., Su, F.-C., Tu, Y.-K., Tsai, T.-T., Lin, C.-F., & Jou, I.-M. (2017) · Scientific Reports · doi:10.1038/srep44245 · Cited by 51

Effect of the antioxidant action of Ginkgo biloba extract (EGb 761) on aging and oxidative stress

Droy-Lefaix, M. T. (1997) · AGE · doi:10.1007/s11357-997-0013-1 · Cited by 49

Quartz Exposure of the Rat Lung Leads to a Linear Dose Response in Inflammation but Not in Oxidative DNA Damage and Mutagenicity

Seiler, F., Rehn, B., Rehn, S., Hermann, M., & Bruch, J. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.4.4181 · Cited by 41

Phytochemistry, Pharmacology and Toxicity of Medicinal Plants

Tariq, L., Bhat, B. A., Hamdani, S. S., & Mir, R. A. (2021) · Medicinal and Aromatic Plants · doi:10.1007/978-3-030-58975-2_8 · Cited by 38

Analysis of Hexanal and Heptanal in Human Blood by Simultaneous Derivatization and Dispersive Liquid–Liquid Microextraction then LC–APCI–MS–MS

Xu, H., Song, D., Cui, Y., Hu, S., Yu, Q.-W., & Feng, Y.-Q. (2009) · Chromatographia · doi:10.1365/s10337-009-1208-7 · Cited by 37

Taxifolin Shows Anticataractogenesis and Attenuates Diabetic Retinopathy in STZ-Diabetic Rats via Suppression of Aldose Reductase, Oxidative Stress, and MAPK Signaling Pathway

Liu, F., Ma, Y., & Xu, Y. (2020) · Endocrine, Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666191018122821 · Cited by 26