Functional recordings from awake, behaving rodents through a microchannel based regenerative neural interface
Open accessAbstract
OBJECTIVE: Neural interface technologies could provide controlling connections between the nervous system and external technologies, such as limb prosthetics. The recording of efferent, motor potentials is a critical requirement for a peripheral neural interface, as these signals represent the user-generated neural output intended to drive external devices. Our objective was to evaluate structural and functional neural regeneration through a microchannel neural interface and to characterize potentials recorded from electrodes placed within the microchannels in awake and behaving animals. APPROACH: Female rats were implanted with muscle EMG electrodes and, following unilateral sciatic nerve transection, the cut nerve was repaired either across a microchannel neural interface or with end-to-end surgical repair. During a 13 week recovery period, direct muscle responses to nerve stimulation proximal to the transection were monitored weekly. In two rats repaired with the neural interface, four wire electrodes were embedded in the microchannels and recordings were obtained within microchannels during proximal stimulation experiments and treadmill locomotion. MAIN RESULTS: In these proof-of-principle experiments, we found that axons from cut nerves were capable of functional reinnervation of distal muscle targets, whether regenerating through a microchannel device or after direct end-to-end repair. Discrete stimulation-evoked and volitional potentials were recorded within interface microchannels in a small group of awake and behaving animals and their firing patterns correlated directly with intramuscular recordings during locomotion. Of 38 potentials extracted, 19 were identified as motor axons reinnervating tibialis anterior or soleus muscles using spike triggered averaging. SIGNIFICANCE: These results are evidence for motor axon regeneration through microchannels and are the first report of in vivo recordings from regenerated motor axons within microchannels in a small group of awake and behaving animals. These unique findings provide preliminary evidence that efferent, volitional motor potentials can be recorded from the microchannel-based peripheral neural interface; a critical requirement for any neural interface intended to facilitate direct neural control of external technologies.
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Studies have achieved long-term recordings in freely moving animals using microchannel devices for periods 4 months post-implantation, while only small signals in response to electrical stimulation have been recorded at such chronic timepoint with sieve electrodes.
“Studies have achieved long-term recordings in freely moving animals using microchannel devices for periods 4 months post-implantation (Gore et al., 2015), while only small signals in response to electrical stimulation have been recorded at such chronic timepoint with sieve electrodes (Ramachandran et al., 2006).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Gore et al., 2015
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Improving Suturing Skills for Surgical Residents and Advancing Prosthesis Control for Amputees.
Ursu, D. C. (2016) · Deep Blue (University of Michigan)
- Authors
- Gore, R. K., Choi, Y., Bellamkonda, R., & English, A.
- Affiliations
- Georgia Institute of Technology (US)
- The University of Texas System (US)
- Emory University (US)
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2015-01-21
- Volume
- 12
- Issue
- 1
- Pages
- 016017
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- PMC
- PMC4324563
- OpenAlex
- W2009867546
- Cited by
- 26
- References
- 48
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 3
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NS065109 (RVB))
- National Institute of Neurological Disorders and Stroke (R25 (RKG))
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- motor axon regeneration, sciatic nerve transection, treadmill locomotion, tibialis anterior, soleus muscle, spike-triggered averaging, functional reinnervation, artificial limbs
- MeSH terms
- Action Potentials, Animals, Electrodes, Implanted, Female, Nerve Regeneration, Neural Conduction, Prosthesis Design, Rats, Inbred Lew, Sensitivity and Specificity, Reproducibility of Results, Monitoring, Ambulatory, Equipment Failure Analysis, Guided Tissue Regeneration, Rats, Tissue Scaffolds
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