Design,in vitro and in vivo assessment of a multi-channel sieve electrode with integrated multiplexer
Abstract
This paper reports on the design, in vitro and in vivo investigation of a flexible, lightweight, polyimide based implantable sieve electrode with a hybrid assembly of multiplexers and polymer encapsulation. The integration of multiplexers enables us to connect a large number of electrodes on the sieve using few input connections. The implant assembly of the sieve electrode with the electronic circuitry was verified by impedance measurement. The 27 platinum electrodes of the sieve were coated with platinum black to reduce the electrode impedance. The impedance magnitude of the electrode sites on the sieve (geometric surface area 2,200 microm(2)) was |Z(f=1kHz)| = 5.7 kOmega. The sieve electrodes, encased in silicone, have been implanted in the transected sciatic nerve of rats. Initial experiments showed that axons regenerated through the holes of the sieve and reinnervated distal target organs. Nerve signals were recorded in preliminary tests after 3-7 months post-implantation.
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Silicon sieves were observed to lead to extensive axon death after implantation and were replaced by more flexible materials such as polyimide in later designs.
“Silicon sieves were observed to lead to extensive axon death after implantation and were replaced by more flexible materials such as polyimide in later designs (Shimatani et al., 2003; Ramachandran et al., 2006).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Ramachandran et al., 2006
Sieve electrodes implanted into regenerating nerves in rodent models have been successfully used to record gustatory and sensorimotor signals weeks after implantation.
“Sieve electrodes implanted into regenerating nerves in rodent models have been successfully used to record gustatory (Shimatani et al., 2003) as well as sensorimotor (Ramachandran et al., 2006) signals weeks after implantation.”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Ramachandran et al., 2006
Studies have achieved long-term recordings in freely moving animals using microchannel devices for periods 4 months post-implantation, while only small signals in response to electrical stimulation have been recorded at such chronic timepoint with sieve electrodes.
“Studies have achieved long-term recordings in freely moving animals using microchannel devices for periods 4 months post-implantation (Gore et al., 2015), while only small signals in response to electrical stimulation have been recorded at such chronic timepoint with sieve electrodes (Ramachandran et al., 2006).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Ramachandran et al., 2006
Cites
Navarro, X., Krueger, T. B., Lago, N., Micera, S., Stieglitz, T., & Dario, P. (2005) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2005.10303.x · Cited by 845 · see citing works
Self-citationMicromachined, Polyimide-Based Devices for Flexible Neural Interfaces
Stieglitz, T., Beutel, H., Schuettler, M., & Meyer, J.-U. (2000) · Biomedical Microdevices · doi:10.1023/a:1009955222114 · Cited by 343 · see citing works
Self-citationLago, N., Ceballos, D., J Rodrı́guez, F., Stieglitz, T., & Navarro, X. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.06.025 · Cited by 178 · see citing works
Self-citationEdell, D. J. (1986) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1986.325892 · Cited by 177 · see citing works
Regeneration microelectrode array for peripheral nerve recording and stimulation
Kovacs, G. T. A., Storment, C. W., & Rosen, J. M. (1992) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.256422 · Cited by 164 · see citing works
High density interconnects and flexible hybrid assemblies for active biomedical implants
Meyer, J.-U., Stieglitz, T., Scholz, O., Haberer, W., & Beutel, H. (2001) · IEEE Transactions on Advanced Packaging · doi:10.1109/6040.938305 · Cited by 145 · see citing works
Self-citationA micromachined silicon sieve electrode for nerve regeneration applications
Akin, T., Najafi, K., Smoke, R. H., & Bradley, R. M. (1994) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.284958 · Cited by 144 · see citing works
Stieglitz, T., Beutel, H., & Meyer, J.-U. (1997) · Sensors and Actuators A: Physical · doi:10.1016/s0924-4247(97)01494-5 · Cited by 125 · see citing works
Self-citation(1998) · PubMed · Cited by 107 · see citing works
Riso, R. R. (1999) · Technology and Health Care · doi:10.3233/thc-1999-7604 · Cited by 98 · see citing works
Preparation of strongly adherent platinum black coatings
Marrese, C. A. (1987) · Analytical Chemistry · doi:10.1021/ac00128a049 · Cited by 96 · see citing works
Struijk, J. J. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78890-8 · Cited by 93 · see citing works
Stieglitz, T., Ruf, H. H., Gross, M., Schüettler, M., & Meyer, J.-U. (2002) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(02)00019-2 · Cited by 77 · see citing works
Self-citationLong term chronic recordings from peripheral sensory fibers using a sieve electrode array
Bradley, R. M., Cao, X., Akin, T., & Najafi, K. (1997) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(97)02225-5 · Cited by 69 · see citing works
Klinge, P. M., Vafa, M. A., Brinker, T., Brandis, A., Walter, G. F., Stieglitz, T., Samii, M., & Wewetzer, K. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00420-8 · Cited by 64 · see citing works
Self-citationGómez, N., Cuadras, J., Butı́, M., & Navarro, X. (1996) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-1996-10401 · Cited by 62 · see citing works
Self-citationCeballos, D., Valero‐Cabré, A., Valderrama, E., Schüttler, M., Stieglitz, T., & Navarro, X. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.10099 · Cited by 61 · see citing works
Self-citationLago, N., & Navarro, X. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.227 · Cited by 57 · see citing works
Self-citationNegredo, P., Castro, J. E., Lago, N., Navarro, X., & Avendaño, C. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.017 · Cited by 55 · see citing works
Self-citationWallman, L. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00342-2 · Cited by 49 · see citing works
Peripheral nerve regeneration through microelectrode arrays based on silicon technology
Navarro, X., Calvet, S., Butí, M., Gómez, N., Cabruja, E., Garrido, P., Villa, R., & Valderrama, E. (1996) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-1996-9303 · Cited by 46 · see citing works
Self-citationWallman, L., Levinsson, A., Schouenborg, J., Holmberg, H., Danielsen, N., & Laurell, T. (1999) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.784137 · Cited by 29 · see citing works
Flexible, polyimide-based neural interfaces
Stieglitz, T., Beutel, H., Keller, R., Schüettler, M., & Meyer, J.-U. (1999) · International Conference on Microelectronics for Neural, Fuzzy and Bio-Inspired Systems (MicroNeuro) · doi:10.1109/mn.1999.758853 · Cited by 20 · see citing works
Self-citationInterfacing regenerating peripheral nerves with a micromachined polyimide sieve electrode
Stieglitz, T., Navarro, X., Calvet, S., Blau, C., & Meyer, J.-U. (1996) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.1996.656995 · Cited by 20 · see citing works
Self-citationMultichannel neural cuff electrodes with integrated multiplexer circuit
Schüettler, M., Koch, K. P., Stieglitz, T., Scholz, O., Haberer, W., Keller, R., & Meyer, J.-U. (2000) · International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology (MMB) · doi:10.1109/mmb.2000.893861 · Cited by 15 · see citing works
Self-citationWorld Congress on Medical Physics and Biomedical Engineering
Sakuma, I. (2000) · BME · doi:10.11239/jsmbe1987.14.10_69 · Cited by 14 · see citing works
Stieglitz, T., Rosahl, S. K., Poessnecker, J., Haastert‐Talini, K., Brinker, T., & Meyer, J.-U. (2002) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2002.1053165 · Cited by 1 · see citing works
Self-citation
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Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics
Carnicer-Lombarte, A., Chen, S.-T., Malliaras, G. G., & Barone, D. G. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.622524 · Cited by 454 · see citing works
“Silicon sieves were observed to lead to extensive axon death after implantation and were replaced by more flexible materials such as polyimide in later designs (Shimatani et al., 2003; Ramachandran et al., 2006).”
BackgroundMethodInfluentialA review for the peripheral nerve interface designer
Larson, C. E., & Meng, E. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108523 · Cited by 133 · see citing works
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Chew, D. J., Zhu, L., Delivopoulos, E., Minev, I. R., Musick, K. M., Mosse, C. A., Craggs, M., Donaldson, N., Lacour, S. P., McMahon, S. B., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007186 · Cited by 123 · see citing works
Tissue-engineered peripheral nerve interfaces
Spearman, B. S., Desai, V. H., Mobini, S., McDermott, M. D., Graham, J. B., Otto, K. J., Judy, J. W., & Schmidt, C. E. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201701713 · Cited by 96 · see citing works
Long Micro-Channel Electrode Arrays: A Novel Type of Regenerative Peripheral Nerve Interface
Lacour, S. P., Fitzgerald, J. J., Lago, N., Tarte, E., McMahon, S., & Fawcett, J. (2009) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2009.2031241 · Cited by 75 · see citing works
Self-citationMicrochannels as Axonal Amplifiers
FitzGerald, J. J., Lacour, S. P., McMahon, S. B., & Fawcett, J. W. (2008) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2007.909533 · Cited by 76 · see citing works
FitzGerald, J. J., Lago, N., Benmerah, S., Serra, J., Watling, C. P., Cameron, R. E., Tarte, E., Lacour, S. P., McMahon, S. B., & Fawcett, J. W. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/1/016010 · Cited by 73 · see citing works
Self-citationLago, N., Udina, E., Ramachandran, A., & Navarro, X. (2007) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2007.891168 · Cited by 68 · see citing works
Self-citationDelivopoulos, E., Chew, D. J., Minev, I. R., Fawcett, J. W., & Lacour, S. P. (2012) · Lab on a Chip · doi:10.1039/c2lc21277c · Cited by 68 · see citing works
Microchannel-based regenerative scaffold for chronic peripheral nerve interfacing in amputees
Srinivasan, A., Tahilramani, M., Bentley, J. T., Gore, R. K., Millard, D. C., Mukhatyar, V. J., Joseph, A., Haque, A. S., Stanley, G. B., English, A. W., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.11.035 · Cited by 67 · see citing works
Compliant peripheral nerve interfaces.
Paggi, V., Akouissi, O., Micera, S., & Lacour, S. P. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abcdbe · Cited by 60 · see citing works
“To increase the number of addressable electrodes for recording and stimulation, sieves have been also integrated with analog multiplexers [122].”
BackgroundPolymeric C-shaped cuff electrode for recording of peripheral nerve signal
Xue, N., Sun, T., Tsang, W. M., Delgado-Martinez, I., Lee, S.-H., Sheshadri, S., Xiang, Z., Merugu, S., Gu, Y., Yen, S.-C., et al. (2015) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2015.01.006 · Cited by 48 · see citing works
Material considerations for peripheral nerve interfacing
Kim, Y.-T., & Romero-Ortega, M. I. (2012) · MRS Bulletin · doi:10.1557/mrs.2012.99 · Cited by 47 · see citing works
Gore, R. K., Choi, Y., Bellamkonda, R., & English, A. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/1/016017 · Cited by 26 · see citing works
Stoyanova, I. I., van Wezel, R. J. A., & Rutten, W. L. C. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/6/066018 · Cited by 18 · see citing works
Jeong, J., Jung, W., Kim, O., Chu, J.-U., Youn, I., Kim, K., Oh, S. R., Park, J. W., & Kim, J. (2016) · 2016 6th IEEE International Conference on Biomedical Robotics and Biomechatronics (BioRob) · doi:10.1109/biorob.2016.7523786 · Cited by 14 · see citing works
Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review
Habibollahi, M., Jiang, D., Lancashire, H. T., & Demosthenous, A. (2024) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2024.3430038 · Cited by 11 · see citing works
“An external tube may be used to provide mechanical support, join multiple sieves, or enhance performance, such as the cuff and sieve electrode (CASE), as a hybrid method [31].”
- Authors
- Ramachandran, A., Schuettler, M., Lago, N., Doerge, T., Koch, K. P., Navarro, X., Hoffmann, K.-P., & Stieglitz, T.
- Affiliations
- Fraunhofer Institute for Biomedical Engineering (DE)
- Universitat Autònoma de Barcelona (ES)
- University of Freiburg (DE)
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2006-04-18
- Volume
- 3
- Issue
- 2
- Pages
- 114-124
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- OpenAlex
- W2066044990
- Cited by
- 46
- References
- 27
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- implanted electrodes, multiplexer, polyimide, electrode impedance, sciatic nerve transection, nerve regeneration, axon reinnervation, peripheral nerve recording, silicone encapsulation, flexible electronics
- MeSH terms
- Action Potentials, Animals, Electric Stimulation, Electrodes, Implanted, Equipment Design, Microelectrodes, Sciatic Nerve, Signal Processing, Computer-Assisted, Rats, Sprague-Dawley, Systems Integration, Equipment Failure Analysis, Rats
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